Alzheimer's disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes

Alzheimer's disease (AD) is characterized by deficits in cerebral metabolic rates of glucose in the posterior cingulate (PC) and precuneus in AD subjects, and in APOEε4 carriers, decades before the onset of measureable cognitive deficits. However, the cellular and molecular basis of this phenot...

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Published inNeurobiology of aging Vol. 36; no. 2; pp. 583 - 591
Main Authors Sekar, Shobana, McDonald, Jacquelyn, Cuyugan, Lori, Aldrich, Jessica, Kurdoglu, Ahmet, Adkins, Jonathan, Serrano, Geidy, Beach, Thomas G., Craig, David W., Valla, Jonathan, Reiman, Eric M., Liang, Winnie S.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.02.2015
Subjects
Aged
Aged, 80 and over
Alzheimer Disease - genetics
Alzheimer Disease - immunology
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Alzheimer's disease
Amyloid beta-Peptides - genetics
Amyloid beta-Peptides - metabolism
Antigens, Differentiation, B-Lymphocyte - physiology
Astrocytes
Astrocytes - immunology
Astrocytes - metabolism
Brain - cytology
Brain - immunology
Clusterin - physiology
Complement C3 - physiology
Electron Transport Complex IV - genetics
Electron Transport Complex IV - metabolism
Energy Metabolism - genetics
Female
Gene Expression - genetics
Histocompatibility Antigens Class II - physiology
Humans
Immune response
Immunity, Cellular - genetics
Internal Medicine
Male
Mitochondria
Mitochondria - genetics
Mitochondria - metabolism
Neurology
Posterior cingulate
Protein-Serine-Threonine Kinases - genetics
Protein-Serine-Threonine Kinases - metabolism
RNA sequencing
Sequence Analysis, RNA
tRNA Methyltransferases - genetics
tRNA Methyltransferases - metabolism
Posterior cingulate
RNA sequencing
Mitochondria
Immune response
Astrocytes
Alzheimer's disease
Online AccessGet full text
ISSN0197-4580
1558-1497
1558-1497
DOI10.1016/j.neurobiolaging.2014.09.027

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Abstract Alzheimer's disease (AD) is characterized by deficits in cerebral metabolic rates of glucose in the posterior cingulate (PC) and precuneus in AD subjects, and in APOEε4 carriers, decades before the onset of measureable cognitive deficits. However, the cellular and molecular basis of this phenotype remains to be clarified. Given the roles of astrocytes in energy storage and brain immunity, we sought to characterize the transcriptome of AD PC astrocytes. Cells were laser capture microdissected from AD (n = 10) and healthy elderly control (n = 10) subjects for RNA sequencing. We generated >5.22 billion reads and compared sequencing data between controls and AD patients. We identified differentially expressed mitochondria-related genes including TRMT61B, FASTKD2, and NDUFA4L2, and using pathway and weighted gene coexpression analyses, we identified differentially expressed immune response genes. A number of these genes, including CLU, C3, and CD74, have been implicated in beta amyloid generation or clearance. These data provide key insights into astrocyte-specific contributions to AD, and we present this data set as a publicly available resource.
AbstractList Alzheimer's disease (AD) is characterized by deficits in cerebral metabolic rates of glucose in the posterior cingulate (PC) and precuneus in AD subjects, and in APOEε4 carriers, decades before the onset of measureable cognitive deficits. However, the cellular and molecular basis of this phenotype remains to be clarified. Given the roles of astrocytes in energy storage and brain immunity, we sought to characterize the transcriptome of AD PC astrocytes. Cells were laser capture microdissected from AD (n = 10) and healthy elderly control (n = 10) subjects for RNA sequencing. We generated >5.22 billion reads and compared sequencing data between controls and AD patients. We identified differentially expressed mitochondria-related genes including TRMT61B, FASTKD2, and NDUFA4L2, and using pathway and weighted gene coexpression analyses, we identified differentially expressed immune response genes. A number of these genes, including CLU, C3, and CD74, have been implicated in beta amyloid generation or clearance. These data provide key insights into astrocyte-specific contributions to AD, and we present this data set as a publicly available resource.
Alzheimer’s disease (AD) is characterized by deficits in cerebral metabolic rates of glucose in the posterior cingulate (PC) and precuneus in AD subjects, and in APOEε4 carriers, decades prior to the onset of measureable cognitive deficits. However, the cellular and molecular basis of this phenotype remains to be clarified. Given the roles of astrocytes in energy storage and brain immunity, we sought to characterize the transcriptome of AD PC astrocytes. Cells were laser capture microdissected from AD (n=10) and healthy elderly control (n=10) subjects for RNA sequencing. We generated >5.22 billion reads and compared sequencing data between controls and AD patients. We identified differentially expressed mitochondria-related genes including TRMT61B, FASTKD2, and NDUFA4L2, and using pathway and weighted gene co-expression analyses, we identified differentially expressed immune response genes. A number of these genes, including CLU, C3, and CD74, have been implicated in Abeta generation or clearance. This data provides key insights into astrocyte-specific contributions to AD and we present this data set as a publicly available resource.
