Malignant oligoastrocytoma in the spinal cord of a cat
A 12-year and 3-month spayed female mixed cat was presented with severe lumbar pain. Magnetic resonance imaging and postmortem examination revealed a swollen lesion in the spinal cord at L3 level. Histologic examination identified extensive neoplastic cell proliferation with massive necrosis in the...
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| Published in | Journal of Veterinary Medical Science Vol. 84; no. 9; pp. 1277 - 1282 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
JAPANESE SOCIETY OF VETERINARY SCIENCE
2022
The Japanese Society of Veterinary Science |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0916-7250 1347-7439 1347-7439 |
| DOI | 10.1292/jvms.22-0144 |
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| Abstract | A 12-year and 3-month spayed female mixed cat was presented with severe lumbar pain. Magnetic resonance imaging and postmortem examination revealed a swollen lesion in the spinal cord at L3 level. Histologic examination identified extensive neoplastic cell proliferation with massive necrosis in the tumor tissue. Two types of neoplastic cells were recognized. One type of neoplastic cells were large cells characterized by round to polygonal shape and abundant eosinophilic cytoplasm (referred to as “large cells”). The other neoplastic cells were small, densely proliferated, and had round to irregular shape and scant eosinophilic cytoplasm (referred to as “small cells”). Both types of cells were positive for oligodendrocyte transcription factor 2 and SRY-box transcription factor 10. Glial fibrillary acidic protein was positive in large cells but negative in most small cells. Digital analysis for Ki-67-stained tumor tissues found that total 21.1% ± 6.5% of tumor cells were positive for Ki-67. Based on these findings, we diagnosed malignant oligoastrocytoma in the spinal cord. |
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| AbstractList | A 12-year and 3-month spayed female mixed cat was presented with severe lumbar pain. Magnetic resonance imaging and postmortem examination revealed a swollen lesion in the spinal cord at L3 level. Histologic examination identified extensive neoplastic cell proliferation with massive necrosis in the tumor tissue. Two types of neoplastic cells were recognized. One type of neoplastic cells were large cells characterized by round to polygonal shape and abundant eosinophilic cytoplasm (referred to as "large cells"). The other neoplastic cells were small, densely proliferated, and had round to irregular shape and scant eosinophilic cytoplasm (referred to as "small cells"). Both types of cells were positive for oligodendrocyte transcription factor 2 and SRY-box transcription factor 10. Glial fibrillary acidic protein was positive in large cells but negative in most small cells. Digital analysis for Ki-67-stained tumor tissues found that total 21.1% ± 6.5% of tumor cells were positive for Ki-67. Based on these findings, we diagnosed malignant oligoastrocytoma in the spinal cord.A 12-year and 3-month spayed female mixed cat was presented with severe lumbar pain. Magnetic resonance imaging and postmortem examination revealed a swollen lesion in the spinal cord at L3 level. Histologic examination identified extensive neoplastic cell proliferation with massive necrosis in the tumor tissue. Two types of neoplastic cells were recognized. One type of neoplastic cells were large cells characterized by round to polygonal shape and abundant eosinophilic cytoplasm (referred to as "large cells"). The other neoplastic cells were small, densely proliferated, and had round to irregular shape and scant eosinophilic cytoplasm (referred to as "small cells"). Both types of cells were positive for oligodendrocyte transcription factor 2 and SRY-box transcription factor 10. Glial fibrillary acidic protein was positive in large cells but negative in most small cells. Digital analysis for Ki-67-stained tumor tissues found that total 21.1% ± 6.5% of tumor cells were positive for Ki-67. Based on these