TTI-621 (SIRPαFc), a CD47-blocking cancer immunotherapeutic, triggers phagocytosis of lymphoma cells by multiple polarized macrophage subsets - Lin, Gloria H. Y.; Chai, Vien; Lee, Vivian; Dodge, Karen; Truong, Tran; Wong, Mark; Johnson, Lisa D.; Linderoth, Emma; Pang, Xinli; Winston, Jeff; Petrova, Penka S.; Uger, Robert A.; et al. (PloS one, 2017)
Keywords: Animals; Antigens, Differentiation - physiology; Cancer; Cancer cells; Cell activation; Cell Line, Tumor; Cell Polarity; Cell surface; Cytokines; Cytokines - biosynthesis; Female; Fusion protein; Genetic aspects; Genotype & phenotype; Humans; Immunoglobulin Fc Fragments - physiology; Immunophenotyping; Inflammation; Interferon; Interleukin 10; Interleukin 4; Lipopolysaccharides; Lymphoma; Lymphoma, Large B-Cell, Diffuse - immunology; Macrophages; Macrophages - immunology; Medical prognosis; Membrane proteins; Mice; Mice, Hairless; Phagocytes; Phagocytosis; Phagocytosis - physiology; Physiological aspects; Proteins; Receptors; Receptors, Immunologic - physiology; Rodents; Surface markers; Tumor cells; Tumors; γ-Interferon; Canada