Alzheimer's disease (AD) is characterized by deficits in cerebral metabolic rates of glucose in the posterior cingulate (PC) and precuneus in AD subjects, and in APOEε4 carriers, decades before the onset of measureable cognitive deficits. However, the cellular and molecular basis of this phenotype remains to be clarified. Given the roles of astrocytes in energy storage and brain immunity, we sought to characterize the transcriptome of AD PC astrocytes. Cells were laser capture microdissected from AD (n = 10) and healthy elderly control (n = 10) subjects for RNA sequencing. We generated >5.22 billion reads and compared sequencing data between controls and AD patients. We identified differentially expressed mitochondria-related genes including TRMT61B, FASTKD2, and NDUFA4L2, and using pathway and weighted gene coexpression analyses, we identified differentially expressed immune response genes. A number of these genes, including CLU, C3, and CD74, have been implicated in beta amyloid generation or clearance. These data provide key insights into astrocyte-specific contributions to AD, and we present this data set as a publicly available resource.
Alzheimer's disease (AD) is characterized by deficits in cerebral metabolic rates of glucose in the posterior cingulate (PC) and precuneus in AD subjects, and in APOE epsilon 4 carriers, decades before the onset of measureable cognitive deficits. However, the cellular and molecular basis of this phenotype remains to be clarified. Given the roles of astrocytes in energy storage and brain immunity, we sought to characterize the transcriptome of AD PC astrocytes. Cells were laser capture microdissected from AD (n = 10) and healthy elderly control (n = 10) subjects for RNA sequencing. We generated >5.22 billion reads and compared sequencing data between controls and AD patients. We identified differentially expressed mitochondria-related genes including TRMT61B, FASTKD2, and NDUFA4L2, and using pathway and weighted gene coexpression analyses, we identified differentially expressed immune response genes. A number of these genes, including CLU, C3, and CD74, have been implicated in beta amyloid generation or clearance. These data provide key insights into astrocyte-specific contributions to AD, and we present this data set as a publicly available resource.
Abstract Alzheimer's disease (AD) is characterized by deficits in cerebral metabolic rates of glucose in the posterior cingulate (PC) and precuneus in AD subjects, and in APOEε4 carriers, decades before the onset of measureable cognitive deficits. However, the cellular and molecular basis of this phenotype remains to be clarified. Given the roles of astrocytes in energy storage and brain immunity, we sought to characterize the transcriptome of AD PC astrocytes. Cells were laser capture microdissected from AD (n = 10) and healthy elderly control (n = 10) subjects for RNA sequencing. We generated >5.22 billion reads and compared sequencing data between controls and AD patients. We identified differentially expressed mitochondria-related genes including TRMT61B , FASTKD2 , and NDUFA4L2 , and using pathway and weighted gene coexpression analyses, we identified differentially expressed immune response genes. A number of these genes, including CLU , C3 , and CD74 , have been implicated in beta amyloid generation or clearance. These data provide key insights into astrocyte-specific contributions to AD, and we present this data set as a publicly available resource.
Alzheimer's disease (AD) is characterized by deficits in cerebral metabolic rates of glucose in the posterior cingulate (PC) and precuneus in AD subjects, and in APOEε4 carriers, decades before the onset of measureable cognitive deficits. However, the cellular and molecular basis of this phenotype remains to be clarified. Given the roles of astrocytes in energy storage and brain immunity, we sought to characterize the transcriptome of AD PC astrocytes. Cells were laser capture microdissected from AD (n = 10) and healthy elderly control (n = 10) subjects for RNA sequencing. We generated >5.22 billion reads and compared sequencing data between controls and AD patients. We identified differentially expressed mitochondria-related genes including TRMT61B, FASTKD2, and NDUFA4L2, and using pathway and weighted gene coexpression analyses, we identified differentially expressed immune response genes. A number of these genes, including CLU, C3, and CD74, have been implicated in beta amyloid generation or clearance. These data provide key insights into astrocyte-specific contributions to AD, and we present this data set as a publicly available resource.Alzheimer's disease (AD) is characterized by deficits in cerebral metabolic rates of glucose in the posterior cingulate (PC) and precuneus in AD subjects, and in APOEε4 carriers, decades before the onset of measureable cognitive deficits. However, the cellular and molecular basis of this phenotype remains to be clarified. Given the roles of astrocytes in energy storage and brain immunity, we sought to characterize the transcriptome of AD PC astrocytes. Cells were laser capture microdissected from AD (n = 10) and healthy elderly control (n = 10) subjects for RNA sequencing. We generated >5.22 billion reads and compared sequencing data between controls and AD patients. We identified differentially expressed mitochondria-related genes including TRMT61B, FASTKD2, and NDUFA4L2, and using pathway and weighted gene coexpression analyses, we identified differentially expressed immune response genes. A number of these genes, including CLU, C3, and CD74, have been implicated in beta amyloid generation or clearance. These data provide key insights into astrocyte-specific contributions to AD, and we present this data set as a publicly available resource.
Author Aldrich, Jessica
Liang, Winnie S.
McDonald, Jacquelyn
Craig, David W.
Reiman, Eric M.
Kurdoglu, Ahmet
Sekar, Shobana
Adkins, Jonathan
Valla, Jonathan
Beach, Thomas G.
