Quantifying Retinal Microvascular Changes in Uveitis Using Spectral-Domain Optical Coherence Tomography Angiography

To quantify retinal capillary density and morphology in uveitis using spectral-domain optical coherence tomography angiography (SD-OCTA). Cross-sectional, observational study. Healthy and uveitic subjects were recruited from 2 tertiary care eye centers. Prototype SD-OCTA devices (Cirrus; Carl Zeiss...

Full description

Saved in:
Bibliographic Details
Published inAmerican journal of ophthalmology Vol. 171; pp. 101 - 112
Main Authors Kim, Alice Y., Rodger, Damien C., Shahidzadeh, Anoush, Chu, Zhongdi, Koulisis, Nicole, Burkemper, Bruce, Jiang, Xuejuan, Pepple, Kathryn L., Wang, Ruikang K., Puliafito, Carmen A., Rao, Narsing A., Kashani, Amir H.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.2016
Elsevier Limited
Subjects
Online AccessGet full text
ISSN0002-9394
1879-1891
1879-1891
DOI10.1016/j.ajo.2016.08.035

Cover

Abstract To quantify retinal capillary density and morphology in uveitis using spectral-domain optical coherence tomography angiography (SD-OCTA). Cross-sectional, observational study. Healthy and uveitic subjects were recruited from 2 tertiary care eye centers. Prototype SD-OCTA devices (Cirrus; Carl Zeiss Meditec, Inc, Dublin, California, USA) were used to generate 3 × 3-mm2 OCTA images centered on the fovea. Subjects were placed into 3 groups based on the type of optical microangiography (OMAG) algorithm used for image processing (intensity and/or phase) and type of retinal segmentation (automatic or manual). A semi-automated method was used to calculate skeleton density (SD), vessel density (VD), fractal dimension (FD), and vessel diameter index (VDI). Retinal vasculature was assessed in the superficial retinal layer (SRL), deep retinal layer (DRL), and nonsegmented retinal layer (NS-RL). A generalized estimating equations model was used to analyze associations between the OCTA measures and disease status within each retinal layer. A P value < .05 was accepted as significant. Reproducibility and repeatability were assessed using the intraclass correlation coefficient (ICC). The SD, VD, and FD of the parafoveal capillaries were lower in uveitic eyes compared with healthy eyes in all retinal segments. In addition, SD and VD were significantly lower in the DRL of subjects with uveitic macular edema. There was no correlation in any capillary parameters and anatomic classification of uveitis. Quantitative analysis of parafoveal capillary density and morphology in uveitis demonstrates significantly lower capillary density and complexity. SD-OCTA algorithms are robust enough to detect these changes and can provide a novel diagnostic index of disease for uveitis subjects.
AbstractList To quantify retinal capillary density and morphology in uveitis using spectral-domain optical coherence tomography angiography (SD-OCTA). Cross-sectional, observational study. Healthy and uveitic subjects were recruited from 2 tertiary care eye centers. Prototype SD-OCTA devices (Cirrus; Carl Zeiss Meditec, Inc, Dublin, California, USA) were used to generate 3 × 3-mm OCTA images centered on the fovea. Subjects were placed into 3 groups based on the type of optical microangiography (OMAG) algorithm used for image processing (intensity and/or phase) and type of retinal segmentation (automatic or manual). A semi-automated method was used to calculate skeleton density (SD), vessel density (VD), fractal dimension (FD), and vessel diameter index (VDI). Retinal vasculature was assessed in the superficial retinal layer (SRL), deep retinal layer (DRL), and nonsegmented retinal layer (NS-RL). A generalized estimating equations model was used to analyze associations between the OCTA measures and disease status within each retinal layer. A P value < .05 was accepted as significant. Reproducibility and repeatability were assessed using the intraclass correlation coefficient (ICC). The SD, VD, and FD of the parafoveal capillaries were lower in uveitic eyes compared with healthy eyes in all retinal segments. In addition, SD and VD were significantly lower in the DRL of subjects with uveitic macular edema. There was no correlation in any capillary parameters and anatomic classification of uveitis. Quantitative analysis of parafoveal capillary density and morphology in uveitis demonstrates significantly lower capillary density and complexity. SD-OCTA algorithms are robust enough to detect these changes and can provide a novel diagnostic index of disease for uveitis subjects.
To quantify retinal capillary density and morphology in uveitis using spectral-domain optical coherence tomography angiography (SD-OCTA). Cross-sectional, observational study. Healthy and uveitic subjects were recruited from 2 tertiary care eye centers. Prototype SD-OCTA devices (Cirrus; Carl Zeiss Meditec, Inc, Dublin, California, USA) were used to generate 3 × 3-mm2 OCTA images centered on the fovea. Subjects were placed into 3 groups based on the type of optical microangiography (OMAG) algorithm used for image processing (intensity and/or phase) and type of retinal segmentation (automatic or manual). A semi-automated method was used to calculate skeleton density (SD), vessel density (VD), fractal dimension (FD), and vessel diameter index (VDI). Retinal vasculature was assessed in the superficial retinal layer (SRL), deep retinal layer (DRL), and nonsegmented retinal layer (NS-RL). A generalized estimating equations model was used to analyze associations between the OCTA measures and disease status within each retinal layer. A P value < .05 was accepted as significant. Reproducibility and repeatability were assessed using the intraclass correlation coefficient (ICC). The SD, VD, and FD of the parafoveal capillaries were lower in uveitic eyes compared with healthy eyes in all retinal segments. In addition, SD and VD were significantly lower in the DRL of subjects with uveitic macular edema. There was no correlation in any capillary parameters and anatomic classification of uveitis. Quantitative analysis of parafoveal capillary density and morphology in uveitis demonstrates significantly lower capillary density and complexity. SD-OCTA algorithms are robust enough to detect these changes and can provide a novel diagnostic index of disease for uveitis subjects.
Abstract Purpose To quantify retinal capillary density and morphology in uveitis using SD-OCTA. Design Cross-sectional, observational study Methods Healthy and uveitic subjects were recruited from two tertiary care eye centers. Prototype SD-OCTA devices (Cirrus, Carl Zeiss Meditec, Inc., Dublin, CA) were used to generate 3x3 mm2 OCTA images centered on the fovea. Subjects were placed into 3 groups based on the type of optical microangiography (OMAG) algorithm used for image processing (intensity- and/or phase) and type of retinal segmentation (automatic or manual). A semi-automated method was used to calculate skeleton density (SD), vessel density (VD), fractal dimension (FD), and vessel diameter index (VDI). Retinal vasculature was assessed in the superficial retinal layer (SRL), deep retinal layer (DRL), and non-segmented retinal layer (NS-RL). A generalized estimating equations model was used to analyze associations between the OCTA measures and disease status within each retinal layer. A P value < 0.05 was accepted as significant. Reproducibility and repeatability were assessed using the Intraclass Correlation Coefficient (ICC). Results The SD, VD, and FD of the parafoveal capillaries were lower in uveitic eyes compared to healthy eyes in all retinal segments. In addition, SD and VD were significantly lower in the DRL of subjects with uveitic macular edema. There was no correlation in any capillary parameters and anatomic classification of uveitis. Conclusions Quantitative analysis of parafoveal capillary density and morphology in uveitis demonstrates significantly lower capillary density and complexity. SD-OCTA algorithms are robust enough to detect these changes and can provide a novel diagnostic index of disease for uveitis subjects.
