Surgical Management of Endolymphatic Sac Tumor: A Systematic Review and Meta-Analysis
The aim of our study was to report rates of facial nerve palsy and residual tumor following surgical intervention and subsequent tumor recurrence in patients with endolymphatic sac tumors. A systematic literature review of preoperative assessment and surgical management is also included. Studies inc...
Saved in:
| Published in | Journal of International Advanced Otology Vol. 19; no. 3; pp. 248 - 254 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Turkey
AVES
01.05.2023
AVES Yayincilik A.S Mediterranean Society for Otology and Audiology European Academy of Otology and Neurotology and the Politzer Society |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2148-3817 1308-7649 2148-3817 |
| DOI | 10.5152/iao.2023.22957 |
Cover
| Abstract | The aim of our study was to report rates of facial nerve palsy and residual tumor following surgical intervention and subsequent tumor recurrence in patients with endolymphatic sac tumors. A systematic literature review of preoperative assessment and surgical management is also included. Studies including patient/s affected by sporadic or von Hippel-Lindau disease related endolymphatic sac tumors, reporting levels of facial nerve function, residual and recurrence pathology following a surgical procedure, were considered. Data were combined for proportional meta-analysis, and the selected studies’ methodological quality was also evaluated. Overall 34 papers, including 202 subjects (209 cases of endolymphatic sac tumors) were analyzed. Pooled proportion rate (95% CI) of overall facial nerve palsy was 39.7% (28.2-51.9) and residual tumor was 16.5% (10.3-23.7) after surgical procedure. Pooled proportion rate (95% CI) of tumor recurrence was 14.0% (9.7-19.3) during a mean follow-up period of 49.7 months (8-136). Our results showed that preoperative facial nerve function is impaired in almost 30% of patients with endolymphatic sac tumors. Surgical management of endolymphatic sac tumor may cause a worsening of facial nerve function in a low percentage of treated subjects. Residual and/or recurrence of endolymphatic sac tumors are not rare events, and follow-up strategies should be designed accordingly. Cite this article as: Maria Gioacchini F, Chiarella G, Kaleci S, et al. Surgical management of endolymphatic sac tumor: A systematic review and meta-analysis. J Int Adv Otol. 2023;19(3):248-254. |
|---|---|
| AbstractList | The aim of our study was to report rates of facial nerve palsy and residual tumor following surgical intervention and subsequent tumor recurrence in patients with endolymphatic sac tumors. A systematic literature review of preoperative assessment and surgical management is also included. Studies including patient/s affected by sporadic or von Hippel-Lindau disease related endolymphatic sac tumors, reporting levels of facial nerve function, residual and recurrence pathology following a surgical procedure, were considered. Data were combined for proportional meta-analysis, and the selected studies' methodological quality was also evaluated. Overall 34 papers, including 202 subjects (209 cases of endolymphatic sac tumors) were analyzed. Pooled proportion rate (95% CI) of overall facial nerve palsy was 39.7% (28.2-51.9) and residual tumor was 