Yuzu (Citrus junos Tanaka) Peel Attenuates Dextran Sulfate Sodium-induced Murine Experimental Colitis
Ulcerative colitis is a well-known inflammatory bowel disease. Although there are drugs that are effective against this disease, the prevention and attenuation of ulcerative colitis by food rich in functional ingredients without side effects is desired because some drugs have side effects. In this s...
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| Published in | Journal of Oleo Science Vol. 67; no. 3; pp. 335 - 344 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
Japan Oil Chemists' Society
01.03.2018
Japan Science and Technology Agency |
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| Online Access | Get full text |
| ISSN | 1345-8957 1347-3352 1347-3352 |
| DOI | 10.5650/jos.ess17184 |
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| Abstract | Ulcerative colitis is a well-known inflammatory bowel disease. Although there are drugs that are effective against this disease, the prevention and attenuation of ulcerative colitis by food rich in functional ingredients without side effects is desired because some drugs have side effects. In this study, we investigated the effects of yuzu (Citrus junos Tanaka), a citrus fruit native to northeast Asia, on a mouse dextran sulfate sodium (DSS)-induced colitis model. Mice given drinking water containing DSS showed significant weight loss, colon shortening, diarrhea, and visible fecal blood. In contrast, mice fed a diet containing 5% yuzu peel for 14 d before receiving DSS showed significant attenuation of these phenotypes. To clarify the mechanism underlying the attenuation, we investigated the anti-inflammatory and antioxidant effects of yuzu peel. We found that yuzu peel extract suppressed tumor necrosis factor-α (TNF-α) production in lipopolysaccharide (LPS)-stimulated mice and murine macrophage cell line through suppression of nuclear factor-κB (NF-κB) activation. In addition, we confirmed that yuzu peel extract had a moderate antioxidant effect. These results suggest that yuzu peel attenuates the pathologies of DSS-induced colitis by coordinately suppressing inflammation and oxidative stress against lipids in vivo. |
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| AbstractList | Ulcerative colitis is a well-known inflammatory bowel disease. Although there are drugs that are effective against this disease, the prevention and attenuation of ulcerative colitis by food rich in functional ingredients without side effects is desired because some drugs have side effects. In this study, we investigated the effects of yuzu (Citrus junos Tanaka), a citrus fruit native to northeast Asia, on a mouse dextran sulfate sodium (DSS)-induced colitis model. Mice given drinking water containing DSS showed significant weight loss, colon shortening, diarrhea, and visible fecal blood. In contrast, mice fed a diet containing 5% yuzu peel for 14 d before receiving DSS showed significant attenuation of these phenotypes. To clarify the mechanism underlying the attenuation, we investigated the anti-inflammatory and antioxidant effects of yuzu peel. We found that yuzu peel extract suppressed tumor necrosis factor-α (TNF-α) production in lipopolysaccharide (LPS)-stimulated mice and murine macrophage cell line through suppression of nuclear factor-κB (NF-κB) activation. In addition, we confirmed that yuzu peel extract had a moderate antioxidant effect. These results suggest that yuzu peel attenuates the pathologies of DSS-induced colitis by coordinately suppressing inflammation and oxidative stress against lipids in vivo. Abstract: Ulcerative colitis is a well-known inflammatory bowel disease. Although there are drugs that are effective against this disease, the prevention and attenuation of ulcerative colitis by food rich in functional ingredients without side effects is desired because some drugs have side effects. In this study, we investigated the effects of yuzu (Citrus junos Tanaka), a citrus fruit native to northeast Asia, on a mouse dextran sulfate sodium (DSS)-induced colitis model. Mice given drinking water containing DSS showed significant weight loss, colon shortening, diarrhea, and visible fecal blood. In