A novel multiplex-protein array for serum diagnostics of colon cancer: a case–control study

Background More than 1.2 million new cases of colorectal cancer are reported each year worldwide. Despite actual screening programs, about 50% of the patients are diagnosed at advanced tumor stages presenting poor prognosis. Innovative screening tools could aid the detection at early stages and allo...

Full description

Saved in:
Bibliographic Details
Published inBMC cancer Vol. 12; no. 1; p. 393
Main Authors Bünger, Stefanie, Haug, Ulrike, Kelly, Maria, Posorski, Nicole, Klempt-Giessing, Katja, Cartwright, Andrew, Fitzgerald, Stephen P, Toner, Vicki, McAleer, Damien, Gemoll, Timo, Laubert, Tilman, Büning, Jürgen, Fellermann, Klaus, Bruch, Hans-Peter, Roblick, Uwe J, Brenner, Hermann, von Eggeling, Ferdinand, Habermann, Jens K
Format Journal Article
LanguageEnglish
Published London BioMed Central 07.09.2012
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects
Adenoma - blood
Adenoma - diagnosis
Adult
Aged
Aged, 80 and over
Algorithms
Biomarkers, Tumor - blood
Biomedical and Life Sciences
Biomedicine
Blood
Blood proteins
C-Reactive Protein - metabolism
Cancer
Cancer Research
Carcinoembryonic Antigen - blood
Case-Control Studies
CEA
Colon
Colon cancer
Colon cancer screening
Colonic Neoplasms - blood
Colonic Neoplasms - diagnosis
Colorectal cancer
Computational Biology
CRP
Diagnosis
Female
Health Promotion and Disease Prevention
High-Throughput Screening Assays
High-throughput seromics
Humans
IL-8
Interleukin-8 - blood
Male
Medical examination
Medical research
Medical screening
Medicine/Public Health
Middle Aged
Molecular Diagnostic Techniques - methods
Mortality
Multiplex protein array biochip
Oncology
Oncology, Experimental
Patient compliance
Prognosis
Protein Array Analysis - methods
Protein microarrays
Research Article
ROC Curve
Serum diagnostics
Surgical Oncology
Vascular endothelial growth factor
CRP
Multiplex protein array biochip
High-throughput seromics
Serum diagnostics
IL-8
Colon cancer screening
CEA
Online AccessGet full text
ISSN1471-2407
1471-2407
DOI10.1186/1471-2407-12-393

Cover

Abstract Background More than 1.2 million new cases of colorectal cancer are reported each year worldwide. Despite actual screening programs, about 50% of the patients are diagnosed at advanced tumor stages presenting poor prognosis. Innovative screening tools could aid the detection at early stages and allow curative treatment interventions. Methods A nine target multiplex serum protein biochip was generated and evaluated using a training- and validation-set of 317 highly standardized, liquid nitrogen preserved serum samples comprising controls, adenomas, and colon cancers. Results Serum levels of CEA, IL-8, VEGF, S100A11, MCSF, C3adesArg, CD26, and CRP showed significant differences between cases and controls. The largest areas under the receiver operating characteristics curve were observed for CEA, IL-8, and CRP. At threshold levels yielding 90% specificity, sensitivities for CEA, IL-8 and CRP were 26%, 22%, and 17%, respectively. The most promising marker combinations were CEA + IL-8 reaching 37% sensitivity at 83% specificity and CEA + CRP with 35% sensitivity at 81% specificity. In an independent validation set CEA + IL-8 reached 47% sensitivity at 86% specificity while CEA + CRP obtained 39% sensitivity at 86% specificity. Early carcinomas were detected with 33% sensitivity for CEA + IL-8 and 28% for CEA + CRP. Conclusions Apart from CEA, IL-8, and CRP, the screening value of additional blood markers and the potential advantage of combining serum biochip testing with fecal occult blood testing needs to be studied. Multiplex biochip array technology utilizing serum samples offers an innovative approach to colorectal cancer screening.
AbstractList Background More than 1.2 million new cases of colorectal cancer are reported each year worldwide. Despite actual screening programs, about 50% of the patients are diagnosed at advanced tumor stages presenting poor prognosis. Innovative screening tools could aid the detection at early stages and allow curative treatment interventions. Methods A nine target multiplex serum protein biochip was generated and evaluated using a training- and validation-set of 317 highly standardized, liquid nitrogen preserved serum samples comprising controls, adenomas, and colon cancers. Results Serum levels of CEA, IL-8, VEGF, S100A11, MCSF, C3adesArg, CD26, and CRP showed significant differences between cases and controls. The largest areas under the receiver operating characteristics curve were observed for CEA, IL-8, and CRP. At threshold levels yielding 90% specificity, sensitivities for CEA, IL-8 and CRP were 26%, 22%, and 17%, respectively. The most promising marker combinations were CEA + IL-8 reaching 37% sensitivity at 83% specificity and CEA + CRP with 35% sensitivity at 81% specificity. In an independent validation set CEA + IL-8 reached 47% sensitivity at 86% specificity while CEA + CRP obtained 39% sensitivity at 86% specificity. Early carcinomas were detected with 33% sensitivity for CEA + IL-8 and 28% for CEA + CRP. Conclusions Apart from CEA, IL-8, and CRP, the screening value of additional blood markers and the potential advantage of combining serum biochip testing with fecal occult blood testing needs to be studied. Multiplex biochip array technology utilizing serum samples offers an innovative approach to colorectal cancer screening.
More than 1.2 million new cases of colorectal cancer are reported each year worldwide. Despite actual screening programs, about 50% of the patients are diagnosed at advanced tumor stages presenting poor prognosis. Innovative screening tools could aid the detection at early stages and allow curative treatment interventions. A nine target multiplex serum protein biochip was generated and evaluated using a training- and validation-set of 317 highly standardized, liquid nitrogen preserved serum samples comprising controls, adenomas, and colon cancers. Serum levels of CEA, IL-8, VEGF, S100A11, MCSF, C3adesArg, CD26, and CRP showed significant differences between cases and controls. The largest areas under the receiver operating characteristics curve were observed for CEA, IL-8, and CRP. At threshold levels yielding 90% specificity, sensitivities for CEA, IL-8 and CRP were 26%, 22%, and 17%, respectively. The most promising marker combinations were CEA + IL-8 reaching 37% sensitivity at 83% specificity and CEA + CRP with 35% sensitivity at 81% specificity. In an independent validation set CEA + IL-8 reached 47% sensitivity at 86% specificity while CEA + CRP obtained 39% sensitivity at 86% specificity. Early carcinomas were detected with 33% sensitivity for CEA + IL-8 and 28% for CEA + CRP. Apart from CEA, IL-8, and CRP, the screening value of additional blood markers and the potential advantage of combining serum biochip testing with fecal occult blood testing needs to be studied. Multiplex biochip array technology utilizing serum samples offers an innovative approach to colorectal cancer screening.
Background More than 1.2 million new cases of colorectal cancer are reported each year worldwide. Despite actual screening programs, about 50% of the patients are diagnosed at advanced tumor stages presenting poor prognosis. Innovative screening tools could aid the detection at early stages and allow curative treatment interventions. Methods A nine target multiplex serum protein biochip was generated and evaluated using a training- and validation-set of 317 highly standardized, liquid nitrogen preserved serum samples comprising controls, adenomas, and colon cancers. Results Serum levels of CEA, IL-8, VEGF, S100A11, MCSF, C3adesArg, CD26, and CRP showed significant differences between cases and controls. The largest areas under the receiver operating characteristics curve were observed for CEA, IL-8, and CRP. At threshold levels yielding 90% specificity, sensitivities for CEA, IL-8 and CRP were 26%, 22%, and 17%, respectively. The most promising marker combinations were CEA + IL-8 reaching 37% sensitivity at 83% specificity and CEA + CRP with 35% sensitivity at 81% specificity. In an independent validation set CEA + IL-8 reached 47% sensitivity at 86% specificity while CEA + CRP obtained 39% sensitivity at 86% specificity. Early carcinomas were detected with 33% sensitivity for CEA + IL-8 and 28% for CEA + CRP. Conclusions Apart from CEA, IL-8, and CRP, the screening value of additional blood markers and the potential advantage of combining serum biochip testing with fecal occult blood testing needs to be studied. Multiplex biochip array technology utilizing serum samples offers an innovative approach to colorectal cancer screening. Keywords: Multiplex protein array biochip, Colon cancer screening, Serum diagnostics, High-throughput seromics, IL-8, CEA, CRP
More than 1.2 million new cases of colorectal cancer are reported each year worldwide. Despite actual screening programs, about 50% of the patients are diagnosed at advanced tumor stages presenting poor prognosis. Innovative screening tools could aid the detection at early stages and allow curative treatment interventions.BACKGROUNDMore than 1.2 million new cases of colorectal cancer are reported each year worldwide. Despite actual screening programs, about 50% of the patients are diagnosed at advanced tumor stages presenting poor prognosis. Innovative screening tools could aid the detection at early stages and allow curative treatment interventions.A nine target multiplex serum protein biochip was generated and evaluated using a training- and validation-set of 317 highly standardized, liquid nitrogen preserved serum samples comprising controls, adenomas, and colon cancers.METHODSA nine target multiplex serum protein biochip was generated and evaluated using a training- and validation-set of 317 highly standardized, liquid nitrogen preserved serum samples comprising controls, adenomas, and colon cancers.Serum levels of CEA, IL-8, VEGF, S100A11, MCSF, C3adesArg, CD26, and CRP showed significant differences between cases and controls. The largest areas under the receiver operating characteristics curve were observed for CEA, IL-8, and CRP. At threshold levels yielding 90% specificity, sensitivities for CEA, IL-8 and CRP were 26%, 22%, and 17%, respectively. The most promising marker combinations were CEA + IL-8 reaching 37% sensitivity at 83% specificity and CEA + CRP with 35% sensitivity at 81% specificity. In an independent validation set CEA + IL-8 reached 47% sensitivity at 86% specificity while CEA + CRP obtained 39% sensitivity at 86% specificity. Early carcinomas were detected with 33% sensitivity for CEA + IL-8 and 28% for CEA + CRP.RESULTSSerum levels of CEA, IL-8, VEGF, S100A11, MCSF, C3adesArg, CD26, and CRP showed significant differences between cases and controls. The largest areas under the receiver operating characteristics curve were observed for CEA, IL-8, and CRP. At threshold levels yielding 90% specificity, sensitivities for CEA, IL-8 and CRP were 26%, 22%, and 17%, respectively. The most promising marker combinations were CEA + IL-8 reaching 37% sensitivity at 83% specificity and CEA + CRP with 35% sensitivity at 81% specificity. In an independent validation set CEA + IL-8 reached 47% sensitivity at 86% specificity while CEA + CRP obtained 39% sensitivity at 86% specificity. Early carcinomas were detected with 33% sensitivity for CEA + IL-8 and 28% for CEA + CRP.Apart from CEA, IL-8, and CRP, the screening value of additional blood markers and the potential advantage of combining serum biochip testing with fecal occult blood testing needs to be studied. Multiplex biochip array technology utilizing serum samples offers an innovative approach to colorectal cancer screening.CONCLUSIONSApart from CEA, IL-8, and CRP, the screening value of additional blood markers and the potential advantage of combining serum biochip testing with fecal occult blood testing needs to be studied. Multiplex biochip array technology utilizing serum samples offers an innovative approach to colorectal cancer screening.