16.5% (10.3-23.7) after surgical procedure. Pooled proportion rate (95% CI) of tumor recurrence was 14.0% (9.7-19.3) during a mean follow-up period of 49.7 months (8-136). Our results showed that preoperative facial nerve function is impaired in almost 30% of patients with endolymphatic sac tumors. Surgical management of endolymphatic sac tumor may cause a worsening of facial nerve function in a low percentage of treated subjects. Residual and/or recurrence of endolymphatic sac tumors are not rare events, and follow-up strategies should be designed accordingly.The aim of our study was to report rates of facial nerve palsy and residual tumor following surgical intervention and subsequent tumor recurrence in patients with endolymphatic sac tumors. A systematic literature review of preoperative assessment and surgical management is also included. Studies including patient/s affected by sporadic or von Hippel-Lindau disease related endolymphatic sac tumors, reporting levels of facial nerve function, residual and recurrence pathology following a surgical procedure, were considered. Data were combined for proportional meta-analysis, and the selected studies' methodological quality was also evaluated. Overall 34 papers, including 202 subjects (209 cases of endolymphatic sac tumors) were analyzed. Pooled proportion rate (95% CI) of overall facial nerve palsy was 39.7% (28.2-51.9) and residual tumor was 16.5% (10.3-23.7) after surgical procedure. Pooled proportion rate (95% CI) of tumor recurrence was 14.0% (9.7-19.3) during a mean follow-up period of 49.7 months (8-136). Our results showed that preoperative facial nerve function is impaired in almost 30% of patients with endolymphatic sac tumors. Surgical management of endolymphatic sac tumor may cause a worsening of facial nerve function in a low percentage of treated subjects. Residual and/or recurrence of endolymphatic sac tumors are not rare events, and follow-up strategies should be designed accordingly. The aim of our study was to report rates of facial nerve palsy and residual tumor following surgical intervention and subsequent tumor recurrence in patients with endolymphatic sac tumors. A systematic literature review of preoperative assessment and surgical management is also included. Among VHL patients, 3.6%-'6% develop an ELST, and overall, '/3 of ELSTs are related to VHL disease.4 The clinical manifestations of ELST are nonspecific and can include hearing loss or episodes of vertigo.5 Differential diagnosis for ELST includes all intrinsic temporal bone neoplasms (most commonly paraganglioma).6 Surgical resection is the treatment of choice, and although currently controversial, some tumors may require pre-/postoperative radiation therapy.5 Endolymphatic sac tumors often invade adjacent structures located within all 4 vectors, including lateral, medial, superior, and anterior. Tumors including involvement of the middle ear are best managed with a petrosectomy2 while for extensive tumors with complete exenteration of the otic capsule requiring exposure of the petrous carotid artery, the transcochlear approach is recommended.3 Furthermore, various combined skull-based approaches have been described in literature, according to tumor extension and surgeons' experience. The summary effect derived from the fixed-effects model assumes that studies share