contrast, mice fed a diet containing 5% yuzu peel for 14 d before receiving DSS showed significant attenuation of these phenotypes. To clarify the mechanism underlying the attenuation, we investigated the anti-inflammatory and antioxidant effects of yuzu peel. We found that yuzu peel extract suppressed tumor necrosis factor-α (TNF-α) production in lipopolysaccharide (LPS)-stimulated mice and murine macrophage cell line through suppression of nuclear factor-кB (NF-кB) activation. In addition, we confirmed that yuzu peel extract had a moderate antioxidant effect. These results suggest that yuzu peel attenuates the pathologies of DSS-induced colitis by coordinately suppressing inflammation and oxidative stress against lipids in vivo. |
| Author | Fujita, Yasuko Ishioka, Mika Suzuki, Shingo Sato, Akihiko Ohnishi, Shigehiko Umeno, Aya Abe, Hiroko Yasunaga, Mayu Nakajima, Yoshihiro Yoshida, Yasukazu Ishida, Noriko Shichiri, Mototada |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29459515$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_heliyon_2023_e18137 crossref_primary_10_1080_14786419_2019_1601196 crossref_primary_10_1016_j_intimp_2019_105768 crossref_primary_10_1016_j_jep_2022_115056 crossref_primary_10_1016_j_ultsonch_2023_106507 crossref_primary_10_1080_01480545_2022_2158848 crossref_primary_10_3390_nu14051101 crossref_primary_10_3390_antiox13111369 crossref_primary_10_3136_fstr_27_281 crossref_primary_10_3390_antiox10020140 crossref_primary_10_1186_s40104_022_00690_7 crossref_primary_10_3390_nu14235024 crossref_primary_10_2331_suisan_22_00030 crossref_primary_10_1093_nutrit_nuae224 crossref_primary_10_3390_foods10020240 crossref_primary_10_1002_fft2_38 crossref_primary_10_3390_nu14112270 crossref_primary_10_3390_molecules24040680 crossref_primary_10_1016_j_jnutbio_2022_109206 crossref_primary_10_31146_1682_8658_ecg_223_3_119_133 crossref_primary_10_3390_antiox12040972 |
| Cites_doi | 10.1038/nri910 10.1016/j.gtc.2006.09.008 10.1016/j.lfs.2005.04.051 10.1016/0891-5849(92)90079-V 10.1016/j.mce.2016.09.026 10.1371/journal.pone.0110596 10.1111/j.1750-3841.2010.01717.x 10.1016/j.foodchem.2016.08.026 10.1016/j.dld.2008.01.007 10.1152/ajpgi.00467.2004 10.1016/j.jnutbio.2004.09.007 10.1172/JCI115137 10.1016/j.foodchem.2011.03.011 10.1016/j.phymed.2009.02.021 10.1021/jf047816u 10.1016/j.fct.2011.09.038 10.1073/pnas.1010030108 10.5650/jos.ess15042 10.1021/jf0498158 10.1007/s00011-013-0595-2 10.1111/j.1750-3841.2010.01541.x 10.1089/ars.2012.4530 |
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Anti-platelet effects of yuzu extract and its component. Food Chem. Toxicol. 49, 3018-3024 (2011). 14) Yoo, K.M.; Lee, K.W.; Park, J.B.; Lee, H.J.; Hwang, I.K. Variation in major antioxidants and total antioxidant activity of Yuzu (Citrus junos Sieb ex Tanaka) during maturation and between cultivars. J. Agric. Food Chem. 52, 5907-5913 (2004). 26) Kang, J.; Xie, C.; Li, Z.; Nagarajan, S.; Schauss, A.G.; Wu, T.; Wu, X. Flavonoids from acai (Euterpe oleracea Mart.) pulp and their antioxidant and anti-inflammatory activities. Food Chem. 128, 152-157 (2011). 17) Kim, S.H.; Hur, H.J.; Yang, H.J.; Kim, H.J.; Kim, M.J.; Park, J.H.; Sung, M.J.; Kim, M.S.; Kwon, D.Y.; Hwang, J.T. Citrus junos Tanaka peel extract exerts antidiabetic effects via AMPK and PPAR-gamma both in vitro and in vivo in mice fed a high-fat diet. Evid. Based Complement. Alternat. Med. 2013, 921012 (2013). 23) Tsuboi, Y.; Abe, H.; Nakagawa, R.; Oomizu, S.; Watanabe, K.; Nishi, N.; Nakamura, T.; Yamauchi, A.; Hirashima, M. Galectin-9 protects mice from the Shwartzman reaction by attracting prostaglandin E2-producing polymorphonuclear leukocytes. Clin. Immunol. 124, 221-233 (2007). 8) Petronilho, F.; Michels, M.; Danielski, L.G.; Goldim, M.P.; Florentino, D.; Vieira, A.; Mendonca, M.G.; Tournier, M.; Piacentini, B.; Giustina, A.D.; Leffa, D.D.; Pereira, G.W.; Pereira, V.D.; Rocha, J.B. Diphenyl diselenide attenuates oxidative stress and inflammatory parameters in ulcerative colitis: A comparison with ebselen. Pathol. Res. Pract. 212, 755-760 (2016). 29) Tan, Z.; Cheng, J.; Liu, Q.; Zhou, L.; Kenny, J.; Wang, T.; Lin, X.; Yuan, J.; Quinn, J.M.; Tickner, J.; Hong, G.; Qin, A.; Zhao, J.; Xu, J. Neohesperidin suppresses osteoclast differentiation, bone resorption and ovariecto-mised-induced osteoporosis in mice. Mol. Cell Endocrinol. 