Cuyugan, Lori
Serrano, Geidy
AuthorAffiliation 4 Banner Alzheimer’s Institute, Phoenix, AZ, 85006, USA
2 Arizona Alzheimer’s Consortium, Phoenix, AZ, 85014, USA
5 Midwestern University, Glendale, AZ 85308, USA
3 Banner Sun Health Research Institute, Sun City, AZ, 85351, USA
1 Translational Genomics Research Institute, Phoenix, AZ, 85004, USA
AuthorAffiliation_xml – name: 1 Translational Genomics Research Institute, Phoenix, AZ, 85004, USA
– name: 2 Arizona Alzheimer’s Consortium, Phoenix, AZ, 85014, USA
– name: 3 Banner Sun Health Research Institute, Sun City, AZ, 85351, USA
– name: 5 Midwestern University, Glendale, AZ 85308, USA
– name: 4 Banner Alzheimer’s Institute, Phoenix, AZ, 85006, USA
Author_xml – sequence: 1
  givenname: Shobana
  surname: Sekar
  fullname: Sekar, Shobana
  organization: Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA
– sequence: 2
  givenname: Jacquelyn
  surname: McDonald
  fullname: McDonald, Jacquelyn
  organization: Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA
– sequence: 3
  givenname: Lori
  surname: Cuyugan
  fullname: Cuyugan, Lori
  organization: Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA
– sequence: 4
  givenname: Jessica
  surname: Aldrich
  fullname: Aldrich, Jessica
  organization: Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA
– sequence: 5
  givenname: Ahmet
  surname: Kurdoglu
  fullname: Kurdoglu, Ahmet
  organization: Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA
– sequence: 6
  givenname: Jonathan
  surname: Adkins
  fullname: Adkins, Jonathan
  organization: Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA
– sequence: 7
  givenname: Geidy
  surname: Serrano
  fullname: Serrano, Geidy
  organization: Arizona Alzheimer's Consortium, Phoenix, AZ, USA
– sequence: 8
  givenname: Thomas G.
  surname: Beach
  fullname: Beach, Thomas G.
  organization: Arizona Alzheimer's Consortium, Phoenix, AZ, USA
– sequence: 9
  givenname: David W.
  surname: Craig
  fullname: Craig, David W.
  organization: Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA
– sequence: 10
  givenname: Jonathan
  surname: Valla
  fullname: Valla, Jonathan
  organization: Arizona Alzheimer's Consortium, Phoenix, AZ, USA
– sequence: 11
  givenname: Eric M.
  surname: Reiman
  fullname: Reiman, Eric M.
  organization: Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA
– sequence: 12
  givenname: Winnie S.
  surname: Liang
  fullname: Liang, Winnie S.
  email: wliang@tgen.org
  organization: Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25448601$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/j.ajhg.2008.08.009
10.1016/j.jchemneu.2011.06.007
10.1007/BF00308809
10.1152/physiolgenomics.00242.2007
10.1126/science.462184
10.1261/rna.035600.112
10.1038/nature11405
10.1093/bioinformatics/btp120
10.1002/aja.1001530405
10.1126/scisignal.2002858
10.1073/pnas.0608396103
10.1186/gb-2010-11-10-r106
10.1093/brain/awt171
10.1016/j.neurobiolaging.2013.07.008
10.1186/1750-1326-4-41
10.1016/j.tins.2003.08.008
10.1016/j.neurobiolaging.2011.04.013
10.1523/JNEUROSCI.21-13-04923.2001
10.1007/s00401-009-0619-8
10.1186/1742-2094-8-150
10.1002/glia.20243
10.1016/j.cmet.2011.10.008
10.1186/gb-2003-4-5-p3
10.1021/bi8016125
10.1128/MCB.01381-10
10.1097/01.wad.0000191420.61260.a8
10.2202/1544-6115.1128
10.1523/JNEUROSCI.4178-07.2008
10.1073/pnas.061509598
10.1023/A:1007677003387
10.1523/JNEUROSCI.17-03-01046.1997
10.1002/glia.22619
10.1007/s11481-013-9480-6
10.3233/JAD-2011-101716
10.1056/NEJM199603213341202
10.1016/j.cell.2008.06.016
10.1186/2040-2392-4-3
10.1093/cercor/6.1.50
10.1002/path.1645
10.1073/pnas.91.22.10625
10.1073/pnas.2635903100
10.1016/j.tins.2009.08.002
10.1007/BF00988599
10.1089/10445490152717541
10.1176/appi.ajp.159.5.738
10.1038/nprot.2012.016
10.1101/gr.227202. Article published online before print in May 2002
10.1097/00002093-200000001-00008
10.1001/archneur.57.3.339
10.1074/jbc.M602532200
10.1038/ng.439
10.1073/pnas.0709259105
10.1016/j.neurobiolaging.2008.05.013
10.1038/ng.440
10.1093/geronj/32.1.3
10.1002/j.1460-2075.1995.tb07147.x
10.1186/1742-2094-6-35
10.1073/pnas.0605843103
