Serum Insulin-like growth factor-1 levels of healthy adults in southern China
It is to establish the normal range and investigate the distribution characteristics of serum Insulin-like growth factor-1 (IGF-1) for healthy adults in southern China. IGF-1 levels of 515 healthy adults (254 males and 261 females) were measured by automated chemiluminescence immunoassay. The subjec...
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| Published in | ENDOCRINE JOURNAL Vol. 63; no. 12; pp. 1081 - 1086 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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Japan
The Japan Endocrine Society
2016
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| ISSN | 0918-8959 1348-4540 1348-4540 |
| DOI | 10.1507/endocrj.EJ16-0144 |
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| Abstract | It is to establish the normal range and investigate the distribution characteristics of serum Insulin-like growth factor-1 (IGF-1) for healthy adults in southern China. IGF-1 levels of 515 healthy adults (254 males and 261 females) were measured by automated chemiluminescence immunoassay. The subjects were strictly selected healthy volunteers, aged 20 to 84 years old, with equal five year intervals and without abnormal conditions that impacted IGF-1 levels. The reference ranges were calculated using the smooth centile curves of the LMS method (L: coefficient of skewness, M: median, S: coefficient of variation). IGF-1 declined with aging in adults. There were statistically significant differences for the IGF-1 levels between men and women in some subgroups of age. Gender differences varied depending on the age. Middle-aged females had higher IGF-1 whilst elder females had lower IGF-1. The statistical differences were seen in three subgroups of age between this study and a German cohort that is the reference range for the laboratory test kit. Here, the age- and gender-specific normal range was established for Chinese adults. A Z Score of IGF-1 for an individual could be obtained via the LMSchartmaker application, which standardized IGF-1 research worldwide. |
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| AbstractList | It is to establish the normal range and investigate the distribution characteristics of serum Insulin-like growth factor-1 (IGF-1) for healthy adults in southern China. IGF-1 levels of 515 healthy adults (254 males and 261 females) were measured by automated chemiluminescence immunoassay. The subjects were strictly selected healthy volunteers, aged 20 to 84 years old, with equal five year intervals and without abnormal conditions that impacted IGF-1 levels. The reference ranges were calculated using the smooth centile curves of the LMS method (L: coefficient of skewness, M: median, S: coefficient of variation). IGF-1 declined with aging in adults. There were statistically significant differences for the IGF-1 levels between men and women in some subgroups of age. Gender differences varied depending on the age. Middle-aged females had higher IGF-1 whilst elder females had lower IGF-1. The statistical differences were seen in three subgroups of age between this study and a German cohort that is the reference range for the laboratory test kit. Here, the age- and gender-specific normal range was established for Chinese adults. A Z Score of IGF-1 for an individual could be obtained via the LMSchartmaker application, which standardized IGF-1 research worldwide. Abstract. It is to establish the normal range and investigate the distribution characteristics of serum Insulin-like growth factor-1 (IGF-1) for healthy adults in southern China. IGF-1 levels of 515 healthy adults (254 males and 261 females) were measured by automated chemiluminescence immunoassay. The subjects were strictly selected healthy volunteers, aged 20 to 84 years old, with equal five year intervals and without abnormal conditions that impacted IGF-1 levels. The reference ranges were calculated using the smooth centile curves of the LMS method (L : coefficient of skewness, M : median, S : coefficient of variation). IGF-1 declined with aging in adults. There were statistically significant differences for the IGF-1 levels between men and women in some subgroups of age. Gender differences varied depending on the age. Middle-aged females had higher IGF-1 whilst elder females had lower IGF-1. The statistical differences were seen in three subgroups of age between this study and a German cohort that is the reference range for the laboratory test kit. Here, the age- and gender-specific normal range was established for Chinese adults. AZ Score of IGF-1 for an individual could be obtained via the LMSchartmaker application, which standardized IGF-1 research worldwide. |
