A high-fat challenge increases airway inflammation and impairs bronchodilator recovery in asthma - Wood, Lisa G.; Garg, Manohar L.; Gibson, Peter G. (Journal of allergy and clinical immunology, 2011)
Keywords: Adult; airway inflammation; Allergy and Immunology; Asthma; Asthma - immunology; Asthma - physiopathology; Biological and medical sciences; Bronchi - drug effects; Bronchi - immunology; Bronchi - physiopathology; Bronchodilator Agents - pharmacology; bronchodilator recovery; bronchodilators; C-reactive protein; Chronic obstructive pulmonary disease, asthma; Dietary fat; Dietary Fats - administration & dosage; Dietary Fats - immunology; Dietary Fats - pharmacology; enzyme-linked immunosorbent assay; fat intake; Fatty acids; Fatty Acids - blood; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; gene expression; Humans; Immune system; Immunity, Innate - drug effects; Immunopathology; inflammation; Inflammation - immunology; innate immunity; interleukin-6; lung function; Male; Medical sciences; messenger RNA; Middle Aged; neutrophils; Neutrophils - immunology; Obesity - complications; Obesity - immunology; Oils & fats; patients; Pneumology; quantitative polymerase chain reaction; Respiratory System - drug effects; Respiratory System - immunology; Respiratory System - physiopathology; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Sputum - immunology; Toll-like receptor 4; Trans fats; trans fatty acids; Treatment Outcome; tumor necrosis factor-alpha; airway inflammation; CRP; DRS; MUFA; SFA; NF-κB; innate immunity; HCHF; TLR; neutrophils; BMI; fatty acids; PUFA; Toll-like receptor 4; eNO; Dietary fat; asthma; ACQ; AHF-NonO; TE; FVC; AHF-O; ALF; bronchodilator recovery; AHF; Total energy; C-reactive protein; Forced vital capacity; Monounsaturated fatty acid; Asthma low-fat/low-energy; Body mass index; Asthma high-fat/high energy—nonobese; Toll-like receptor; Healthy controls high-fat; Exhaled nitric oxide; Polyunsaturated fatty acid; Asthma high-fat; Nuclear factor-κB; Asthma Control Questionnaire; Dose response slope; Saturated fatty acid; Asthma high-fat/high energy—obese