10.1212/WNL.34.7.939
10.1523/JNEUROSCI.16-03-00877.1996
10.1002/ana.410420114
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Issue 2
Keywords Posterior cingulate
RNA sequencing
Mitochondria
Immune response
Astrocytes
Alzheimer's disease
Language English
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References Harold, Abraham, Hollingworth, Sims, Gerrish, Hamshere, Pahwa, Moskvina, Dowzell, Williams, Jones, Thomas, Stretton, Morgan, Lovestone, Powell, Proitsi, Lupton, Brayne, Rubinsztein, Gill, Lawlor, Lynch, Morgan, Brown, Passmore, Craig, McGuinness, Todd, Holmes, Mann, Smith, Love, Kehoe, Hardy, Mead, Fox, Rossor, Collinge, Maier, Jessen, Schürmann, Heun, van den Bussche, Heuser, Kornhuber, Wiltfang, Dichgans, Frölich, Hampel, Hüll, Rujescu, Goate, Kauwe, Cruchaga, Nowotny, Morris, Mayo, Sleegers, Bettens, Engelborghs, De Deyn, Van Broeckhoven, Livingston, Bass, Gurling, McQuillin, Gwilliam, Deloukas, Al-Chalabi, Shaw, Tsolaki, Singleton, Guerreiro, Mühleisen, Nöthen, Moebus, Jöckel, Klopp, Wichmann, Carrasquillo, Pankratz, Younkin, Holmans, O'Donovan, Owen, Williams (bib16) 2009; 41
Simpson, Ince, Shaw, Heath, Raman, Garwood, Gelsthorpe, Baxter, Forster, Matthews, Brayne, Wharton (bib50) 2011; 32
Falkevall, Alikhani, Bhushan, Pavlov, Busch, Johnson, Eneqvist, Tjernberg, Ankarcrona, Glaser (bib12) 2006; 281
Geinisman, Bondareff, Dodge (bib14) 1978; 153
Sherwood, Stimpson, Raghanti, Wildman, Uddin, Grossman, Goodman, Redmond, Bonar, Erwin, Hof (bib49) 2006; 103
Tello, Balsa, Acosta-Iborra, Fuertes-Yebra, Elorza, Ordonez, Corral-Escariz, Soro, López-Bernardo, Perales-Clemente, Martínez-Ruiz, Enríquez, Aragonés, Cadenas, Landázuri (bib53) 2011; 14
Pekny, Pekna (bib38) 2004; 204
Blalock, Buechel, Popovic, Geddes, Landfield (bib5) 2011; 42
Hawrylycz, Lein, Guillozet-Bongaarts, Shen, Ng, Miller, van de Lagemaat, Smith, Ebbert, Riley, Abajian, Beckmann, Bernard, Bertagnolli, Boe, Cartagena, Chakravarty, Chapin, Chong, Dalley, Daly, Dang, Datta, Dee, Dolbeare, Faber, Feng, Fowler, Goldy, Gregor, Haradon, Haynor, Hohmann, Horvath, Howard, Jeromin, Jochim, Kinnunen, Lau, Lazarz, Lee, Lemon, Li, Li, Morris, Overly, Parker, Parry, Reding, Royall, Schulkin, Sequeira, Slaughterbeck, Smith, Sodt, Sunkin, Swanson, Vawter, Williams, Wohnoutka, Zielke, Geschwind, Hof, Smith, Koch, Grant, Jones (bib17) 2012; 489
Poliseno (bib42) 2012; 5
Horvath, Zhang, Carlson, Lu, Zhu, Felciano, Laurance, Zhao, Qi, Chen, Lee, Scheck, Liau, Wu, Geschwind, Febbo, Kornblum, Cloughesy, Nelson, Mischel (bib18) 2006; 103
Roelofs, Fischer, Houtman, Sluijs, Van Haren, Van Leeuwen, Hol (bib47) 2005; 52
Trapnell, Pachter, Salzberg (bib55) 2009; 25
Liang, Reiman, Valla, Dunckley, Beach, Grover, Niedzielko, Schneider, Mastroeni, Caselli, Kukull, Morris, Hulette, Schmechel, Rogers, Stephan (bib24) 2008; 105
Sofroniew, Vinters (bib52) 2010; 119
Magistretti, Pellerin (bib26) 1996; 6
Piert, Koeppe, Giordani, Berent, Kuhl (bib41) 1996; 37
Valla, Berndt, Gonzalez-Lima (bib58) 2001; 21
Pagliarini, Calvo, Chang, Sheth, Vafai, Ong, Walford, Sugiana, Boneh, Chen, Hill, Vidal, Evans, Thorburn, Carr, Mootha (bib34) 2008; 134
Tsacopoulos, Magistretti (bib57) 1996; 16
Reichwald, Danner, Wiederhold, Staufenbiel (bib43) 2009; 6
Reiman, Caselli, Chen, Alexander, Bandy, Frost (bib44) 2001; 98
Thal, Kantarci, Reiman, Klunk, Weiner, Zetterberg, Galasko, Praticò, Griffin, Schenk, Siemers (bib54) 2006; 20
Anders, Huber (bib4) 2010; 11
McKhann, Drachman, Folstein, Katzman, Price, Stadlan (bib29) 1984; 34
Perez-Nievas, Stein, Tai, Dols-Icardo, Scotton, Barroeta-Espar, Fernandez-Carballo, de Munain, Perez, Marquie, Serrano-Pozo, Frosch, Lowe, Parisi, Petersen, Ikonomovic, López, Klunk, Hyman, Gómez-Isla (bib40) 2013; 136
Pekny, Leveen, Pekna, Eliasson, Berthold, Westermark, Betsholtz (bib37) 1995; 14
Zhao, O'Connor, Vassar (bib63) 2011; 8
Chow, Gakh, Payne, Juliano, Juliano, Isaya, Hersch (bib8) 2009; 48
Minoshima, Giordani, Berent, Frey, Foster, Kuhl (bib30) 1997; 42
Mulder, Nielsen, Blankenstein, Eikelenboom, Veerhuis (bib31) 2014; 62
Ghezzi, Saada, D'Adamo, Fernandez-Vizarra, Gasparini, Tiranti, Elpeleg, Zeviani (bib15) 2008; 83