| Author | Li, Yan-bing Liao, Zhi-hong Yin, Qi-qi Ji, Wen Wan, Jian-xin He, Wei Zhang, Lu-yao |
| Author_xml | – sequence: 1 fullname: Ji, Wen organization: Endocrinology Department, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, P.R. China – sequence: 1 fullname: Li, Yan-bing organization: Endocrinology Department, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, P.R. China – sequence: 1 fullname: Zhang, Lu-yao organization: Endocrinology Department, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, P.R. China – sequence: 1 fullname: Wan, Jian-xin organization: Central Laboratory, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, P.R. China – sequence: 1 fullname: He, Wei organization: Endocrinology Department, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, P.R. China – sequence: 1 fullname: Liao, Zhi-hong organization: Endocrinology Department, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, P.R. China – sequence: 1 fullname: Yin, Qi-qi organization: Endocrinology Department, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, P.R. China |
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| Cites_doi | 10.1590/S0004-27302010000500008 10.1159/000071871 10.1210/jc.2014-2700 10.1016/j.clinbiochem.2007.06.004 10.1210/jc.85.2.526 10.1507/endocrj.EJ12-0110 10.1016/j.ghir.2008.08.005 10.1007/s11102-007-0035-9 10.1016/j.ghir.2012.04.005 10.1530/eje.1.02131 10.1530/EJE-09-0247 10.1007/BF03346389 10.1515/CCLM.2004.112 10.1002/sim.4780111005 |
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| References | 3. Giustina A, Barkan A, Casanueva FF, Cavagnini F, Frohman L, et al. (2000) Criteria for cure of acromegaly: a consensus statement. J Clin Endocrinol Metab 85: 526-529. 12. Schneider HJ, Saller B, Klotsche J, Marz W, Erwa W, et al. (2006) Opposite associations of age-dependent insulin-like growth factor-I standard deviation scores with nutritional state in normal weight and obese subjects. Eur J Endocrinol 154: 699-706. 8. Isojima T, Shimatsu A, Yokoya S, Chihara K, Tanaka T, et al. (2012) Standardized centile curves and reference intervals of serum insulin-like growth factor-I (IGF-I) levels in a normal Japanese population using the LMS method. Endocr J 59: 771-780. 4. Aimaretti G, Boschetti M, Corneli G, Gasco V, Valle D, et al. (2008) Normal age-dependent values of serum insulin growth factor-I: Results from a healthy Italian population. J Endocrinol Invest 31: 445-449. 11. Brabant G, Wallaschofski H (2007) Normal levels of serum IGF-I: determinants and validity of current reference ranges. Pituitary 10: 129-133. 16. Brabant G, von zur Mühlen A, Wüster C, Ranke MB, Kratzsch J, et al. (2003) Serum Insulin-Like Growth Factor I Reference Values for an Automated Chemiluminescence Immunoassay System: Results from a Multicenter Study. Horm Res 60: 53-60. 1. Katznelson L, Laws ER Jr, Melmed S, Molitch ME, Murad MH, et al. (2014) Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 99: 3933-3951. 15. Tiryakioglu Ö, Kadiolgu P, Canerolgu NÜ, Hatemi H (2003) Age dependency of serum insulin like growth factor (IGF)-1 in healthy Turkish adolescents and adults. Indian J Med Sci 57: 543-548. 6. Plengpanich W, Mangkala J, Buranasukajorn P, Boonruang K, Sunthornyothin S, et al. (2008) Normal Reference Range of Serum Insulin-Like Growth Factor (IGF)-I in Healthy Thai Adults. J Med Assoc Thai 91: 1681-1684. 5. Elmlinger MW, Kuhnel W, Weber MM, Ranke MB (2004) Reference ranges for two automated chemiluminescent assays for serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3). Clin Chem Lab Med 42: 654-664. 10. Mukherjee A, Shalet SM (2010) The value of IGF1 estimation in adults with GH deficiency. Eur J Endocrinol 161: S33-S39. 2. Berrigan D, Potischman N, Dodd KW, Hursting SD, Lavigne J, et al. (2009) Race/ethnic variation in serum levels of IGF-I and IGFBP-3 in US adults. Growth Horm IGF Res 19: 146-155. 7. Rosario PW (2010) Normal values of serum IGF-1 in adults: results from a Brazilian population. Arq Bras Endocrinol Metabol 54: 477-481. 14. Kong AP, Wong GW, Choi KC, Ho CS, Chan MH, et al. (2007) Reference values for serum levels of insulin-like growth factor (IGF-1) and IGF-binding protein 3 (IGFBP-3) and their ratio in Chinese adolescents. Clin Biochem 40: 1093-1099. 13. Bedogni G, Giannone G, Maghnie M, Giacomozzi C, Di Iorgi N, et al. (2012) Serum insulin-like growth factor-I (IGF-I) reference ranges for chemiluminescence assay in childhood and adolescence. Data from a population of in- and out-patients. Growth Horm IGF Res 22: 134-138. 9. Cole TJ, Green PJ (1992) Smoothing reference centile curves: the LMS method and penalized likelihood. Stat Med 11: 1305-1319. 11 12 13 14 15 16 1 2 3 4 5 6 7 8 9 10 |
