3-(4-Hydroxy-3-methoxyphenyl) propionic acid contributes to improved hepatic lipid metabolism via GPR41
3-(4-hydroxy-3-methoxyphenyl) propionic acid (HMPA) is a metabolite produced by the gut microbiota through the conversion of 4-hydroxy-3-methoxycinnamic acid (HMCA), which is a widely distributed hydroxycinnamic acid-derived metabolite found abundantly in plants. Several beneficial effects of HMPA h...
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| Published in | Scientific reports Vol. 13; no. 1; pp. 21246 - 11 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.12.2023
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2045-2322 2045-2322 |
| DOI | 10.1038/s41598-023-48525-3 |
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| Abstract | 3-(4-hydroxy-3-methoxyphenyl) propionic acid (HMPA) is a metabolite produced by the gut microbiota through the conversion of 4-hydroxy-3-methoxycinnamic acid (HMCA), which is a widely distributed hydroxycinnamic acid-derived metabolite found abundantly in plants. Several beneficial effects of HMPA have been suggested, such as antidiabetic properties, anticancer activities, and cognitive function improvement, in animal models and human studies. However, the intricate molecular mechanisms underlying the bioaccessibility and bioavailability profile following HMPA intake and the substantial modulation of metabolic homeostasis by HMPA require further elucidation. In this study, we effectively identified and characterized HMPA-specific GPR41 receptor, with greater affinity than HMCA. The activation of this receptor plays a crucial role in the anti-obesity effects and improvement of hepatic steatosis by stimulating the lipid catabolism pathway. For the improvement of metabolic disorders, our results provide insights into the development of functional foods, including HMPA, and preventive pharmaceuticals targeting GPR41. |
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| AbstractList | 3-(4-hydroxy-3-methoxyphenyl) propionic acid (HMPA) is a metabolite produced by the gut microbiota through the conversion of 4-hydroxy-3-methoxycinnamic acid (HMCA), which is a widely distributed hydroxycinnamic acid-derived metabolite found abundantly in plants. Several beneficial effects of HMPA have been suggested, such as antidiabetic properties, anticancer activities, and cognitive function improvement, in animal models and human studies. However, the intricate molecular mechanisms underlying the bioaccessibility and bioavailability profile following HMPA intake and the substantial modulation of metabolic homeostasis by HMPA require further elucidation. In this study, we effectively identified and characterized HMPA-specific GPR41 receptor, with greater affinity than HMCA. The activation of this receptor plays a crucial role in the anti-obesity effects and improvement of hepatic steatosis by stimulating the lipid catabolism pathway. For the improvement of metabolic disorders, our results provide insights into the development of functional foods, including HMPA, and preventive pharmaceuticals targeting GPR41.3-(4-hydroxy-3-methoxyphenyl) propionic acid (HMPA) is a metabolite produced by the gut microbiota through the conversion of 4-hydroxy-3-methoxycinnamic acid (HMCA), which is a widely distributed hydroxycinnamic acid-derived metabolite found abundantly in plants. Several beneficial effects of HMPA have been suggested, such as antidiabetic properties, anticancer activities, and cognitive function improvement, in animal models and human studies. However, the intricate molecular mechanisms underlying the bioaccessibility and bioavailability profile following HMPA intake and the substantial modulation of metabolic homeostasis by HMPA require further elucidation. In this study, we effectively identified and characterized HMPA-specific GPR41 receptor, with greater affinity than HMCA. The activation of this receptor plays a crucial role in the anti-obesity effects and improvement of hepatic steatosis by stimulating the lipid catabolism pathway. For the improvement of metabolic disorders, our results provide insights into the development of functional foods, including HMPA, and preventive pharmaceuticals targeting GPR41. 