Mark, Pang, Geddes, Uchida, Mattson (bib27) 1997; 17
Pasternack, Abraham, Van Dyke, Potter, Younkin (bib36) 1989; 135
Pellerin, Magistretti (bib39) 1994; 91
Lambert, Heath, Even, Campion, Sleegers, Hiltunen, Combarros, Zelenika, Bullido, Tavernier, Letenneur, Bettens, Berr, Pasquier, Fiévet, Barberger-Gateau, Engelborghs, De Deyn, Mateo, Franck, Helisalmi, Porcellini, Hanon, European Alzheimer's Disease Initiative Investigators, de Pancorbo, Lendon, Dufouil, Jaillard, Leveillard, Alvarez, Bosco, Mancuso, Panza, Nacmias, Bossù, Piccardi, Annoni, Seripa, Galimberti, Hannequin, Licastro, Soininen, Ritchie, Blanché, Dartigues, Tzourio, Gut, Van Broeckhoven, Alpérovitch, Lathrop, Amouyel (bib20) 2009; 41
Fox, Cousens, Scahill, Harvey, Rossor (bib13) 2000; 57
Landfield, Rose, Sandles, Wohlstadter, Lynch (bib21) 1977; 32
Chujo, Suzuki (bib9) 2012; 18
Alikhani, Guo, Yan, Du, Pinho, Chen, Glaser, Yan (bib3) 2011; 27
Panter, McSwigan, Sheppard, Emory, Frey (bib35) 1985; 10
Zhang, Horvath (bib62) 2005; 4
Braak, Braak (bib6) 1991; 82
Dennis, Sherman, Hosack, Yang, Gao, Lane, Lempicki (bib10) 2003; 4
Yeung, Das, Zhang, Lomniczi, Ojeda, Xu, Neubert, Samuels (bib61) 2011; 31
Akiyama, Arai, Kondo, Tanno, Haga, Ikeda (bib1) 2000; 14
Reiman, Chen, Alexander, Caselli, Bandy, Osborne, Saunders, Hardy (bib46) 2004; 101
Woischnik, Moraes (bib59) 2002; 12
Nedergaard, Ransom, Goldman (bib32) 2003; 26
Liang, Dunckley, Beach, Grover, Mastroeni, Ramsey, Caselli, Kukull, McKeel, Morris, Hulette, Schmechel, Reiman, Rogers, Stephan (bib22) 2008; 33
Schwartz, Smith, Davidsen, Savaki, Sokoloff, Mata, Fink, Gainer (bib48) 1979; 205
Liang, Dunckley, Beach, Grover, Mastroeni, Ramsey, Caselli, Kukull, McKeel, Morris, Hulette, Schmechel, Reiman, Rogers, Stephan (bib23) 2010; 31
Orre, Kamphuis, Osborn, Melief, Kooijman, Huitinga, Klooster, Bossers, Hol (bib33) 2014; 35
Sofroniew (bib51) 2009; 32
Eng, Ghirnikar, Lee (bib11) 2000; 25
Matsuda, Matsuda, D'Adamio (bib28) 2009; 4
Yasui, Xu, Dunaway, Lasalle, Jin, Maezawa (bib60) 2013; 4
Cahoy, Emery, Kaushal, Foo, Zamanian, Christopherson, Xing, Lubischer, Krieg, Krupenko, Thompson, Barres (bib7) 2008; 28
Trapnell, Roberts, Goff, Pertea, Kim, Kelley, Pimentel, Salzberg, Rinn, Pachter (bib56) 2012; 7
Jensen, Massie, De Keyser (bib19) 2013; 8
Alexander, Chen, Pietrini, Rapoport, Reiman (bib2) 2002; 159
Loring, Wen, Lee, Seilhamer, Somogyi (bib25) 2001; 20
Reiman, Caselli, Yun, Chen, Bandy, Minoshima, Thibodeau, Osborne (bib45) 1996; 334
Pagliarini (10.1016/j.neurobiolaging.2014.09.027_bib34) 2008; 134
Lambert (10.1016/j.neurobiolaging.2014.09.027_bib20) 2009; 41
Sherwood (10.1016/j.neurobiolaging.2014.09.027_bib49) 2006; 103
Minoshima (10.1016/j.neurobiolaging.2014.09.027_bib30) 1997; 42
Reiman (10.1016/j.neurobiolaging.2014.09.027_bib46) 2004; 101
Woischnik (10.1016/j.neurobiolaging.2014.09.027_bib59) 2002; 12
Falkevall (10.1016/j.neurobiolaging.2014.09.027_bib12) 2006; 281
Chow (10.1016/j.neurobiolaging.2014.09.027_bib8) 2009; 48
Liang (10.1016/j.neurobiolaging.2014.09.027_bib23) 2010; 31
McKhann (10.1016/j.neurobiolaging.2014.09.027_bib29) 1984; 34
Zhao (10.1016/j.neurobiolaging.2014.09.027_bib63) 2011; 8
Dennis (10.1016/j.neurobiolaging.2014.09.027_bib10) 2003; 4
Roelofs (10.1016/j.neurobiolaging.2014.09.027_bib47) 2005; 52
Alexander (10.1016/j.neurobiolaging.2014.09.027_bib2) 2002; 159
Reichwald (10.1016/j.neurobiolaging.2014.09.027_bib43) 2009; 6
Pasternack (10.1016/j.neurobiolaging.2014.09.027_bib36) 1989; 135
Simpson (10.1016/j.neurobiolaging.2014.09.027_bib50) 2011; 32
Pellerin (10.1016/j.neurobiolaging.2014.09.027_bib39) 1994; 91
Valla (10.1016/j.neurobiolaging.2014.09.027_bib58) 2001; 21
Landfield (10.1016/j.neurobiolaging.2014.09.027_bib21) 1977; 32
Piert (10.1016/j.neurobiolaging.2014.09.027_bib41) 1996; 37
Liang (10.1016/j.neurobiolaging.2014.09.027_bib24) 2008; 105
Magistretti (10.1016/j.neurobiolaging.2014.09.027_bib26) 1996; 6
Alikhani (10.1016/j.neurobiolaging.2014.09.027_bib3) 2011; 27
Mark (10.1016/j.neurobiolaging.2014.09.027_bib27) 1997; 17
Blalock (10.1016/j.neurobiolaging.2014.09.027_bib5) 2011; 42
