Fasting unmasks differential fat and muscle transcriptional regulation of metabolic gene sets in low versus normal birth weight men
Individuals born with low birth weight (LBW) have an increased risk of metabolic diseases when exposed to diets rich in calories and fat but may respond to fasting in a metabolically preferential manner. We hypothesized that impaired foetal growth is associated with differential regulation of gene e...
Saved in:
| Published in | EBioMedicine Vol. 47; pp. 341 - 351 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.09.2019
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2352-3964 2352-3964 |
| DOI | 10.1016/j.ebiom.2019.08.017 |
Cover
| Abstract | Individuals born with low birth weight (LBW) have an increased risk of metabolic diseases when exposed to diets rich in calories and fat but may respond to fasting in a metabolically preferential manner. We hypothesized that impaired foetal growth is associated with differential regulation of gene expression and epigenetics in metabolic tissues in response to fasting in young adulthood.
Genome-wide expression and DNA methylation were analysed in subcutaneous adipose tissue (SAT) and skeletal muscle from LBW and normal birth weight (NBW) men after 36 h fasting and after an isocaloric control study using microarrays.
Transcriptome analyses revealed that expression of genes involved in oxidative phosphorylation (OXPHOS) and other key metabolic pathways were lower in SAT from LBW vs NBW men after the control study, but paradoxically higher in LBW vs NBW men after 36 h fasting. Thus, fasting was associated with downregulated OXPHOS and metabolic gene sets in NBW men only. Likewise, in skeletal muscle only NBW men downregulated OXPHOS genes with fasting. Few epigenetic changes were observed in SAT and muscle between the groups.
Our results provide insights into the molecular mechanisms in muscle and adipose tissue governing a differential metabolic response in subjects with impaired foetal growth when exposed to fasting in adulthood. The results support the concept of developmental programming of metabolic diseases including type 2 diabetes.
The Swedish Research Council, the Danish Council for Strategic Research, the Novo Nordisk foundation, the Swedish Foundation for Strategic Research, The European Foundation for the Study of Diabetes, The EU 6th Framework EXGENESIS grant and Rigshospitalet. |
|---|---|
| AbstractList | AbstractBackgroundIndividuals born with low birth weight (LBW) have an increased risk of metabolic diseases when exposed to diets rich in calories and fat but may respond to fasting in a metabolically preferential manner. We hypothesized that impaired foetal growth is associated with differential regulation of gene expression and epigenetics in metabolic tissues in response to fasting in young adulthood. MethodsGenome-wide expression and DNA methylation were analysed in subcutaneous adipose tissue (SAT) and skeletal muscle from LBW and normal birth weight (NBW) men after 36 h fasting and after an isocaloric control study using microarrays. FindingsTranscriptome analyses revealed that expression of genes involved in oxidative phosphorylation (OXPHOS) and other key metabolic pathways were lower in SAT from LBW vs NBW men after the control study, but paradoxically higher in LBW vs NBW men after 36 h fasting. Thus, fasting was associated with downregulated OXPHOS and metabolic gene sets in NBW men only. Likewise, in skeletal muscle only NBW men downregulated OXPHOS genes with fasting. Few epigenetic changes were observed in SAT and muscle between the groups. InterpretationOur results provide insights into the molecular mechanisms in muscle and adipose tissue governing a differential metabolic response in subjects with impaired foetal growth when exposed to fasting in adulthood. The results support the concept of developmental programming of metabolic diseases including type 2 diabetes. FundThe Swedish Research Council, the Danish Council for Strategic Research, the Novo Nordisk foundation, the Swedish Foundation for Strategic Research, The European Foundation for the Study of Diabetes, The EU 6th Framework EXGENESIS grant and Rigshospitalet. Individuals born with low birth weight (LBW) have an increased risk of metabolic diseases when exposed to diets rich in calories and fat but may respond to fasting in a metabolically preferential manner. We hypothesized that impaired foetal growth is associated with differential regulation of gene expression and epigenetics in metabolic tissues in response to fasting in young adulthood. Genome-wide expression and DNA methylation were analysed in subcutaneous adipose tissue (SAT) and skeletal muscle from LBW and normal birth weight (NBW) men after 36 h fasting and after an isocaloric control study using microarrays. Transcriptome analyses revealed that expression of genes involved in oxidative phosphorylation (OXPHOS) and other key metabolic pathways were lower in SAT from LBW vs NBW men after the control study, but paradoxically higher in LBW vs NBW men after 36 h fasting. Thus, fasting was associated with downregulated OXPHOS and metabolic gene sets in NBW men only. Likewise, in skeletal muscle only NBW men downregulated OXPHOS genes with fasting. Few epigenetic changes were observed in SAT and muscle between the groups. Our results provide insights into the molecular mechanisms in muscle and adipose tissue governing a differential metabolic response in subjects with impaired foetal growth when exposed to fasting in adulthood. The results support the concept of developmental programming of metabolic diseases including type 2 diabetes. FUND: The Swedish Research Council, the Danish Council for Strategic Research, the Novo Nordisk foundation, the Swedish Foundation for Strategic Research, The European Foundation for the Study of Diabetes, The EU 6th Framework EXGENESIS grant and Rigshospitalet. Individuals born with low birth weight (LBW) have an increased risk of metabolic diseases when exposed to diets rich in calories and fat but may respond to fasting in a metabolically preferential manner. We hypothesized that impaired foetal