Doc number: 393 Abstract Background: More than 1.2 million new cases of colorectal cancer are reported each year worldwide. Despite actual screening programs, about 50% of the patients are diagnosed at advanced tumor stages presenting poor prognosis. Innovative screening tools could aid the detection at early stages and allow curative treatment interventions. Methods: A nine target multiplex serum protein biochip was generated and evaluated using a training- and validation-set of 317 highly standardized, liquid nitrogen preserved serum samples comprising controls, adenomas, and colon cancers. Results: Serum levels of CEA, IL-8, VEGF, S100A11, MCSF, C3adesArg, CD26, and CRP showed significant differences between cases and controls. The largest areas under the receiver operating characteristics curve were observed for CEA, IL-8, and CRP. At threshold levels yielding 90% specificity, sensitivities for CEA, IL-8 and CRP were 26%, 22%, and 17%, respectively. The most promising marker combinations were CEA + IL-8 reaching 37% sensitivity at 83% specificity and CEA + CRP with 35% sensitivity at 81% specificity. In an independent validation set CEA + IL-8 reached 47% sensitivity at 86% specificity while CEA + CRP obtained 39% sensitivity at 86% specificity. Early carcinomas were detected with 33% sensitivity for CEA + IL-8 and 28% for CEA + CRP. Conclusions: Apart from CEA, IL-8, and CRP, the screening value of additional blood markers and the potential advantage of combining serum biochip testing with fecal occult blood testing needs to be studied. Multiplex biochip array technology utilizing serum samples offers an innovative approach to colorectal cancer screening.
Abstract Background More than 1.2 million new cases of colorectal cancer are reported each year worldwide. Despite actual screening programs, about 50% of the patients are diagnosed at advanced tumor stages presenting poor prognosis. Innovative screening tools could aid the detection at early stages and allow curative treatment interventions. Methods A nine target multiplex serum protein biochip was generated and evaluated using a training- and validation-set of 317 highly standardized, liquid nitrogen preserved serum samples comprising controls, adenomas, and colon cancers. Results Serum levels of CEA, IL-8, VEGF, S100A11, MCSF, C3adesArg, CD26, and CRP showed significant differences between cases and controls. The largest areas under the receiver operating characteristics curve were observed for CEA, IL-8, and CRP. At threshold levels yielding 90% specificity, sensitivities for CEA, IL-8 and CRP were 26%, 22%, and 17%, respectively. The most promising marker combinations were CEA + IL-8 reaching 37% sensitivity at 83% specificity and CEA + CRP with 35% sensitivity at 81% specificity. In an independent validation set CEA + IL-8 reached 47% sensitivity at 86% specificity while CEA + CRP obtained 39% sensitivity at 86% specificity. Early carcinomas were detected with 33% sensitivity for CEA + IL-8 and 28% for CEA + CRP. Conclusions Apart from CEA, IL-8, and CRP, the screening value of additional blood markers and the potential advantage of combining serum biochip testing with fecal occult blood testing needs to be studied. Multiplex biochip array technology utilizing serum samples offers an innovative approach to colorectal cancer screening.
More than 1.2 million new cases of colorectal cancer are reported each year worldwide. Despite actual screening programs, about 50% of the patients are diagnosed at advanced tumor stages presenting poor prognosis. Innovative screening tools could aid the detection at early stages and allow curative treatment interventions. A nine target multiplex serum protein biochip was generated and evaluated using a training- and validation-set of 317 highly standardized, liquid nitrogen preserved serum samples comprising controls, adenomas, and colon cancers. Serum levels of CEA, IL-8, VEGF, S100A11, MCSF, C3adesArg, CD26, and CRP showed significant differences between cases and controls. The largest areas under the receiver operating characteristics curve were observed for CEA, IL-8, and CRP. At threshold levels yielding 90% specificity, sensitivities for CEA, IL-8 and CRP were 26%, 22%, and 17%, respectively. The most promising marker combinations were CEA + IL-8 reaching 37% sensitivity at 83% specificity and CEA + CRP with 35% sensitivity at 81% specificity. In an independent validation set CEA + IL-8 reached 47% sensitivity at 86% specificity while CEA + CRP obtained 39% sensitivity at 86% specificity. Early carcinomas were detected with 33% sensitivity for CEA + IL-8 and 28% for CEA + CRP. Apart from CEA, IL-8, and CRP, the screening value of additional blood markers and the potential advantage of combining serum biochip testing with fecal occult blood testing needs to be studied. Multiplex biochip array technology utilizing serum samples offers an innovative approach to colorectal cancer screening.
ArticleNumber 393
Audience Academic
Author Habermann, Jens K
Haug, Ulrike
von Eggeling, Ferdinand
Kelly, Maria
Fellermann, Klaus
Büning, Jürgen
Brenner, Hermann
Bünger, Stefanie
Klempt-Giessing, Katja
McAleer, Damien
Laubert, Tilman
Bruch, Hans-Peter
Roblick, Uwe J
Toner, Vicki
Gemoll, Timo
Cartwright, Andrew
Fitzgerald, Stephen P
Posorski, Nicole
AuthorAffiliation 3 Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Bergheimer Str. 20, 69115, Heidelberg, Germany
5 Core Unit Chip Application, Institute of Human Genetics, Jena University Hospital, Leutragraben 3, 07743, Jena, Germany
6 Department of Internal Medicine I, University Hospital of Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23528, Lübeck, Germany
2 Division of Preventive Oncology, National Center for Tumor Diseases/German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
1 Laboratory for Surgical Research, Department of Surgery, University of Lübeck, Ratzeburger Allee 160, D-23538, Lübeck, Germany
4 Randox Laboratories GmbH, Wilhelmstr, 147a, 42489, Wulfrath, Germany
AuthorAffiliation_xml – name: 2 Division of Preventive Oncology, National Center for Tumor Diseases/German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
– name: 4 Randox Laboratories GmbH, Wilhelmstr, 147a, 42489, Wulfrath, Germany
– name: 1 Laboratory for Surgical Research, Department of Surgery, University of Lübeck, Ratzeburger Allee 160, D-23538, Lübeck, Germany
– name: 3 Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Bergheimer Str. 20, 69115, Heidelberg, Germany
– name: 6 Department of Internal Medicine I, University Hospital of Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23528, Lübeck, Germany
– name: 5 Core Unit Chip Application, Institute of Human Genetics, Jena University Hospital, Leutragraben 3, 07743, Jena, Germany
Author_xml – sequence: 1
  givenname: Stefanie
  surname: Bünger
  fullname: Bünger, Stefanie
  organization: Laboratory for Surgical Research, Department of Surgery, University of Lübeck
– sequence: 2
  givenname: Ulrike
  surname: Haug
  fullname: Haug, Ulrike
  organization: Division of Preventive Oncology, National Center for Tumor Diseases/German Cancer Research Center (DKFZ)
– sequence: 3
  givenname: Maria
  surname: Kelly
  fullname: Kelly, Maria
  organization: Randox Laboratories GmbH
– sequence: 4
  givenname: Nicole
  surname: Posorski
  fullname: Posorski, Nicole
  organization: Core Unit Chip Application, Institute of Human Genetics, Jena University Hospital
– sequence: 5
  givenname: Katja
  surname: Klempt-Giessing
  fullname: Klempt-Giessing, Katja
  organization: Laboratory for Surgical Research, Department of Surgery, University of Lübeck
– sequence: 6
  givenname: Andrew
  surname: Cartwright
  fullname: Cartwright, Andrew
  organization: Randox Laboratories GmbH
– sequence: 7
  givenname: Stephen P
  surname: Fitzgerald
  fullname: Fitzgerald, Stephen P
  organization: Randox Laboratories GmbH
– sequence: 8
  givenname: Vicki
  surname: Toner
  fullname: Toner, Vicki
  organization: Randox Laboratories GmbH
– sequence: 9
  givenname: Damien
  surname: McAleer
  fullname: McAleer, Damien
  organization: Randox Laboratories GmbH
– sequence: 10
  givenname: Timo
  surname: Gemoll
  fullname: Gemoll, Timo
  organization: Laboratory for Surgical Research, Department of Surgery, University of Lübeck
– sequence: 11
  givenname: Tilman
  surname: Laubert
  fullname: Laubert, Tilman
  organization: Laboratory for Surgical Research, Department of Surgery, University of Lübeck
– sequence: 12
  givenname: Jürgen
  surname: Büning
  fullname: Büning, Jürgen
  organization: Department of Internal Medicine I, University Hospital of Schleswig-Holstein
– sequence: 13
  givenname: Klaus
  surname: Fellermann
  fullname: Fellermann, Klaus
  organization: Department of Internal Medicine I, University Hospital of Schleswig-Holstein
– sequence: 14
  givenname: Hans-Peter
  surname: Bruch
  fullname: Bruch, Hans-Peter
  organization: Laboratory for Surgical Research, Department of Surgery, University of Lübeck
– sequence: 15
  givenname: Uwe J
  surname: Roblick
  fullname: Roblick, Uwe J
  organization: Laboratory for Surgical Research, Department of Surgery, University of Lübeck
– sequence: 16
  givenname: Hermann
  surname: Brenner