a common true effect, producing an estimate of a common effect size, while the random effects model assumes that true effects vary between studies and reports the summary effect as a weighted average of those reported in the different studies. An overall effect (95% CI) was calculated with forest plots for each symptom, with the marker size relative to the individual study weight. The aim of our study was to report rates of facial nerve palsy and residual tumor following surgical intervention and subsequent tumor recurrence in patients with endolymphatic sac tumors. A systematic literature review of preoperative assessment and surgical management is also included. Studies including patient/s affected by sporadic or von Hippel-Lindau disease related endolymphatic sac tumors, reporting levels of facial nerve function, residual and recurrence pathology following a surgical procedure, were considered. Data were combined for proportional meta-analysis, and the selected studies’ methodological quality was also evaluated. Overall 34 papers, including 202 subjects (209 cases of endolymphatic sac tumors) were analyzed. Pooled proportion rate (95% CI) of overall facial nerve palsy was 39.7% (28.2-51.9) and residual tumor was 16.5% (10.3-23.7) after surgical procedure. Pooled proportion rate (95% CI) of tumor recurrence was 14.0% (9.7-19.3) during a mean follow-up period of 49.7 months (8-136). Our results showed that preoperative facial nerve function is impaired in almost 30% of patients with endolymphatic sac tumors. Surgical management of endolymphatic sac tumor may cause a worsening of facial nerve function in a low percentage of treated subjects. Residual and/or recurrence of endolymphatic sac tumors are not rare events, and follow-up strategies should be designed accordingly. The aim of our study was to report rates of facial nerve palsy and residual tumor following surgical intervention and subsequent tumor recurrence in patients with endolymphatic sac tumors. A systematic literature review of preoperative assessment and surgical management is also included. Studies including patient/s affected by sporadic or von Hippel-Lindau disease related endolymphatic sac tumors, reporting levels of facial nerve function, residual and recurrence pathology following a surgical procedure, were considered. Data were combined for proportional meta-analysis, and the selected studies' methodological quality was also evaluated. Overall 34 papers, including 202 subjects (209 cases of endolymphatic sac tumors) were analyzed. Pooled proportion rate (95% CI) of overall facial nerve palsy was 39.7% (28.2-51.9) and residual tumor was 16.5% (10.3-23.7) after surgical procedure. Pooled proportion rate (95% CI) of tumor recurrence was 14.0% (9.7-19.3) during a mean follow-up period of 49.7 months (8-136). Our results showed that preoperative facial nerve function is impaired in almost 30% of patients with endolymphatic sac tumors. Surgical management of endolymphatic sac tumor may cause a worsening of facial nerve function in a low percentage of treated subjects. Residual and/or recurrence of endolymphatic sac tumors are not rare events, and follow-up strategies should be designed accordingly. KEYWORDS: Ear surgery, endolymphatic sac tumor, facial nerve, middle ear surgery, otology The aim of our study was to report