Purpose To quantify retinal capillary density and morphology in uveitis using spectral-domain optical coherence tomography angiography (SD-OCTA). Design Cross-sectional, observational study. Methods Healthy and uveitic subjects were recruited from 2 tertiary care eye centers. Prototype SD-OCTA devices (Cirrus; Carl Zeiss Meditec, Inc, Dublin, California, USA) were used to generate 3 x 3-mm2OCTA images centered on the fovea. Subjects were placed into 3 groups based on the type of optical microangiography (OMAG) algorithm used for image processing (intensity and/or phase) and type of retinal segmentation (automatic or manual). A semi-automated method was used to calculate skeleton density (SD), vessel density (VD), fractal dimension (FD), and vessel diameter index (VDI). Retinal vasculature was assessed in the superficial retinal layer (SRL), deep retinal layer (DRL), and nonsegmented retinal layer (NS-RL). A generalized estimating equations model was used to analyze associations between the OCTA measures and disease status within each retinal layer. APvalue < .05 was accepted as significant. Reproducibility and repeatability were assessed using the intraclass correlation coefficient (ICC). Results The SD, VD, and FD of the parafoveal capillaries were lower in uveitic eyes compared with healthy eyes in all retinal segments. In addition, SD and VD were significantly lower in the DRL of subjects with uveitic macular edema. There was no correlation in any capillary parameters and anatomic classification of uveitis. Conclusions Quantitative analysis of parafoveal capillary density and morphology in uveitis demonstrates significantly lower capillary density and complexity. SD-OCTA algorithms are robust enough to detect these changes and can provide a novel diagnostic index of disease for uveitis subjects.
To quantify retinal capillary density and morphology in uveitis using spectral-domain optical coherence tomography angiography (SD-OCTA).PURPOSETo quantify retinal capillary density and morphology in uveitis using spectral-domain optical coherence tomography angiography (SD-OCTA).Cross-sectional, observational study.DESIGNCross-sectional, observational study.Healthy and uveitic subjects were recruited from 2 tertiary care eye centers. Prototype SD-OCTA devices (Cirrus; Carl Zeiss Meditec, Inc, Dublin, California, USA) were used to generate 3 × 3-mm2 OCTA images centered on the fovea. Subjects were placed into 3 groups based on the type of optical microangiography (OMAG) algorithm used for image processing (intensity and/or phase) and type of retinal segmentation (automatic or manual). A semi-automated method was used to calculate skeleton density (SD), vessel density (VD), fractal dimension (FD), and vessel diameter index (VDI). Retinal vasculature was assessed in the superficial retinal layer (SRL), deep retinal layer (DRL), and nonsegmented retinal layer (NS-RL). A generalized estimating equations model was used to analyze associations between the OCTA measures and disease status within each retinal layer. A P value < .05 was accepted as significant. Reproducibility and repeatability were assessed using the intraclass correlation coefficient (ICC).METHODSHealthy and uveitic subjects were recruited from 2 tertiary care eye centers. Prototype SD-OCTA devices (Cirrus; Carl Zeiss Meditec, Inc, Dublin, California, USA) were used to generate 3 × 3-mm2 OCTA images centered on the fovea. Subjects were placed into 3 groups based on the type of optical microangiography (OMAG) algorithm used for image processing (intensity and/or phase) and type of retinal segmentation (automatic or manual). A semi-automated method was used to calculate skeleton density (SD), vessel density (VD), fractal dimension (FD), and vessel diameter index (VDI). Retinal vasculature was assessed in the superficial retinal layer (SRL), deep retinal layer (DRL), and nonsegmented retinal layer (NS-RL). A generalized estimating equations model was used to analyze associations between the OCTA measures and disease status within each retinal layer. A P value < .05 was accepted as significant. Reproducibility and repeatability were assessed using the intraclass correlation coefficient (ICC).The SD, VD, and FD of the parafoveal capillaries were lower in uveitic eyes compared with healthy eyes in all retinal segments. In addition, SD and VD were significantly lower in the DRL of subjects with uveitic macular edema. There was no correlation in any capillary parameters and anatomic classification of uveitis.RESULTSThe SD, VD, and FD of the parafoveal capillaries were lower in uveitic eyes compared with healthy eyes in all retinal segments. In addition, SD and VD were significantly lower in the DRL of subjects with uveitic macular edema. There was no correlation in any capillary parameters and anatomic classification of uveitis.Quantitative analysis of parafoveal capillary density and morphology in uveitis demonstrates significantly lower capillary density and complexity. SD-OCTA algorithms are robust enough to detect these changes and can provide a novel diagnostic index of disease for uveitis subjects.CONCLUSIONSQuantitative analysis of parafoveal capillary density and morphology in uveitis demonstrates significantly lower capillary density and complexity. SD-OCTA algorithms are robust enough to detect these changes and can provide a novel diagnostic index of disease for uveitis subjects.
Author Kim, Alice Y.
Rodger, Damien C.
Jiang, Xuejuan
Shahidzadeh, Anoush
Puliafito, Carmen A.
Chu, Zhongdi
Pepple, Kathryn L.
Kashani, Amir H.
Burkemper, Bruce
Koulisis, Nicole
Rao, Narsing A.
Wang, Ruikang K.
AuthorAffiliation 1 Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, 1450 San Pablo St., Suite 4700, Los Angeles, CA 90033, United States
3 Department of Ophthalmology, University of Washington, Box 359608, 325 9th Ave. Seattle, WA 98104, United States
2 Departments of Bioengineering and Ophthalmology, University of Washington, Box 355061, 3720 15th Ave. NE, Seattle, WA 98195-5061, United States
AuthorAffiliation_xml – name: 1 Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, 1450 San Pablo St., Suite 4700, Los Angeles, CA 90033, United States
– name: 2 Departments of Bioengineering and Ophthalmology, University of Washington, Box 355061, 3720 15th Ave. NE, Seattle, WA 98195-5061, United States
– name: 3 Department of Ophthalmology, University of Washington, Box 359608, 325 9th Ave. Seattle, WA 98104, United States
Author_xml – sequence: 1
  givenname: Alice Y.
  surname: Kim
  fullname: Kim, Alice Y.
  organization: Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California
– sequence: 2
  givenname: Damien C.
  surname: Rodger
  fullname: Rodger, Damien C.
  organization: Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California
– sequence: 3
  givenname: Anoush
  orcidid: 0000-0003-2269-9257
  surname: Shahidzadeh
  fullname: Shahidzadeh, Anoush
  organization: Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California
– sequence: 4
  givenname: Zhongdi
  orcidid: 0000-0001-7430-5032
  surname: Chu
  fullname: Chu, Zhongdi
  organization: Department of Bioengineering, University of Washington, Seattle, Washington
– sequence: 5
  givenname: Nicole
  surname: Koulisis
  fullname: Koulisis, Nicole
  organization: Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California
– sequence: 6
  givenname: Bruce
  orcidid: 0000-0003-3689-7481
  surname: Burkemper
  fullname: Burkemper, Bruce
  organization: Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California
– sequence: 7
  givenname: Xuejuan
  orcidid: 0000-0002-5637-666X
  surname: Jiang
  fullname: Jiang, Xuejuan
  organization: Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California
– sequence: 8
  givenname: Kathryn L.
  surname: Pepple
  fullname: Pepple, Kathryn L.
  organization: Department of Ophthalmology, University of Washington, Seattle, Washington
– sequence: 9
  givenname: Ruikang K.
  surname: Wang
  fullname: Wang, Ruikang K.
  organization: Department of Bioengineering, University of Washington, Seattle, Washington
– sequence: 10
  givenname: Carmen A.
  surname: Puliafito
  fullname: Puliafito, Carmen A.