  fullname: Brenner, Hermann
  organization: Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
– sequence: 17
  givenname: Ferdinand
  surname: von Eggeling
  fullname: von Eggeling, Ferdinand
  organization: Core Unit Chip Application, Institute of Human Genetics, Jena University Hospital
– sequence: 18
  givenname: Jens K
  surname: Habermann
  fullname: Habermann, Jens K
  email: Jens.habermann@uni-luebeck.de
  organization: Laboratory for Surgical Research, Department of Surgery, University of Lübeck
BackLink https://www.ncbi.nlm.nih.gov/pubmed/22954206$$D View this record in MEDLINE/PubMed
BookMark eNqNkl2L1DAUhousuB9675UUBNGLrkmaJq0XwrD4MbAg-HEpIU1POxkyyZi0686d_8F_6C8x3RnH6aIiuWg4fd73JO_JaXJknYUkeYjROcYle44pxxmhiGeYZHmV30lO9qWjg_1xchrCEiHMS1TeS44JqQpKEDtJPs9S667ApKvB9Hpt4Dpbe9eDtqn0Xm7S1vk0gB9WaaNlZ13otQqpa1PljLOpklaBf5HKuAvw49t35WzvnUlDPzSb-8ndVpoAD3bfs-TT61cfL95ml-_ezC9ml5lijPaZpIDbusoZYE4Ja0tOEC0lRorhgkGdcwQlEKVK1mJJOClJw4qW1IwwgiqWnyXzrW_j5FKsvV5JvxFOanFTcL4T0seDGxCVLHEjqSLRl5YVq3HT5iWri4ZxUvEyeuGt12DXcvNVGrM3xEiMsYsxVzHmKjARMfaoebnVrId6BY2CmIE0k4NM_1i9EJ27EnmBSFHRaPB0Z-DdlwFCL1Y6KDBGWnBDuGlb5VVsFdHHt9ClG7yN8UaKU4p5wflvqpPx0tq2LvZVo6mYFTmNsdIKRer8D1RcDax0nCS0OtYngmcTwThtuO47OYQg5h_eT9knB-wCpOkXwZmh186GKfjoML19bL9eaQTQFlDeheCh_Z-JsFsSpXs5to431OZfwt34Q-xhO_AH8f5N8xObBBVv
CitedBy_id crossref_primary_10_1177_1010428317705337
crossref_primary_10_1371_journal_pone_0270232
crossref_primary_10_1016_j_clnu_2019_12_005
crossref_primary_10_3390_microarrays3030168
crossref_primary_10_3892_ol_2022_13443
crossref_primary_10_1089_bio_2013_0050
crossref_primary_10_1186_s12860_019_0210_7
crossref_primary_10_12659_MSM_900590
crossref_primary_10_1177_1178646917691739
crossref_primary_10_3389_fonc_2025_1514009
crossref_primary_10_1586_14789450_2014_905743
crossref_primary_10_1038_s41598_019_51999_9
crossref_primary_10_3109_02656736_2013_796529
crossref_primary_10_18632_oncotarget_7359
crossref_primary_10_1186_1471_2407_14_912
crossref_primary_10_1007_s12325_021_01645_6
crossref_primary_10_1016_j_trsl_2013_07_010
crossref_primary_10_1038_bjc_2014_605
crossref_primary_10_1074_mcp_M116_062273
crossref_primary_10_1159_000438860
crossref_primary_10_3233_CBM_203211
crossref_primary_10_1038_srep38524
crossref_primary_10_3748_wjg_v20_i43_16334
crossref_primary_10_3390_diagnostics10070444
crossref_primary_10_1002_1878_0261_13734
crossref_primary_10_1016_j_canlet_2013_05_033
Cites_doi 10.1074/mcp.M110.004978
10.1016/j.ophtha.2008.09.036
10.1093/jnci/91.5.434
10.1007/s00432-010-0965-x
10.1053/bega.2002.0268
10.1016/j.ejca.2006.01.008
10.1093/anatox/35.1.40
10.1002/ijc.25516
10.3389/fnagi.2011.00001
10.7326/0003-4819-126-10-199705150-00014
10.1186/1471-2407-11-408
10.3322/CA.2007.0018
10.1080/15321810600862298
10.1001/jama.289.10.1297
10.1515/CCLM.2007.321
10.2215/CJN.02010507
10.1007/BF02990108
10.1258/096914107782066220
10.1053/gast.2003.50044
10.3748/wjg.v11.i5.645
10.1158/1078-0432.CCR-05-0983
10.1053/j.gastro.2008.03.040
10.7326/0003-4819-149-9-200811040-00245
10.1016/S1052-5157(03)00053-9
10.3322/caac.20107
10.1097/CEJ.0b013e328305a0fa
10.1093/jnci/djp436
10.1177/1087057111414894
10.1016/j.suronc.2008.05.008
10.1073/pnas.64.1.161
10.1038/ajg.2009.668
10.1002/cncr.11911
10.1021/pr070409o
10.1016/S1052-5157(03)00054-0
10.1158/1055-9965.EPI-06-0994
10.1054/bjoc.2000.1410
10.1111/j.1365-3083.2007.01906.x
10.1053/j.gastro.2006.07.011
10.1515/CCLM.2005.224
10.1007/s00384-006-0099-4
10.1111/j.1572-0241.2004.40829.x
10.1097/00043764-198608000-00033
ContentType Journal Article
Copyright Bünger et al.; licensee BioMed Central Ltd. 2012 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
COPYRIGHT 2012 BioMed Central Ltd.
2012 Bünger et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright ©2012 Bünger et al.; licensee BioMed Central Ltd. 2012 Bünger et al.; licensee BioMed Central Ltd.
Copyright_xml – notice: Bünger et al.; licensee BioMed Central Ltd. 2012 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
– notice: COPYRIGHT 2012 BioMed Central Ltd.
– notice: 2012 Bünger et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
– notice: Copyright ©2012 Bünger et al.; licensee BioMed Central Ltd. 2012 Bünger et al.; licensee BioMed Central Ltd.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
ISR
3V.
7TO
7X7
7XB
88E
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
H94
K9.
M0S
M1P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
ADTOC
UNPAY
DOA
DOI 10.1186/1471-2407-12-393
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Gale In Context: Science
ProQuest Central (Corporate)
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Hospital Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
ProQuest Central
ProQuest One
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
ProQuest Health & Medical Collection
Medical Database
Proquest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
Unpaywall for CDI: Periodical Content
Unpaywall
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
Oncogenes and Growth Factors Abstracts
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Central China
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Health & Medical Research Collection
AIDS and Cancer Research Abstracts
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList



MEDLINE - Academic
Publicly Available Content Database


MEDLINE
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 5
  dbid: UNPAY
  name: Unpaywall
  url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/
  sourceTypes: Open Access Repository
– sequence: 6
  dbid: BENPR
  name: ProQuest Central
  url: http://www.proquest.com/pqcentral?accountid=15518
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1471-2407
EndPage 393
ExternalDocumentID oai_doaj_org_article_9a81da4c26eb4896b1df386b5d672978
10.1186/1471-2407-12-393
PMC3502594
2820025051
A534156490
22954206
10_1186_1471_2407_12_393
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
0R~
23N
2VQ
2WC
4.4
53G
5VS
6J9
6PF
7X7
88E
8FI
8FJ
AAFWJ
AAJSJ
AASML
AAWTL
ABDBF
ABUWG
ACGFO
ACGFS
ACIHN
ACMJI
ACPRK
ACUHS
ADBBV
ADRAZ
ADUKV
AEAQA
AENEX
AFKRA
AFPKN
AHBYD
AHMBA
AHSBF
AHYZX
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMTXH
AOIJS
BAPOH
BAWUL
BCNDV
BENPR
BFQNJ
BMC
BPHCQ
BVXVI
C6C
CCPQU
CS3
DIK
DU5
E3Z
EAD
EAP
EAS
EBD
EBLON
EBS
EJD
EMB
EMK
EMOBN
ESX
F5P
FYUFA
GROUPED_DOAJ
GX1
H13
HMCUK
HYE
IAO
IHR
IHW
INH
INR
IPNFZ
ISR
ITC
KQ8
M1P
M48
M~E
O5R
O5S
OK1
OVT
P2P
PGMZT
PHGZM
PHGZT
PIMPY
PJZUB
PPXIY
PQQKQ
PROAC
PSQYO
PUEGO
RBZ
RIG
RNS
ROL
RPM
RSV
SBL
SOJ
SV3
TR2
TUS
U2A
UKHRP
W2D
WOQ
WOW
XSB
AAYXX
CITATION
ALIPV
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7TO
7XB
8FK
AZQEC
DWQXO
H94
K9.
PKEHL
PQEST
PQUKI
PRINS
7X8
5PM
ADTOC
C1A
LGEZI
LOTEE
NADUK
NXXTH
UNPAY
ID FETCH-LOGICAL-c664t-a4e1fb936e17426f872048a10c6156eb370e8e2cc86f1a27282d65f2b62620963
IEDL.DBID U2A
ISSN 1471-2407
IngestDate Tue Oct 14 19:03:29 EDT 2025
Sun Oct 26 04:07:36 EDT 2025
Tue Sep 30 16:45:57 EDT 2025
Fri Sep 05 13:41:29 EDT 2025
Mon Oct 06 18:22:42 EDT 2025
Mon Oct 20 22:49:34 EDT 2025
Mon Oct 20 16:57:50 EDT 2025
Thu Oct 16 16:17:18 EDT 2025
Thu May 22 21:24:11 EDT 2025
Mon Jul 21 05:59:51 EDT 2025
Wed Oct 01 03:44:15 EDT 2025
Thu Apr 24 23:01:51 EDT 2025
Sat Sep 06 07:24:38 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords CRP
Multiplex protein array biochip
High-throughput seromics
Serum diagnostics
IL-8
Colon cancer screening
CEA
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
cc-by
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c664t-a4e1fb936e17426f872048a10c6156eb370e8e2cc86f1a27282d65f2b62620963
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
OpenAccessLink https://link.springer.com/10.1186/1471-2407-12-393
PMID 22954206
PQID 1174417577
PQPubID 44074
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_9a81da4c26eb4896b1df386b5d672978
unpaywall_primary_10_1186_1471_2407_12_393
pubmedcentral_primary_oai_pubmedcentral_nih_gov_3502594
proquest_miscellaneous_1186939933
proquest_journals_1174417577
gale_infotracmisc_A534156490
gale_infotracacademiconefile_A534156490
gale_incontextgauss_ISR_A534156490
gale_healthsolutions_A534156490
pubmed_primary_22954206
crossref_primary_10_1186_1471_2407_12_393
crossref_citationtrail_10_1186_1471_2407_12_393
springer_journals_10_1186_1471_2407_12_393
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2012-09-07
PublicationDateYYYYMMDD 2012-09-07
PublicationDate_xml – month: 09
  year: 2012
  text: 2012-09-07
  day: 07
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle BMC cancer
PublicationTitleAbbrev BMC Cancer
PublicationTitleAlternate BMC Cancer
PublicationYear 2012
Publisher BioMed Central
BioMed Central Ltd
Springer Nature B.V
BMC
Publisher_xml – name: BioMed Central
– name: BioMed Central Ltd
– name: Springer Nature B.V
– name: BMC
References Schulmann, Reiser, Schmiegel (CR7) 2002; 16
De Vita, Orditura, Lieto, Infusino, Morgillo, Martinelli, Castellano, Romano, Ciardiello, Catalano (CR9) 2004; 100
Sertic, Slavicek, Bozina, Malenica, Kes, Reiner (CR24) 2007; 45
Roh, Kim, Song, Lim, Kwon (CR26) 2009; 116
Whitlock, Lin, Liles, Beil, Fu (CR41) 2008; 149
Burch, Soares-Weiser, St John, Duffy, Smith, Kleijnen, Westwood (CR42) 2007; 14
Bond (CR34) 2002; 12
