Effect of severe renal impairment on pharmacokinetics, safety, and tolerability of lemborexant - Landry, Ishani; Aluri, Jagadeesh; Hall, Nancy; Filippov, Gleb; Dayal, Satish; Moline, Margaret; Reyderman, Larisa (Pharmacology research & perspectives, 2021)
Keywords: Adolescent; Adult; Aged; Area Under Curve; Body mass index; Chromatography; chronic kidney disease; clinical pharmacology; Drug dosages; drug safety; Female; Glomerular Filtration Rate - physiology; Glycoproteins; Half-Life; Humans; Insomnia; lemborexant; Male; Metabolism; Metabolites; Middle Aged; Orexin Receptor Antagonists - administration & dosage; Orexin Receptor Antagonists - adverse effects; Orexin Receptor Antagonists - pharmacokinetics; Original; Pharmacokinetics; Pharmacology; phase 1; Plasma; Proteins; Pyridines - administration & dosage; Pyridines - adverse effects; Pyridines - pharmacokinetics; Pyrimidines - administration & dosage; Pyrimidines - adverse effects; Pyrimidines - pharmacokinetics; Renal Elimination - physiology; renal impairment; Renal Insufficiency - diagnosis; Renal Insufficiency - metabolism; Renal Insufficiency - physiopathology; Severity of Illness Index; Sleep; Sleep Initiation and Maintenance Disorders - drug therapy; Urine; Young Adult; United States--US; Japan; chronic kidney disease; phase 1; drug safety; pharmacokinetics; clinical pharmacology; lemborexant; renal impairment