临床药师参与1例华法林个体化抗凝中基因型检测的临床实践

目的：探讨临床药师参与华法林个体化抗凝中基因型CYP2C9和VKORC1检测的临床实践。方法：回顾分析临床药师参与1例基于药物基因组学华法林个体化给药的成功案例。结果：临床药师依据基因检测结果制订和调整华法林给药剂量,为患者提供了药学监护。结论：临床药师基于药物基因组学的华法林个体化给药,为调整华法林给药提供科学依据,减少传统经验给药模式的盲目性和潜在风险,增加了患者依从性,提高了抗凝治疗的成功率。...

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Published in中国医院用药评价与分析 no. 9; pp. 1256 - 1258
Main Author 徐婵娟 徐玉萍 王春松 张本荣 刘俊
Format Journal Article
LanguageChinese
Published 安徽省庐江县中医院药剂科,安徽合肥,231500%皖南医学院弋矶山医院药剂科,安徽芜湖,241001 2015
Subjects
个体化给药
临床药师
华法林
药物基因组学
临床药师
Warfarin
药物基因组学
华法林
Individualized medication
Clinical pharmacist
个体化给药
Pharmacogenomics
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ISSN1672-2124
DOI10.14009/j.issn.1672-2124.2015.09.046

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Summary:目的：探讨临床药师参与华法林个体化抗凝中基因型CYP2C9和VKORC1检测的临床实践。方法：回顾分析临床药师参与1例基于药物基因组学华法林个体化给药的成功案例。结果：临床药师依据基因检测结果制订和调整华法林给药剂量,为患者提供了药学监护。结论：临床药师基于药物基因组学的华法林个体化给药,为调整华法林给药提供科学依据,减少传统经验给药模式的盲目性和潜在风险,增加了患者依从性,提高了抗凝治疗的成功率。
Bibliography:OBJECTIVE： To investigate the clinical practice of the CYP2C9 and VKORC1 genotype detection in warfarin individualized anticoagulation participated by clinical pharmacists. METHODS： Retrospective analysis was conducted on one successful case participared by clinical pharmacists based on pharmacogenomics of warfarinindividualized medication. RESULTS： According to the genetic detection results,the clinic pharmacists formulated and adjusted the warfarin anticoagulation dosage for the patient, and then provided the pharmaceutical care.CONCLUSIONS： Warfarin individualized medication based on pharmacogenomics by clinical pharmacists can provide scientific basis for warfarin adjustment,which can reduce the blindness of traditional experience and potential risks,increase patients＇ compliance and improve the success rate of anticoagulation treatment.
Pharmacogenomics; Warfarin; Clinical pharmacist; Individualized medication
XU Chanjuan, XU Yuping, WANG Chunsong, ZHANG Benrong, LIU Jun（ 1. Dept. of Pharmacy, Lujiang Coun
ISSN:1672-2124
DOI:10.14009/j.issn.1672-2124.2015.09.046