Chujo (10.1016/j.neurobiolaging.2014.09.027_bib9) 2012; 18
Eng (10.1016/j.neurobiolaging.2014.09.027_bib11) 2000; 25
Perez-Nievas (10.1016/j.neurobiolaging.2014.09.027_bib40) 2013; 136
Sofroniew (10.1016/j.neurobiolaging.2014.09.027_bib52) 2010; 119
Zhang (10.1016/j.neurobiolaging.2014.09.027_bib62) 2005; 4
Horvath (10.1016/j.neurobiolaging.2014.09.027_bib18) 2006; 103
Mulder (10.1016/j.neurobiolaging.2014.09.027_bib31) 2014; 62
Tsacopoulos (10.1016/j.neurobiolaging.2014.09.027_bib57) 1996; 16
Sofroniew (10.1016/j.neurobiolaging.2014.09.027_bib51) 2009; 32
Schwartz (10.1016/j.neurobiolaging.2014.09.027_bib48) 1979; 205
Poliseno (10.1016/j.neurobiolaging.2014.09.027_bib42) 2012; 5
Braak (10.1016/j.neurobiolaging.2014.09.027_bib6) 1991; 82
Geinisman (10.1016/j.neurobiolaging.2014.09.027_bib14) 1978; 153
Yeung (10.1016/j.neurobiolaging.2014.09.027_bib61) 2011; 31
Pekny (10.1016/j.neurobiolaging.2014.09.027_bib38) 2004; 204
Liang (10.1016/j.neurobiolaging.2014.09.027_bib22) 2008; 33
Matsuda (10.1016/j.neurobiolaging.2014.09.027_bib28) 2009; 4
Reiman (10.1016/j.neurobiolaging.2014.09.027_bib44) 2001; 98
Yasui (10.1016/j.neurobiolaging.2014.09.027_bib60) 2013; 4
Cahoy (10.1016/j.neurobiolaging.2014.09.027_bib7) 2008; 28
Jensen (10.1016/j.neurobiolaging.2014.09.027_bib19) 2013; 8
Hawrylycz (10.1016/j.neurobiolaging.2014.09.027_bib17) 2012; 489
Loring (10.1016/j.neurobiolaging.2014.09.027_bib25) 2001; 20
Thal (10.1016/j.neurobiolaging.2014.09.027_bib54) 2006; 20
Trapnell (10.1016/j.neurobiolaging.2014.09.027_bib55) 2009; 25
Orre (10.1016/j.neurobiolaging.2014.09.027_bib33) 2014; 35
Akiyama (10.1016/j.neurobiolaging.2014.09.027_bib1) 2000; 14
Reiman (10.1016/j.neurobiolaging.2014.09.027_bib45) 1996; 334
Harold (10.1016/j.neurobiolaging.2014.09.027_bib16) 2009; 41
Ghezzi (10.1016/j.neurobiolaging.2014.09.027_bib15) 2008; 83
Panter (10.1016/j.neurobiolaging.2014.09.027_bib35) 1985; 10
Tello (10.1016/j.neurobiolaging.2014.09.027_bib53) 2011; 14
Pekny (10.1016/j.neurobiolaging.2014.09.027_bib37) 1995; 14
Nedergaard (10.1016/j.neurobiolaging.2014.09.027_bib32) 2003; 26
Trapnell (10.1016/j.neurobiolaging.2014.09.027_bib56) 2012; 7
Anders (10.1016/j.neurobiolaging.2014.09.027_bib4) 2010; 11
Fox (10.1016/j.neurobiolaging.2014.09.027_bib13) 2000; 57
20979621 - Genome Biol. 2010;11(10):R106
18171944 - J Neurosci. 2008 Jan 2;28(1):264-78
6610841 - Neurology. 1984 Jul;34(7):939-44
23097428 - RNA. 2012 Dec;18(12):2269-76
14522144 - Trends Neurosci. 2003 Oct;26(10):523-30
20012068 - Acta Neuropathol. 2010 Jan;119(1):7-35
15495269 - J Pathol. 2004 Nov;204(4):428-37
19849849 - Mol Neurodegener. 2009 Oct 22;4:41
8667045 - J Nucl Med. 1996 Feb;37(2):201-8
1759558 - Acta Neuropathol. 1991;82(4):239-59
23824488 - Brain. 2013 Aug;136(Pt 8):2510-26
21444724 - Mol Cell Biol. 2011 Jun;31(11):2287-98
11059815 - Neurochem Res. 2000 Oct;25(9-10):1439-51
22996553 - Nature. 2012 Sep 20;489(7416):391-9
19734903 - Nat Genet. 2009 Oct;41(10):1094-9
8558256 - J Neurosci. 1996 Feb 1;16(3):877-85
22047170 - J Neuroinflammation. 2011;8:150
16849325 - J Biol Chem. 2006 Sep 29;281(39):29096-104
9225689 - Ann Neurol. 1997 Jul;42(1):85-94
8592548 - N Engl J Med. 1996 Mar 21;334(12):752-8
22990117 - Sci Signal. 2012;5(242):re5
14688411 - Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):284-9
12734009 - Genome Biol. 2003;4(5):P3
23821340 - J Neuroimmune Pharmacol. 2013 Sep;8(4):824-39
12045142 - Genome Res. 2002 Jun;12(6):885-93
4088432 - Neurochem Res. 1985 Dec;10(12):1567-76
16938869 - Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13606-11
21750375 - J Alzheimers Dis. 2011;27(1):75-87
11425920 - J Neurosci. 2001 Jul 1;21(13):4923-30
18270320 - Physiol Genomics. 2008 Apr 22;33(2):240-56
18572275 - Neurobiol Aging. 2010 Apr;31(4):549-66
19196155 - Biochemistry. 2009 Apr 7;48(13):2868-77
22100406 - Cell Metab. 2011 Dec 7;14(6):768-79
727153 - Am J Anat. 1978 Dec;153(4):537-43
18332434 - Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4441-6
7737111 - EMBO J. 1995 Apr 18;14(8):1590-8
18614015 - Cell. 2008 Jul 11;134(1):112-23
16493230 - Alzheimer Dis Assoc Disord. 2006 Jan-Mar;20(1):6-15