rates of facial nerve palsy and residual tumor following surgical intervention and subsequent tumor recurrence in patients with endolymphatic sac tumors. A systematic literature review of preoperative assessment and surgical management is also included. Studies including patient/s affected by sporadic or von Hippel-Lindau disease related endolymphatic sac tumors, reporting levels of facial nerve function, residual and recurrence pathology following a surgical procedure, were considered. Data were combined for proportional meta-analysis, and the selected studies' methodological quality was also evaluated. Overall 34 papers, including 202 subjects (209 cases of endolymphatic sac tumors) were analyzed. Pooled proportion rate (95% CI) of overall facial nerve palsy was 39.7% (28.2-51.9) and residual tumor was 16.5% (10.3-23.7) after surgical procedure. Pooled proportion rate (95% CI) of tumor recurrence was 14.0% (9.7-19.3) during a mean follow-up period of 49.7 months (8-136). Our results showed that preoperative facial nerve function is impaired in almost 30% of patients with endolymphatic sac tumors. Surgical management of endolymphatic sac tumor may cause a worsening of facial nerve function in a low percentage of treated subjects. Residual and/or recurrence of endolymphatic sac tumors are not rare events, and follow-up strategies should be designed accordingly. The aim of our study was to report rates of facial nerve palsy and residual tumor following surgical intervention and subsequent tumor recurrence in patients with endolymphatic sac tumors. A systematic literature review of preoperative assessment and surgical management is also included. Studies including patient/s affected by sporadic or von Hippel-Lindau disease related endolymphatic sac tumors, reporting levels of facial nerve function, residual and recurrence pathology following a surgical procedure, were considered. Data were combined for proportional meta-analysis, and the selected studies’ methodological quality was also evaluated. Overall 34 papers, including 202 subjects (209 cases of endolymphatic sac tumors) were analyzed. Pooled proportion rate (95% CI) of overall facial nerve palsy was 39.7% (28.2-51.9) and residual tumor was 16.5% (10.3-23.7) after surgical procedure. Pooled proportion rate (95% CI) of tumor recurrence was 14.0% (9.7-19.3) during a mean follow-up period of 49.7 months (8-136). Our results showed that preoperative facial nerve function is impaired in almost 30% of patients with endolymphatic sac tumors. Surgical management of endolymphatic sac tumor may cause a worsening of facial nerve function in a low percentage of treated subjects. Residual and/or recurrence of endolymphatic sac tumors are not rare events, and follow-up strategies should be designed accordingly. Cite this article as: Maria Gioacchini F, Chiarella G, Kaleci S, et al. Surgical management of endolymphatic sac tumor: A systematic review and meta-analysis. J Int Adv Otol. 2023;19(3):248-254. |
| Audience | Academic |
| Author | Viola, Pasquale Pisani, Davide Re, Massimo Scarpa, Alfonso Chiarella, Giuseppe Gioacchini, Federico Maria Iannella, Giannicola Tulli, Michele Kaleci, Shaniko |
