A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury
Exposure to moderate doses of ionizing radiation (IR), which is sufficient for causing skin injury, can occur during radiation therapy as well as in radiation accidents. Radiation-induced skin injury occasionally recovers, although its underlying mechanism remains unclear. Moderate-dose IR is freque...
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| Published in | Scientific reports Vol. 11; no. 1; pp. 5653 - 14 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
11.03.2021
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2045-2322 2045-2322 |
| DOI | 10.1038/s41598-021-84818-1 |
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| Abstract | Exposure to moderate doses of ionizing radiation (IR), which is sufficient for causing skin injury, can occur during radiation therapy as well as in radiation accidents. Radiation-induced skin injury occasionally recovers, although its underlying mechanism remains unclear. Moderate-dose IR is frequently utilized for bone marrow transplantation in mice; therefore, this mouse model can help understand the mechanism. We had previously reported that bone marrow-derived cells (BMDCs) migrate to the epidermis-dermis junction in response to IR, although their role remains unknown. Here, we investigated the role of BMDCs in radiation-induced skin injury in BMT mice and observed that BMDCs contributed to skin recovery after IR-induced barrier dysfunction. One of the important mechanisms involved the action of CCL17 secreted by BMDCs on irradiated basal cells, leading to accelerated proliferation and recovery of apoptosis caused by IR. Our findings suggest that BMDCs are key players in IR-induced skin injury recovery. |
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| AbstractList | Exposure to moderate doses of ionizing radiation (IR), which is sufficient for causing skin injury, can occur during radiation therapy as well as in radiation accidents. Radiation-induced skin injury occasionally recovers, although its underlying mechanism remains unclear. Moderate-dose IR is frequently utilized for bone marrow transplantation in mice; therefore, this mouse model can help understand the mechanism. We had previously reported that bone marrow-derived cells (BMDCs) migrate to the epidermis-dermis junction in response to IR, although their role remains unknown. Here, we investigated the role of BMDCs in radiation-induced skin injury in BMT mice and observed that BMDCs contributed to skin recovery after IR-induced barrier dysfunction. One of the important mechanisms involved the action of CCL17 secreted by BMDCs on irradiated basal cells, leading to accelerated proliferation and recovery of apoptosis caused by IR. Our findings suggest that BMDCs are key players in IR-induced skin injury recovery. Exposure to moderate doses of ionizing radiation (IR), which is sufficient for causing skin injury, can occur during radiation therapy as well as in radiation accidents. Radiation-induced skin injury occasionally recovers, although its underlying mechanism remains unclear. Moderate-dose IR is frequently utilized for bone marrow transplantation in mice; therefore, this mouse model can help understand the mechanism. We had previously reported that bone marrow-derived cells (BMDCs) migrate to the epidermis-dermis junction in response to IR, although their role remains unknown. Here, we investigated the role of BMDCs in radiation-induced skin injury in BMT mice and observed that BMDCs contributed to skin recovery after IR-induced barrier dysfunction. One of the important mechanisms involved the action of CCL17 secreted by BMDCs on irradiated basal cells, leading to accelerated proliferation and recovery of apoptosis caused by IR. Our findings suggest that BMDCs are key players in IR-induced skin injury recovery.Exposure to moderate doses of ionizing radiation (IR), which is sufficient for causing skin injury, can occur during radiation therapy as well as in radiation accidents. Radiation-induced skin injury occasionally recovers, although its underlying mechanism remains unclear. Moderate-dose IR is frequently utilized for bone marrow transplantation in mice; therefore, this mouse model can help understand the mechanism. We had previously reported that bone marrow-derived cells (BMDCs) migrate to the epidermis-dermis junction in response to IR, although their role remains unknown. Here, we investigated the role of BMDCs in radiation-induced skin injury in BMT mice and observed that BMDCs contributed to skin recovery after IR-induced barrier dysfunction. One of the important