Ramos, Llagostera, Esteva, Cabeza, Cantero, Segarra, Martin-Rabadan, Artigues, Torrent, Taltavull (CR45) 2011; 11
Ferlay, Shin, Bray, Forman, Mathers, Parkin (CR1) 2010; 127
Helzlsouer, Erlinger, Platz (CR12) 2006; 42
Almog, Ezra, Lavi, Rennert, Hagoel (CR44) 2008; 17
Mandel, Church, Ederer, Bond (CR35) 1999; 91
Sachdeva, Yoon, Oshima, Garcia, Goodkin, Asthana (CR23) 2007; 65
Tan, Gouvas, Nicholls, Ziprin, Xynos, Tekkis (CR28) 2009; 18
Molloy, Mc Connell, Lamont, FitzGerald (CR16) 2005; 43
Ransohoff, Lang (CR39) 1997; 126
Brenner, Hoffmeister, Arndt, Stegmaier, Altenhofen, Haug (CR4) 2010; 102
Fernandes, Kim, Matos (CR30) 2005; 11
Mroczko, Szmitkowski, Wereszczynska-Siemiatkowska, Okulczyk, Kedra (CR10) 2007; 22
Connell (CR3) 2004; 99
Badiou, Cristol, Jaussent, Terrier, Morena, Maurice, Leray-Moragues, Rivory, Chalabi, Delcourt (CR25) 2008; 3
Bond (CR33) 2002; 37
Walsh, Terdiman (CR36) 2003; 289
Lundberg, Thorsen, Assarsson, Villablanca, Tran, Gee, Knowles, Nielsen, Gonzalez Couto, Martin (CR31) 2011; 10
Jemal, Bray, Center, Ferlay, Ward, Forman (CR2) 2011; 61
Winawer, Zauber (CR43) 2002; 12
Winawer, Fletcher, Rex, Bond, Burt, Ferrucci, Ganiats, Levin, Woolf, Johnson (CR37) 2003; 124
Cordero, Ayude, Nogueira, Rodriguez-Berrocal, de la Cadena (CR8) 2000; 83
Levin, Lieberman, McFarland, Smith, Brooks, Andrews, Dash, Giardiello, Glick, Levin (CR6) 2008; 58
Melle, Ernst, Schimmel, Bleul, Mothes, Kaufmann, Settmacher, Von Eggeling (CR14) 2006; 28
Bünger, Haug, Kelly, Klempt-Giessing, Cartwright, Posorski, Dibbelt, Fitzgerald, Bruch, Roblick (CR13) 2011; 16
Thomson, Krupey, Freedman, Gold (CR27) 1969; 64
Bang, Tillett, Hoar, Blair, McDougall (CR38) 1986; 28
Rosen, Mattsson, Johansson, Andreasson, Wallin, Hansson, Johansson, Lamont, Svensson, Blennow (CR18) 2011; 3
Hundt, Haug, Brenner (CR22) 2007; 16
Marin, Merrell, McMillin (CR21) 2011; 35
van Rossum, van Rijn, Laheij, van Oijen, Fockens, van Krieken, Verbeek, Jansen, Dekker (CR40) 2008; 135
Habermann, Roblick, Luke, Prieto, Finlay, Podust, Roman, Oevermann, Schiedeck, Homann (CR15) 2006; 131
Vasatova, Tichy, Horacek, Pudil, Horakova, Palicka (CR19) 2009; 148
McAleer, McPhillips, FitzGerald, McConnell, Rodriguez (CR20) 2006; 27
Bünger, Laubert, Roblick, Habermann (CR29) 2011; 137
Roessler, Rollinger, Palme, Hagmann, Berndt, Engel, Schneidinger, Pfeffer, Andres, Karl (CR11) 2005; 11
Stamatiadis, Manouras, Triantos, Katergiannakis, Apostolidis (CR32) 1992; 18
Haug, Hundt, Brenner (CR5) 2010; 105
Fitzgerald, McConnell, Huxley (CR17) 2008; 7
OJ Cordero (3402_CR8) 2000; 83
DM Thomson (3402_CR27) 1969; 64
KJ Helzlsouer (3402_CR12) 2006; 42
R Almog (3402_CR44) 2008; 17
S Bünger (3402_CR13) 2011; 16
H Brenner (3402_CR4) 2010; 102
U Haug (3402_CR5) 2010; 105
JM Walsh (3402_CR36) 2003; 289
M Roessler (3402_CR11) 2005; 11
S Winawer (3402_CR37) 2003; 124
JK Habermann (3402_CR15) 2006; 131
S Badiou (3402_CR25) 2008; 3
RM Molloy (3402_CR16) 2005; 43
M Lundberg (3402_CR31) 2011; 10
A Jemal (3402_CR2) 2011; 61
M Vasatova (3402_CR19) 2009; 148
S Bünger (3402_CR29) 2011; 137
M Ramos (3402_CR45) 2011; 11
F De Vita (3402_CR9) 2004; 100
D McAleer (3402_CR20) 2006; 27
E Tan (3402_CR28) 2009; 18
C Rosen (3402_CR18) 2011; 3
JH Bond (3402_CR34) 2002; 12
SP Fitzgerald (3402_CR17) 2008; 7
B Mroczko (3402_CR10) 2007; 22
AP Stamatiadis (3402_CR32) 1992; 18
DF Ransohoff (3402_CR39) 1997; 126
JA Burch (3402_CR42) 2007; 14
K Schulmann (3402_CR7) 2002; 16
KM Bang (3402_CR38) 1986; 28
JS Mandel (3402_CR35) 1999; 91
MI Roh (3402_CR26) 2009; 116
LC Fernandes (3402_CR30) 2005; 11
W Connell (3402_CR3) 2004; 99
J Sertic (3402_CR24) 2007; 45
J Ferlay (3402_CR1) 2010; 127
EP Whitlock (3402_CR41) 2008; 149
SJ Marin (3402_CR21) 2011; 35
N Sachdeva (3402_CR23) 2007; 65
C Melle (3402_CR14) 2006; 28
S Hundt (3402_CR22) 2007; 16
LG van Rossum (3402_CR40) 2008; 135
SJ Winawer (3402_CR43) 2002; 12
JH Bond (3402_CR33) 2002; 37
B Levin (3402_CR6) 2008; 58
16513341 - Eur J Cancer. 2006 Apr;42(6):704-7
1737592 - Eur J Surg Oncol. 1992 Feb;18(1):41-3
18322143 - CA Cancer J Clin. 2008 May-Jun;58(3):130-60
21296855 - CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
10070942 - J Natl Cancer Inst. 1999 Mar 3;91(5):434-7
12557158 - Gastroenterology. 2003 Feb;124(2):544-60
9148658 - Ann Intern Med. 1997 May 15;126(10):811-22
12109675 - J Gastroenterol. 2002;37 Suppl 13:92-6
16166432 - Clin Cancer Res. 2005 Sep 15;11(18):6550-7
21193998 - J Cancer Res Clin Oncol. 2011 Mar;137(3):375-89
21807963 - J Biomol Screen. 2011 Oct;16(9):1018-26
18714185 - Eur J Cancer Prev. 2008 Oct;17(5):430-7
11027426 - Br J Cancer. 2000 Nov;83(9):1139-46
17523947 - Scand J Immunol. 2007 Jun;65(6):549-54
11916153 - Gastrointest Endosc Clin N Am. 2002 Jan;12(1):1-9, v
21442044 - Front Aging Neurosci. 2011 Jan 31;3:1
15330891 - Am J Gastroenterol. 2004 Sep;99(9):1631-3
18838718 - Ann Intern Med. 2008 Nov 4;149(9):638-58
16327996 - Int J Oncol. 2006 Jan;28(1):195-200
19118699 - Ophthalmology. 2009 Jan;116(1):80-6
16981649 - J Immunoassay Immunochem. 2006;27(4):363-78
17925085 - J Med Screen. 2007;14(3):132-7
18020322 - J Proteome Res. 2008 Jan;7(1):450-5
16309365 - Clin Chem Lab Med. 2005;43(12):1303-13
11916154 - Gastrointest Endosc Clin N Am. 2002 Jan;12(1):11-21
21351269 - Int J Cancer. 2010 Dec 15;127(12):2893-917
12633192 - JAMA. 2003 Mar 12;289(10):1297-302
14716760 - Cancer. 2004 Jan 15;100(2):270-8
17924848 - Clin Chem Lab Med. 2007;45(10):1347-52
20042716 - J Natl Cancer Inst. 2010 Jan 20;102(2):89-95
17030172 - Gastroenterology. 2006 Oct;131(4):1020-9; quiz 1284
21219702 - J Anal Toxicol. 2011 Jan;35(1):40-5
15655814 - World J Gastroenterol. 2005 Feb 7;11(5):645-8
11977931 - Best Pract Res Clin Gastroenterol. 2002 Feb;16(1):91-114
3746495 - J Occup Med. 1986 Aug;28(8):709-13
21242282 - Mol Cell Proteomics. 2011 Apr;10(4):M110.004978
19953091 - Am J Gastroenterol. 2010 Mar;105(3):682-90
20662394 - Cas Lek Cesk. 2009;148(12):591-6
18235144 - Clin J Am Soc Nephrol. 2008 Mar;3(2):423-30
21942990 - BMC Cancer. 2011 Sep 25;11(1):408
18619834 - Surg Oncol. 2009 Mar;18(1):15-24
18482589 - Gastroenterology. 2008 Jul;135(1):82-90
17932341 - Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):1935-53
16520929 - Int J Colorectal Dis. 2007 Jan;22(1):33-8
5262998 - Proc Natl Acad Sci U S A. 1969 Sep;64(1):161-7
References_xml – volume: 10
  start-page: M110 004978
  issue: 4
  year: 2011
  ident: CR31
  article-title: Multiplexed homogeneous proximity ligation assays for high-throughput protein biomarker research in serological material
  publication-title: Mol Cell Proteomics
  doi: 10.1074/mcp.M110.004978
– volume: 116
  start-page: 80
  issue: 1
  year: 2009
  end-page: 86
  ident: CR26
  article-title: Effect of intravitreal bevacizumab injection on aqueous humor cytokine levels in clinically significant macular edema
  publication-title: Ophthalmology
  doi: 10.1016/j.ophtha.2008.09.036
– volume: 91
  start-page: 434
  issue: 5
  year: 1999
  end-page: 437
  ident: CR35
  article-title: Colorectal cancer mortality: effectiveness of biennial screening for fecal occult blood
  publication-title: J Natl Cancer Inst
  doi: 10.1093/jnci/91.5.434
– volume: 137
  start-page: 375
  issue: 3
  year: 2011
  end-page: 389
  ident: CR29
  article-title: Serum biomarkers for improved diagnostic of pancreatic cancer: a current overview
  publication-title: J Cancer Res Clin Oncol
  doi: 10.1007/s00432-010-0965-x
– volume: 16
  start-page: 91
  issue: 1
  year: 2002
  end-page: 114
  ident: CR7
  article-title: Colonic cancer and polyps
  publication-title: Best Pract Res Clin Gastroenterol
  doi: 10.1053/bega.2002.0268
– volume: 148
  start-page: 591
  issue: 12
  year: 2009
  end-page: 596
  ident: CR19
  article-title: [Multi-marker approach in the diagnostics of cardiac diseases by protein biochip technology]
  publication-title: Cas Lek Cesk
– volume: 42
  start-page: 704
  issue: 6
  year: 2006
  end-page: 707
  ident: CR12
  article-title: C-reactive protein levels and subsequent cancer outcomes: results from a prospective cohort study
  publication-title: Eur J Cancer
  doi: 10.1016/j.ejca.2006.01.008
– volume: 35
  start-page: 40
  issue: 1
  year: 2011
  end-page: 45
  ident: CR21
  article-title: Drugs of abuse detection in meconium: a comparison between ELISA and biochip microarray
  publication-title: J Anal Toxicol
  doi: 10.1093/anatox/35.1.40
– volume: 127
  start-page: 2893
  issue: 12
  year: 2010
  end-page: 917
  ident: CR1
  article-title: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
  publication-title: Int J Cancer
  doi: 10.1002/ijc.25516
– volume: 3
  start-page: 1
  year: 2011
  ident: CR18
  article-title: Discriminatory Analysis of Biochip-Derived Protein Patterns in CSF and Plasma in Neurodegenerative Diseases
  publication-title: Front Aging Neurosci
  doi: 10.3389/fnagi.2011.00001
– volume: 18
  start-page: 41
  issue: 1
  year: 1992
  end-page: 43
  ident: CR32
  article-title: Combination of serum carcino-embryonic antigen and C-reactive protein–a useful test in preoperative staging of colorectal cancer
  publication-title: Eur J Surg Oncol
– volume: 126
  start-page: 811
  issue: 10
  year: 1997
  end-page: 822
  ident: CR39
  article-title: Screening for colorectal cancer with the fecal occult blood test: a background paper