  organization: Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California
– sequence: 11
  givenname: Narsing A.
  surname: Rao
  fullname: Rao, Narsing A.
  organization: Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California
– sequence: 12
  givenname: Amir H.
  surname: Kashani
  fullname: Kashani, Amir H.
  email: ahkashan@usc.edu
  organization: Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27594138$$D View this record in MEDLINE/PubMed
BookMark eNqFklFv0zAUhS00xLrBD-AFReKFlwQ7dmJbSJOmwgBpaIKtEm-W69y0Lqld7KRS__0ctQyoxJAf4sjnHN_r756hE-cdIPSS4IJgUr9dFXrlizJtCywKTKsnaEIElzkRkpygCca4zCWV7BSdxbhKvzVn_Bk6LXklGaFiguLXQbvetjvrFtk36K3TXfbFmuC3Opqh0yGbLrVbQMysy2ZbsL2N2SyO8tsNmD7oLn_v1zqd3mx6a5J96pcQwBnI7vzaL4LeLHfZpVvYw_45etrqLsKLw_ccza4-3E0_5dc3Hz9PL69zU1e4z0VlJJEVp2mVpJW8bKgwdN7MASpZN6mDlnPcmjkIBmJOK8yoES3WRotK1_QcXexzN8N8DY0BN1arNsGuddgpr636-8TZpVr4raoISRfIFPDmEBD8zwFir9Y2Gug67cAPURHBCJeU41H6-ki68kNIj3lQ1YwxmlSv_qzooZRfPJKA7AUJQIwB2gcJwWpkrlYqMVcjc4WFSsyThx95jO11b_3YlO0edb7bOyFR2FoIKho7gmtsSGhV4-2j7osjt-msGyfgB-wg_u5fxVJhdTtO4ziMpKaYlex7CpD_DvjP5fc7N_Aa
CODEN AJOPAA
CitedBy_id crossref_primary_10_1080_17434440_2021_1902301
crossref_primary_10_1167_tvst_8_3_57
crossref_primary_10_1016_j_ajo_2020_05_027
crossref_primary_10_1186_s12348_019_0190_y
crossref_primary_10_3390_diagnostics14030336
crossref_primary_10_1016_j_preteyeres_2017_07_002
crossref_primary_10_1111_ene_15378
crossref_primary_10_1364_OSAC_402623
crossref_primary_10_21516_2072_0076_2020_13_4_91_98
crossref_primary_10_1080_09273948_2019_1612452
crossref_primary_10_3390_healthcare12161589
crossref_primary_10_1007_s10792_024_03114_9
crossref_primary_10_1080_09273948_2022_2084421
crossref_primary_10_1097_APO_0000000000000354
crossref_primary_10_1016_j_jcjo_2019_06_005
crossref_primary_10_1007_s10384_024_01080_4
crossref_primary_10_3928_23258160_20231107_01
crossref_primary_10_1111_ceo_13470
crossref_primary_10_1016_j_ajo_2019_07_003
crossref_primary_10_1007_s10792_022_02299_1
crossref_primary_10_1038_s41598_022_08781_1
crossref_primary_10_1007_s10792_022_02327_0
crossref_primary_10_1007_s10792_019_01080_1
crossref_primary_10_1016_j_oret_2019_02_013
crossref_primary_10_1038_s41598_023_44234_z
crossref_primary_10_1167_iovs_19_27055
crossref_primary_10_1136_bjophthalmol_2021_320021
crossref_primary_10_3390_diagnostics14070750
crossref_primary_10_1155_2023_9479183
crossref_primary_10_2337_dbi24_0036
crossref_primary_10_1177_1535370219899893
crossref_primary_10_1001_jamaophthalmol_2018_1319
crossref_primary_10_1016_j_ajo_2020_05_006
crossref_primary_10_1080_09273948_2022_2054433
crossref_primary_10_1016_j_yaoo_2017_03_018
crossref_primary_10_1167_iovs_64_2_9
crossref_primary_10_1038_eye_2017_181
crossref_primary_10_3390_jcm13102835
crossref_primary_10_1080_09273948_2023_2279683
crossref_primary_10_1016_j_jfo_2019_10_004
crossref_primary_10_1136_bjophthalmol_2016_309837
crossref_primary_10_1186_s12348_017_0138_z
crossref_primary_10_1371_journal_pone_0230260
crossref_primary_10_1007_s10792_021_02129_w
crossref_primary_10_1016_j_oret_2017_11_001
crossref_primary_10_1080_08820538_2019_1620797
crossref_primary_10_1080_09273948_2022_2049316
crossref_primary_10_1007_s00417_020_04676_x
crossref_primary_10_1016_j_cyto_2023_156407
crossref_primary_10_1038_s41598_024_54306_3
crossref_primary_10_3389_fimmu_2021_630022
crossref_primary_10_1111_aos_14024
crossref_primary_10_1080_09273948_2019_1603313
crossref_primary_10_1007_s00417_022_05763_x
crossref_primary_10_1364_OE_465255
crossref_primary_10_1016_j_mvr_2019_103882
crossref_primary_10_1097_IAE_0000000000003891
crossref_primary_10_1016_j_survophthal_2021_11_002
crossref_primary_10_1016_j_oret_2021_02_007
crossref_primary_10_1136_bjophthalmol_2020_316881
crossref_primary_10_1364_BOE_439625
crossref_primary_10_1177_2474126419833590
crossref_primary_10_1186_s12886_020_01692_7
crossref_primary_10_1007_s10792_020_01561_8
crossref_primary_10_1109_JBHI_2020_3023308
crossref_primary_10_1038_s41598_024_67801_4
crossref_primary_10_1007_s00417_020_04687_8
crossref_primary_10_1016_j_jcjo_2020_06_016
crossref_primary_10_1159_000526487
crossref_primary_10_1016_j_ophtha_2019_06_028
crossref_primary_10_1186_s40942_024_00599_5
crossref_primary_10_1177_2515841419840249
crossref_primary_10_1159_000517521
crossref_primary_10_1109_TMI_2019_2948867
crossref_primary_10_1016_j_ajo_2020_04_019
crossref_primary_10_1186_s12886_018_1007_8
crossref_primary_10_1111_aos_14087
crossref_primary_10_1186_s12348_017_0134_3
crossref_primary_10_1186_s12348_019_0176_9
crossref_primary_10_1167_tvst_9_8_42
crossref_primary_10_1167_tvst_8_6_17
crossref_primary_10_1159_000539608
crossref_primary_10_1167_tvst_8_3_28
crossref_primary_10_1038_s41433_020_1063_1
crossref_primary_10_1038_s41598_020_80697_0
crossref_primary_10_1007_s10792_021_01892_0
crossref_primary_10_1136_bjophthalmol_2018_311874
crossref_primary_10_1097_MCP_0000000000000409
crossref_primary_10_1080_08820538_2021_1896753