growth is associated with differential regulation of gene expression and epigenetics in metabolic tissues in response to fasting in young adulthood.BACKGROUNDIndividuals born with low birth weight (LBW) have an increased risk of metabolic diseases when exposed to diets rich in calories and fat but may respond to fasting in a metabolically preferential manner. We hypothesized that impaired foetal growth is associated with differential regulation of gene expression and epigenetics in metabolic tissues in response to fasting in young adulthood.Genome-wide expression and DNA methylation were analysed in subcutaneous adipose tissue (SAT) and skeletal muscle from LBW and normal birth weight (NBW) men after 36 h fasting and after an isocaloric control study using microarrays.METHODSGenome-wide expression and DNA methylation were analysed in subcutaneous adipose tissue (SAT) and skeletal muscle from LBW and normal birth weight (NBW) men after 36 h fasting and after an isocaloric control study using microarrays.Transcriptome analyses revealed that expression of genes involved in oxidative phosphorylation (OXPHOS) and other key metabolic pathways were lower in SAT from LBW vs NBW men after the control study, but paradoxically higher in LBW vs NBW men after 36 h fasting. Thus, fasting was associated with downregulated OXPHOS and metabolic gene sets in NBW men only. Likewise, in skeletal muscle only NBW men downregulated OXPHOS genes with fasting. Few epigenetic changes were observed in SAT and muscle between the groups.FINDINGSTranscriptome analyses revealed that expression of genes involved in oxidative phosphorylation (OXPHOS) and other key metabolic pathways were lower in SAT from LBW vs NBW men after the control study, but paradoxically higher in LBW vs NBW men after 36 h fasting. Thus, fasting was associated with downregulated OXPHOS and metabolic gene sets in NBW men only. Likewise, in skeletal muscle only NBW men downregulated OXPHOS genes with fasting. Few epigenetic changes were observed in SAT and muscle between the groups.Our results provide insights into the molecular mechanisms in muscle and adipose tissue governing a differential metabolic response in subjects with impaired foetal growth when exposed to fasting in adulthood. The results support the concept of developmental programming of metabolic diseases including type 2 diabetes. FUND: The Swedish Research Council, the Danish Council for Strategic Research, the Novo Nordisk foundation, the Swedish Foundation for Strategic Research, The European Foundation for the Study of Diabetes, The EU 6th Framework EXGENESIS grant and Rigshospitalet.INTERPRETATIONOur results provide insights into the molecular mechanisms in muscle and adipose tissue governing a differential metabolic response in subjects with impaired foetal growth when exposed to fasting in adulthood. The results support the concept of developmental programming of metabolic diseases including type 2 diabetes. FUND: The Swedish Research Council, the Danish Council for Strategic Research, the Novo Nordisk foundation, the Swedish Foundation for Strategic Research, The European Foundation for the Study of Diabetes, The EU 6th Framework EXGENESIS grant and Rigshospitalet. Individuals born with low birth weight (LBW) have an increased risk of metabolic diseases when exposed to diets rich in calories and fat but may respond to fasting in a metabolically preferential manner. We hypothesized that impaired foetal growth is associated with differential regulation of gene expression and epigenetics in metabolic tissues in response to fasting in young adulthood. Genome-wide expression and DNA methylation were analysed in subcutaneous adipose tissue (SAT) and skeletal muscle from LBW and normal birth weight (NBW) men after 36 h fasting and after an isocaloric control study using microarrays. Transcriptome analyses revealed that expression of genes involved in oxidative phosphorylation (OXPHOS) and other key metabolic pathways were lower in SAT from LBW vs NBW men after the control study, but paradoxically higher in LBW vs NBW men after 36 h fasting. Thus, fasting was associated with downregulated OXPHOS and metabolic gene sets in NBW men only. Likewise, in skeletal muscle only NBW men downregulated OXPHOS genes with fasting. Few epigenetic changes were observed in SAT and muscle between the groups. Our results provide insights into the molecular mechanisms in muscle and adipose tissue governing a differential metabolic response in subjects with impaired foetal growth when exposed to fasting in adulthood. The results support the concept of developmental programming of metabolic diseases including type 2 diabetes. The Swedish Research Council, the Danish Council for Strategic Research, the Novo Nordisk foundation, the Swedish Foundation for Strategic Research, The European Foundation for the Study of Diabetes, The EU 6th Framework EXGENESIS grant and Rigshospitalet. Background: Individuals born with low birth weight (LBW) have an increased risk of metabolic diseases when exposed to diets rich in calories and fat but may respond to fasting in a metabolically preferential manner. We hypothesized that impaired foetal growth is associated with differential regulation of gene expression and epigenetics in metabolic tissues in response to fasting in young adulthood. Methods: Genome-wide expression and DNA methylation were analysed in subcutaneous adipose tissue (SAT) and skeletal muscle from LBW and normal birth weight (NBW) men after 36 h fasting and after an isocaloric control study using microarrays. Findings: Transcriptome analyses revealed that expression of genes involved in oxidative phosphorylation (OXPHOS) and other key metabolic pathways were lower in SAT from LBW vs NBW men after the control study, but paradoxically higher in LBW vs NBW men after 36 h fasting. Thus, fasting was associated with downregulated OXPHOS and metabolic gene sets in NBW men only. Likewise, in skeletal muscle only NBW men downregulated OXPHOS genes with fasting. Few epigenetic changes were observed in SAT and muscle between the groups. Interpretation: Our results provide insights into the molecular mechanisms in muscle and adipose tissue governing a differential metabolic response in subjects with impaired foetal growth when exposed to fasting in adulthood. The results support the concept of developmental programming of metabolic diseases including type 2 diabetes. Fund: The Swedish Research Council, the Danish Council for Strategic Research, the Novo Nordisk foundation, the Swedish Foundation for Strategic Research, The European Foundation for the Study of Diabetes, The EU 6th Framework EXGENESIS grant and Rigshospitalet. |