  publication-title: American College of Physicians. Annals of internal medicine
  doi: 10.7326/0003-4819-126-10-199705150-00014
– volume: 11
  start-page: 408
  issue: 1
  year: 2011
  ident: CR45
  article-title: Knowledge and attitudes of primary healthcare patients regarding population-based screening for colorectal cancer
  publication-title: BMC Cancer
  doi: 10.1186/1471-2407-11-408
– volume: 58
  start-page: 130
  issue: 3
  year: 2008
  end-page: 160
  ident: CR6
  article-title: Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology
  publication-title: CA Cancer J Clin
  doi: 10.3322/CA.2007.0018
– volume: 27
  start-page: 363
  issue: 4
  year: 2006
  end-page: 378
  ident: CR20
  article-title: Application of Evidence Investigator for the simultaneous measurement of soluble adhesion molecules: L-, P-, E- selectins, VCAM-1, ICAM-1 in a biochip platform
  publication-title: J Immunoassay Immunochem
  doi: 10.1080/15321810600862298
– volume: 289
  start-page: 1297
  issue: 10
  year: 2003
  end-page: 1302
  ident: CR36
  article-title: Colorectal cancer screening: clinical applications
  publication-title: JAMA
  doi: 10.1001/jama.289.10.1297
– volume: 45
  start-page: 1347
  issue: 10
  year: 2007
  end-page: 1352
  ident: CR24
  article-title: Cytokines and growth factors in mostly atherosclerotic patients on hemodialysis determined by biochip array technology
  publication-title: Clin Chem Lab Med
  doi: 10.1515/CCLM.2007.321
– volume: 3
  start-page: 423
  issue: 2
  year: 2008
  end-page: 430
  ident: CR25
  article-title: Fine-tuning of the prediction of mortality in hemodialysis patients by use of cytokine proteomic determination
  publication-title: Clin J Am Soc Nephrol
  doi: 10.2215/CJN.02010507
– volume: 37
  start-page: 92
  issue: Suppl 13
  year: 2002
  end-page: 96
  ident: CR33
  article-title: Colorectal cancer screening: the potential role of virtual colonoscopy
  publication-title: J Gastroenterol
  doi: 10.1007/BF02990108
– volume: 14
  start-page: 132
  issue: 3
  year: 2007
  end-page: 137
  ident: CR42
  article-title: Diagnostic accuracy of faecal occult blood tests used in screening for colorectal cancer: a systematic review
  publication-title: J Med Screen
  doi: 10.1258/096914107782066220
– volume: 124
  start-page: 544
  issue: 2
  year: 2003
  end-page: 560
  ident: CR37
  article-title: Colorectal cancer screening and surveillance: clinical guidelines and rationale-Update based on new evidence
  publication-title: Gastroenterology
  doi: 10.1053/gast.2003.50044
– volume: 11
  start-page: 645
  issue: 5
  year: 2005
  end-page: 648
  ident: CR30
  article-title: Cytokeratins and carcinoembryonic antigen in diagnosis, staging and prognosis of colorectal adenocarcinoma
  publication-title: World J Gastroenterol
  doi: 10.3748/wjg.v11.i5.645
– volume: 11
  start-page: 6550
  issue: 18
  year: 2005
  end-page: 6557
  ident: CR11
  article-title: Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-05-0983
– volume: 135
  start-page: 82
  issue: 1
  year: 2008
  end-page: 90
  ident: CR40
  article-title: Random comparison of guaiac and immunochemical fecal occult blood tests for colorectal cancer in a screening population
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2008.03.040
– volume: 149
  start-page: 638
  issue: 9
  year: 2008
  end-page: 658
  ident: CR41
  article-title: Screening for colorectal cancer: a targeted, updated systematic review for the U.S. Preventive Services Task Force
  publication-title: Ann Intern Med
  doi: 10.7326/0003-4819-149-9-200811040-00245
– volume: 12
  start-page: 1
  issue: 1)
  year: 2002
  end-page: 9
  ident: CR43
  article-title: The advanced adenoma as the primary target of screening
  publication-title: Gastrointest Endosc Clin N Am
  doi: 10.1016/S1052-5157(03)00053-9
– volume: 61
  start-page: 69
  issue: 2
  year: 2011
  end-page: 90
  ident: CR2
  article-title: Global cancer statistics
  publication-title: CA Cancer J Clin
  doi: 10.3322/caac.20107
– volume: 17
  start-page: 430
  issue: 5
  year: 2008
  end-page: 437
  ident: CR44
  article-title: The public prefers fecal occult blood test over colonoscopy for colorectal cancer screening
  publication-title: Eur J Cancer Prev
  doi: 10.1097/CEJ.0b013e328305a0fa
– volume: 102
  start-page: 89
  issue: 2
  year: 2010
  end-page: 95
  ident: CR4
  article-title: Protection from right- and left-sided colorectal neoplasms after colonoscopy: population-based study
  publication-title: J Natl Cancer Inst
  doi: 10.1093/jnci/djp436
– volume: 16
  start-page: 1018
  issue: 9
  year: 2011
  end-page: 1026
  ident: CR13
  article-title: Toward Standardized High-Throughput Serum Diagnostics: Multiplex-Protein Array Identifies IL-8 and VEGF as Serum Markers for Colon Cancer
  publication-title: J Biomol Screen
  doi: 10.1177/1087057111414894
– volume: 18
  start-page: 15
  issue: 1
  year: 2009
  end-page: 24
  ident: CR28
  article-title: Diagnostic precision of carcinoembryonic antigen in the detection of recurrence of colorectal cancer
  publication-title: Surg Oncol
  doi: 10.1016/j.suronc.2008.05.008
– volume: 64
  start-page: 161
  issue: 1
  year: 1969
  end-page: 167
  ident: CR27
  article-title: The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.64.1.161
– volume: 105
  start-page: 682
  issue: 3
  year: 2010
  end-page: 690
  ident: CR5
  article-title: Quantitative immunochemical fecal occult blood testing for colorectal adenoma detection: evaluation in the target population of screening and comparison with qualitative tests
  publication-title: Am J Gastroenterol
  doi: 10.1038/ajg.2009.668
– volume: 100
  start-page: 270
  issue: 2
  year: 2004
  end-page: 278
  ident: CR9
  article-title: Elevated perioperative serum vascular endothelial growth factor levels in patients with colon carcinoma
  publication-title: Cancer
  doi: 10.1002/cncr.11911
– volume: 7
  start-page: 450
  issue: 1
  year: 2008
  end-page: 455
  ident: CR17
  article-title: Simultaneous analysis of circulating human cytokines using a high-sensitivity cytokine biochip array
  publication-title: J Proteome Res
  doi: 10.1021/pr070409o
– volume: 12
  start-page: 11
  issue: 1
  year: 2002
  end-page: 21
  ident: CR34
  article-title: Fecal occult blood test screening for colorectal cancer
  publication-title: Gastrointest Endosc Clin N Am
  doi: 10.1016/S1052-5157(03)00054-0
– volume: 16
  start-page: 1935
  issue: 10
  year: 2007
  end-page: 1953
  ident: CR22
  article-title: Blood markers for early detection of colorectal cancer: a systematic review
  publication-title: Cancer Epidemiol Biomarkers Prev
  doi: 10.1158/1055-9965.EPI-06-0994
– volume: 83
  start-page: 1139
  issue: 9
  year: 2000
  end-page: 1146
  ident: CR8
  article-title: Preoperative serum CD26 levels: diagnostic efficiency and predictive value for colorectal cancer
  publication-title: Br J Cancer
  doi: 10.1054/bjoc.2000.1410
– volume: 65
  start-page: 549
  issue: 6
  year: 2007
  end-page: 554
  ident: CR23
  article-title: Biochip array-based analysis of plasma cytokines in HIV patients with immunological and virological discordance
  publication-title: Scand J Immunol
  doi: 10.1111/j.1365-3083.2007.01906.x
– volume: 131
  start-page: 1020
  issue: 4)
  year: 2006
  end-page: 1029
  ident: CR15
  article-title: Increased serum levels of complement C3a anaphylatoxin indicate the presence of colorectal tumors
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2006.07.011
– volume: 43
  start-page: 1303
  issue: 12
  year: 2005
  end-page: 1313
  ident: CR16
  article-title: Automation of biochip array technology for quality results
  publication-title: Clin Chem Lab Med
  doi: 10.1515/CCLM.2005.224
– volume: 22
  start-page: 33
  issue: 1
  year: 2007
  end-page: 38
  ident: CR10
  article-title: Pretreatment serum levels of hematopoietic cytokines in patients with colorectal adenomas and cancer
  publication-title: Int J Colorectal Dis
  doi: 10.1007/s00384-006-0099-4
– volume: 99
  start-page: 1631
  issue: 9
  year: 2004
  end-page: 1633
  ident: CR3
  article-title: PRO: Endoscopic surveillance minimizes the risk of cancer
  publication-title: Am J Gastroenterol
  doi: 10.1111/j.1572-0241.2004.40829.x
– volume: 28
  start-page: 709
  issue: 8
  year: 1986
  end-page: 713
  ident: CR38
  article-title: Sensitivity of fecal hemoccult testing and flexible sigmoidoscopy for colorectal cancer screening
  publication-title: J Occup Med
  doi: 10.1097/00043764-198608000-00033
– volume: 28
  start-page: 195
  issue: 1
  year: 2006
  end-page: 200
  ident: CR14
  article-title: Different expression of calgizzarin (S100A11) in normal colonic epithelium, adenoma and colorectal carcinoma
  publication-title: Int J Oncol
– volume: 99
  start-page: 1631
  issue: 9
  year: 2004
  ident: 3402_CR3
  publication-title: Am J Gastroenterol
  doi: 10.1111/j.1572-0241.2004.40829.x
– volume: 16
  start-page: 91
  issue: 1
  year: 2002
  ident: 3402_CR7
  publication-title: Best Pract Res Clin Gastroenterol
  doi: 10.1053/bega.2002.0268
– volume: 35
  start-page: 40
  issue: 1
  year: 2011
  ident: 3402_CR21
  publication-title: J Anal Toxicol
  doi: 10.1093/anatox/35.1.40
– volume: 126
  start-page: 811
  issue: 10
  year: 1997