crossref_primary_10_1159_000527957
crossref_primary_10_21561_jor_2022_7_1_59
crossref_primary_10_1177_2474126420936199
crossref_primary_10_1080_09273948_2020_1803923
crossref_primary_10_1371_journal_pone_0262996
crossref_primary_10_1016_j_ejr_2022_11_010
crossref_primary_10_4103_sjopt_sjopt_69_22
crossref_primary_10_1080_02713683_2024_2323520
crossref_primary_10_1080_09273948_2020_1797112
crossref_primary_10_1007_s00417_022_05699_2
crossref_primary_10_1167_iovs_61_3_50
crossref_primary_10_1186_s12348_023_00331_8
crossref_primary_10_1016_j_xops_2024_100696
crossref_primary_10_1186_s12348_022_00291_5
crossref_primary_10_1002_dad2_12181
crossref_primary_10_3389_fmed_2021_696447
crossref_primary_10_3389_fnins_2024_1361413
crossref_primary_10_1080_09273948_2020_1860231
crossref_primary_10_1167_tvst_10_9_5
crossref_primary_10_1177_1120672120920214
crossref_primary_10_1371_journal_pone_0197588
crossref_primary_10_1016_j_preteyeres_2017_04_005
crossref_primary_10_1177_24741264221080376
crossref_primary_10_1007_s00417_018_4057_y
crossref_primary_10_1080_02713683_2024_2327054
crossref_primary_10_1186_s40942_020_00255_8
crossref_primary_10_1007_s00717_024_00575_2
crossref_primary_10_1016_j_ajo_2018_06_023
crossref_primary_10_1186_s12886_022_02638_x
crossref_primary_10_1007_s10792_022_02464_6
crossref_primary_10_1080_09273948_2025_2464716
crossref_primary_10_22608_APO_201812
crossref_primary_10_1364_OE_382369
crossref_primary_10_1038_s41598_023_41054_z
crossref_primary_10_1016_j_preteyeres_2020_100938
crossref_primary_10_3390_app8122441
crossref_primary_10_1016_j_autrev_2018_09_011
crossref_primary_10_1136_bjophthalmol_2018_313078
crossref_primary_10_4103_ijo_IJO_1298_22
crossref_primary_10_1080_09273948_2018_1530364
crossref_primary_10_1167_tvst_9_4_8
crossref_primary_10_1364_BOE_8_001056
crossref_primary_10_1080_09273948_2023_2211161
crossref_primary_10_1186_s40942_020_00262_9
Cites_doi 10.1097/OPX.0000000000000645
10.3928/23258160-20140909-08
10.1136/bjo.2007.136846
10.1136/bjo.71.11.826
10.1016/S0161-6420(99)00087-1
10.1364/BOE.6.004130
10.1038/eye.2001.5
10.3928/23258160-20141118-04
10.2147/OPTH.S4033
10.1016/j.jcjo.2013.05.009
10.1001/archopht.1978.03910060294024
10.1016/j.ajo.2012.01.032
10.1016/j.ajo.2005.03.057
10.1167/iovs.10-5333
10.1001/archopht.1995.01100080071031
10.1016/j.ajo.2015.02.009
10.1136/bjo.2003.037226
10.1155/2012/509783
10.1001/jamaophthalmol.2014.3616
10.1364/OE.20.004710
10.1016/j.ophtha.2003.08.037
10.1097/IAE.0000000000000811
10.1167/iovs.15-18904
10.3760/cma.j.issn.0366-6999.20130282
10.1364/OL.35.001467
10.3928/23258160-20150909-03
ContentType Journal Article
Copyright 2016 Elsevier Inc.
Elsevier Inc.
Copyright © 2016 Elsevier Inc. All rights reserved.
Copyright Elsevier Limited Nov 01, 2016
Copyright_xml – notice: 2016 Elsevier Inc.
– notice: Elsevier Inc.
– notice: Copyright © 2016 Elsevier Inc. All rights reserved.
– notice: Copyright Elsevier Limited Nov 01, 2016
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
K9.
NAPCQ
7X8
5PM
DOI 10.1016/j.ajo.2016.08.035
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Premium
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Premium
MEDLINE - Academic
DatabaseTitleList MEDLINE



ProQuest Health & Medical Complete (Alumni)
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1879-1891
EndPage 112
ExternalDocumentID PMC5115969
4256423871
27594138
10_1016_j_ajo_2016_08_035
S000293941630424X
1_s2_0_S000293941630424X
Genre Multicenter Study
Journal Article
Observational Study
GrantInformation_xml – fundername: NEI NIH HHS
  grantid: K08 EY023998
– fundername: NEI NIH HHS
  grantid: R01 EY024158
– fundername: NEI NIH HHS
  grantid: K08 EY027006
GroupedDBID ---
--K
--M
-~X
.1-
.55
.FO
.GJ
.~1
0R~
1B1
1CY
1P~
1~.
1~5
23M
4.4
457
4G.
53G
5GY
5RE
5VS
6J9
7-5
71M
8P~
AABNK
AAEDT
AAEDW
AAHTB
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQQT
AAQXK
AATTM
AAWTL
AAXKI
AAXUO
AAYWO
ABBQC
ABCQX
ABDPE
ABFNM
ABFRF
ABJNI
ABLJU
ABMAC
ABMZM
ABOCM
ABPEJ
ABWVN
ABXDB
ACDAQ
ACGFO
ACGFS
ACIEU
ACIUM
ACNCT
ACRLP
ACRPL
ACVFH
ADBBV
ADCNI
ADEZE
ADFRT
ADMUD
ADNMO
AEBSH
AEFWE
AEIPS
AEKER
AENEX
AEUPX
AEVXI
AFFNX
AFJKZ
AFPUW
AFRHN
AFTJW
AFXIZ
AGCQF
AGHFR
AGQPQ
AGUBO
AGYEJ
AHMBA
AI.
AIEXJ
AIGII
AIIUN
AIKHN
AITUG
AJRQY
AJUYK
AKBMS
AKRWK
AKYEP
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
ANKPU
ANZVX
APXCP
ASPBG
AVWKF
AXJTR
AZFZN
BKEYQ
BKOJK
BLXMC
BNPGV
BPHCQ
BVXVI
CS3
EBS
EFJIC
EFKBS
EJD
EMOBN
EO8
EO9
EP2
EP3
EX3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-Q
GBLVA
HVGLF
HZ~
IHE
J1W
J5H
K-O
KOM
L7B
M41
MO0
N4W
N9A
O-L
O9-
OAUVE
OF-
OPF
OQ~
OZT
P-8
P-9
P2P
PC.
PQQKQ
PROAC
Q38
R2-
ROL
RPZ
SCC
SDF
SDG
SDP
SEL
SES
SPCBC
SSH
SSZ
SV3
T5K
UNMZH
UV1
VH1
WH7
WOW
X7M
XPP
Z5R
ZGI
ZXP
~G-
3V.
7RV
7X7
8FI
AACTN
AFCTW
AFKRA
AFKWA
AJOXV
AMFUW
AZQEC
BENPR
FYUFA
GUQSH
M1P
M2O
PKN
RIG
AAIAV
ABLVK
ABYKQ
AHPSJ
AJBFU
EFLBG
G8K
LCYCR
ZA5
AAYXX
CITATION
~HD
CGR
CUY
CVF
ECM
EIF
NPM
AGRNS
K9.
