EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment - Gu, Chao-Jiang; Borjabad, Alejandra; Hadas, Eran; Kelschenbach, Jennifer; Kim, Boe-Hyun; Chao, Wei; Arancio, Ottavio; Suh, Jin; Polsky, Bruce; McMillan, JoEllyn; Edagwa, Benson; Gendelman, Howard E.; et al. (PLoS pathogens, 2018)
Keywords: Acquired immune deficiency syndrome; Adoptive Transfer; Aged; AIDS; Animal cognition; Animal tissues; Animals; Anti-Retroviral Agents - therapeutic use; Antigens; Antiretroviral agents; Antiretroviral drugs; Antiretroviral therapy; Biology and Life Sciences; Brain; Brain - virology; CD4 antigen; CD4-Positive T-Lymphocytes - virology; Chronic illnesses; Cognition; Cognitive ability; Dementia; Deoxyribonucleic acid; Disease Reservoirs; DNA; Dosage and administration; Drug therapy; Epigenetics; Female; Health aspects; HIV; HIV - genetics; HIV - immunology; HIV - pathogenicity; HIV - physiology; HIV infections; HIV Infections - complications; HIV Infections - drug therapy; Human immunodeficiency virus; Humans; Immunity; Immunization; Immunocompetence; Immunomodulation; Impairment; In vivo methods and tests; Infections; Learning; Leukemia; Lymphocytes; Lymphocytes T; Macrophages; Macrophages, Peritoneal - virology; Male; Medicine; Medicine and Health Sciences; Memory; Memory cells; Mice; Mice, Inbred C57BL; Mice, Nude; Middle Aged; Modulators; Monocytes; Nervous system; Neurocognitive Disorders - virology; Neuromodulation; Neuropathogenesis; Neurosciences; Pathogenesis; Pharmacology; Physiological aspects; Plasmids; Potash; Prophylaxis; Replication; Research and Analysis Methods; Spleen - cytology; Spleen - immunology; Systematic review; T cells; Therapy; Transgenic animals; Virus replication; Viruses; New York; United States--US; Nebraska