| Author_xml | – sequence: 1 givenname: Federico Maria surname: Gioacchini fullname: Gioacchini, Federico Maria – sequence: 2 givenname: Giuseppe surname: Chiarella fullname: Chiarella, Giuseppe – sequence: 3 givenname: Shaniko surname: Kaleci fullname: Kaleci, Shaniko – sequence: 4 givenname: Giannicola surname: Iannella fullname: Iannella, Giannicola – sequence: 5 givenname: Pasquale surname: Viola fullname: Viola, Pasquale – sequence: 6 givenname: Davide surname: Pisani fullname: Pisani, Davide – sequence: 7 givenname: Alfonso surname: Scarpa fullname: Scarpa, Alfonso – sequence: 8 givenname: Michele surname: Tulli fullname: Tulli, Michele – sequence: 9 givenname: Massimo surname: Re fullname: Re, Massimo |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37272644$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNks1v0zAYhyM0xMbYlSOK4AKHFn8ldrigatqgYgNEt7P11h-ZpyTu7GSs_z1uN7Z2GhLKwdGb531iv_69zHY635kse43RuMAF-ejAjwkidExIVfBn2R7BTIyowHxn4303O4jRzRErS4YKQV5ku5QTTkrG9rLz2RBqp6DJT6GD2rSm63Nv86NO-2bZLi6gdyqfgcrPhtaHT_kkny1jb9p1_Ze5duZ3Dp3OT00Po0kHzTK6-Cp7bqGJ5uBu3c_Oj4_ODr-OTn58mR5OTkaqZLwfmYpR0AqoAUGssUwrxrFCXOuSAOZaWSSKoqyYFaAA00KIRHFTgUCGzOl-Nr31ag-XchFcC2EpPTi5LvhQSwhpo42RaRJWlCW3POnonCW9UUqD5ZYIzVVyfb51LYZ5a7RKgwjQbEm3v3TuQtb-WmJEKS4rngzv7wzBXw0m9rJ1UZmmgc74IUoiCOFIpGMk9N0j9NIPIU1vRVFEC1Zh_kDVkE7gOuvTj9VKKie8ILzkRUET9fYJSi3cldyExk9A6dGmdSrFyrpU37J-2GpITG9u-hqGGOW3n9P_Zqez79vsm80x38_3byQfdqqCjzEYe49gJFexlyn2chV7uY59amCPGpTrUzz96ppc86-2P29RAdY |
| CitedBy_id | crossref_primary_10_3389_fonc_2024_1463526 crossref_primary_10_1097_MAO_0000000000004307 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2023 AVES COPYRIGHT 2023 AVES Yayincilik A.S. Copyright Mediterranean Society for Otology and Audiology May 2023 2023 authors 2023 authors |
| Copyright_xml | – notice: COPYRIGHT 2023 AVES – notice: COPYRIGHT 2023 AVES Yayincilik A.S. – notice: Copyright Mediterranean Society for Otology and Audiology May 2023 – notice: 2023 authors 2023 authors |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM ISN KPI 3V. 7X7 7XB 88E 8FI 8FJ 8FK ABUWG AFKRA BENPR CCPQU EDSIH FYUFA GHDGH K9. M0S M1P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 5PM DOA |
| DOI | 10.5152/iao.2023.22957 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Canada Gale In Context: Global Issues ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central ProQuest One Community College Turkey Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Central China ProQuest Hospital Collection (Alumni) ProQuest Central ProQuest Health & Medical Complete ProQuest Health & Medical Research Collection Health Research Premium Collection ProQuest Medical Library ProQuest One Academic UKI Edition Health and Medicine Complete (Alumni Edition) Health & Medical Research Collection Turkey Database ProQuest Central (New) ProQuest One Academic ProQuest One Academic (New) ProQuest Medical Library (Alumni) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic ProQuest One Academic Middle East (New) MEDLINE CrossRef |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2148-3817 |
| EndPage | 254 |
| ExternalDocumentID | oai_doaj_org_article_381f8667f76943b4a17eccdaf7f28d7c PMC10331697 A752767553 37272644 10_5152_iao_2023_22957 |
| Genre | Meta-Analysis Systematic Review Journal Article |