  ident: 3402_CR39
  publication-title: American College of Physicians. Annals of internal medicine
  doi: 10.7326/0003-4819-126-10-199705150-00014
– volume: 12
  start-page: 1
  issue: 1)
  year: 2002
  ident: 3402_CR43
  publication-title: Gastrointest Endosc Clin N Am
  doi: 10.1016/S1052-5157(03)00053-9
– volume: 100
  start-page: 270
  issue: 2
  year: 2004
  ident: 3402_CR9
  publication-title: Cancer
  doi: 10.1002/cncr.11911
– volume: 37
  start-page: 92
  issue: Suppl 13
  year: 2002
  ident: 3402_CR33
  publication-title: J Gastroenterol
  doi: 10.1007/BF02990108
– volume: 28
  start-page: 709
  issue: 8
  year: 1986
  ident: 3402_CR38
  publication-title: J Occup Med
  doi: 10.1097/00043764-198608000-00033
– volume: 58
  start-page: 130
  issue: 3
  year: 2008
  ident: 3402_CR6
  publication-title: CA Cancer J Clin
  doi: 10.3322/CA.2007.0018
– volume: 43
  start-page: 1303
  issue: 12
  year: 2005
  ident: 3402_CR16
  publication-title: Clin Chem Lab Med
  doi: 10.1515/CCLM.2005.224
– volume: 135
  start-page: 82
  issue: 1
  year: 2008
  ident: 3402_CR40
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2008.03.040
– volume: 127
  start-page: 2893
  issue: 12
  year: 2010
  ident: 3402_CR1
  publication-title: Int J Cancer
  doi: 10.1002/ijc.25516
– volume: 16
  start-page: 1935
  issue: 10
  year: 2007
  ident: 3402_CR22
  publication-title: Cancer Epidemiol Biomarkers Prev
  doi: 10.1158/1055-9965.EPI-06-0994
– volume: 83
  start-page: 1139
  issue: 9
  year: 2000
  ident: 3402_CR8
  publication-title: Br J Cancer
  doi: 10.1054/bjoc.2000.1410
– volume: 27
  start-page: 363
  issue: 4
  year: 2006
  ident: 3402_CR20
  publication-title: J Immunoassay Immunochem
  doi: 10.1080/15321810600862298
– volume: 289
  start-page: 1297
  issue: 10
  year: 2003
  ident: 3402_CR36
  publication-title: JAMA
  doi: 10.1001/jama.289.10.1297
– volume: 64
  start-page: 161
  issue: 1
  year: 1969
  ident: 3402_CR27
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.64.1.161
– volume: 14
  start-page: 132
  issue: 3
  year: 2007
  ident: 3402_CR42
  publication-title: J Med Screen
  doi: 10.1258/096914107782066220
– volume: 11
  start-page: 408
  issue: 1
  year: 2011
  ident: 3402_CR45
  publication-title: BMC Cancer
  doi: 10.1186/1471-2407-11-408
– volume: 42
  start-page: 704
  issue: 6
  year: 2006
  ident: 3402_CR12
  publication-title: Eur J Cancer
  doi: 10.1016/j.ejca.2006.01.008
– volume: 149
  start-page: 638
  issue: 9
  year: 2008
  ident: 3402_CR41
  publication-title: Ann Intern Med
  doi: 10.7326/0003-4819-149-9-200811040-00245
– volume: 124
  start-page: 544
  issue: 2
  year: 2003
  ident: 3402_CR37
  publication-title: Gastroenterology
  doi: 10.1053/gast.2003.50044
– volume: 28
  start-page: 195
  issue: 1
  year: 2006
  ident: 3402_CR14
  publication-title: Int J Oncol
– volume: 61
  start-page: 69
  issue: 2
  year: 2011
  ident: 3402_CR2
  publication-title: CA Cancer J Clin
  doi: 10.3322/caac.20107
– volume: 116
  start-page: 80
  issue: 1
  year: 2009
  ident: 3402_CR26
  publication-title: Ophthalmology
  doi: 10.1016/j.ophtha.2008.09.036
– volume: 18
  start-page: 41
  issue: 1
  year: 1992
  ident: 3402_CR32
  publication-title: Eur J Surg Oncol
– volume: 137
  start-page: 375
  issue: 3
  year: 2011
  ident: 3402_CR29
  publication-title: J Cancer Res Clin Oncol
  doi: 10.1007/s00432-010-0965-x
– volume: 3
  start-page: 1
  year: 2011
  ident: 3402_CR18
  publication-title: Front Aging Neurosci
  doi: 10.3389/fnagi.2011.00001
– volume: 105
  start-page: 682
  issue: 3
  year: 2010
  ident: 3402_CR5
  publication-title: Am J Gastroenterol
  doi: 10.1038/ajg.2009.668
– volume: 148
  start-page: 591
  issue: 12
  year: 2009
  ident: 3402_CR19
  publication-title: Cas Lek Cesk
– volume: 22
  start-page: 33
  issue: 1
  year: 2007
  ident: 3402_CR10
  publication-title: Int J Colorectal Dis
  doi: 10.1007/s00384-006-0099-4
– volume: 102
  start-page: 89
  issue: 2
  year: 2010
  ident: 3402_CR4
  publication-title: J Natl Cancer Inst
  doi: 10.1093/jnci/djp436
– volume: 16
  start-page: 1018
  issue: 9
  year: 2011
  ident: 3402_CR13
  publication-title: J Biomol Screen
  doi: 10.1177/1087057111414894
– volume: 65
  start-page: 549
  issue: 6
  year: 2007
  ident: 3402_CR23
  publication-title: Scand J Immunol
  doi: 10.1111/j.1365-3083.2007.01906.x
– volume: 11
  start-page: 6550
  issue: 18
  year: 2005
  ident: 3402_CR11
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-05-0983
– volume: 45
  start-page: 1347
  issue: 10
  year: 2007
  ident: 3402_CR24
  publication-title: Clin Chem Lab Med
  doi: 10.1515/CCLM.2007.321
– volume: 18
  start-page: 15
  issue: 1
  year: 2009
  ident: 3402_CR28
  publication-title: Surg Oncol
  doi: 10.1016/j.suronc.2008.05.008
– volume: 131
  start-page: 1020
  issue: 4)
  year: 2006
  ident: 3402_CR15
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2006.07.011
– volume: 12
  start-page: 11
  issue: 1
  year: 2002
  ident: 3402_CR34
  publication-title: Gastrointest Endosc Clin N Am
  doi: 10.1016/S1052-5157(03)00054-0
– volume: 17
  start-page: 430
  issue: 5
  year: 2008
  ident: 3402_CR44
  publication-title: Eur J Cancer Prev
  doi: 10.1097/CEJ.0b013e328305a0fa
– volume: 7
  start-page: 450
  issue: 1
  year: 2008
  ident: 3402_CR17
  publication-title: J Proteome Res
  doi: 10.1021/pr070409o
– volume: 91
  start-page: 434
  issue: 5
  year: 1999
  ident: 3402_CR35
  publication-title: J Natl Cancer Inst
  doi: 10.1093/jnci/91.5.434
– volume: 3
  start-page: 423
  issue: 2
  year: 2008
  ident: 3402_CR25
  publication-title: Clin J Am Soc Nephrol
  doi: 10.2215/CJN.02010507
– volume: 11
  start-page: 645
  issue: 5
  year: 2005
  ident: 3402_CR30
  publication-title: World J Gastroenterol
  doi: 10.3748/wjg.v11.i5.645
– volume: 10
  start-page: M110 004978
  issue: 4
  year: 2011
  ident: 3402_CR31
  publication-title: Mol Cell Proteomics
  doi: 10.1074/mcp.M110.004978
– reference: 18235144 - Clin J Am Soc Nephrol. 2008 Mar;3(2):423-30
– reference: 1737592 - Eur J Surg Oncol. 1992 Feb;18(1):41-3
– reference: 18322143 - CA Cancer J Clin. 2008 May-Jun;58(3):130-60
– reference: 17932341 - Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):1935-53
– reference: 19953091 - Am J Gastroenterol. 2010 Mar;105(3):682-90
– reference: 10070942 - J Natl Cancer Inst. 1999 Mar 3;91(5):434-7
– reference: 18482589 - Gastroenterology. 2008 Jul;135(1):82-90
– reference: 20662394 - Cas Lek Cesk. 2009;148(12):591-6
– reference: 21219702 - J Anal Toxicol. 2011 Jan;35(1):40-5
– reference: 11916154 - Gastrointest Endosc Clin N Am. 2002 Jan;12(1):11-21
– reference: 3746495 - J Occup Med. 1986 Aug;28(8):709-13
– reference: 16520929 - Int J Colorectal Dis. 2007 Jan;22(1):33-8
– reference: 16327996 - Int J Oncol. 2006 Jan;28(1):195-200
– reference: 18619834 - Surg Oncol. 2009 Mar;18(1):15-24
– reference: 12557158 - Gastroenterology. 2003 Feb;124(2):544-60
– reference: 16166432 - Clin Cancer Res. 2005 Sep 15;11(18):6550-7
– reference: 21807963 - J Biomol Screen. 2011 Oct;16(9):1018-26
– reference: 14716760 - Cancer. 2004 Jan 15;100(2):270-8
– reference: 18838718 - Ann Intern Med. 2008 Nov 4;149(9):638-58
– reference: 9148658 - Ann Intern Med. 1997 May 15;126(10):811-22
– reference: 17924848 - Clin Chem Lab Med. 2007;45(10):1347-52
– reference: 21942990 - BMC Cancer. 2011 Sep 25;11(1):408
– reference: 17925085 - J Med Screen. 2007;14(3):132-7
– reference: 17523947 - Scand J Immunol. 2007 Jun;65(6):549-54
– reference: 12633192 - JAMA. 2003 Mar 12;289(10):1297-302
– reference: 5262998 - Proc Natl Acad Sci U S A. 1969 Sep;64(1):161-7
– reference: 12109675 - J Gastroenterol. 2002;37 Suppl 13:92-6
– reference: 20042716 - J Natl Cancer Inst. 2010 Jan 20;102(2):89-95
– reference: 21296855 - CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
– reference: 21242282 - Mol Cell Proteomics. 2011 Apr;10(4):M110.004978
– reference: 16513341 - Eur J Cancer. 2006 Apr;42(6):704-7
– reference: 21193998 - J Cancer Res Clin Oncol. 2011 Mar;137(3):375-89
– reference: 18020322 - J Proteome Res. 2008 Jan;7(1):450-5
– reference: 16981649 - J Immunoassay Immunochem. 2006;27(4):363-78
– reference: 18714185 - Eur J Cancer Prev. 2008 Oct;17(5):430-7
– reference: 11916153 - Gastrointest Endosc Clin N Am. 2002 Jan;12(1):1-9, v
– reference: 17030172 - Gastroenterology. 2006 Oct;131(4):1020-9; quiz 1284
– reference: 19118699 - Ophthalmology. 2009 Jan;116(1):80-6
– reference: 16309365 - Clin Chem Lab Med. 2005;43(12):1303-13
– reference: 11977931 - Best Pract Res Clin Gastroenterol. 2002 Feb;16(1):91-114
– reference: 11027426 - Br J Cancer. 2000 Nov;83(9):1139-46
– reference: 15330891 - Am J Gastroenterol. 2004 Sep;99(9):1631-3
– reference: 21351269 - Int J Cancer. 2010 Dec 15;127(12):2893-917
– reference: 15655814 - World J Gastroenterol. 2005 Feb 7;11(5):645-8
– reference: 21442044 - Front Aging Neurosci. 2011 Jan 31;3:1
SSID ssj0017808
Score 2.1945946
Snippet Background More than 1.2 million new cases of colorectal cancer are reported each year worldwide. Despite actual screening programs, about 50% of the patients...
More than 1.2 million new cases of colorectal cancer are reported each year worldwide. Despite actual screening programs, about 50% of the patients are...
