Structural basis for gating pore current in periodic paralysis - Jiang, Daohua; Gamal El-Din, Tamer M.; Ing, Christopher; Lu, Peilong; Pomès, Régis; Zheng, Ning; Catterall, William A. (Nature (London), 2018)
Keywords: 631/378; 631/535/1266; 82/16; 9/74; Binding Sites; Calcium; Calcium channels; Calcium channels (voltage-gated); Cations; Causes of; Channel gating; Computer simulation; Crystal structure; Electric Conductivity; Electric potential; Familial periodic paralysis; Gene mutation; Genetic aspects; Guanidine - metabolism; Health aspects; Humanities and Social Sciences; Humans; Hydrophobicity; Hypokalemic Periodic Paralysis - genetics; Hypokalemic Periodic Paralysis - metabolism; Ion Channel Gating - genetics; Ions; Letter; Molecular chains; Molecular dynamics; Molecular Dynamics Simulation; Molecular modelling; multidisciplinary; Muscles; Mutation; NAV1.4 Voltage-Gated Sodium Channel - chemistry; NAV1.4 Voltage-Gated Sodium Channel - genetics; NAV1.4 Voltage-Gated Sodium Channel - metabolism; Observations; Paralyses, Familial Periodic - genetics; Paralyses, Familial Periodic - metabolism; Paralysis; Potassium; Resveratrol; Science; Science (multidisciplinary); Skeletal muscle; Sodium; Sodium - metabolism; Sodium channels; Sodium channels (voltage-gated); Thermodynamics; Variation; United States--US