| GroupedDBID | AAYXX ALMA_UNASSIGNED_HOLDINGS CITATION GROUPED_DOAJ CGR CUY CVF ECM EIF NPM 53G 7X7 88E 8FI 8FJ ABDBF ABUWG ACUHS ADBBV AENEX AFKRA AHMBA BENPR BPHCQ BVXVI CCPQU EDSIH EOJEC ESX FYUFA HMCUK HYE IAO ICQ IER IHR INH IPC ISN ITC KPI M1P OBODZ OK1 PHGZM PHGZT PQQKQ PROAC PSQYO RPM TUS UKHRP ~8M M~E PMFND 3V. 7XB 8FK K9. PJZUB PKEHL PPXIY PQEST PQUKI PRINS 7X8 5PM |
| ID | FETCH-LOGICAL-c647t-e943adca3ea82fef4dc471c07dd62a17dcf0855694f8aca13588ef47e9a80e2b3 |
| IEDL.DBID | 7X7 |
| ISSN | 2148-3817 1308-7649 |
| IngestDate | Wed Aug 27 01:31:21 EDT 2025 Thu Aug 21 18:37:23 EDT 2025 Fri Jul 11 14:42:38 EDT 2025 Fri Jul 25 21:41:23 EDT 2025 Tue Jun 17 21:59:00 EDT 2025 Tue Jun 10 15:35:06 EDT 2025 Tue Jun 10 21:01:23 EDT 2025 Fri Jun 27 05:13:02 EDT 2025 Fri Jun 27 05:48:13 EDT 2025 Thu Jan 02 22:50:42 EST 2025 Wed Aug 13 23:58:30 EDT 2025 Thu Apr 24 23:08:52 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Language | English |
| License | Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c647t-e943adca3ea82fef4dc471c07dd62a17dcf0855694f8aca13588ef47e9a80e2b3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3 Cite this article as: Maria Gioacchini F, Chiarella G, Kaleci S, et al. Surgical management of endolymphatic sac tumor: A systematic review and meta-analysis. J Int Adv Otol. 2023;19(3):248-254. ORCID iDs of the authors: F.M.G. 0000-0002-1148-4384, G.C. 0000-0002-9829-2229, S.K. 0000-0002-1166-2961, G.I. 0000-0003-1781-2809, P.V. 0000-0002-2352-1146, D.P. 0000-0001-7486-0140, A.S. 0000-0001-9219-6175, M.T. 0000-0002-1958-7177, M.R. 0000-0002-9217-1282. |
| ORCID | 0000-0002-9829-2229 0000-0002-1148-4384 0000-0003-1781-2809 0000-0002-2352-1146 0000-0002-9217-1282 0000-0002-1166-2961 0000-0001-7486-0140 0000-0001-9219-6175 0000-0002-1958-7177 |
| OpenAccessLink | https://doaj.org/article/381f8667f76943b4a17eccdaf7f28d7c |
| PMID | 37272644 |
| PQID | 2830354917 |
| PQPubID | 376311 |
| PageCount | 7 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_381f8667f76943b4a17eccdaf7f28d7c pubmedcentral_primary_oai_pubmedcentral_nih_gov_10331697 proquest_miscellaneous_2822708135 proquest_journals_2830354917 gale_infotracmisc_A752767553 gale_infotraccpiq_752767553 gale_infotracacademiconefile_A752767553 gale_incontextgauss_KPI_A752767553 gale_incontextgauss_ISN_A752767553 pubmed_primary_37272644 crossref_primary_10_5152_iao_2023_22957 crossref_citationtrail_10_5152_iao_2023_22957 |
| PublicationCentury | 2000 |
| PublicationDate | 2023-05-01 |
| PublicationDateYYYYMMDD | 2023-05-01 |
| PublicationDate_xml | – month: 05 year: 2023 text: 2023-05-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Turkey |
| PublicationPlace_xml | – name: Turkey – name: Ankara |
| PublicationTitle | Journal of International Advanced Otology |
| PublicationTitleAlternate | J Int Adv Otol |
| PublicationYear | 2023 |
| Publisher | AVES AVES Yayincilik A.S Mediterranean Society for Otology and Audiology European Academy of Otology and Neurotology and the Politzer Society |
| Publisher_xml | – name: AVES – name: AVES Yayincilik A.S – name: Mediterranean Society for Otology and Audiology – name: European Academy of Otology and Neurotology and the Politzer Society |
| SSID | ssib046640582 ssj0000627434 |
| Score | 2.2639368 |
| SecondaryResourceType | review_article |
| Snippet | The aim of our study was to report rates of facial nerve palsy and residual tumor following surgical intervention and subsequent tumor recurrence in patients... Among VHL patients, 3.6%-'6% develop an ELST, and overall, '/3 of ELSTs are related to VHL disease.4 The clinical manifestations of ELST are nonspecific and... |