Background More than 1.2 million new cases of colorectal cancer are reported each year worldwide. Despite actual screening programs, about 50% of the patients...
Doc number: 393 Abstract Background: More than 1.2 million new cases of colorectal cancer are reported each year worldwide. Despite actual screening programs,...
Abstract Background More than 1.2 million new cases of colorectal cancer are reported each year worldwide. Despite actual screening programs, about 50% of the...
SourceID doaj
unpaywall
pubmedcentral
proquest
gale
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 393
SubjectTerms Adenoma - blood
Adenoma - diagnosis
Adult
Aged
Aged, 80 and over
Algorithms
Biomarkers, Tumor - blood
Biomedical and Life Sciences
Biomedicine
Blood
Blood proteins
C-Reactive Protein - metabolism
Cancer
Cancer Research
Carcinoembryonic Antigen - blood
Case-Control Studies
CEA
Colon
Colon cancer
Colon cancer screening
Colonic Neoplasms - blood
Colonic Neoplasms - diagnosis
Colorectal cancer
Computational Biology
CRP
Diagnosis
Female
Health Promotion and Disease Prevention
High-Throughput Screening Assays
High-throughput seromics
Humans
IL-8
Interleukin-8 - blood
Male
Medical examination
Medical research
Medical screening
Medicine/Public Health
Middle Aged
Molecular Diagnostic Techniques - methods
Mortality
Multiplex protein array biochip
Oncology
Oncology, Experimental
Patient compliance
Prognosis
Protein Array Analysis - methods
Protein microarrays
Research Article
ROC Curve
Serum diagnostics
Surgical Oncology
Vascular endothelial growth factor
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQDzwOFW9SChiEhKgUbR6O7XBbEFVBKgegUi_IshMbKi1OtbsBeuM_8A_5Jcw4D21A0Au3KB5LyczY_kYz_oaQx1JIBqjextqYJGZOi1jr0sVZLqTJhDYydG84fMMPjtjr4-J4o9UX1oR19MCd4malBkSlWZVxa5gsuUlrl0tuipoDLhThmm8iyyGY6vMHQoZedClsvZg_EEOCUvLZ-C7Q9ZX55EAKvP1_7s4bx9PvpZNj_vQKudT6U332VS8WG0fU_lWy3WNLOu_-6Rq5YP11cvGwz57fIB_m1Ddf7IIOVYTf4kDTcOKpXi71GQUAS8El28-07irwkMOZNo4itbWnFXrI8hnV8LSyP7__6OvcaeCovUmO9l--f3EQ9-0V4opzto41s6kzZc4tRCUZdxL71UidJhWgHNB2LhIrbVZVkrtUZwKCs5oXLjMcSexh4d4iW77x9g6hzuqkqGuX2iRnxoH9DYjLqqhL61KXRmQ26FhVPfc4tsBYqBCDSK7QKgqtotJMgVUi8nSccdrxbvxD9jmabZRDxuzwAvxI9X6kzvOjiDxAo6vu-um47tW8yDHGZWUSkUdBAlkzPJblfNTtaqVevXs7EXrSC7kG_rDS_S0H0BMSbU0kdyeSsKyr6fDgfarfVlbIzI4t4wohIvJwHMaZWCrnbdOugopKhJ2gl9uds46awd7tLEt4RMTEjSeqm474k0-BdDwvAB2XLCJ7g8NvfNZfDbM3LolzrbjzP6x4l1wGRJuFIkCxS7bWy9beA9S4NvfDBvELuapipw
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3ra9RAEF_qFXx8EN-NVl1FEAvhks1mdyOIXKWlCj2kWij4Ydkku23hTM57qP3vndlL4kWxfgu3E8jOa2duZn9DyAslFYeo3oYmz6OQOyNDYzIXskSqnEmTKz-94XAsDo75h5P0ZIOM27sw2FbZ-kTvqMu6wP_IhzGEzhzOOinfTr-FODUKq6vtCA3TjFYo33iIsStkkyEy1oBs7u6NPx51dQWpItUWK5UYxuCasb4gPXRflvQOJ4_h_7enXjuq_myj7GqpN8i1ZTU1Fz_MZLJ2XO3fIjebOJOOVopxm2zY6g65ethU0u-SLyNa1d_thLYdhT9DD9lwXlEzm5kLCsEsBfVcfqXlqhsP8Zxp7SjCXFe0QG2ZvaYGnuY2bDreqUervUeO9_c-vzsIm0ELYSEEX4SG29jlWSIsMJkJp3ByjTJxVEC8IyDdlpFVlhWFEi42TEKaVorUsVwgnD2Y8H0yqOrKbhHqrInSsnSxjRKeO9CEHMhVkZaZdbGLAzJsOayLBoUch2FMtM9GlNAoE40y0THTIJOAvOremK4QOC6h3UWhdXSIne1_qGenujFFnRmI0Q0vGOyMq0zkcekSJfK0FJBpSBWQpyhyvbqI2nkAPUoTzHZ5FgXkuadA_IwKG3ROzXI-1-8_HfWIXjZEroYdFqa57wB8QsitHuV2jxIMvOgvt7qnGwcz17_NISDPumV8E5vmKlsv555FGQagwJcHK1XtOINT3DmLREBkT4l7rOuvVOdnHn48SSFOznhAdlp1X_usfwpmpzOI_0rx4eUbfkSuQ9TKfKOf3CaDxWxpH0NkuMifNOb-CwgqXSY
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELagSDwOiDeBAgYhISqF5uHYDhJCC6IqSMsBqNRLZdmJXSotScnuQvfGf-Af8kuY8SbpBgqIWxKPo3ge8Yxm_A0hD6WQDLx6G2pjopA5LUKtcxcmqZAmEdpI371h_JZv77A3u9nu8fHoloHTE0M77Ce100yeHH1ePAeDf-YNXvLNGH6wmCUQHoAvT0-TM3CXYyOHMTvOKQgZyS5RecKswcbk8ft__0uvbFO_llD2edQL5Ny8OtSLr3oyWdmqti6Ri62PSUdLpbhMTtnqCjk7brPoV8neiFb1FzuhXTXhUejhGg4qqptGLyg4shRUc_6JlstKPMRyprWjCHFd0QI1pXlKNVxN7Y9v39t6d-qxaq-Rna1XH15uh22bhbDgnM1CzWzsTJ5yC9FJwp3EvjVSx1EB3g6HYFtEVtqkKCR3sU4EBGklz1xiOILZgwFfJ2tVXdmbhDqro6wsXWyjlBkHemCAXBZZmVsXuzggmx2PVdFikGMrjInysYjkCqWiUCoqThRIJSCP-xmHS_yNv9C-QLH1dIic7R_Uzb5qDVHlGjx0zYoEVsZkzk1culRyk5Uc4gwhA3IPha6Wx1B7-1ejLMVYl-VRQB54CkTPqLA8Z1_Pp1P1-v27AdGjlsjVsMJCt6cdgE8IuDWgXB9QgnkXw-FO-1RnHYjQjq3jMiECcr8fxplYMlfZej71LMrR_QS-3Fgqa88Z7OHOkogHRAzUeMC64Uh18NGDj6cZeMk5C8hGp_Arn_VHwWz0JvFPKd76nzffJufBg0180Z9YJ2uzZm7vgJc4M3e98f8EHVBeew
  priority: 102
  providerName: Scholars Portal
– databaseName: Unpaywall
  dbid: UNPAY
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Zb9QwELbKVuJ44KYEChiEhKiU3Zy2w9uCqBakVghYqTwgy07sdsU2WWU3QHniP_AP-SWMnUObcgmJtygeR_F4Zjwjz3yD0ENGWQRevXKFlJ4baUFdIRLtBiFlMqBCMtu9YW-fTKbRy4P4YANN2loYeWw-mapyuF5-Pq-rG0z3BFWOFpmulZ2RkQ_G1dwQUAu-l4Rn0CaJwSsfoM3p_qvxO1tc1JC0t5S_mNY7lSx4_88meu2MOp0_2V2iXkDnqnwhTj6J-XztnNq9hGbtCuv0lA_DaiWH6ZdT4I__gwWX0cXGmcXjWvquoA2VX0Vn95rr-mvo_RjnxUc1x23a4mfX4kLMcizKUpxg8Jgx6EB1jLM65c-ARuNCY4OlneP6B59gAU9L9f3rtyaxHltQ3Otouvv87bOJ2_RzcFNCopUrIuVrmYREQRgUEM1MgxwmfC8Ft4pAVE89xVSQpoxoXwQUosGMxDqQxKDmg6W4gQZ5kaubCGslvDjLtK-8MJIaBE4COUvjLFHa176DRu1-8rQBOzc9N-bcBj2McMM1brjG_YAD1xz0uJuxqIE-_kD71IhIR2cguu2LojzkjcbzREAoIKI0gJVFLCHSz3TIiIwzAgENZQ66ZwSM1_WunaHh4zg0QXWUeA56YCkMTEdu8oAORbVc8hdvXveIHjVEuoAVpqIpqwA-GWSvHuV2jxLsSNofbiWdN3ZsaaDgTY-6mFIH3e-GzUyTm5erolpaFiXGzwW-bNWK0XHGNIuPAo84iPZUpse6_kg-O7Io52EM7ngSOWinVa613_rtxux06vfXXbz1L8S30XlwlQObXUi30WBVVuoOuKMrebexND8AmsyA3g
  priority: 102
  providerName: Unpaywall
Title A novel multiplex-protein array for serum diagnostics of colon cancer: a case–control study
URI https://link.springer.com/article/10.1186/1471-2407-12-393
https://www.ncbi.nlm.nih.gov/pubmed/22954206
https://www.proquest.com/docview/1174417577
https://www.proquest.com/docview/1186939933
https://pubmed.ncbi.nlm.nih.gov/PMC3502594
https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-12-393
https://doaj.org/article/9a81da4c26eb4896b1df386b5d672978
UnpaywallVersion publishedVersion
Volume 12
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVADU
  databaseName: BioMedCentral
  customDbUrl:
  eissn: 1471-2407
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017808
  issn: 1471-2407
  databaseCode: RBZ
  dateStart: 20010101
  isFulltext: true
  titleUrlDefault: https://www.biomedcentral.com/search/
  providerName: BioMedCentral
– providerCode: PRVAFT
  databaseName: Open Access Digital Library
  customDbUrl:
  eissn: 1471-2407
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017808
  issn: 1471-2407
  databaseCode: KQ8
  dateStart: 20010101
  isFulltext: true
  titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html
  providerName: Colorado Alliance of Research Libraries
– providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 1471-2407
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017808
  issn: 1471-2407
  databaseCode: DOA
  dateStart: 20010101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVEBS
  databaseName: EBSCOhost Academic Search Ultimate
  customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn
  eissn: 1471-2407
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017808
  issn: 1471-2407
  databaseCode: ABDBF
  dateStart: 20010101
  isFulltext: true
  titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn
  providerName: EBSCOhost
– providerCode: PRVBFR
  databaseName: Free Medical Journals
  customDbUrl:
  eissn: 1471-2407
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017808
  issn: 1471-2407
  databaseCode: DIK