NAPCQ
7X8
ACLOT
5PM
ID FETCH-LOGICAL-c650t-85c91957373721f972d38c3bdbee596d941f770fcbe84e8b35043c8f0aca85a63
IEDL.DBID AIKHN
ISSN 0002-9394
1879-1891
IngestDate Thu Aug 21 18:13:12 EDT 2025
Sun Sep 28 10:27:47 EDT 2025
Sat Jul 26 02:10:16 EDT 2025
Wed Feb 19 01:57:49 EST 2025
Thu Apr 24 23:07:05 EDT 2025
Thu Sep 18 00:18:44 EDT 2025
Fri Feb 23 02:32:59 EST 2024
Tue Feb 25 19:57:50 EST 2025
Tue Aug 26 17:24:35 EDT 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Language English
License Copyright © 2016 Elsevier Inc. All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c650t-85c91957373721f972d38c3bdbee596d941f770fcbe84e8b35043c8f0aca85a63
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ObjectType-Undefined-3
ORCID 0000-0003-3689-7481
0000-0003-2269-9257
0000-0001-7430-5032
0000-0002-5637-666X
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/5115969
PMID 27594138
PQID 1841764443
PQPubID 41749
PageCount 12
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_5115969
proquest_miscellaneous_1841793709
proquest_journals_1841764443
pubmed_primary_27594138
crossref_primary_10_1016_j_ajo_2016_08_035
crossref_citationtrail_10_1016_j_ajo_2016_08_035
elsevier_sciencedirect_doi_10_1016_j_ajo_2016_08_035
elsevier_clinicalkeyesjournals_1_s2_0_S000293941630424X
elsevier_clinicalkey_doi_10_1016_j_ajo_2016_08_035
PublicationCentury 2000
PublicationDate 2016-11-01
PublicationDateYYYYMMDD 2016-11-01
PublicationDate_xml – month: 11
  year: 2016
  text: 2016-11-01
  day: 01
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: Chicago
PublicationTitle American journal of ophthalmology
PublicationTitleAlternate Am J Ophthalmol
PublicationYear 2016
Publisher Elsevier Inc
Elsevier Limited
Publisher_xml – name: Elsevier Inc
– name: Elsevier Limited
References Markomichelakis, Halkiadakis, Pantelia (bib12) 2004; 111
Tran, de Smet, Bodaghi, Fardeau, Cassoux, Lehoang (bib11) 2008; 92
Zhang, Zhang, Wang (bib22) 2015; 6
Jabs, Nussenblatt, Rosenbaum (bib5) 2005; 140
Huang, Zhang, Thorell (bib20) 2014; 45
Nazari, Dustin, Heussen, Sadda, Rao (bib7) 2012; 154
Howes, Cruse (bib24) 1978; 96
Matsunaga, Yi, De Koo, Ameri, Puliafito, Kashani (bib16) 2015; 46
Jia, Tan, Tokayer (bib21) 2012; 20
Reif, Qin, An, Zhi, Dziennis, Wang (bib18) 2012; 2012
Antcliff, Stanford, Chauhan (bib4) 2000; 107
Hong, Nazari Khanamiri, Rao (bib6) 2013; 48
Feng, Kedhar, Bhoomibunchoo (bib14) 2013; 126
Freeman, Matos, Pavesio (bib3) 2001; 15
Matsunaga, Yi, Puliafito, Kashani (bib8) 2014; 45
Spaide, Klancnik, Cooney (bib9) 2015; 133
Graham, Stanford, Shilling, Sanders (bib23) 1987; 71
Rotsos, Moschos (bib25) 2008; 2
Kim, Chu, Shahidzadeh, Wang, Puliafito, Kashani (bib26) 2016; 57
Kashani, Lee, Moshfeghi, Durbin, Puliafito (bib17) 2015; 35
Hee, Puliafito, Wong (bib13) 1995; 113
Wang, An, Francis, Wilson (bib19) 2010; 35
Durrani, Tehrani, Marr, Moradi, Stavrou, Murray (bib2) 2004; 88
Karampelas, Sim, Chu (bib15) 2015; 159
Liu, Bi, Wang, Gao, Wang, Ma (bib1) 2015; 92
Mendis, Balaratnasingam, Yu (bib10) 2010; 51
Mendis (10.1016/j.ajo.2016.08.035_bib10) 2010; 51
Wang (10.1016/j.ajo.2016.08.035_bib19) 2010; 35
Jabs (10.1016/j.ajo.2016.08.035_bib5) 2005; 140
Rotsos (10.1016/j.ajo.2016.08.035_bib25) 2008; 2
Feng (10.1016/j.ajo.2016.08.035_bib14) 2013; 126
Antcliff (10.1016/j.ajo.2016.08.035_bib4) 2000; 107
Zhang (10.1016/j.ajo.2016.08.035_bib22) 2015; 6
Tran (10.1016/j.ajo.2016.08.035_bib11) 2008; 92
Matsunaga (10.1016/j.ajo.2016.08.035_bib16) 2015; 46
Durrani (10.1016/j.ajo.2016.08.035_bib2) 2004; 88
Nazari (10.1016/j.ajo.2016.08.035_bib7) 2012; 154
Liu (10.1016/j.ajo.2016.08.035_bib1) 2015; 92
Hee (10.1016/j.ajo.2016.08.035_bib13) 1995; 113
Kim (10.1016/j.ajo.2016.08.035_bib26) 2016; 57
Huang (10.1016/j.ajo.2016.08.035_bib20) 2014; 45
Jia (10.1016/j.ajo.2016.08.035_bib21) 2012; 20
Markomichelakis (10.1016/j.ajo.2016.08.035_bib12) 2004; 111
Matsunaga (10.1016/j.ajo.2016.08.035_bib8) 2014; 45
Kashani (10.1016/j.ajo.2016.08.035_bib17) 2015; 35
Howes (10.1016/j.ajo.2016.08.035_bib24) 1978; 96
Karampelas (10.1016/j.ajo.2016.08.035_bib15) 2015; 159
Hong (10.1016/j.ajo.2016.08.035_bib6) 2013; 48
Graham (10.1016/j.ajo.2016.08.035_bib23) 1987; 71
Freeman (10.1016/j.ajo.2016.08.035_bib3) 2001; 15
Reif (10.1016/j.ajo.2016.08.035_bib18) 2012; 2012
Spaide (10.1016/j.ajo.2016.08.035_bib9) 2015; 133
25230403 - Ophthalmic Surg Lasers Imaging Retina. 2014 Sep-Oct;45(5):382-9
25317632 - JAMA Ophthalmol. 2015 Jan;133(1):45-50
687212 - Arch Ophthalmol. 1978 Sep;96(9):1668-76
15121373 - Ophthalmology. 2004 May;111(5):946-53
25423629 - Ophthalmic Surg Lasers Imaging Retina. 2014 Nov-Dec;45(6):510-5
19668445 - Clin Ophthalmol. 2008 Dec;2(4):919-30
24314409 - Can J Ophthalmol. 2013 Dec;48(6):489-93
26457395 - Retina. 2015 Nov;35(11):2323-31
25709064 - Am J Ophthalmol. 2015 Jun;159(6):1161-1168.e1
23673115 - Chin Med J (Engl). 2013;126(10):1944-7
2446653 - Br J Ophthalmol. 1987 Nov;71(11):826-33
16196117 - Am J Ophthalmol. 2005 Sep;140(3):509-16
7639652 - Arch Ophthalmol. 1995 Aug;113(8):1019-29
15317708 - Br J Ophthalmol. 2004 Sep;88(9):1159-62
22541930 - Am J Ophthalmol. 2012 Jul;154(1):78-86.e1
26107024 - Optom Vis Sci. 2015 Aug;92(8):858-62
20436605 - Opt Lett. 2010 May 1;35(9):1467-9
26431294 - Ophthalmic Surg Lasers Imaging Retina. 2015 Sep;46(8):796-805
26504660 - Biomed Opt Express. 2015 Sep 28;6(10):4130-43
10711901 - Ophthalmology. 2000 Mar;107(3):593-9
18577643 - Br J Ophthalmol. 2008 Jul;92(7):922-7
20505200 - Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5864-9
22792084 - Int J Biomed Imaging. 2012;2012:509783
22418228 - Opt Express. 2012 Feb 13;20(4):4710-25
11318279 - Eye (Lond). 2001 Feb;15(Pt 1):12-7
27409494 - Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT362-70
References_xml – volume: 92
  start-page: 858
  year: 2015
  end-page: 862
  ident: bib1
  article-title: Macular abnormalities in Chinese patients with uveitis
  publication-title: Optom Vis Sci
– volume: 140
  start-page: 509
  year: 2005
  end-page: 516
  ident: bib5
  article-title: Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop
  publication-title: Am J Ophthalmol
– volume: 133
  start-page: 45
  year: 2015
  end-page: 50
  ident: bib9
  article-title: Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography
  publication-title: JAMA Ophthalmol
– volume: 6
  start-page: 4130
  year: 2015
  end-page: 4143
  ident: bib22
  article-title: Minimizing projection artifacts for accurate presentation of choroidal neovascularization in OCT micro-angiography
  publication-title: Biomed Opt Express
– volume: 51
  start-page: 5864
  year: 2010
  end-page: 5869
  ident: bib10
  article-title: Correlation of histologic and clinical images to determine the diagnostic value of fluorescein angiography for studying retinal capillary detail
  publication-title: Invest Ophthalmol Vis Sci
– volume: 113
  start-page: 1019
  year: 1995
  end-page: 1029
