Variation of DNA methylation on the IRX1/2 genes is responsible for the neural differentiation propensity in human induced pluripotent stem cells - Sekiya, Asato; Takasawa, Ken; Arai, Yoshikazu; Horike, Shin-ichi; Akutsu, Hidenori; Umezawa, Akihiro; Nishino, Koichiro (Regenerative therapy, 2022)
Keywords: Differentiation propensity; DNA methylation; Human iPSCs; Machine learning; Neural stem cells; Original; PSC; Lasso; Human iPSCs; PAX6; EGFP; IRX; NSCs; C5orf38; dpc; Machine learning; DNA methylation; Differentiation propensity; Neural stem cells; EGFP, enhanced green fluorescent protein; PAX6, Paired Box 6; NSCs, neural stem cells; dpc, days post coitum; PSC, pluripotent stem cell; IRX, Iroquois Homeobox; Lasso, least absolute shrinkage and selection operator; C5orf38, Chromosome 5 open reading frame 38