3-(4-hydroxy-3-methoxyphenyl) propionic acid (HMPA) is a metabolite produced by the gut microbiota through the conversion of 4-hydroxy-3-methoxycinnamic acid (HMCA), which is a widely distributed hydroxycinnamic acid-derived metabolite found abundantly in plants. Several beneficial effects of HMPA have been suggested, such as antidiabetic properties, anticancer activities, and cognitive function improvement, in animal models and human studies. However, the intricate molecular mechanisms underlying the bioaccessibility and bioavailability profile following HMPA intake and the substantial modulation of metabolic homeostasis by HMPA require further elucidation. In this study, we effectively identified and characterized HMPA-specific GPR41 receptor, with greater affinity than HMCA. The activation of this receptor plays a crucial role in the anti-obesity effects and improvement of hepatic steatosis by stimulating the lipid catabolism pathway. For the improvement of metabolic disorders, our results provide insights into the development of functional foods, including HMPA, and preventive pharmaceuticals targeting GPR41. Abstract 3-(4-hydroxy-3-methoxyphenyl) propionic acid (HMPA) is a metabolite produced by the gut microbiota through the conversion of 4-hydroxy-3-methoxycinnamic acid (HMCA), which is a widely distributed hydroxycinnamic acid-derived metabolite found abundantly in plants. Several beneficial effects of HMPA have been suggested, such as antidiabetic properties, anticancer activities, and cognitive function improvement, in animal models and human studies. However, the intricate molecular mechanisms underlying the bioaccessibility and bioavailability profile following HMPA intake and the substantial modulation of metabolic homeostasis by HMPA require further elucidation. In this study, we effectively identified and characterized HMPA-specific GPR41 receptor, with greater affinity than HMCA. The activation of this receptor plays a crucial role in the anti-obesity effects and improvement of hepatic steatosis by stimulating the lipid catabolism pathway. For the improvement of metabolic disorders, our results provide insights into the development of functional foods, including HMPA, and preventive pharmaceuticals targeting GPR41. |
| ArticleNumber | 21246 |
| Author | Masujima, Yuki Kuwahara, Hiroshige Nishitani, Yosuke Kimura, Ikuo Iwasa, Masayo Kawakami, Hideaki Ohue-Kitano, Ryuji Nishikawa, Shota |
| Author_xml | – sequence: 1 givenname: Ryuji surname: Ohue-Kitano fullname: Ohue-Kitano, Ryuji email: ohue.ryuji.8e@kyoto-u.ac.jp organization: Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Laboratory of Molecular Endocrinology, Graduate School of Pharmaceutical Sciences, Kyoto University, Center for Living Systems Information Science (CeLiSIS), Kyoto University – sequence: 2 givenname: Yuki surname: Masujima fullname: Masujima, Yuki organization: Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University – sequence: 3 givenname: Shota surname: Nishikawa fullname: Nishikawa, Shota organization: Laboratory of Molecular Endocrinology, Graduate School of Pharmaceutical Sciences, Kyoto University – sequence: 4 givenname: Masayo surname: Iwasa fullname: Iwasa, Masayo organization: Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University – sequence: 5 givenname: Yosuke surname: Nishitani fullname: Nishitani, Yosuke organization: Research Center, Maruzen Pharmaceuticals Co., Ltd – sequence: 6 givenname: Hideaki surname: Kawakami fullname: Kawakami, Hideaki organization: Research Center, Maruzen Pharmaceuticals Co., Ltd – sequence: 7 givenname: Hiroshige surname: Kuwahara fullname: Kuwahara, Hiroshige organization: Research Center, Maruzen Pharmaceuticals Co., Ltd – sequence: 8 givenname: Ikuo surname: Kimura fullname: Kimura, Ikuo email: kimura.ikuo.7x@kyoto-u.ac.jp organization: Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Laboratory of Molecular Endocrinology, Graduate School of Pharmaceutical Sciences, Kyoto University, Department of Applied Biological Science, Graduate School of Agriculture, Tokyo University of Agriculture and Technology |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38040866$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1080_10408398_2024_2410874 crossref_primary_10_1093_bbb_zbaf003 crossref_primary_10_3390_ijms25126627 crossref_primary_10_1016_j_bmcl_2024_129758 crossref_primary_10_1021_acsomega_4c09008 crossref_primary_10_1016_j_biopha_2024_116735 |
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| Snippet | 3-(4-hydroxy-3-methoxyphenyl) propionic acid (HMPA) is a metabolite produced by the gut microbiota through the conversion of 4-hydroxy-3-methoxycinnamic acid... Abstract 3-(4-hydroxy-3-methoxyphenyl) propionic acid (HMPA) is a metabolite produced by the gut microbiota through the conversion of... |
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| Title | 3-(4-Hydroxy-3-methoxyphenyl) propionic acid contributes to improved hepatic lipid metabolism via GPR41 |
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