| Author | Gillberg, Linn Rönn, Tina Nilsson, Emma Perfilyev, Alexander Brøns, Charlotte Jørgensen, Sine Wanda Hjort, Line Vaag, Allan Ling, Charlotte |
| AuthorAffiliation | b Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark a Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark c Department of Clinical Sciences, Epigenetics and Diabetes Unit, Lund University Diabetes Centre, Scania University Hospital, Malmö, Sweden d Cardiovascular, Renal and Metabolism (CVRM), Translational Medical Unit, Early Clinical Development, IMED Biotech Unit, AstraZeneca, Mölndal, Sweden |
| AuthorAffiliation_xml | – name: a Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark – name: c Department of Clinical Sciences, Epigenetics and Diabetes Unit, Lund University Diabetes Centre, Scania University Hospital, Malmö, Sweden – name: b Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark – name: d Cardiovascular, Renal and Metabolism (CVRM), Translational Medical Unit, Early Clinical Development, IMED Biotech Unit, AstraZeneca, Mölndal, Sweden |
| Author_xml | – sequence: 1 givenname: Linn orcidid: 0000-0003-0588-1663 surname: Gillberg fullname: Gillberg, Linn email: linn.gillberg@rh.regionh.dk organization: Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark – sequence: 2 givenname: Tina surname: Rönn fullname: Rönn, Tina organization: Department of Clinical Sciences, Epigenetics and Diabetes Unit, Lund University Diabetes Centre, Scania University Hospital, Malmö, Sweden – sequence: 3 givenname: Sine Wanda surname: Jørgensen fullname: Jørgensen, Sine Wanda organization: Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark – sequence: 4 givenname: Alexander surname: Perfilyev fullname: Perfilyev, Alexander organization: Department of Clinical Sciences, Epigenetics and Diabetes Unit, Lund University Diabetes Centre, Scania University Hospital, Malmö, Sweden – sequence: 5 givenname: Line orcidid: 0000-0003-4673-4176 surname: Hjort fullname: Hjort, Line organization: Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark – sequence: 6 givenname: Emma surname: Nilsson fullname: Nilsson, Emma organization: Department of Clinical Sciences, Epigenetics and Diabetes Unit, Lund University Diabetes Centre, Scania University Hospital, Malmö, Sweden – sequence: 7 givenname: Charlotte surname: Brøns fullname: Brøns, Charlotte organization: Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark – sequence: 8 givenname: Allan surname: Vaag fullname: Vaag, Allan organization: Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark – sequence: 9 givenname: Charlotte surname: Ling fullname: Ling, Charlotte email: charlotte.ling@med.lu.se organization: Department of Clinical Sciences, Epigenetics and Diabetes Unit, Lund University Diabetes Centre, Scania University Hospital, Malmö, Sweden |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31439477$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkl1rFDEUhgep2Fr7CwTJpTe75mMyH4iFUqwKBS9U8O6QyZzZzTaTrElml177x812W2kL2qt8ned9OTnvy-LAeYdF8ZrROaOsereaY2f8OOeUtXPazCmrnxVHXEg-E21VHtzbHxYnMa4opUyW-bJ5URwKVoq2rOuj4veFism4BZncqOJVJL0ZBgzoklGWDCoR5XoyTlFbJCkoF3Uw62S8y88BF5NVuwPxAxkxqc5bo8kCHZKIKRLjiPVbssEQp0icD2PGOhPSkmzRLJYpU-5V8XxQNuLJ7Xpc_Lj4-P388-zy66cv52eXM13JKs1K7MpKV63WvRo6HOquKhHrXmrEtm4aLhivatpw2lQMedtz2WPHJPZMyLpl4rhQe924xfXUwTqYUYVr8MrA2oekLASMqIJegp0gIuSq3M9NhxG01EoK1QJvSwklHxR0om6goW3XUdnrHnX2ON17ZHTEXuePDFn3gdWDF2eWsPAbqOq2kk2ZBd7eCgT_a8KYYDRRo7XKoZ8icN7UklNO61z65r7XX5O76eaCdl-gg48x4ADapJtusrWxwCjswgQruAkT7MIEtIEcpsyKR-yd_P-pD3sK8xw3BgNEbdBp7E1AnaD35gn-9BGvrXF5BPYKrzGu_BRy8CIwiBwofNuFfJdx1goqhfiZBd7_W-BJ-z92MBNF |
| CitedBy_id | crossref_primary_10_1249_MSS_0000000000003049 crossref_primary_10_1371_journal_pgen_1009325 crossref_primary_10_1080_17501911_2024_2439782 crossref_primary_10_1038_s10038_020_00848_z crossref_primary_10_1093_ajcn_nqab209 crossref_primary_10_1093_hmg_ddad024 crossref_primary_10_1016_j_lfs_2021_120007 crossref_primary_10_1038_s41574_022_00671_w crossref_primary_10_1111_joim_13049 crossref_primary_10_1111_joim_13574 crossref_primary_10_1016_j_cca_2023_117527 |
| Cites_doi | 10.1007/s00125-005-1669-7 10.3945/ajcn.116.143164 10.1093/nar/gkp464 10.1007/s00125-014-3198-8 10.1186/s13148-017-0340-8 10.1073/pnas.0506580102 10.1007/s00125-008-1018-8 10.1152/ajpregu.00085.2012 10.1007/s00125-016-4099-9 10.1038/ncomms11089 10.1093/biostatistics/4.2.249 10.1056/NEJM197608122950701 10.1074/jbc.RA117.000184 10.1155/2014/418975 10.2337/db13-0621 10.1093/biostatistics/kxj037 10.1007/s00125-014-3406-6 10.1007/BF00400248 10.1007/s00125-015-3852-9 10.1371/journal.pone.0051302 10.1007/978-1-4614-3567-9_14 10.1038/ng.609 10.1073/pnas.0806560105 10.1530/EJE-11-0282 10.1093/emboj/20.13.3587 10.2337/db13-1459 10.14814/phy2.13044 10.1136/bmj.303.6809.1019 10.1007/s00125-006-0466-2 10.1016/j.cell.2018.09.043 10.1038/ng1180 10.1210/jc.2009-2413 10.1038/s41598-018-21419-5 10.2337/diacare.28.1.151 10.2217/epi-2016-0087 10.14814/phy2.12977 10.1126/science.aau2095 10.1093/bioinformatics/btn224 10.1093/nar/gkt997 10.1152/ajpendo.00095.2011 |
| ContentType | Journal Article |
| Copyright | 2019 The Authors The Authors Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved. 2019 The Authors 2019 |
| Copyright_xml | – notice: 2019 The Authors – notice: The Authors – notice: Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved. – notice: 2019 The Authors 2019 |
| CorporateAuthor | Diabetes - Epigenetics Lunds universitet Profile areas and other strong research environments Department of Clinical Sciences, Malmö Lund University Strategiska forskningsområden (SFO) EXODIAB: Excellence of Diabetes Research in Sweden Faculty of Medicine Strategic research areas (SRA) Diabetes - epigenetik Medicinska fakulteten Profilområden och andra starka forskningsmiljöer Institutionen för kliniska vetenskaper, Malmö |
