Transient receptor potential vanilloid 1 (TRPV1) antagonism in patients with refractory chronic cough: A double-blind randomized controlled trial - Khalid, Saifudin; Murdoch, Robert; Newlands, Amy; Smart, Kevin; Kelsall, Angela; Holt, Kimberley; Dockry, Rachel; Woodcock, Ashley; Smith, Jaclyn A. (Journal of allergy and clinical immunology, 2014)
Keywords: Administration, Inhalation; Adult; Aged; Allergy and Immunology; Animals; Antitussive Agents - therapeutic use; Biological and medical sciences; Capsaicin; Chronic Disease; Cough; Cough - chemically induced; Cough - drug therapy; Cough - genetics; Cough - physiopathology; cough sounds; Cross-Over Studies; Double-Blind Method; Drug therapy; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gene Expression; Humans; Immunopathology; Male; Medical sciences; Middle Aged; Plasma; Pneumology; Pyrrolidines - therapeutic use; Quality of Life; Respiratory system : syndromes and miscellaneous diseases; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; sensory nerves; Severity of Illness Index; Studies; transient receptor potential vanilloid 1; Treatment Outcome; TRPV Cation Channels - antagonists & inhibitors; TRPV Cation Channels - genetics; Urea - analogs & derivatives; Urea - therapeutic use; transient receptor potential vanilloid 1; VAS; HRT; IQR; TRPV1; CQLQ; Cough; sensory nerves; C2; C5; capsaicin; Tmax; cough sounds; Concentration of capsaicin inducing at least 5 coughs; Time to maximum observed plasma concentration; Visual analog scale; Interquartile range; T max; Concentration of capsaicin inducing at least 2 coughs; Hormone replacement therapy; Cough Quality of Life Questionnaire; Human; Immunopathology; Treatment resistance; Capsaicin; Randomized controlled trial; Transitory; Antagonism; Chronic; Immunology; Double blind study; Sensory nerve; Biological receptor