| SourceID | doaj pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 248 |
| SubjectTerms | Bone cancer Bone Neoplasms - pathology Ear Neoplasms - pathology Ear Neoplasms - surgery Endolymphatic Sac - surgery Facial Paralysis Humans Literature reviews Meta-analysis Neoplasm Recurrence, Local - surgery Neoplasm, Residual - pathology Neurological disorders Otolaryngology Otology Patients Radiation therapy Review Software Systematic review Tumors von Hippel-Lindau Disease |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwELVQT1wQiK-lS2UQUk-hGzuJbW5b1KotaoW0Xak3y_EHrNQmZXdz4N8zk2RDLFRx6TV-VpI3Y49HHj8T8knJ0igBaYlUBSQomfCJkiZPuPE8KAcL9PZs1eVVcbbMLm7ym9FVX1gT1skDd8QdQUQJsihEEIXKeJmZVMBbnQkiMOmExdkXwtgomQJPQs30WS5Zp9IIIZsdrQwe9WP8M95fLaIo1Ir1_zslj2JSXC85CkCnz8mzfuVI590XvyBPfPWSLBfNup276N86FloHelK5-vY3WAoFWenCWHrd3NXrL3ROF4N2M-02BqipHL30W5PsFEpekeXpyfXXs6S_KSGxRSa2iQdqjLOGeyNZ8CFzFoKOnQnnCgaMORuwHg0YDNJYk_JcSkAJr4yceVby12Svqiv_ltDcYsKsSoCLLLcG8icnlBeQpzDFZD4hyY45bXsZcbzN4lZDOoFMa2BaI9O6ZXpCDgf8fSeg8SDyGA0xoFD4un0A7qB7d9D_c4cJ-Yhm1ChtUWHtzA_TbDb6fHGl5yJnKF2T8wdA376fR6DDHhRq-EFr-vMKQBNKZkXI_Qhp71e_9Kh1GrXC8LVR5-nO4XQ_fWw0qrJxyNxTIOXD0Iw9sSSu8nWDGMYELOg4mORN558DdRy312GYTYiMPDfiNm6pVj9bcfF0xnlaKPHuMayxT56ifbsC0SnZ264b_x4WcdvyoB2vfwC06EKz priority: 102 providerName: Directory of Open Access Journals |
| Title | Surgical Management of Endolymphatic Sac Tumor: A Systematic Review and Meta-Analysis |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/37272644 https://www.proquest.com/docview/2830354917 https://www.proquest.com/docview/2822708135 https://pubmed.ncbi.nlm.nih.gov/PMC10331697 https://doaj.org/article/381f8667f76943b4a17eccdaf7f28d7c |
| Volume | 19 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2148-3817 dateEnd: 99991231 omitProxy: true ssIdentifier: ssib046640582 issn: 2148-3817 databaseCode: DOA dateStart: 20190101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVEBS databaseName: EBSCOhost Academic Search Ultimate customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn eissn: 2148-3817 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000627434 issn: 2148-3817 databaseCode: ABDBF dateStart: 20090101 isFulltext: true titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn providerName: EBSCOhost – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 2148-3817 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000627434 issn: 2148-3817 databaseCode: RPM dateStart: 20180101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: http://www.proquest.com/pqcentral?accountid=15518 eissn: 2148-3817 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000627434 issn: 2148-3817 databaseCode: BENPR dateStart: 20101001 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Health & Medical Collection customDbUrl: eissn: 2148-3817 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000627434 issn: 2148-3817 databaseCode: 7X7 dateStart: 20101001 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Turkey Database customDbUrl: eissn: 2148-3817 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000627434 issn: 2148-3817 databaseCode: EDSIH dateStart: 20101001 isFulltext: true titleUrlDefault: https://search.proquest.com/turkey providerName: ProQuest |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LbxMxELaglRAXxLuhITIIqael2fXu2uaCUpSqBSWqSCPlZjl-lEhlN83jwL9nZtfZZoXKNf5WimfG87DHnwn5JMVcSw5liZA5FCgpd5EUOouYdsxLCwl6dbdqNM4vpun3WTYLG27r0Fa584mVo7alwT3yUySqYlDMxPzr8i7CV6PwdDU8ofGYHMaQqqBV81kTTpE5vZ8F7pbaM0MNVh80s76IeJ7KmscRgnpyutB4GTBhn_GFa96KUxWd_79Oey9qtTsq90LU-XPyLOSWdFAbwwvyyBUvyZNROD1_RaaT7apydPS-6YWWng4LW97-AbUieyudaEOvt7_L1Rc6oJOG6JnWpwhUF5aO3EZHOzqT12R6Prz-dhGFZxUik6d8EzmZMm2NZk6LxDufWgMRyvS5tXmiY26Nx-a1XKZeaKNjlgkBKO6kFn2XzNkbclCUhTsiNDNYXcs5wHmaGQ3FluXSgWBBhonIOiTaCVGZwDmOT1_cKqg9UOgKhK5Q6KoSeoecNPhlzbbxIPIMddKgkCW7-qFc3aiw6BRkI17kOfccJsPmKUwOLNZqz30iLDcd8hE1qpAHo8BGmxu9Xa_V5WSsBjxLkOcmYw-AflxdtkAnAeRLmKDR4XIDiAn5tVrI4xbSLBd3am-02xqFtW5aH3d3tqeCr1mr-5XRIR-aYfwS--cKV24RkyQcsj8GKnlbm2ojOoZn8bAmO0S0jLgl2_ZIsfhVMZHHfcbiXPJ3__9fx-Qpaq7uE-2Sg81q695DLreZ96oF2yOHZ8Px1c9etSPSq7bc_gI6e0Wi |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLbGkIAXxJ2yAgaB9pQttZPYRkKowKaWrhVSO6lvxnWcUWkkXS9C-1P8Rs7JbY3QeNtrfFLFn4_PpT7-DiHvlJwZJSAtkSqCBCUQzlPShB43jicqhgA9v1s1HEW90-DbNJzukD_VXRgsq6xsYm6o48zif-SHSFTFIZnpiE-LCw-7RuHpatVCo1CLgbv8DSnb6mP_K6zve8aOjyZfel7ZVcCzUSDWnlMBN7E13BnJEpcEsQUDbX0RxxEzHRHbBGu3IhUk0ljT4aGUICWcMtJ3bMbhd2-R2wH3A-TqF9PafSNTux-WXDGFJ4CcrzjY5r70RBSogjcSggh2ODd4-ZDxA-yoLRp-MW8f8K-T2PKSzQrOLZd4_IDcL2NZ2i2U7yHZcekjcmdYntY_JqfjzTI3rPSqyIZmCT1K4-z8EtQI2WLp2Fg62fzKlh9ol45rYmlanFpQk8Z06NbGq-hTnpDTGwH8KdlNs9Q9JzS0mM2rGYiLILQGkrtYKAfAAoZMhi3iVSBqW3KcY6uNcw25DoKuAXSNoOsc9BbZr-UXBbvHtZKfcU1qKWTlzh9kyzNdbnIN0U8io0gkAibDZwFMDnZIbBKRMBkL2yJvcUU18m6kWNhzZjarle6PR7orQoa8OiG_Rmjwvd8Q2i-FkgwmaE15mQJgQj6vhuReQ9Iu5hd6a7TdGAXbYhsvtyvd06VtW-mrndgib-phfBPr9VKXbVCGMQHRJocleVaoag0dx7N_sAEtIhtK3MC2OZLOf-bM5x2f806kxIv_f9drcrc3GZ7ok_5osEfu4SoWNaptsrtebtxLiCPXs1f55qXkx01bi79XaICl |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1ZbxMxELZKkSpeEDehAQwC9WlJYu-uvUgIBdqoISSqlEbqm3F8lEhlN80h1L_Gr2NmjzQrVN76up6N1p_Hc8Tjbwh5l8ipTgSkJTKJIUEJhQsSqaOAa8d9YiFAz-9WDUfx8ST8dhad7ZA_1V0YLKusbGJuqG1m8D_yFhJVcUhmOqLly7KIk8Pe5_llgB2k8KS1aqdRqMjAXf2G9G35qX8Ia_2esd7R6dfjoOwwEJg4FKvAJSHX1mjutGTe-dAaMNamLayNme4IazzWccVJ6KU2usMjKUFKuETLtmNTDr97h9wVPORYTibONq4cWdvbUckbU3gFyP-KQ27eloGIw6TgkISAgrVmGi8iMv4Bu2uLmo_MWwn86zC2PGa9mnPLPfYekPtlXEu7hSI-JDsufUT2huXJ_WMyGa8XuZGl1wU3NPP0KLXZxRWoFDLH0rE29HT9K1t8pF063pBM0-IEg-rU0qFb6aCiUnlCJrcC-FOym2ape05oZDCzT6YgLsLIaEj0rEgcAAsYMhk1SFCBqEzJd45tNy4U5D0IugLQFYKuctAb5GAjPy-YPm6U_IJrspFChu78QbY4V-WGVxAJeRnHwguYDJ-GMDnYLVZ74Zm0wjTIW1xRhRwcKWrzuV4vl6o_HqmuiBhy7ET8BqHBSb8mdFAK-QwmaHR5sQJgQm6vmuR-TdLMZ5dqa7RZGwU7Y2ovNyvdU6WdW6rrXdkgbzbD-CbW7qUuW6MMYwIiTw5L8qxQ1Q10HOsAwB40iKwpcQ3b-kg6-5mzoHfanHfiRLz4_3e9JntgJ9T3_miwT-7hIhblqk2yu1qs3UsIKVfTV_nepeTHbRuLv65rhOA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Surgical+Management+of+Endolymphatic+Sac+Tumor%3A+A+Systematic+Review+and+Meta-Analysis&rft.jtitle=The+journal+of+international+advanced+otology&rft.au=Gioacchini%2C+Federico+Maria&rft.au=Chiarella%2C+Giuseppe&rft.au=Kaleci%2C+Shaniko&rft.au=Iannella%2C+Giannicola&rft.date=2023-05-01&rft.pub=AVES+Yayincilik+A.S&rft.issn=1308-7649&rft.volume=19&rft.issue=3&rft.spage=248&rft_id=info:doi/10.5152%2Fiao.2023.22957&rft.externalDocID=A752767553 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2148-3817&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2148-3817&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2148-3817&client=summon |