| CorporateAuthor_xml | – name: Faculty of Medicine – name: Medicinska fakulteten – name: Diabetes - Epigenetics – name: Strategiska forskningsområden (SFO) – name: Institutionen för kliniska vetenskaper, Malmö – name: Diabetes - epigenetik – name: Strategic research areas (SRA) – name: Lunds universitet – name: Profilområden och andra starka forskningsmiljöer – name: Lund University – name: EXODIAB: Excellence of Diabetes Research in Sweden – name: Profile areas and other strong research environments – name: Department of Clinical Sciences, Malmö |
| DBID | 6I. AAFTH AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM ADTPV AGCHP AOWAS D8T D95 ZZAVC |
| DOI | 10.1016/j.ebiom.2019.08.017 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) SwePub SWEPUB Lunds universitet full text SwePub Articles SWEPUB Freely available online SWEPUB Lunds universitet SwePub Articles full text |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2352-3964 |
| EndPage | 351 |
| ExternalDocumentID | oai_portal_research_lu_se_publications_c5ca53a9_2945_42fa_b378_809bb05dcdec PMC6796584 31439477 10_1016_j_ebiom_2019_08_017 S235239641930533X 1_s2_0_S235239641930533X |
| Genre | Journal Article |
| GroupedDBID | .1- .FO 0R~ 4.4 457 53G 5VS AAEDT AAEDW AAIKJ AALRI AAMRU AAXUO AAYWO ABMAC ACGFS ACVFH ADBBV ADCNI ADEZE ADRAZ ADVLN AEUPX AEXQZ AFPUW AFRHN AFTJW AGHFR AIGII AITUG AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS APXCP BCNDV EBS EJD FDB GROUPED_DOAJ HYE HZ~ IPNFZ KQ8 M41 M48 O9- OK1 RIG ROL RPM SSZ Z5R 0SF 6I. AACTN AAFTH AFCTW NCXOZ AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM ADTPV AGCHP AOWAS D8T D95 ZZAVC |
| ID | FETCH-LOGICAL-c656t-4eb46c69ccdafbef7b64ee7d5cee97882312670820861e29d25deb15ed1357913 |
| IEDL.DBID | M48 |
| ISSN | 2352-3964 |
| IngestDate | Tue Sep 09 22:52:57 EDT 2025 Thu Aug 21 18:14:39 EDT 2025 Thu Sep 04 21:21:22 EDT 2025 Thu Apr 03 07:08:02 EDT 2025 Tue Jul 01 00:38:51 EDT 2025 Thu Apr 24 22:56:25 EDT 2025 Wed May 17 00:05:49 EDT 2023 Sun Feb 23 10:19:34 EST 2025 Tue Aug 26 16:43:54 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Type 2 diabetes Epigenetics Birth weight Fasting Metabolism Transcriptomics |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c656t-4eb46c69ccdafbef7b64ee7d5cee97882312670820861e29d25deb15ed1357913 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0003-0588-1663 0000-0003-4673-4176 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1016/j.ebiom.2019.08.017 |
| PMID | 31439477 |
| PQID | 2287520207 |
| PQPubID | 23479 |
| PageCount | 11 |
| ParticipantIDs | swepub_primary_oai_portal_research_lu_se_publications_c5ca53a9_2945_42fa_b378_809bb05dcdec pubmedcentral_primary_oai_pubmedcentral_nih_gov_6796584 proquest_miscellaneous_2287520207 pubmed_primary_31439477 crossref_citationtrail_10_1016_j_ebiom_2019_08_017 crossref_primary_10_1016_j_ebiom_2019_08_017 elsevier_sciencedirect_doi_10_1016_j_ebiom_2019_08_017 elsevier_clinicalkeyesjournals_1_s2_0_S235239641930533X elsevier_clinicalkey_doi_10_1016_j_ebiom_2019_08_017 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2019-09-01 |
| PublicationDateYYYYMMDD | 2019-09-01 |
| PublicationDate_xml | – month: 09 year: 2019 text: 2019-09-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | EBioMedicine |
| PublicationTitleAlternate | EBioMedicine |
| PublicationYear | 2019 |
| Publisher | Elsevier B.V Elsevier |
| Publisher_xml | – name: Elsevier B.V – name: Elsevier |
| References | Rönn, Volkov, Gillberg (bb0205) 2015; 24 Schultz, Broholm, Gillberg (bb0045) 2014; 63 Ribel-Madsen, Ribel-Madsen, Brøns, Newgard, Vaag, Hellgren (bb0190) 2016; 4 Perfilyev, Dahlman, Gillberg (bb0100) 2017; 105 Segovia, Vickers, Gray, Reynolds (bb0215) 2014; 2014 Frayn (bb0085) 1983; 55 Ozanne, Jensen, Tingey (bb0035) 2006; 49 Bysani, Perfilyev, de Mello (bb0210) 2017; 9 Hjort, Jørgensen, Gillberg (bb0080) 2017; 9 Nilsson, Jansson, Perfilyev (bb0125) 2014; 63 Wang, Tong, Gu (bb0195) 2017; 292 Heijmans, Tobi, Stein (bb0070) 2008; 105 Voight, Scott, Steinthorsdottir (bb0200) 2010; 42 Ozanne, Jensen, Tingey, Storgaard, Madsbad, Vaag (bb0030) 2005; 48 Jørgensen, Brøns, Bluck (bb0055) 2015; 58 Gillberg, Perfilyev, Brøns (bb0120) 2016; 59 Rönn, Poulsen, Hansson (bb0165) 2008; 51 Kimata, Tanaka, Inada, Aiba (bb0160) 2001; 20 Ravelli, Stein, Susser (bb0005) 1976; 295 Hales, Barker, Clark (bb0010) 1991; 303 Ribel-Madsen, Hellgren, Brøns, Ribel-Madsen, Newgard, Vaag (bb0185) 2016; 4 Irizarry, Hobbs, Collin (bb0095) 2003; 4 Brøns, Jacobsen, Hiscock (bb0040) 2012; 302 Johnson, Li, Rabinovic (bb0105) 2007; 8 Stekel, Jenkins (bb0150) 2012; 751 Mootha, Lindgren, Eriksson (bb0110) 2003; 34 Zambelli, Pesole, Pavesi (bb0135) 2009; 37 Kazachenka, Bertozzi, Sjoberg-Herrera (bb0175) 2018; 175 D'souza, Lai, Shuen, Hood (bb0155) 2012; 303 Brøns, Jacobsen, Nilsson (bb0065) 2010; 95 Broholm, Olsson, Perfilyev (bb0170) 2016; 59 Mathelier, Zhao, Zhang (bb0130) 2014; 42 Hales, Barker (bb0015) 1992; 35 Jacobsen, Gillberg, Bork-Jensen (bb0075) 2014; 57 Ribel-Madsen, Fraga, Jacobsen (bb0140) 2012; 7 Rasmussen, Malis, Jensen (bb0020) 2005; 28 Du, Kibbe, Lin (bb0090) 2008; 24 Olsson, Yang, Hall (bb0145) 2011; 165 Alibegovic, Sonne, Hojbjerre (bb0025) 2010; 299 Ribel-Madsen, Ribel-Madsen, Nielsen, Brix, Vaag, Brøns (bb0180) 2018; 8 Bacos, Gillberg, Volkov (bb0060) 2016; 7 Subramanian, Tamayo, Mootha (bb0115) 2005; 102 Di Francesco, Di Germanio, Bernier, de Cabo (bb0050) 2018; 362 Rönn (10.1016/j.ebiom.2019.08.017_bb0165) 2008; 51 Ribel-Madsen (10.1016/j.ebiom.2019.08.017_bb0190) 2016; 4 Hales (10.1016/j.ebiom.2019.08.017_bb0015) 1992; 35 Hales (10.1016/j.ebiom.2019.08.017_bb0010) 1991; 303 Ribel-Madsen (10.1016/j.ebiom.2019.08.017_bb0140) 2012; 7 Brøns (10.1016/j.ebiom.2019.08.017_bb0065) 2010; 95 Mootha (10.1016/j.ebiom.2019.08.017_bb0110) 2003; 34 Ribel-Madsen (10.1016/j.ebiom.2019.08.017_bb0185) 2016; 4 Subramanian (10.1016/j.ebiom.2019.08.017_bb0115) 2005; 102 Rasmussen (10.1016/j.ebiom.2019.08.017_bb0020) 2005; 28 Hjort (10.1016/j.ebiom.2019.08.017_bb0080) 2017; 9 Nilsson (10.1016/j.ebiom.2019.08.017_bb0125) 2014; 63 Perfilyev (10.1016/j.ebiom.2019.08.017_bb0100) 2017; 105 Jørgensen (10.1016/j.ebiom.2019.08.017_bb0055) 2015; 58 Olsson (10.1016/j.ebiom.2019.08.017_bb0145) 2011; 165 Kimata (10.1016/j.ebiom.2019.08.017_bb0160) 2001; 20 Heijmans (10.1016/j.ebiom.2019.08.017_bb0070) 2008; 105 D'souza (10.1016/j.ebiom.2019.08.017_bb0155) 2012; 303 Voight (10.1016/j.ebiom.2019.08.017_bb0200) 2010; 42 Di Francesco (10.1016/j.ebiom.2019.08.017_bb0050) 2018; 362 Brøns (10.1016/j.ebiom.2019.08.017_bb0040) 2012; 302 Irizarry (10.1016/j.ebiom.2019.08.017_bb0095) 2003; 4 Kazachenka (10.1016/j.ebiom.2019.08.017_bb0175) 2018; 175 Johnson (10.1016/j.ebiom.2019.08.017_bb0105) 2007; 8 Ribel-Madsen (10.1016/j.ebiom.2019.08.017_bb0180) 2018; 8 Rönn (10.1016/j.ebiom.2019.08.017_bb0205) 2015; 24 Du (10.1016/j.ebiom.2019.08.017_bb0090) 2008; 24 Ozanne (10.1016/j.ebiom.2019.08.017_bb0030) 2005; 48 Alibegovic (10.1016/j.ebiom.2019.08.017_bb0025) 2010; 299 Wang (10.1016/j.ebiom.2019.08.017_bb0195) 2017; 292 Bacos (10.1016/j.ebiom.2019.08.017_bb0060) 2016; 7 Mathelier (10.1016/j.ebiom.2019.08.017_bb0130) 2014; 42 Broholm (10.1016/j.ebiom.2019.08.017_bb0170) 2016; 59 Segovia (10.1016/j.ebiom.2019.08.017_bb0215) 2014; 2014 Frayn (10.1016/j.ebiom.2019.08.017_bb0085) 1983; 55 Ravelli (10.1016/j.ebiom.2019.08.017_bb0005) 1976; 295 Stekel (10.1016/j.ebiom.2019.08.017_bb0150) 2012; 751 Ozanne (10.1016/j.ebiom.2019.08.017_bb0035) 2006; 49 Zambelli (10.1016/j.ebiom.2019.08.017_bb0135) 2009; 37 Schultz (10.1016/j.ebiom.2019.08.017_bb0045) 2014; 63 Jacobsen (10.1016/j.ebiom.2019.08.017_bb0075) 2014; 57 Gillberg (10.1016/j.ebiom.2019.08.017_bb0120) 2016; 59 Bysani (10.1016/j.ebiom.2019.08.017_bb0210) 2017; 9 |
| References_xml | – volume: 303 start-page: R408 year: 2012 end-page: R417 ident: bb0155 article-title: mRNA stability as a function of striated muscle oxidative capacity publication-title: Am J Physiol Regul Integr Comp Physiol – volume: 4 year: 2016 ident: bb0185 article-title: Plasma amino acid levels are elevated in young, healthy low birth weight men exposed to short-term high-fat overfeeding publication-title: Physiol Rep – volume: 51 start-page: 1159 year: 2008 end-page: 1168 ident: bb0165 article-title: Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle publication-title: Diabetologia – volume: 299 start-page: E752 year: 2010 end-page: E763 ident: bb0025 article-title: Insulin resistance induced by physical inactivity is associated with multiple transcriptional changes in skeletal muscle in young men publication-title: AJP\ – volume: 4 start-page: 249 year: 2003 end-page: 264 ident: bb0095 article-title: Exploration, normalization, and summaries of high density oligonucleotide array probe level data publication-title: Biostatistics – volume: 9 start-page: 105 year: 2017 end-page: 122 ident: bb0210 article-title: Epigenetic alterations in blood mirror age-associated DNA methylation and gene expression changes in human liver publication-title: Epigenomics – volume: 57 start-page: 1154 year: 2014 end-page: 1158 ident: bb0075 article-title: Young men with low birthweight exhibit decreased plasticity of genome-wide muscle DNA methylation by high-fat overfeeding publication-title: Diabetologia – volume: 8 start-page: 118 year: 2007 end-page: 127 ident: bb0105 article-title: Adjusting batch effects in microarray expression data using empirical Bayes methods publication-title: Biostatistics – volume: 24 start-page: 3792 year: 2015 end-page: 3813 ident: bb0205 article-title: Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood publication-title: Hum Mol Genet – volume: 8 start-page: 3452 year: 2018 ident: bb0180 article-title: Plasma ceramide levels are altered in low and normal birth weight men in response to short-term high-fat overfeeding publication-title: Sci Rep – volume: 28 start-page: 151 year: 2005 end-page: 153 ident: bb0020 article-title: Altered fat tissue distribution in young adult men who had low birth weight publication-title: Diabetes Care – volume: 20 start-page: 3587 year: 2001 end-page: 3595 ident: bb0160 article-title: Expression of the glucose transporter gene, ptsG, is regulated at the mRNA degradation step in response to glycolytic flux in Escherichia coli publication-title: EMBO J – volume: 362 start-page: 770 year: 2018 end-page: 775 ident: bb0050 article-title: A time to fast publication-title: Science – volume: 42 start-page: 579 year: 2010 end-page: 589 ident: bb0200 article-title: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis publication-title: Nat Genet – volume: 303 start-page: 1019 year: 1991 end-page: 1022 ident: bb0010 article-title: Fetal and infant growth and impaired glucose tolerance at age 64 publication-title: BMJ – volume: 9 start-page: 40 year: 2017 ident: bb0080 article-title: 36 h fasting of young men influences adipose tissue DNA methylation of LEP and ADIPOQ in a birth weight-dependent manner publication-title: Clin Epigenetics – volume: 2014 start-page: 418975 year: 2014 ident: bb0215 article-title: Maternal obesity, inflammation, and developmental programming publication-title: Biomed Res Int – volume: 105 start-page: 17046 year: 2008 end-page: 17049 ident: bb0070 article-title: Persistent epigenetic differences associated with prenatal exposure to famine in humans publication-title: Proc Natl Acad Sci U S A – volume: 24 start-page: 1547 year: 2008 end-page: 1548 ident: bb0090 article-title: lumi: a pipeline for processing Illumina microarray publication-title: Bioinformatics – volume: 105 start-page: 991 year: 2017 end-page: 1000 ident: bb0100 article-title: Impact of polyunsaturated and saturated fat overfeeding on the DNA-methylation pattern in human adipose tissue: a randomized controlled trial publication-title: Am J Clin Nutr – volume: 49 start-page: 2993 year: 2006 end-page: 2999 ident: bb0035 article-title: Decreased protein levels of key insulin signalling molecules in adipose tissue from young men with a low birthweight: potential link to increased risk of diabetes? publication-title: Diabetologia – volume: 292 start-page: 21631 year: 2017 end-page: 21642 ident: bb0195 article-title: The KLF14 transcription factor regulates hepatic gluconeogenesis in mice publication-title: J Biol Chem – volume: 42 start-page: D142 year: 2014 end-page: D147 ident: bb0130 article-title: JASPAR 2014: an extensively expanded and updated open-access database of transcription factor binding profiles publication-title: Nucleic Acids Res – volume: 48 start-page: 547 year: 2005 end-page: 552 ident: bb0030 article-title: Low birthweight is associated with specific changes in muscle insulin-signalling protein expression publication-title: Diabetologia – volume: 102 start-page: 15545 year: 2005 end-page: 15550 ident: bb0115 article-title: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles publication-title: Proc Natl Acad Sci U S A – volume: 7 year: 2016 ident: bb0060 article-title: Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes publication-title: Nat Commun – volume: 59 start-page: 2664 year: 2016 end-page: 2673 ident: bb0170 article-title: Epigenetic programming of adipose-derived stem cells in low birthweight individuals publication-title: Diabetologia – volume: 35 start-page: 595 year: 1992 end-page: 601 ident: bb0015 article-title: Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis publication-title: Diabetologia – volume: 302 start-page: E43 year: 2012 end-page: E51 ident: bb0040 article-title: Effects of high-fat overfeeding on mitochondrial function, glucose and fat metabolism, and adipokine levels in low-birth-weight subjects publication-title: Am J Physiol Endocrinol Metab – volume: 165 start-page: 589 year: 2011 end-page: 595 ident: bb0145 article-title: Decreased expression of genes involved in oxidative phosphorylation in human pancreatic islets from patients with type 2 diabetes publication-title: Eur J Endocrinol – volume: 59 start-page: 799 year: 2016 end-page: 812 ident: bb0120 article-title: Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding publication-title: Diabetologia – volume: 37 start-page: W247 year: 2009 end-page: W252 ident: bb0135 article-title: Pscan: finding over-represented transcription factor binding site motifs in sequences from co-regulated or co-expressed genes publication-title: Nucleic Acids Res – volume: 95 start-page: 3048 year: 2010 end-page: 3056 ident: bb0065 article-title: Deoxyribonucleic acid methylation and gene expression of PPARGC1A in human muscle is influenced by high-fat overfeeding in a birth-weight-dependent manner publication-title: J Clin Endocrinol Metab – volume: 34 start-page: 267 year: 2003 end-page: 273 ident: bb0110 article-title: PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes publication-title: Nat Genet – volume: 4 year: 2016 ident: bb0190 article-title: Plasma acylcarnitine profiling indicates increased fatty acid oxidation relative to tricarboxylic acid cycle capacity in young, healthy low birth weight men publication-title: Physiol Rep – volume: 63 start-page: 111 year: 2014 end-page: 121 ident: bb0045 article-title: Impaired leptin gene expression and release in cultured preadipocytes isolated from individuals born with low birth weight publication-title: Diabetes – volume: 58 start-page: 178 year: 2015 end-page: 187 ident: bb0055 article-title: Metabolic response to 36 hours of fasting in young men born small vs appropriate for gestational age publication-title: Diabetologia – volume: 175 start-page: 1259 year: 2018 end-page: 1271.e13 ident: bb0175 article-title: Identification, characterization, and heritability of murine metastable epialleles: implications for non-genetic inheritance publication-title: Cell – volume: 63 start-page: 2962 year: 2014 end-page: 2976 ident: bb0125 article-title: Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes publication-title: Diabetes – volume: 7 year: 2012 ident: bb0140 article-title: Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes publication-title: PLoS One – volume: 55 start-page: 628 year: 1983 end-page: 634 ident: bb0085 article-title: Calculation of substrate oxidation rates in vivo from gaseous exchange publication-title: J Appl Physiol Respir Environ Exerc Physiol – volume: 751 start-page: 301 year: 2012 end-page: 328 ident: bb0150 article-title: Evolution of resource and energy management in biologically realistic gene regulatory network models publication-title: Adv Exp Med Biol – volume: 295 start-page: 349 year: 1976 end-page: 353 ident: bb0005 article-title: Obesity in young men after famine exposure in utero and early infancy publication-title: N Engl J Med – volume: 48 start-page: 547 year: 2005 ident: 10.1016/j.ebiom.2019.08.017_bb0030 article-title: Low birthweight is associated with specific changes in muscle insulin-signalling protein expression publication-title: Diabetologia doi: 10.1007/s00125-005-1669-7 – volume: 105 start-page: 991 year: 2017 ident: 10.1016/j.ebiom.2019.08.017_bb0100 article-title: Impact of polyunsaturated and saturated fat overfeeding on the DNA-methylation pattern in human adipose tissue: a randomized controlled trial publication-title: Am J Clin Nutr doi: 10.3945/ajcn.116.143164 – volume: 37 start-page: W247 year: 2009 ident: 10.1016/j.ebiom.2019.08.017_bb0135 article-title: Pscan: finding over-represented transcription factor binding site motifs in sequences from co-regulated or co-expressed genes publication-title: Nucleic Acids Res doi: 10.1093/nar/gkp464 – volume: 57 start-page: 1154 year: 2014 ident: 10.1016/j.ebiom.2019.08.017_bb0075 article-title: Young men with low birthweight exhibit decreased plasticity of genome-wide muscle DNA methylation by high-fat overfeeding publication-title: Diabetologia doi: 10.1007/s00125-014-3198-8 – volume: 24 start-page: 3792 year: 2015 ident: 10.1016/j.ebiom.2019.08.017_bb0205 article-title: Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood publication-title: Hum Mol Genet – volume: 9 start-page: 40 year: 2017 ident: 10.1016/j.ebiom.2019.08.017_bb0080 article-title: 36 h fasting of young men influences adipose tissue DNA methylation of LEP and ADIPOQ in a birth weight-dependent manner publication-title: Clin Epigenetics