findings, we diagnosed malignant oligoastrocytoma in the spinal cord. A 12-year and 3-month spayed female mixed cat was presented with severe lumbar pain. Magnetic resonance imaging and postmortem examination revealed a swollen lesion in the spinal cord at L3 level. Histologic examination identified extensive neoplastic cell proliferation with massive necrosis in the tumor tissue. Two types of neoplastic cells were recognized. One type of neoplastic cells were large cells characterized by round to polygonal shape and abundant eosinophilic cytoplasm (referred to as “large cells”). The other neoplastic cells were small, densely proliferated, and had round to irregular shape and scant eosinophilic cytoplasm (referred to as “small cells”). Both types of cells were positive for oligodendrocyte transcription factor 2 and SRY-box transcription factor 10. Glial fibrillary acidic protein was positive in large cells but negative in most small cells. Digital analysis for Ki-67-stained tumor tissues found that total 21.1% ± 6.5% of tumor cells were positive for Ki-67. Based on these findings, we diagnosed malignant oligoastrocytoma in the spinal cord. A 12-year and 3-month spayed female mixed cat was presented with severe lumbar pain. Magnetic resonance imaging and postmortem examination revealed a swollen lesion in the spinal cord at L3 level. Histologic examination identified extensive neoplastic cell proliferation with massive necrosis in the tumor tissue. Two types of neoplastic cells were recognized. One type of neoplastic cells were large cells characterized by round to polygonal shape and abundant eosinophilic cytoplasm (referred to as “large cells”). The other neoplastic cells were small, densely proliferated, and had round to irregular shape and scant eosinophilic cytoplasm (referred to as “small cells”). Both types of cells were positive for oligodendrocyte transcription factor 2 and SRY-box transcription factor 10. Glial fibrillary acidic protein was positive in large cells but negative in most small cells. Digital analysis for Ki-67-stained tumor tissues found that total 21.1% ± 6.5% of tumor cells were positive for Ki-67. Based on these findings, we diagnosed malignant oligoastrocytoma in the spinal cord. |
| ArticleNumber | 22-0144 |
| Author | AOSHIMA, Keisuke TAKIGUCHI, Mitsuyoshi KOBAYASHI, Atsushi HASEGAWA, Dai SASAOKA, Kazuyoshi KIMURA, Takashi |
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| References | 7. Hammond JJ, deLahunta A, Glass EN, Kent M, Summers BA, Miller AD. 2014. Feline spinal cord gliomas: Clinicopathologic and diagnostic features of seven cases. J Vet Diagn Invest 26: 513–520. 22. Shimizu T, Saito N, Aihara M, Kurihara H, Nakazato Y, Ueki K, Sasaki T. 2004. Primary spinal oligoastrocytoma: a case report. Surg Neurol 61: 77–81, discussion 81. 12. Kuhlbrodt K, Herbarth B, Sock E, Hermans-Borgmeyer I, Wegner M. 1998. Sox10, a novel transcriptional modulator in glial cells. J Neurosci 18: 237–250. 6. Grzybicki DM, Liu Y, Moore SA, Brown HG, Silverman JF, D’Amico F, Raab SS. 2001. Interobserver variability associated with the MIB-1 labeling index: high levels suggest limited prognostic usefulness for patients with primary brain tumors. Cancer 92: 2720–2726. 9. Ide T, Uchida K, Tamura S, Nakayama H. 2010. Histiocytic sarcoma in the brain of a cat. J Vet Med Sci 72: 99–102. 10. Johnson GC, Coates JR, Wininger F. 2014. Diagnostic immunohistochemistry of canine and feline intracalvarial tumors in the age of brain biopsies. Vet Pathol 51: 146–160. 17. Marioni-Henry K, Vite CH, Newton AL, Van Winkle TJ. 2004. Prevalence of diseases of the spinal cord of cats. J Vet Intern Med 18: 851–858. 14. Ligon KL, Alberta JA, Kho AT, Weiss J, Kwaan MR, Nutt CL, Louis DN, Stiles CD, Rowitch DH. 2004. The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas. J Neuropathol Exp Neurol 63: 499–509. 21. Rissi DR, Miller AD. 2017. Feline glioma: a retrospective study and review of the literature. J Feline Med Surg 19: 1307–1314. 