  ident: bib13
  article-title: Quantitative assessment of macular edema with optical coherence tomography
  publication-title: Arch Ophthalmol
– volume: 15
  start-page: 12
  year: 2001
  end-page: 17
  ident: bib3
  article-title: Cystoid macular oedema in uveitis: an unsolved problem
  publication-title: Eye (Lond)
– volume: 57
  start-page: OCT362
  year: 2016
  end-page: OCT370
  ident: bib26
  article-title: Quantifying microvascular density and morphology in diabetic retinopathy using spectral domain optical coherence tomography angiography
  publication-title: Invest Ophthalmol Vis Sci
– volume: 159
  start-page: 1161
  year: 2015
  end-page: 1168e1
  ident: bib15
  article-title: Quantitative analysis of peripheral vasculitis, ischemia, and vascular leakage in uveitis using ultra-widefield fluorescein angiography
  publication-title: Am J Ophthalmol
– volume: 111
  start-page: 946
  year: 2004
  end-page: 953
  ident: bib12
  article-title: Patterns of macular edema in patients with uveitis: qualitative and quantitative assessment using optical coherence tomography
  publication-title: Ophthalmology
– volume: 96
  start-page: 1668
  year: 1978
  end-page: 1676
  ident: bib24
  article-title: The structural basis of altered vascular permeability following intraocular inflammation
  publication-title: Arch Ophthalmol
– volume: 107
  start-page: 593
  year: 2000
  end-page: 599
  ident: bib4
  article-title: Comparison between optical coherence tomography and fundus fluorescein angiography for the detection of cystoid macular edema in patients with uveitis
  publication-title: Ophthalmology
– volume: 92
  start-page: 922
  year: 2008
  end-page: 927
  ident: bib11
  article-title: Uveitic macular oedema: correlation between optical coherence tomography patterns with visual acuity and fluorescein angiography
  publication-title: Br J Ophthalmol
– volume: 126
  start-page: 1944
  year: 2013
  end-page: 1947
  ident: bib14
  article-title: Retinal blood flow velocity in patients with active uveitis using the retinal function imager
  publication-title: Chin Med J (Engl)
– volume: 48
  start-page: 489
  year: 2013
  end-page: 493
  ident: bib6
  article-title: Role of ultra-widefield fluorescein angiography in the management of uveitis
  publication-title: Can J Ophthalmol
– volume: 2012
  start-page: 509783
  year: 2012
  ident: bib18
  article-title: Quantifying optical microangiography images obtained from a spectral domain optical coherence tomography system
  publication-title: Int J Biomed Imaging
– volume: 35
  start-page: 2323
  year: 2015
  end-page: 2331
  ident: bib17
  article-title: Optical coherence tomography angiography of retinal venous occlusion
  publication-title: Retina
– volume: 71
  start-page: 826
  year: 1987
  end-page: 833
  ident: bib23
  article-title: Neovascularisation associated with posterior uveitis
  publication-title: Br J Ophthalmol
– volume: 20
  start-page: 4710
  year: 2012
  end-page: 4725
  ident: bib21
  article-title: Split-spectrum amplitude-decorrelation angiography with optical coherence tomography
  publication-title: Opt Express
– volume: 45
  start-page: 510
  year: 2014
  end-page: 515
  ident: bib8
  article-title: OCT angiography in healthy human subjects
  publication-title: Ophthalmic Surg Lasers Imaging Retina
– volume: 45
  start-page: 382
  year: 2014
  end-page: 389
  ident: bib20
  article-title: Swept-source OCT angiography of the retinal vasculature using intensity differentiation-based optical microangiography algorithms
  publication-title: Ophthalmic Surg Lasers Imaging Retina
– volume: 35
  start-page: 1467
  year: 2010
  end-page: 1469
  ident: bib19
  article-title: Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiography
  publication-title: Opt Lett
– volume: 2
  start-page: 919
  year: 2008
  end-page: 930
  ident: bib25
  article-title: Cystoid macular edema
  publication-title: Clin Ophthalmol
– volume: 88
  start-page: 1159
  year: 2004
  end-page: 1162
  ident: bib2
  article-title: Degree, duration, and causes of visual loss in uveitis
  publication-title: Br J Ophthalmol
– volume: 154
  start-page: 78
  year: 2012
  end-page: 86e1
  ident: bib7
  article-title: Morphometric spectral-domain optical coherence tomography features of epiretinal membrane correlate with visual acuity in patients with uveitis
  publication-title: Am J Ophthalmol
– volume: 46
  start-page: 796
  year: 2015
  end-page: 805
  ident: bib16
  article-title: Optical coherence tomography angiography of diabetic retinopathy in human subjects
  publication-title: Ophthalmic Surg Lasers Imaging Retina
– volume: 92
  start-page: 858
  issue: 8
  year: 2015
  ident: 10.1016/j.ajo.2016.08.035_bib1
  article-title: Macular abnormalities in Chinese patients with uveitis
  publication-title: Optom Vis Sci
  doi: 10.1097/OPX.0000000000000645
– volume: 45
  start-page: 382
  issue: 5
  year: 2014
  ident: 10.1016/j.ajo.2016.08.035_bib20
  article-title: Swept-source OCT angiography of the retinal vasculature using intensity differentiation-based optical microangiography algorithms
  publication-title: Ophthalmic Surg Lasers Imaging Retina
  doi: 10.3928/23258160-20140909-08
– volume: 92
  start-page: 922
  issue: 7
  year: 2008
  ident: 10.1016/j.ajo.2016.08.035_bib11
  article-title: Uveitic macular oedema: correlation between optical coherence tomography patterns with visual acuity and fluorescein angiography
  publication-title: Br J Ophthalmol
  doi: 10.1136/bjo.2007.136846
– volume: 71
  start-page: 826
  issue: 11
  year: 1987
  ident: 10.1016/j.ajo.2016.08.035_bib23
  article-title: Neovascularisation associated with posterior uveitis
  publication-title: Br J Ophthalmol
  doi: 10.1136/bjo.71.11.826
– volume: 107
  start-page: 593
  issue: 3
  year: 2000
  ident: 10.1016/j.ajo.2016.08.035_bib4
  article-title: Comparison between optical coherence tomography and fundus fluorescein angiography for the detection of cystoid macular edema in patients with uveitis
  publication-title: Ophthalmology
  doi: 10.1016/S0161-6420(99)00087-1
– volume: 6
  start-page: 4130
  issue: 10
  year: 2015
  ident: 10.1016/j.ajo.2016.08.035_bib22
  article-title: Minimizing projection artifacts for accurate presentation of choroidal neovascularization in OCT micro-angiography
  publication-title: Biomed Opt Express
  doi: 10.1364/BOE.6.004130
– volume: 15
  start-page: 12
  issue: Pt 1
  year: 2001
  ident: 10.1016/j.ajo.2016.08.035_bib3
  article-title: Cystoid macular oedema in uveitis: an unsolved problem
  publication-title: Eye (Lond)
  doi: 10.1038/eye.2001.5
– volume: 45
  start-page: 510
  issue: 6
  year: 2014
  ident: 10.1016/j.ajo.2016.08.035_bib8
  article-title: OCT angiography in healthy human subjects
  publication-title: Ophthalmic Surg Lasers Imaging Retina
  doi: 10.3928/23258160-20141118-04
– volume: 2
  start-page: 919