doi: 10.1186/s13148-017-0340-8 – volume: 102 start-page: 15545 year: 2005 ident: 10.1016/j.ebiom.2019.08.017_bb0115 article-title: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0506580102 – volume: 51 start-page: 1159 year: 2008 ident: 10.1016/j.ebiom.2019.08.017_bb0165 article-title: Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle publication-title: Diabetologia doi: 10.1007/s00125-008-1018-8 – volume: 303 start-page: R408 year: 2012 ident: 10.1016/j.ebiom.2019.08.017_bb0155 article-title: mRNA stability as a function of striated muscle oxidative capacity publication-title: Am J Physiol Regul Integr Comp Physiol doi: 10.1152/ajpregu.00085.2012 – volume: 59 start-page: 2664 year: 2016 ident: 10.1016/j.ebiom.2019.08.017_bb0170 article-title: Epigenetic programming of adipose-derived stem cells in low birthweight individuals publication-title: Diabetologia doi: 10.1007/s00125-016-4099-9 – volume: 7 year: 2016 ident: 10.1016/j.ebiom.2019.08.017_bb0060 article-title: Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes publication-title: Nat Commun doi: 10.1038/ncomms11089 – volume: 4 start-page: 249 year: 2003 ident: 10.1016/j.ebiom.2019.08.017_bb0095 article-title: Exploration, normalization, and summaries of high density oligonucleotide array probe level data publication-title: Biostatistics doi: 10.1093/biostatistics/4.2.249 – volume: 295 start-page: 349 year: 1976 ident: 10.1016/j.ebiom.2019.08.017_bb0005 article-title: Obesity in young men after famine exposure in utero and early infancy publication-title: N Engl J Med doi: 10.1056/NEJM197608122950701 – volume: 292 start-page: 21631 year: 2017 ident: 10.1016/j.ebiom.2019.08.017_bb0195 article-title: The KLF14 transcription factor regulates hepatic gluconeogenesis in mice publication-title: J Biol Chem doi: 10.1074/jbc.RA117.000184 – volume: 2014 start-page: 418975 year: 2014 ident: 10.1016/j.ebiom.2019.08.017_bb0215 article-title: Maternal obesity, inflammation, and developmental programming publication-title: Biomed Res Int doi: 10.1155/2014/418975 – volume: 63 start-page: 111 year: 2014 ident: 10.1016/j.ebiom.2019.08.017_bb0045 article-title: Impaired leptin gene expression and release in cultured preadipocytes isolated from individuals born with low birth weight publication-title: Diabetes doi: 10.2337/db13-0621 – volume: 8 start-page: 118 year: 2007 ident: 10.1016/j.ebiom.2019.08.017_bb0105 article-title: Adjusting batch effects in microarray expression data using empirical Bayes methods publication-title: Biostatistics doi: 10.1093/biostatistics/kxj037 – volume: 58 start-page: 178 year: 2015 ident: 10.1016/j.ebiom.2019.08.017_bb0055 article-title: Metabolic response to 36 hours of fasting in young men born small vs appropriate for gestational age publication-title: Diabetologia doi: 10.1007/s00125-014-3406-6 – volume: 35 start-page: 595 year: 1992 ident: 10.1016/j.ebiom.2019.08.017_bb0015 article-title: Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis publication-title: Diabetologia doi: 10.1007/BF00400248 – volume: 59 start-page: 799 year: 2016 ident: 10.1016/j.ebiom.2019.08.017_bb0120 article-title: Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding publication-title: Diabetologia doi: 10.1007/s00125-015-3852-9 – volume: 7 year: 2012 ident: 10.1016/j.ebiom.2019.08.017_bb0140 article-title: Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes publication-title: PLoS One doi: 10.1371/journal.pone.0051302 – volume: 751 start-page: 301 year: 2012 ident: 10.1016/j.ebiom.2019.08.017_bb0150 article-title: Evolution of resource and energy management in biologically realistic gene regulatory network models publication-title: Adv Exp Med Biol doi: 10.1007/978-1-4614-3567-9_14 – volume: 42 start-page: 579 year: 2010 ident: 10.1016/j.ebiom.2019.08.017_bb0200 article-title: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis publication-title: Nat Genet doi: 10.1038/ng.609 – volume: 105 start-page: 17046 year: 2008 ident: 10.1016/j.ebiom.2019.08.017_bb0070 article-title: Persistent epigenetic differences associated with prenatal exposure to famine in humans publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0806560105 – volume: 165 start-page: 589 year: 2011 ident: 10.1016/j.ebiom.2019.08.017_bb0145 article-title: Decreased expression of genes involved in oxidative phosphorylation in human pancreatic islets from patients with type 2 diabetes publication-title: Eur J Endocrinol doi: 10.1530/EJE-11-0282 – volume: 55 start-page: 628 year: 1983 ident: 10.1016/j.ebiom.2019.08.017_bb0085 article-title: Calculation of substrate oxidation rates in vivo from gaseous exchange publication-title: J Appl Physiol Respir Environ Exerc Physiol – volume: 20 start-page: 3587 year: 2001 ident: 10.1016/j.ebiom.2019.08.017_bb0160 article-title: Expression of the glucose transporter gene, ptsG, is regulated at the mRNA degradation step in response to glycolytic flux in Escherichia coli publication-title: EMBO J doi: 10.1093/emboj/20.13.3587 – volume: 63 start-page: 2962 year: 2014 ident: 10.1016/j.ebiom.2019.08.017_bb0125 article-title: Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes publication-title: Diabetes doi: 10.2337/db13-1459 – volume: 4 year: 2016 ident: 10.1016/j.ebiom.2019.08.017_bb0185 article-title: Plasma amino acid levels are elevated in young, healthy low birth weight men exposed to short-term high-fat overfeeding publication-title: Physiol Rep doi: 10.14814/phy2.13044 – volume: 303 start-page: 1019 year: 1991 ident: 10.1016/j.ebiom.2019.08.017_bb0010 article-title: Fetal and infant growth and impaired glucose tolerance at age 64 publication-title: BMJ doi: 10.1136/bmj.303.6809.1019 – volume: 49 start-page: 2993 year: 2006 ident: 10.1016/j.ebiom.2019.08.017_bb0035 article-title: Decreased protein levels of key insulin signalling molecules in adipose tissue from young men with a low birthweight: potential link to increased risk of diabetes? publication-title: Diabetologia doi: 10.1007/s00125-006-0466-2 – volume: 299 start-page: E752 year: 2010 ident: 10.1016/j.ebiom.2019.08.017_bb0025 article-title: Insulin resistance induced by physical inactivity is associated with multiple