GLT1 gene delivery based on bone marrow-derived cells ameliorates motor function and survival in a mouse model of ALS - Ohashi, Natsuko; Terashima, Tomoya; Katagi, Miwako; Nakae, Yuki; Okano, Junko; Suzuki, Yoshihisa; Kojima, Hideto (Scientific reports, 2021)
Keywords: 631/1647/2300/1850; 692/617/375; Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - complications; Amyotrophic Lateral Sclerosis - physiopathology; Animals; Arginase; Biomarkers - metabolism; Bone marrow; Bone Marrow Cells - metabolism; Bone Marrow Transplantation; Cell Survival; Cytokines - genetics; Cytokines - metabolism; Disease Models, Animal; Disease Progression; Excitatory Amino Acid Transporter 2 - genetics; Gene Expression Regulation; Gene therapy; Gene transfer; Gene Transfer Techniques; Genetic Therapy; Gliosis - complications; Gliosis - pathology; Gliosis - physiopathology; Glutamic Acid - metabolism; Glutamic acid transporter; Humanities and Social Sciences; Interleukin 4; Lentivirus - metabolism; Lesions; Leukocytes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia - metabolism; Motor Activity - physiology; Motor Neurons - metabolism; multidisciplinary; Muscular Atrophy - complications; Muscular Atrophy - pathology; Muscular Atrophy - physiopathology; Nerve Degeneration - complications; Nerve Degeneration - pathology; Nerve Degeneration - physiopathology; Neurodegenerative diseases; RNA, Messenger - genetics; RNA, Messenger - metabolism; Science; Science (multidisciplinary); Spinal cord; Spinal Cord - metabolism; Superoxide dismutase; Superoxide Dismutase-1 - metabolism; Survival Analysis; Toxicity; Transplantation