  issue: 4
  year: 2008
  ident: 10.1016/j.ajo.2016.08.035_bib25
  article-title: Cystoid macular edema
  publication-title: Clin Ophthalmol
  doi: 10.2147/OPTH.S4033
– volume: 48
  start-page: 489
  issue: 6
  year: 2013
  ident: 10.1016/j.ajo.2016.08.035_bib6
  article-title: Role of ultra-widefield fluorescein angiography in the management of uveitis
  publication-title: Can J Ophthalmol
  doi: 10.1016/j.jcjo.2013.05.009
– volume: 96
  start-page: 1668
  issue: 9
  year: 1978
  ident: 10.1016/j.ajo.2016.08.035_bib24
  article-title: The structural basis of altered vascular permeability following intraocular inflammation
  publication-title: Arch Ophthalmol
  doi: 10.1001/archopht.1978.03910060294024
– volume: 154
  start-page: 78
  issue: 1
  year: 2012
  ident: 10.1016/j.ajo.2016.08.035_bib7
  article-title: Morphometric spectral-domain optical coherence tomography features of epiretinal membrane correlate with visual acuity in patients with uveitis
  publication-title: Am J Ophthalmol
  doi: 10.1016/j.ajo.2012.01.032
– volume: 140
  start-page: 509
  issue: 3
  year: 2005
  ident: 10.1016/j.ajo.2016.08.035_bib5
  article-title: Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop
  publication-title: Am J Ophthalmol
  doi: 10.1016/j.ajo.2005.03.057
– volume: 51
  start-page: 5864
  issue: 11
  year: 2010
  ident: 10.1016/j.ajo.2016.08.035_bib10
  article-title: Correlation of histologic and clinical images to determine the diagnostic value of fluorescein angiography for studying retinal capillary detail
  publication-title: Invest Ophthalmol Vis Sci
  doi: 10.1167/iovs.10-5333
– volume: 113
  start-page: 1019
  issue: 8
  year: 1995
  ident: 10.1016/j.ajo.2016.08.035_bib13
  article-title: Quantitative assessment of macular edema with optical coherence tomography
  publication-title: Arch Ophthalmol
  doi: 10.1001/archopht.1995.01100080071031
– volume: 159
  start-page: 1161
  issue: 6
  year: 2015
  ident: 10.1016/j.ajo.2016.08.035_bib15
  article-title: Quantitative analysis of peripheral vasculitis, ischemia, and vascular leakage in uveitis using ultra-widefield fluorescein angiography
  publication-title: Am J Ophthalmol
  doi: 10.1016/j.ajo.2015.02.009
– volume: 88
  start-page: 1159
  issue: 9
  year: 2004
  ident: 10.1016/j.ajo.2016.08.035_bib2
  article-title: Degree, duration, and causes of visual loss in uveitis
  publication-title: Br J Ophthalmol
  doi: 10.1136/bjo.2003.037226
– volume: 2012
  start-page: 509783
  year: 2012
  ident: 10.1016/j.ajo.2016.08.035_bib18
  article-title: Quantifying optical microangiography images obtained from a spectral domain optical coherence tomography system
  publication-title: Int J Biomed Imaging
  doi: 10.1155/2012/509783
– volume: 133
  start-page: 45
  issue: 1
  year: 2015
  ident: 10.1016/j.ajo.2016.08.035_bib9
  article-title: Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography
  publication-title: JAMA Ophthalmol
  doi: 10.1001/jamaophthalmol.2014.3616
– volume: 20
  start-page: 4710
  issue: 4
  year: 2012
  ident: 10.1016/j.ajo.2016.08.035_bib21
  article-title: Split-spectrum amplitude-decorrelation angiography with optical coherence tomography
  publication-title: Opt Express
  doi: 10.1364/OE.20.004710
– volume: 111
  start-page: 946
  issue: 5
  year: 2004
  ident: 10.1016/j.ajo.2016.08.035_bib12
  article-title: Patterns of macular edema in patients with uveitis: qualitative and quantitative assessment using optical coherence tomography
  publication-title: Ophthalmology
  doi: 10.1016/j.ophtha.2003.08.037
– volume: 35
  start-page: 2323
  issue: 11
  year: 2015
  ident: 10.1016/j.ajo.2016.08.035_bib17
  article-title: Optical coherence tomography angiography of retinal venous occlusion
  publication-title: Retina
  doi: 10.1097/IAE.0000000000000811
– volume: 57
  start-page: OCT362
  issue: 9
  year: 2016
  ident: 10.1016/j.ajo.2016.08.035_bib26
  article-title: Quantifying microvascular density and morphology in diabetic retinopathy using spectral domain optical coherence tomography angiography
  publication-title: Invest Ophthalmol Vis Sci
  doi: 10.1167/iovs.15-18904
– volume: 126
  start-page: 1944
  issue: 10
  year: 2013
  ident: 10.1016/j.ajo.2016.08.035_bib14
  article-title: Retinal blood flow velocity in patients with active uveitis using the retinal function imager
  publication-title: Chin Med J (Engl)
  doi: 10.3760/cma.j.issn.0366-6999.20130282
– volume: 35
  start-page: 1467
  issue: 9
  year: 2010
  ident: 10.1016/j.ajo.2016.08.035_bib19
  article-title: Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiography
  publication-title: Opt Lett
  doi: 10.1364/OL.35.001467
– volume: 46
  start-page: 796
  issue: 8
  year: 2015
  ident: 10.1016/j.ajo.2016.08.035_bib16
  article-title: Optical coherence tomography angiography of diabetic retinopathy in human subjects
  publication-title: Ophthalmic Surg Lasers Imaging Retina
  doi: 10.3928/23258160-20150909-03
– reference: 16196117 - Am J Ophthalmol. 2005 Sep;140(3):509-16
– reference: 10711901 - Ophthalmology. 2000 Mar;107(3):593-9
– reference: 25423629 - Ophthalmic Surg Lasers Imaging Retina. 2014 Nov-Dec;45(6):510-5
– reference: 26107024 - Optom Vis Sci. 2015 Aug;92(8):858-62
– reference: 26457395 - Retina. 2015 Nov;35(11):2323-31
– reference: 22541930 - Am J Ophthalmol. 2012 Jul;154(1):78-86.e1
– reference: 687212 - Arch Ophthalmol. 1978 Sep;96(9):1668-76
– reference: 15121373 - Ophthalmology. 2004 May;111(5):946-53
– reference: 25709064 - Am J Ophthalmol. 2015 Jun;159(6):1161-1168.e1
– reference: 22792084 - Int J Biomed Imaging. 2012;2012:509783
– reference: 26431294 - Ophthalmic Surg Lasers Imaging Retina. 2015 Sep;46(8):796-805
– reference: 20436605 - Opt Lett. 2010 May 1;35(9):1467-9
– reference: 25230403 - Ophthalmic Surg Lasers Imaging Retina. 2014 Sep-Oct;45(5):382-9
– reference: 2446653 - Br J Ophthalmol. 1987 Nov;71(11):826-33
– reference: 22418228 - Opt Express. 2012 Feb 13;20(4):4710-25
– reference: 27409494 - Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT362-70
– reference: 23673115 - Chin Med J (Engl). 2013;126(10):1944-7
– reference: 20505200 - Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5864-9
– reference: 25317632 - JAMA Ophthalmol. 2015 Jan;133(1):45-50
– reference: 19668445 - Clin Ophthalmol. 2008 Dec;2(4):919-30
– reference: 26504660 - Biomed Opt Express. 2015 Sep 28;6(10):4130-43
– reference: 15317708 - Br J Ophthalmol. 2004 Sep;88(9):1159-62
– reference: 7639652 - Arch Ophthalmol. 1995 Aug;113(8):1019-29
– reference: 24314409 - Can J Ophthalmol. 2013 Dec;48(6):489-93
– reference: 11318279 - Eye (Lond). 2001 Feb;15(Pt 1):12-7
– reference: 18577643 - Br J Ophthalmol. 2008 Jul;92(7):922-7
SSID ssj0006747
Score 2.5696356
Snippet To quantify retinal capillary density and morphology in uveitis using spectral-domain optical coherence tomography angiography (SD-OCTA). Cross-sectional,...