439, 369-378 (2017). 21) Xu, L.; Yang, Z.L.; Li, P.; Zhou, Y.Q. Modulating effect of Hesperidin on experimental murine colitis induced by dextran sulfate sodium. 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| References_xml | – reference: 13) Sawamura, M.; Wu, Y.; Fujiwara, C.; Urushibata, M. Inhibitory effect of yuzu essential oil on the formation of N-nitrosodimethylamine in vegetables. J. Agric. Food Chem. 53, 4281-4287 (2005). – reference: 10) Miao, X.P.; Sun, X.N.; Cui, L.J.; Cao, Q.F.; Zhuang, G.F.; Deng, T.Z.; Zhang, D.Y. Suppressive effect of pectic polysaccharides extracted from Rauwolfia verticillata (Lour.) Baill.var.hainanensis Tsiang on inflammation by regulation of NF- kappa B pathway and interleukin-17 in mice with dextran sulphatesodium-induced ulcerative colitis. Asian Pac. J. Trop. Med. 8, 147-152 (2015). – reference: 8) Petronilho, F.; Michels, M.; Danielski, L.G.; Goldim, M.P.; Florentino, D.; Vieira, A.; Mendonca, M.G.; Tournier, M.; Piacentini, B.; Giustina, A.D.; Leffa, D.D.; Pereira, G.W.; Pereira, V.D.; Rocha, J.B. Diphenyl diselenide attenuates oxidative stress and inflammatory parameters in ulcerative colitis: A comparison with ebselen. Pathol. Res. Pract. 212, 755-760 (2016). – reference: 7) Babbs, C.F. Oxygen radicals in ulcerative colitis. Free Radic. Biol. Med. 13, 169-181 (1992). – reference: 29) Tan, Z.; Cheng, J.; Liu, Q.; Zhou, L.; Kenny, J.; Wang, T.; Lin, X.; Yuan, J.; Quinn, J.M.; Tickner, J.; Hong, G.; Qin, A.; Zhao, J.; Xu, J. Neohesperidin suppresses osteoclast differentiation, bone resorption and ovariecto-mised-induced osteoporosis in mice. Mol. Cell Endocrinol. 439, 369-378 (2017). – reference: 9) Reddy, J.G.; Loftus, E.V.Jr. Safety of infliximab and other biologic agents in the inflammatory bowel diseases. Gastroenterol. Clin. North Am. 35, 837-855 (2006). – reference: 15) Kuraya, E.; Nakada, S.; Touyama, A.; Itoh, S. Improving the antioxidant functionality of Citrus junos Tanaka (yuzu) fruit juice by underwater shockwave pretreatment. Food Chem. 216, 123-129 (2017). – reference: 28) Kanno, S.; Shouji, A.; Tomizawa, A.; Hiura, T.; Osanai, Y.; Ujibe, M.; Obara, Y.; Nakahata, N.; Ishikawa, M. Inhibitory effect of naringin on lipopolysaccharide (LPS) - induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages. Life Sci. 78, 673-681 (2006). – reference: 30) Freeman, B.L.; Eggett, D.L.; Parker, T.L. Synergistic and antagonistic interactions of phenolic compounds found in navel oranges. J. Food Sci. 75, C570-576 (2010). – reference: 23) Tsuboi, Y.; Abe, H.; Nakagawa, R.; Oomizu, S.; Watanabe, K.; Nishi, N.; Nakamura, T.; Yamauchi, A.; Hirashima, M. Galectin-9 protects mice from the Shwartzman reaction by attracting prostaglandin E2-producing polymorphonuclear leukocytes. Clin. Immunol. 124, 221-233 (2007). – reference: 17) Kim, S.H.; Hur, H.J.; Yang, H.J.; Kim, H.J.; Kim, M.J.; Park, J.H.; Sung, M.J.; Kim, M.S.; Kwon, D.Y.; Hwang, J.T. Citrus junos Tanaka peel extract exerts antidiabetic effects via AMPK and PPAR-gamma both in vitro and in vivo in mice fed a high-fat diet. Evid. Based Complement. Alternat. 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| SubjectTerms | Administration, Oral Animals Anti-Inflammatory Agents - pharmacology antioxidant against lipids Antioxidants Antioxidants - pharmacology Attenuation Cell Line Citrus - chemistry citrus flavonoid Citrus fruits Colitis, Ulcerative - chemically induced Colitis, Ulcerative - drug therapy Colitis, Ulcerative - prevention & control Colon Dextran Sulfate - adverse effects Disease Models, Animal Drinking water Drugs experimental colitis inflammation Inflammatory bowel disease Lipids Macrophages - metabolism Male Mice Mice, Inbred BALB C NF-kappa B - metabolism Oxidative stress Oxidative Stress - drug effects Phytotherapy Plant Extracts - administration & dosage Plant Extracts - isolation & purification Side effects Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Weight loss yuzu |
| Title | Yuzu (Citrus junos Tanaka) Peel Attenuates Dextran Sulfate Sodium-induced Murine Experimental Colitis |
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