transcriptional changes in skeletal muscle in young men publication-title: AJP\ – volume: 175 start-page: 1259 year: 2018 ident: 10.1016/j.ebiom.2019.08.017_bb0175 article-title: Identification, characterization, and heritability of murine metastable epialleles: implications for non-genetic inheritance publication-title: Cell doi: 10.1016/j.cell.2018.09.043 – volume: 34 start-page: 267 year: 2003 ident: 10.1016/j.ebiom.2019.08.017_bb0110 article-title: PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes publication-title: Nat Genet doi: 10.1038/ng1180 – volume: 95 start-page: 3048 year: 2010 ident: 10.1016/j.ebiom.2019.08.017_bb0065 article-title: Deoxyribonucleic acid methylation and gene expression of PPARGC1A in human muscle is influenced by high-fat overfeeding in a birth-weight-dependent manner publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2009-2413 – volume: 8 start-page: 3452 year: 2018 ident: 10.1016/j.ebiom.2019.08.017_bb0180 article-title: Plasma ceramide levels are altered in low and normal birth weight men in response to short-term high-fat overfeeding publication-title: Sci Rep doi: 10.1038/s41598-018-21419-5 – volume: 28 start-page: 151 year: 2005 ident: 10.1016/j.ebiom.2019.08.017_bb0020 article-title: Altered fat tissue distribution in young adult men who had low birth weight publication-title: Diabetes Care doi: 10.2337/diacare.28.1.151 – volume: 9 start-page: 105 year: 2017 ident: 10.1016/j.ebiom.2019.08.017_bb0210 article-title: Epigenetic alterations in blood mirror age-associated DNA methylation and gene expression changes in human liver publication-title: Epigenomics doi: 10.2217/epi-2016-0087 – volume: 4 year: 2016 ident: 10.1016/j.ebiom.2019.08.017_bb0190 article-title: Plasma acylcarnitine profiling indicates increased fatty acid oxidation relative to tricarboxylic acid cycle capacity in young, healthy low birth weight men publication-title: Physiol Rep doi: 10.14814/phy2.12977 – volume: 362 start-page: 770 year: 2018 ident: 10.1016/j.ebiom.2019.08.017_bb0050 article-title: A time to fast publication-title: Science doi: 10.1126/science.aau2095 – volume: 24 start-page: 1547 year: 2008 ident: 10.1016/j.ebiom.2019.08.017_bb0090 article-title: lumi: a pipeline for processing Illumina microarray publication-title: Bioinformatics doi: 10.1093/bioinformatics/btn224 – volume: 42 start-page: D142 year: 2014 ident: 10.1016/j.ebiom.2019.08.017_bb0130 article-title: JASPAR 2014: an extensively expanded and updated open-access database of transcription factor binding profiles publication-title: Nucleic Acids Res doi: 10.1093/nar/gkt997 – volume: 302 start-page: E43 year: 2012 ident: 10.1016/j.ebiom.2019.08.017_bb0040 article-title: Effects of high-fat overfeeding on mitochondrial function, glucose and fat metabolism, and adipokine levels in low-birth-weight subjects publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00095.2011 |
| SSID | ssj0001542358 |
| Score | 2.2129617 |
| Snippet | Individuals born with low birth weight (LBW) have an increased risk of metabolic diseases when exposed to diets rich in calories and fat but may respond to... AbstractBackgroundIndividuals born with low birth weight (LBW) have an increased risk of metabolic diseases when exposed to diets rich in calories and fat but... Background: Individuals born with low birth weight (LBW) have an increased risk of metabolic diseases when exposed to diets rich in calories and fat but may... |
| SourceID | swepub pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 341 |
| SubjectTerms | Adipose Tissue - metabolism Adult Advanced Basic Science Binding Sites Biomarkers Birth Weight Clinical Medicine DNA Methylation Endocrinology and Diabetes Endokrinologi och diabetes Energy Metabolism - genetics Epigenetics Fasting Gene Expression Profiling Gene Expression Regulation Genome-Wide Association Study Humans Internal Medicine Klinisk medicin Male Medical and Health Sciences Medicin och hälsovetenskap Metabolism Models, Biological Muscle, Skeletal - metabolism Nucleotide Motifs Protein Binding Research paper Sex Factors Transcription Factors Transcription, Genetic Transcriptomics Type 2 diabetes Young Adult |
| Title | Fasting unmasks differential fat and muscle transcriptional regulation of metabolic gene sets in low versus normal birth weight men |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S235239641930533X https://www.clinicalkey.es/playcontent/1-s2.0-S235239641930533X https://dx.doi.org/10.1016/j.ebiom.2019.08.017 https://www.ncbi.nlm.nih.gov/pubmed/31439477 https://www.proquest.com/docview/2287520207 https://pubmed.ncbi.nlm.nih.gov/PMC6796584 |
| Volume | 47 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bi9NAFB7WFWVfxLv1sozgo5FmMpfMg4iIZVEQRAvFl2FuodU0XTsp6z77xz2TZKpl6wq-BErmkHTmOznfmTkXhJ4VkrqKujLjVc4zqkueldLKrJKGm0KA02W6aIsP_GRK383Y7AClrqjDBIa9rl3sJzVd1y9-fD9_BQr_8neslo-56jFOS3b1OHNxBV3tDoxiLN_A9_u0YRpTQ1P1of2yR-h6kceEUSH-ZqwuktGLMZU7lUc7azW5iW4MNBO_7nFxCx345ja61jeePL-Dfk50iPHOeNMsdfgWcOqTAvpe40q3WDcOLzcBhHEbzVn6uMDtdd--Hn7gVYWXvgUc1QuLAYoeB98GvGhwvTrDMeJjE3ATaXGNzWLdzvFZtxULUs1dNJ28_fzmJBvaMWQWSF-bUW8ot1xa63RlfCUMp94Lx8DOgi8azxMJF5FSlDz3RDrCHFgC5l1eMCHz4h46bFaNf4AweClE81IYTS1lkuvcWUk89czZUvjxCJE078oOtcpjy4xapaC0r6pbNxXXTcVGmrkYoedbodO-VMflw2laUJWyUOG7qQBZl4uJfWI-JOiqXAWixuoTII0UklOgyDHheTZCfCs50Juetvz7kU8T3hQofzzR0Y1fbYIi4O8yAowfxtzv8bf96wnD8MI7yNwOiIXFd-80i3lXYDzuLQIxHaEvPYZ3RTqNVEMtqrmqNyp4dfrHJrOyzGpWaKmIpExRUmkFel-qciyNGcMaO28f_vdrPUJHcXL6QL_H6LBdb_wTYIatOe52VOD6_mN53Gn-LzccaxI |
| linkProvider | Scholars Portal |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Fasting+unmasks+differential+fat+and+muscle+transcriptional+regulation+of+metabolic+gene+sets+in+low+versus+normal+birth+weight+men&rft.jtitle=EBioMedicine&rft.au=Gillberg%2C+Linn&rft.au=R%C3%B6nn%2C+Tina&rft.au=J%C3%B8rgensen%2C+Sine+Wanda&rft.au=Perfilyev%2C+Alexander&rft.date=2019-09-01&rft.pub=Elsevier&rft.eissn=2352-3964&rft.volume=47&rft.spage=341&rft.epage=351&rft_id=info:doi/10.1016%2Fj.ebiom.2019.08.017&rft_id=info%3Apmid%2F31439477&rft.externalDocID=PMC6796584 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F23523964%2FS2352396419X00109%2Fcov150h.gif |