11. Keating MK, Sturges BK, Sisó S, Wisner ER, Creighton EK, Lyons LA. 2016. Characterization of an inherited neurologic syndrome in toyger cats with forebrain commissural malformations, ventriculomegaly and interhemispheric cysts. J Vet Intern Med 30: 617–626. 16. Mandara MT, Motta L, Calò P. 2016. Distribution of feline lymphoma in the central and peripheral nervous systems. Vet J 216: 109–116. 3. Bannykh SI, Stolt CC, Kim J, Perry A, Wegner M. 2006. Oligodendroglial-specific transcriptional factor SOX10 is ubiquitously expressed in human gliomas. J Neurooncol 76: 115–127. 19. Masahira N, Takebayashi H, Ono K, Watanabe K, Ding L, Furusho M, Ogawa Y, Nabeshima Y, Alvarez-Buylla A, Shimizu K, Ikenaka K. 2006. Olig2-positive progenitors in the embryonic spinal cord give rise not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cells. Dev Biol 293: 358–369. 13. Li LT, Jiang G, Chen Q, Zheng JN. 2015. Ki67 is a promising molecular target in the diagnosis of cancer (review). Mol Med Rep 11: 1566–1572. 15. Lu QR, Sun T, Zhu Z, Ma N, Garcia M, Stiles CD, Rowitch DH. 2002. Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell 109: 75–86. 23. Stigen O, Ytrehus B, Eggertsdottir AV. 2001. Spinal cord astrocytoma in a cat. J Small Anim Pract 42: 306–310. 26. Zhou Q, Anderson DJ. 2002. The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. Cell 109: 61–73. 25. Zarella MD, Bowman D, Aeffner F, Farahani N, Xthona A, Absar SF, Parwani A, Bui M, Hartman DJ. 2019. A practical guide to whole slide imaging a white paper from the digital pathology association. Arch Pathol Lab Med 143: 222–234. 18. Marioni-Henry K, Van Winkle TJ, Smith SH, Vite CH. 2008. Tumors affecting the spinal cord of cats: 85 cases (1980–2005). J Am Vet Med Assoc 232: 237–243. 1. Acs B, Pelekanou V, Bai Y, Martinez-Morilla S, Toki M, Leung SCY, Nielsen TO, Rimm DL. 2019. Ki67 reproducibility using digital image analysis: an inter-platform and inter-operator study. Lab Invest 99: 107–117. 2. Bankhead P, Loughrey MB, Fernández JA, Dombrowski Y, McArt DG, Dunne PD, McQuaid S, Gray RT, Murray LJ, Coleman HG, James JA, Salto-Tellez M, Hamilton PW. 2017. QuPath: Open source software for digital pathology image analysis. Sci Rep 7: 16878. 5. Ferletta M, Uhrbom L, Olofsson T, Pontén F, Westermark B. 2007. Sox10 has a broad expression pattern in gliomas and enhances platelet-derived growth factor-B—induced gliomagenesis. Mol Cancer Res 5: 891–897. 8. Haynes JS, Leininger JR. 1982. A glioma in the spinal cord of a cat. Vet Pathol 19: 713–715. 4. Dimou L, Simon C, Kirchhoff F, Takebayashi H, Götz M. 2008. Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex. J Neurosci 28: 10434–10442. 20. Oikawa K, Teixeira LBC, Keikhosravi A, Eliceiri KW, McLellan GJ. 2021. Microstructure and resident cell-types of the feline optic nerve head resemble that of humans. Exp Eye Res 202: 108315. 24. Stolt CC, Rehberg S, Ader M, Lommes P, Riethmacher D, Schachner M, Bartsch U, Wegner M. 2002. Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10. Genes Dev 16: 165–170. 22 23 24 25 26 10 11 12 13 14 15 16 17 18 19 1 2 3 4 5 6 7 8 9 20 21 |
| References_xml | – reference: 25. Zarella MD, Bowman D, Aeffner F, Farahani N, Xthona A, Absar SF, Parwani A, Bui M, Hartman DJ. 2019. A practical guide to whole slide imaging a white paper from the digital pathology association. Arch Pathol Lab Med 143: 222–234. – reference: 8. Haynes JS, Leininger JR. 1982. A glioma in the spinal cord of a cat. Vet Pathol 19: 713–715. – reference: 9. Ide T, Uchida K, Tamura S, Nakayama H. 2010. Histiocytic sarcoma in the brain of a cat. J Vet Med Sci 72: 99–102. – reference: 6. Grzybicki DM, Liu Y, Moore SA, Brown HG, Silverman JF, D’Amico F, Raab SS. 2001. Interobserver variability associated with the MIB-1 labeling index: high levels suggest limited prognostic usefulness for patients with primary brain tumors. Cancer 92: 2720–2726. – reference: 11. Keating MK, Sturges BK, Sisó S, Wisner ER, Creighton EK, Lyons LA. 2016. Characterization of an inherited neurologic syndrome in toyger cats with forebrain commissural malformations, ventriculomegaly and interhemispheric cysts. J Vet Intern Med 30: 617–626. – reference: 17. Marioni-Henry K, Vite CH, Newton AL, Van Winkle TJ. 2004. Prevalence of diseases of the spinal cord of cats. J Vet Intern Med 18: 851–858. – reference: 1. Acs B, Pelekanou V, Bai Y, Martinez-Morilla S, Toki M, Leung SCY, Nielsen TO, Rimm DL. 2019. Ki67 reproducibility using digital image analysis: an inter-platform and inter-operator study. Lab Invest 99: 107–117. – reference: 4. Dimou L, Simon C, Kirchhoff F, Takebayashi H, Götz M. 2008. Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex. J Neurosci 28: 10434–10442. – reference: 10. Johnson GC, Coates JR, Wininger F. 2014. Diagnostic immunohistochemistry of canine and feline intracalvarial tumors in the age of brain biopsies. Vet Pathol 51: 146–160. – reference: 24. Stolt CC, Rehberg S, Ader M, Lommes P, Riethmacher D, Schachner M, Bartsch U, Wegner M. 2002. Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10. Genes Dev 16: 165–170. – reference: 23. Stigen O, Ytrehus B, Eggertsdottir AV. 2001. Spinal cord astrocytoma in a cat. J Small Anim Pract 42: 306–310. – reference: 12. Kuhlbrodt K, Herbarth B, Sock E, Hermans-Borgmeyer I, Wegner M. 1998. Sox10, a novel transcriptional modulator in glial cells. J Neurosci 18: 237–250. – reference: 20. Oikawa K, Teixeira LBC, Keikhosravi A, Eliceiri KW, McLellan GJ. 2021. Microstructure and resident cell-types of the feline optic nerve head resemble that of humans. Exp Eye Res 202: 108315. – reference: 18. Marioni-Henry K, Van Winkle TJ, Smith SH, Vite CH. 2008. Tumors affecting the spinal cord of cats: 85 cases (1980–2005). J Am Vet Med Assoc 232: 237–243. – reference: 2. Bankhead P, Loughrey MB, Fernández JA, Dombrowski Y, McArt DG, Dunne PD, McQuaid S, Gray RT, Murray LJ, Coleman HG, James JA, Salto-Tellez M, Hamilton PW. 2017. QuPath: Open source software for digital pathology image analysis. Sci Rep 7: 16878. – reference: 16. Mandara MT, Motta L, Calò P. 2016. Distribution of feline lymphoma in the central and peripheral nervous systems. Vet J 216: 109–116. – reference: 3. Bannykh SI, Stolt CC, Kim J, Perry A, Wegner M. 2006. Oligodendroglial-specific transcriptional factor SOX10 is ubiquitously expressed in human gliomas. J Neurooncol 76: 115–127. – reference: 14. Ligon KL, Alberta JA, Kho AT, Weiss J, Kwaan MR, Nutt CL, Louis DN, Stiles CD, Rowitch DH. 2004. The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas. J Neuropathol Exp Neurol 63: 499–509. – reference: 15. Lu QR, Sun T, Zhu Z, Ma N, Garcia M, Stiles CD, Rowitch DH. 2002. Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell 109: 75–86. – reference: 19. Masahira N, Takebayashi H, Ono K, Watanabe K, Ding L, Furusho M, Ogawa Y, Nabeshima Y, Alvarez-Buylla A, Shimizu K, Ikenaka K. 2006. Olig2-positive progenitors in the embryonic spinal cord give rise not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cells. Dev Biol 293: 358–369. – reference: 13. Li LT, Jiang G, Chen Q, Zheng JN. 2015. Ki67 is a promising molecular target in the diagnosis of cancer (review). Mol Med Rep 11: 1566–1572. – reference: 5. Ferletta M, Uhrbom L, Olofsson T, Pontén F, Westermark B. 2007. Sox10 has a broad expression pattern in gliomas and enhances platelet-derived growth factor-B—induced gliomagenesis. Mol Cancer Res 5: 891–897. – reference: 7. Hammond JJ, deLahunta A, Glass EN, Kent M, Summers BA, Miller AD. 2014. Feline spinal cord gliomas: Clinicopathologic and diagnostic features of seven cases. J Vet Diagn Invest 26: 513–520. – reference: 21. Rissi DR, Miller AD. 2017. Feline glioma: a retrospective study and review of the literature. J Feline Med Surg 19: 1307–1314. – reference: 22. Shimizu T, Saito N, Aihara M, Kurihara H, Nakazato Y, Ueki K, Sasaki T. 2004. Primary spinal oligoastrocytoma: a case report. Surg Neurol 61: 77–81, discussion 81. – reference: 26. Zhou Q, Anderson DJ. 2002. The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. 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| Title | Malignant oligoastrocytoma in the spinal cord of a cat |
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