mechanisms involved the action of CCL17 secreted by BMDCs on irradiated basal cells, leading to accelerated proliferation and recovery of apoptosis caused by IR. Our findings suggest that BMDCs are key players in IR-induced skin injury recovery. Abstract Exposure to moderate doses of ionizing radiation (IR), which is sufficient for causing skin injury, can occur during radiation therapy as well as in radiation accidents. Radiation-induced skin injury occasionally recovers, although its underlying mechanism remains unclear. Moderate-dose IR is frequently utilized for bone marrow transplantation in mice; therefore, this mouse model can help understand the mechanism. We had previously reported that bone marrow-derived cells (BMDCs) migrate to the epidermis-dermis junction in response to IR, although their role remains unknown. Here, we investigated the role of BMDCs in radiation-induced skin injury in BMT mice and observed that BMDCs contributed to skin recovery after IR-induced barrier dysfunction. One of the important mechanisms involved the action of CCL17 secreted by BMDCs on irradiated basal cells, leading to accelerated proliferation and recovery of apoptosis caused by IR. Our findings suggest that BMDCs are key players in IR-induced skin injury recovery. |
| ArticleNumber | 5653 |
| Author | Okano, Junko Katagi, Miwako Terashima, Tomoya Yoshie, Osamu Nagakubo, Daisuke Nakagawa, Takahiko Nakayama, Takashi Nakae, Yuki Suzuki, Yoshihisa Kojima, Hideto |
| Author_xml | – sequence: 1 givenname: Junko surname: Okano fullname: Okano, Junko email: jokano@belle.shiga-med.ac.jp organization: Department of Plastic and Reconstructive Surgery, Shiga University of Medical Science – sequence: 2 givenname: Yuki surname: Nakae fullname: Nakae, Yuki organization: Department of Stem Cell Biology and Regenerative Medicine, Shiga University of Medical Science – sequence: 3 givenname: Takahiko surname: Nakagawa fullname: Nakagawa, Takahiko organization: Department of Nephrology, Otowa Hospital – sequence: 4 givenname: Miwako surname: Katagi fullname: Katagi, Miwako organization: Department of Stem Cell Biology and Regenerative Medicine, Shiga University of Medical Science – sequence: 5 givenname: Tomoya surname: Terashima fullname: Terashima, Tomoya organization: Department of Stem Cell Biology and Regenerative Medicine, Shiga University of Medical Science – sequence: 6 givenname: Daisuke surname: Nagakubo fullname: Nagakubo, Daisuke organization: Faculty of Pharmaceutical Sciences, Division of Health and Hygienic Sciences, Himeji Dokkyo University – sequence: 7 givenname: Takashi surname: Nakayama fullname: Nakayama, Takashi organization: Division of Chemotherapy, Faculty of Pharmacy, Kindai University – sequence: 8 givenname: Osamu surname: Yoshie fullname: Yoshie, Osamu organization: The Health and Kampo Institute – sequence: 9 givenname: Yoshihisa surname: Suzuki fullname: Suzuki, Yoshihisa organization: Department of Plastic and Reconstructive Surgery, Shiga University of Medical Science – sequence: 10 givenname: Hideto surname: Kojima fullname: Kojima, Hideto organization: Department of Stem Cell Biology and Regenerative Medicine, Shiga University of Medical Science |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33707490$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_biopha_2024_117470 crossref_primary_10_1038_s41598_022_24957_1 crossref_primary_10_3389_fphys_2024_1391640 |
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| SubjectTerms | 631/136 631/57 631/61 631/80 Animals Apoptosis Basal cells Bone marrow Bone Marrow Cells - pathology Bone Marrow Cells - radiation effects Bone Marrow Transplantation CCL17 protein Cell migration Cell Movement - radiation effects Cell proliferation Cell Proliferation - radiation effects Chemokine CCL17 - metabolism Dermis Dermis - pathology Dermis - radiation effects Epidermis Epidermis - pathology Epidermis - radiation effects Gene Deletion HaCaT Cells Humanities and Social Sciences Humans Ionizing radiation Keratinocytes Keratinocytes - pathology Keratinocytes - radiation effects Macrophages - radiation effects Mice Mice, Inbred C57BL Mice, Transgenic multidisciplinary Radiation Injuries - pathology Radiation therapy Radiation, Ionizing Receptors, CCR4 - deficiency Receptors, CCR4 - metabolism Recovery (Medical) Science Science (multidisciplinary) Signal Transduction - radiation effects Skin Skin - pathology Skin - radiation effects |
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| Title | A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury |
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