| References_xml | – reference: 6. Plengpanich W, Mangkala J, Buranasukajorn P, Boonruang K, Sunthornyothin S, et al. (2008) Normal Reference Range of Serum Insulin-Like Growth Factor (IGF)-I in Healthy Thai Adults. J Med Assoc Thai 91: 1681-1684. – reference: 12. Schneider HJ, Saller B, Klotsche J, Marz W, Erwa W, et al. (2006) Opposite associations of age-dependent insulin-like growth factor-I standard deviation scores with nutritional state in normal weight and obese subjects. Eur J Endocrinol 154: 699-706. – reference: 16. Brabant G, von zur Mühlen A, Wüster C, Ranke MB, Kratzsch J, et al. (2003) Serum Insulin-Like Growth Factor I Reference Values for an Automated Chemiluminescence Immunoassay System: Results from a Multicenter Study. Horm Res 60: 53-60. – reference: 15. Tiryakioglu Ö, Kadiolgu P, Canerolgu NÜ, Hatemi H (2003) Age dependency of serum insulin like growth factor (IGF)-1 in healthy Turkish adolescents and adults. Indian J Med Sci 57: 543-548. – reference: 5. Elmlinger MW, Kuhnel W, Weber MM, Ranke MB (2004) Reference ranges for two automated chemiluminescent assays for serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3). Clin Chem Lab Med 42: 654-664. – reference: 13. Bedogni G, Giannone G, Maghnie M, Giacomozzi C, Di Iorgi N, et al. (2012) Serum insulin-like growth factor-I (IGF-I) reference ranges for chemiluminescence assay in childhood and adolescence. Data from a population of in- and out-patients. Growth Horm IGF Res 22: 134-138. – reference: 9. Cole TJ, Green PJ (1992) Smoothing reference centile curves: the LMS method and penalized likelihood. Stat Med 11: 1305-1319. – reference: 14. Kong AP, Wong GW, Choi KC, Ho CS, Chan MH, et al. (2007) Reference values for serum levels of insulin-like growth factor (IGF-1) and IGF-binding protein 3 (IGFBP-3) and their ratio in Chinese adolescents. Clin Biochem 40: 1093-1099. – reference: 3. Giustina A, Barkan A, Casanueva FF, Cavagnini F, Frohman L, et al. (2000) Criteria for cure of acromegaly: a consensus statement. J Clin Endocrinol Metab 85: 526-529. – reference: 11. Brabant G, Wallaschofski H (2007) Normal levels of serum IGF-I: determinants and validity of current reference ranges. Pituitary 10: 129-133. – reference: 4. Aimaretti G, Boschetti M, Corneli G, Gasco V, Valle D, et al. (2008) Normal age-dependent values of serum insulin growth factor-I: Results from a healthy Italian population. J Endocrinol Invest 31: 445-449. – reference: 7. Rosario PW (2010) Normal values of serum IGF-1 in adults: results from a Brazilian population. Arq Bras Endocrinol Metabol 54: 477-481. – reference: 1. Katznelson L, Laws ER Jr, Melmed S, Molitch ME, Murad MH, et al. (2014) Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 99: 3933-3951. – reference: 2. Berrigan D, Potischman N, Dodd KW, Hursting SD, Lavigne J, et al. (2009) Race/ethnic variation in serum levels of IGF-I and IGFBP-3 in US adults. Growth Horm IGF Res 19: 146-155. – reference: 10. Mukherjee A, Shalet SM (2010) The value of IGF1 estimation in adults with GH deficiency. Eur J Endocrinol 161: S33-S39. – reference: 8. Isojima T, Shimatsu A, Yokoya S, Chihara K, Tanaka T, et al. (2012) Standardized centile curves and reference intervals of serum insulin-like growth factor-I (IGF-I) levels in a normal Japanese population using the LMS method. Endocr J 59: 771-780. – ident: 7 doi: 10.1590/S0004-27302010000500008 – ident: 16 doi: 10.1159/000071871 – ident: 1 doi: 10.1210/jc.2014-2700 – ident: 14 doi: 10.1016/j.clinbiochem.2007.06.004 – ident: 3 doi: 10.1210/jc.85.2.526 – ident: 8 doi: 10.1507/endocrj.EJ12-0110 – ident: 2 doi: 10.1016/j.ghir.2008.08.005 – ident: 15 – ident: 11 doi: 10.1007/s11102-007-0035-9 – ident: 13 doi: 10.1016/j.ghir.2012.04.005 – ident: 12 doi: 10.1530/eje.1.02131 – ident: 6 – ident: 10 doi: 10.1530/EJE-09-0247 – ident: 4 doi: 10.1007/BF03346389 – ident: 5 doi: 10.1515/CCLM.2004.112 – ident: 9 doi: 10.1002/sim.4780111005 |
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| SubjectTerms | Adult Aged Aged, 80 and over Aging - blood Blood Chemical Analysis - standards Centile curves China Chinese adults Diagnostic Techniques, Endocrine - standards Female Health Healthy Volunteers Humans Insulin-Like Growth Factor I - analysis Insulin-like growth factor-1 LMS method Luminescent Measurements - standards Male Middle Aged Reference range Reference Values Sex Characteristics Young Adult |
| Title | Serum Insulin-like growth factor-1 levels of healthy adults in southern China |
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