Abstract Purpose To quantify retinal capillary density and morphology in uveitis using SD-OCTA. Design Cross-sectional, observational study Methods Healthy and...
Purpose To quantify retinal capillary density and morphology in uveitis using spectral-domain optical coherence tomography angiography (SD-OCTA). Design...
To quantify retinal capillary density and morphology in uveitis using spectral-domain optical coherence tomography angiography (SD-OCTA).PURPOSETo quantify...
SourceID pubmedcentral
proquest
pubmed
crossref
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 101
SubjectTerms Adult
Aged
Algorithms
Automation
Confidence intervals
Cross-Sectional Studies
Diabetes
Diabetic retinopathy
Disease
Edema
Family medical history
Female
Fluorescein Angiography - methods
Fundus Oculi
Humans
Image Processing, Computer-Assisted
Ischemia
Male
Medical imaging
Microcirculation
Microvessels - diagnostic imaging
Middle Aged
Morphology
Ophthalmology
Pathology
Reproducibility of Results
Retinal Vessels - diagnostic imaging
Retrospective Studies
Standard deviation
Studies
Tomography, Optical Coherence - methods
Uveitis - diagnosis
Uveitis - physiopathology
Young Adult
Title Quantifying Retinal Microvascular Changes in Uveitis Using Spectral-Domain Optical Coherence Tomography Angiography
URI https://www.clinicalkey.com/#!/content/1-s2.0-S000293941630424X
https://www.clinicalkey.es/playcontent/1-s2.0-S000293941630424X
https://dx.doi.org/10.1016/j.ajo.2016.08.035
https://www.ncbi.nlm.nih.gov/pubmed/27594138
https://www.proquest.com/docview/1841764443
https://www.proquest.com/docview/1841793709
https://pubmed.ncbi.nlm.nih.gov/PMC5115969
Volume 171
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwED9tnYR4QXxTGJOReEIKS-Ikth-rfaiAOgRapb5ZduJAJpZWpOVxf_vuEidQNg2JtyT2yYnvfHeO73cH8FYUpbEZDwOVFRluUHIeqNjaIOZOOmNszEvaKM7Osuk8-bhIFztw1GNhKKzS6_5Op7fa2j859LN5uKoqwviGaKsUeRR0frfYhb0Yrb0cwd7kw6fp2aCQM5GI3gsmgv5wsw3zMhcEAYyyNpFnW_TtVvN00_38O4ryD7N0-hAeeH-STbpXfgQ7rn4M92b-xPwJNF82huKBCM3EvhK-GXvPKAqvj0FlHcCgYVXN5r8c5ThibSABo9r0NGZwvLw02Pp51f74ZgTpaEGC7Hx56VNes0n9rfLXT2F-enJ-NA18oYUgRwdtHcg0V5FKBaeaNVGpRFxwmXNbWOdSZCLOcSlEWObWycRJyyntWS7L0ORGpibjz2BUL2v3AlgalxZ3ICqUlHnOOKOiQoVKWK5khpuTMYT9_OrcZyGnYhg_dB9udqGRJZpYoqlAJkeSdwPJqkvBcVfnuGea7rGlqA01Goi7iMRtRK7x67nRkW5iHeobMjeGZKDcEtt_Dbjfy5P-PYZMIoHuacLH8GZoxtVORzimdsuN74MeZajG8LwTv2FOYpHii3GJX7MlmEMHyiS-3VJX39uM4uh1I5_Vy__7mldwn-46hOY-jNY_N-41umprewC776-iA78grwGwwT5W
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fb9MwED6NTgJeEL8pDDAST0jRkjiJ7cdqMHVsLQK1Ut8sO3UgE0urpd3fz13iBMqmIfFW1T458Z3Pn-P77gDei2VhbMbDQGXLDA8oOQ9UbG0QcyedMTbmBR0UJ9NsPE8-L9LFHhx1XBgKq_S-v_Xpjbf2_xz62TxclyVxfEPcqxQhCrq_W9yB_YSKWg9gf3RyOp72DjkTiehQMAl0l5tNmJc5JwpglDWJPJuibzduT9fh599RlH9sS8cP4YHHk2zUPvIj2HPVY7g78TfmT6D-ujUUD0RsJvaN-M3Ye0JReF0MKmsJBjUrKza_cpTjiDWBBIxq09OYwcfVhcHWL-vmwzcjSkdDEmSz1YVPec1G1ffS_34K8-NPs6Nx4AstBDkCtE0g01xFKhWcatZEhRLxksuc26V1LkUl4hwXQoRFbp1MnLSc0p7lsghNbmRqMv4MBtWqci-ApXFh8QSiQkmZ54wzKlqqUAnLlczwcDKEsJtfnfss5FQM46fuws3ONapEk0o0FcjkKPKhF1m3KThu6xx3StMdtxS9ocYN4jYhcZOQq_16rnWk61iH-prNDSHpJXfM9l8DHnT2pH-PIZNIIDxN-BDe9c242ukKx1RutfV9EFGGagjPW_Pr5yQWKT4Yl_g2O4bZd6BM4rstVfmjySiOqBv1rF7-39u8hXvj2eRMn51MT1_BfWpp2ZoHMNhcbt1rhG0b-8Yvy18qKUA8
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Quantifying+Retinal+Microvascular+Changes+in+Uveitis+Using+Spectral-Domain+Optical+Coherence+Tomography+Angiography&rft.jtitle=American+journal+of+ophthalmology&rft.au=Kim%2C+Alice+Y&rft.au=Rodger%2C+Damien+C&rft.au=Shahidzadeh%2C+Anoush&rft.au=Chu%2C+Zhongdi&rft.date=2016-11-01&rft.eissn=1879-1891&rft.volume=171&rft.spage=101&rft_id=info:doi/10.1016%2Fj.ajo.2016.08.035&rft_id=info%3Apmid%2F27594138&rft.externalDocID=27594138
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0002-9394&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0002-9394&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0002-9394&client=summon