19917141 - J Neuroinflammation. 2009;6:35
11986126 - Am J Psychiatry. 2002 May;159(5):738-45
19289445 - Bioinformatics. 2009 May 1;25(9):1105-11
17090670 - Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17402-7
11248079 - Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3334-9
462184 - Science. 1979 Aug 17;205(4407):723-5
18771761 - Am J Hum Genet. 2008 Sep;83(3):415-23
23351786 - Mol Autism. 2013 Jan 25;4(1):3
16001427 - Glia. 2005 Dec;52(4):289-300
19782411 - Trends Neurosci. 2009 Dec;32(12):638-47
7938003 - Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10625-9
19734902 - Nat Genet. 2009 Oct;41(10):1088-93
8670638 - Cereb Cortex. 1996 Jan-Feb;6(1):50-61
2817081 - Am J Pathol. 1989 Nov;135(5):827-34
830730 - J Gerontol. 1977 Jan;32(1):3-12
8994059 - J Neurosci. 1997 Feb 1;17(3):1046-54
21705112 - Neurobiol Aging. 2011 Oct;32(10):1795-807
23954174 - Neurobiol Aging. 2014 Jan;35(1):1-14
10850730 - Alzheimer Dis Assoc Disord. 2000;14 Suppl 1:S47-53
16646834 - Stat Appl Genet Mol Biol. 2005;4:Article17
10714659 - Arch Neurol. 2000 Mar;57(3):339-44
24446231 - Glia. 2014 Apr;62(4):493-503
11788046 - DNA Cell Biol. 2001 Nov;20(11):683-95
22383036 - Nat Protoc. 2012 Mar;7(3):562-78
21756998 - J Chem Neuroanat. 2011 Oct;42(2):118-26
References_xml – volume: 135
  start-page: 827
  year: 1989
  end-page: 834
  ident: bib36
  article-title: Astrocytes in Alzheimer's disease gray matter express alpha 1-antichymotrypsin mRNA
  publication-title: Am. J. Pathol.
– volume: 18
  start-page: 2269
  year: 2012
  end-page: 2276
  ident: bib9
  article-title: Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs
  publication-title: RNA
– volume: 205
  start-page: 723
  year: 1979
  end-page: 725
  ident: bib48
  article-title: Metabolic mapping of functional activity in the hypothalamo-neurohypophysial system of the rat
  publication-title: Science
– volume: 28
  start-page: 264
  year: 2008
  end-page: 278
  ident: bib7
  article-title: A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function
  publication-title: J. Neurosci
– volume: 82
  start-page: 239
  year: 1991
  end-page: 259
  ident: bib6
  article-title: Neuropathological stageing of Alzheimer-related changes
  publication-title: Acta Neuropathol.
– volume: 91
  start-page: 10625
  year: 1994
  end-page: 10629
  ident: bib39
  article-title: Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 6
  start-page: 35
  year: 2009
  ident: bib43
  article-title: Expression of complement system components during aging and amyloid deposition in APP transgenic mice
  publication-title: J. Neuroinflammation
– volume: 153
  start-page: 537
  year: 1978
  end-page: 543
  ident: bib14
  article-title: Hypertrophy of astroglial processes in the dentate gyrus of the senescent rat
  publication-title: Am. J. Anat.
– volume: 14
  start-page: 768
  year: 2011
  end-page: 779
  ident: bib53
  article-title: Induction of the mitochondrial NDUFA4L2 protein by HIF-1alpha decreases oxygen consumption by inhibiting complex I activity
  publication-title: Cell Metab
– volume: 136
  start-page: 2510
  year: 2013
  end-page: 2526
  ident: bib40
  article-title: Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology
  publication-title: Brain
– volume: 6
  start-page: 50
  year: 1996
  end-page: 61
  ident: bib26
  article-title: Cellular bases of brain energy metabolism and their relevance to functional brain imaging: evidence for a prominent role of astrocytes
  publication-title: Cereb. Cortex
– volume: 14
  start-page: 1590
  year: 1995
  end-page: 1598
  ident: bib37
  article-title: Mice lacking glial fibrillary acidic protein display astrocytes devoid of intermediate filaments but develop and reproduce normally
  publication-title: Embo J
– volume: 33
  start-page: 240
  year: 2008
  end-page: 256
  ident: bib22
  article-title: Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set
  publication-title: Physiol. Genomics
– volume: 42
  start-page: 85
  year: 1997
  end-page: 94
  ident: bib30
  article-title: Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
  publication-title: Ann. Neurol.