  dateStart: 20010101
  isFulltext: true
  titleUrlDefault: http://www.freemedicaljournals.com
  providerName: Flying Publisher
– providerCode: PRVFQY
  databaseName: GFMER Free Medical Journals
  customDbUrl:
  eissn: 1471-2407
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017808
  issn: 1471-2407
  databaseCode: GX1
  dateStart: 0
  isFulltext: true
  titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php
  providerName: Geneva Foundation for Medical Education and Research
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources
  customDbUrl:
  eissn: 1471-2407
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017808
  issn: 1471-2407
  databaseCode: M~E
  dateStart: 20010101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
– providerCode: PRVAQN
  databaseName: PubMed Central
  customDbUrl:
  eissn: 1471-2407
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017808
  issn: 1471-2407
  databaseCode: RPM
  dateStart: 20010101
  isFulltext: true
  titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/
  providerName: National Library of Medicine
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 1471-2407
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017808
  issn: 1471-2407
  databaseCode: 7X7
  dateStart: 20090101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl: http://www.proquest.com/pqcentral?accountid=15518
  eissn: 1471-2407
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017808
  issn: 1471-2407
  databaseCode: BENPR
  dateStart: 20090101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVFZP
  databaseName: Scholars Portal Journals: Open Access
  customDbUrl:
  eissn: 1471-2407
  dateEnd: 20250930
  omitProxy: true
  ssIdentifier: ssj0017808
  issn: 1471-2407
  databaseCode: M48
  dateStart: 20010801
  isFulltext: true
  titleUrlDefault: http://journals.scholarsportal.info
  providerName: Scholars Portal
– providerCode: PRVAVX
  databaseName: HAS SpringerNature Open Access 2022
  customDbUrl:
  eissn: 1471-2407
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017808
  issn: 1471-2407
  databaseCode: AAJSJ
  dateStart: 20011201
  isFulltext: true
  titleUrlDefault: https://www.springernature.com
  providerName: Springer Nature
– providerCode: PRVAVX
  databaseName: Springer Nature OA Free Journals
  customDbUrl:
  eissn: 1471-2407
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017808
  issn: 1471-2407
  databaseCode: C6C
  dateStart: 20010112
  isFulltext: true
  titleUrlDefault: http://www.springeropen.com/
  providerName: Springer Nature
– providerCode: PRVAVX
  databaseName: SpringerLink Journals (ICM)
  customDbUrl:
  eissn: 1471-2407
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017808
  issn: 1471-2407
  databaseCode: U2A
  dateStart: 20011201
  isFulltext: true
  titleUrlDefault: http://www.springerlink.com/journals/
  providerName: Springer Nature
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Zj9MwELb2kDgeEDeBpRiEhFgp2sRxbIe3ttrVgtRqVahUkJDlJPayUklWPYB94z_wD_kljJ1DDad4iZJ6XDVz2DOd8TcIPRVcUPDqta_SNPCpUdxXKjE-ibhICVepcN0bRmN2PKWvZvFsC5HmLIyrdm9Skm6ldmYt2EEIy6jNBXAHs5dE22g3tmBeoMNT0m8zB1wEoklH_mZWZ_txKP2_rsUbm9HPhZJttvQqurwuztXFZzWfb2xIR9fRtdqTxP1K9DfQli5uokujOld-C73v46L8pOe4qRn84jtQhrMCq8VCXWBwVzEo4Pojzqt6O4vYjEuDLZB1gTOrD4sXWMHdUn__-q2uascOkfY2mh4dvhke-3UzBT9jjK58RXVo0iRiGmIQwoyw3WmECoMMfBoGITUPtNAkywQzoSIcQrGcxYakzELWg5neQTtFWeh7CButgjjPTaiDiKYGpJ0CucjiPNEmNKGHDhoey6xGGrcNL-bSRRyCSSsVaaUiQyJBKh563s44r1A2_kI7sGJr6Sw-tvugXJzK2txkosAPVzQj8GZUJCwNcxMJlsY5g2iCCw89skKX1WHT1splP45sREuTwENPHIXFyChsEc6pWi-X8uXrSYfoWU1kSnjDTNVnGoBPFlarQ7nXoQQjzrrDjfbJehFZWhx22yAu5txDj9thO9MWxhW6XC8dixLrZAJf7lbK2nLGdmqnJGAe4h017rCuO1KcfXAQ41EMvnBCPbTfKPzGz_qjYPZbk_inFO__zzc_QFfATyWutI_voZ3VYq0fgi-4Sntom894D-0ODscnE3gasmHP_a8C1xEVcJ0M3vXcEgFU0_FJ_-0PvHRcAA
linkProvider Springer Nature
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELfGJjF4QHwTGMwgEGJS1Hw4toM0oQ42tWyt0NikSTwYJ7HHpJKUpmX0n-Nv4-wmoQExnvZW1Ze2vjvfR-_8O4Sec8YJRPXKlUniuURL5koZazcIGU8CJhNupzcMhrR3TN6fRCcr6Gd9F8a0VdY20RrqrEjNf-QdH0JnAr6OsTfjb66ZGmWqq_UIDVmNVsi2LcRYdbFjX83PIYUrt_vvQN4vgmBv9-htz62mDLgppWTqSqJ8ncQhVfANAdXcjG3h0vdScPYUck3mKa6CNOVU-zJgkKNkNNJBQg2WO-gvfO4VtEZCEkPyt7azO_xw2NQxGPd4XRzltOODKzD1DGahAuOw5QztzIC_PcOSa_yzbbOp3V5H67N8LOfncjRaco97N9GNKq7F3YUi3kIrKr-Nrg6qyv0d9KmL8-K7GuG6g_GHayEiznIsJxM5xxA8YzgOs684W3T_GfxoXGhsYLVznBrtnLzGEl6Vyq067LFFx72Lji-F5ffQal7k6gHCWkkvyjLtKy8kiQbNS4Ccp1EWK-1r30GdmsMirVDPzfCNkbDZD6fCyEQYmQg_ECATB71qnhgvED8uoN0xQmvoDFa3faOYnIrq6ItYQk4gSRrAzgiPaeJnOuQ0iTIKmQ3jDto0IheLi6-NxRHdKDTZNYk9Bz2zFAavIzcNQadyVpai__GwRfSyItIF7DCV1f0K4JOB-GpRbrQowaCk7eVa90Rl0Erx-_g56GmzbJ40TXq5KmalZVFsAl7gy_2FqjacMVPjSeBRB7GWErdY117Jz75YuPMwgrg8Jg7aqtV96Wf9UzBbzYH4rxQfXrzhTbTeOxociIP-cP8RugYRc2CbDNkGWp1OZuoxRKXT5El19DH6fNnW5hdvyZgO
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Zb9QwELagSAUeEDeBQg1CQlSKNodjO7wtC6sWaIWASn1BlpPYpdKSrDa7QN_4D_xDfgkzzqENp3iL4nGUzGHPZMbfEPJQCsnAqze-zrLAZ1YLX-vU-lEsZBYJnUnXvWH_gO8eshdHyVH7w63uqt27lGRzpgFRmsrlaF7YxsQlH4WwpGJeQDjIvTQ-S84x2Nuwg8GET_osgpCB7FKTv5k12IocYv-v6_LaxvRz0WSfOb1Izq_KuT79rGeztc1peplcar1KOm7U4Ao5Y8qrZHO_zZtfI-_HtKw-mRnt6ge_-A6g4aSkerHQpxRcVwrKuPpIi6b2DtGbaWUpglqXNEfdWDyhGq5q8_3rt7bCnTp02uvkcPr83WTXbxsr-DnnbOlrZkKbpTE3EI9E3ErsVCN1GOTg33AIr0VgpInyXHIb6khAWFbwxEYZR_h6MNkbZKOsSnOLUGt0kBSFDU0Qs8yC5DMgl3lSpMaGNvTIqOOxylvUcWx-MVMu-pBcoVQUSkWFkQKpeORxP2PeIG78hfYpiq2nQ6xsd6NaHKvW9FSqwSfXLI_gy5hMeRYWNpY8SwoOkYWQHtlGoavm4Glv8WqcxBjdsjTwyANHgXgZJRbkHOtVXau9t28GRI9aIlvBF-a6Pd8AfEKIrQHl1oASDDofDnfap9oFpUZMdmwWlwjhkfv9MM7EIrnSVKvasShFhxP4crNR1p4z2LWdRQH3iBio8YB1w5Hy5IODG48T8ItT5pGdTuHXXuuPgtnpTeKfUrz9P0_eJpuvn03Vq72Dl3fIBXBfI1fxJ7bIxnKxMnfBRVxm99w68APpllsm
linkToUnpaywall http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Zb9QwELbKVuJ44KYEChiEhKiU3Zy2w9uCqBakVghYqTwgy07sdsU2WWU3QHniP_AP-SWMnUObcgmJtygeR_F4Zjwjz3yD0ENGWQRevXKFlJ4baUFdIRLtBiFlMqBCMtu9YW-fTKbRy4P4YANN2loYeWw-mapyuF5-Pq-rG0z3BFWOFpmulZ2RkQ_G1dwQUAu-l4Rn0CaJwSsfoM3p_qvxO1tc1JC0t5S_mNY7lSx4_88meu2MOp0_2V2iXkDnqnwhTj6J-XztnNq9hGbtCuv0lA_DaiWH6ZdT4I__gwWX0cXGmcXjWvquoA2VX0Vn95rr-mvo_RjnxUc1x23a4mfX4kLMcizKUpxg8Jgx6EB1jLM65c-ARuNCY4OlneP6B59gAU9L9f3rtyaxHltQ3Otouvv87bOJ2_RzcFNCopUrIuVrmYREQRgUEM1MgxwmfC8Ft4pAVE89xVSQpoxoXwQUosGMxDqQxKDmg6W4gQZ5kaubCGslvDjLtK-8MJIaBE4COUvjLFHa176DRu1-8rQBOzc9N-bcBj2McMM1brjG_YAD1xz0uJuxqIE-_kD71IhIR2cguu2LojzkjcbzREAoIKI0gJVFLCHSz3TIiIwzAgENZQ66ZwSM1_WunaHh4zg0QXWUeA56YCkMTEdu8oAORbVc8hdvXveIHjVEuoAVpqIpqwA-GWSvHuV2jxLsSNofbiWdN3ZsaaDgTY-6mFIH3e-GzUyTm5erolpaFiXGzwW-bNWK0XHGNIuPAo84iPZUpse6_kg-O7Io52EM7ngSOWinVa613_rtxux06vfXXbz1L8S30XlwlQObXUi30WBVVuoOuKMrebexND8AmsyA3g
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+novel+multiplex-protein+array+for+serum+diagnostics+of+colon+cancer%3A+a+case%E2%80%93control+study&rft.jtitle=BMC+cancer&rft.au=B%C3%BCnger%2C+Stefanie&rft.au=Haug%2C+Ulrike&rft.au=Kelly%2C+Maria&rft.au=Posorski%2C+Nicole&rft.date=2012-09-07&rft.pub=BioMed+Central&rft.eissn=1471-2407&rft.volume=12&rft.issue=1&rft_id=info:doi/10.1186%2F1471-2407-12-393&rft.externalDocID=10_1186_1471_2407_12_393
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1471-2407&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1471-2407&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1471-2407&client=summon