FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes - Adams, Elizabeth J.; Karthaus, Wouter R.; Hoover, Elizabeth; Liu, Deli; Gruet, Antoine; Zhang, Zeda; Cho, Hyunwoo; DiLoreto, Rose; Chhangawala, Sagar; Liu, Yang; Watson, Philip A.; Davicioni, Elai; et al. (Nature (London), 2019)
Keywords: 631/208/176; 631/208/199; 631/67/589/466; 631/80/304; 692/420/755; Amino Acid Sequence; Animals; Assaying; Base Sequence; Binding; Binding Sites; Bioinformatics; Biological properties; Cell Differentiation - genetics; Cell Lineage; Chromatin; Chromatin - genetics; Chromatin - metabolism; CRISPR; Deoxyribonucleic acid; Differentiation; Disease Progression; DNA; Forkhead protein; Gene expression; Gene Expression Regulation, Neoplastic; Genetic aspects; Genomes; Genotype & phenotype; Growth factors; Health aspects; Hepatocyte Nuclear Factor 3-alpha - chemistry; Hepatocyte Nuclear Factor 3-alpha - genetics; Histology; Humanities and Social Sciences; Humans; Interrogation; Letter; Male; Mesenchyme; Metastases; Metastasis; Mice; Mice, Inbred NOD; multidisciplinary; Mutants; Mutation; Mutation (Biology); Nucleotide Motifs; Organoids; Organoids - cytology; Organoids - metabolism; Phenotype; Phenotypes; Prostate cancer; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Risk factors; Science; Science (multidisciplinary); Transcription factors; Transposase; Tumors; United States