– volume: 31
  start-page: 2287
  year: 2011
  end-page: 2298
  ident: bib61
  article-title: A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2
  publication-title: Mol. Cell Biol
– volume: 5
  start-page: re5
  year: 2012
  ident: bib42
  article-title: Pseudogenes: newly discovered players in human cancer
  publication-title: Sci. Signal
– volume: 16
  start-page: 877
  year: 1996
  end-page: 885
  ident: bib57
  article-title: Metabolic coupling between glia and neurons
  publication-title: J. Neurosci.
– volume: 11
  start-page: R106
  year: 2010
  ident: bib4
  article-title: Differential expression analysis for sequence count data
  publication-title: Genome Biol.
– volume: 48
  start-page: 2868
  year: 2009
  end-page: 2877
  ident: bib8
  article-title: Mammalian pitrilysin: substrate specificity and mitochondrial targeting
  publication-title: Biochemistry
– volume: 10
  start-page: 1567
  year: 1985
  end-page: 1576
  ident: bib35
  article-title: Glial fibrillary acidic protein and Alzheimer's disease
  publication-title: Neurochem. Res.
– volume: 8
  start-page: 824
  year: 2013
  end-page: 839
  ident: bib19
  article-title: Immune players in the CNS: the astrocyte
  publication-title: J. Neuroimmune Pharmacol.
– volume: 105
  start-page: 4441
  year: 2008
  end-page: 4446
  ident: bib24
  article-title: Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons
  publication-title: Proc. Natl. Acad. Sci. U. S. A
– volume: 35
  start-page: 1
  year: 2014
  end-page: 14
  ident: bib33
  article-title: Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice
  publication-title: Neurobiol. Aging
– volume: 25
  start-page: 1105
  year: 2009
  end-page: 1111
  ident: bib55
  article-title: TopHat: discovering splice junctions with RNA-Seq
  publication-title: Bioinformatics
– volume: 42
  start-page: 118
  year: 2011
  end-page: 126
  ident: bib5
  article-title: Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease
  publication-title: J. Chem. Neuroanat.
– volume: 57
  start-page: 339
  year: 2000
  end-page: 344
  ident: bib13
  article-title: Using serial registered brain magnetic resonance imaging to measure disease progression in Alzheimer disease: power calculations and estimates of sample size to detect treatment effects
  publication-title: Arch. Neurol.
– volume: 103
  start-page: 13606
  year: 2006
  end-page: 13611
  ident: bib49
  article-title: Evolution of increased glia-neuron ratios in the human frontal cortex
  publication-title: Proc. Natl. Acad. Sci. U. S. A
– volume: 32
  start-page: 638
  year: 2009
  end-page: 647
  ident: bib51
  article-title: Molecular dissection of reactive astrogliosis and glial scar formation
  publication-title: Trends Neurosci.
– volume: 4
  year: 2005
  ident: bib62
  article-title: A general framework for weighted gene co-expression network analysis
  publication-title: Stat. Appl. Genet. Mol. Biol.
– volume: 37
  start-page: 201
  year: 1996
  end-page: 208
  ident: bib41
  article-title: Diminished glucose transport and phosphorylation in Alzheimer's disease determined by dynamic FDG-PET
  publication-title: J. Nucl. Med.
– volume: 101
  start-page: 284
  year: 2004
  end-page: 289
  ident: bib46
  article-title: Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia
  publication-title: Proc. Natl. Acad. Sci. U. S. A
– volume: 119
  start-page: 7
  year: 2010
  end-page: 35
  ident: bib52
  article-title: Astrocytes: biology and pathology
  publication-title: Acta Neuropathol.
– volume: 41
  start-page: 1088
  year: 2009
  end-page: 1093
  ident: bib16
  article-title: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
  publication-title: Nat. Genet
– volume: 4
  start-page: 41
  year: 2009
  ident: bib28
  article-title: CD74 interacts with APP and suppresses the production of Abeta
  publication-title: Mol. Neurodegener.
– volume: 25
  start-page: 1439
  year: 2000
  end-page: 1451
  ident: bib11
  article-title: Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000)
  publication-title: Neurochem. Res.
– volume: 52
  start-page: 289
  year: 2005
  end-page: 300
  ident: bib47
  article-title: Adult human subventricular, subgranular, and subpial zones contain astrocytes with a specialized intermediate filament cytoskeleton
  publication-title: Glia
– volume: 12
  start-page: 885
  year: 2002
  end-page: 893
  ident: bib59
  article-title: Pattern of organization of human mitochondrial pseudogenes in the nuclear genome
  publication-title: Genome Res.
– volume: 14
  start-page: S47
  year: 2000
  end-page: S53
  ident: bib1
  article-title: Cell mediators of inflammation in the Alzheimer disease brain
  publication-title: Alzheimer Dis. Assoc. Disord.
– volume: 20
  start-page: 683
  year: 2001
  end-page: 695
  ident: bib25
  article-title: A gene expression profile of Alzheimer's disease
  publication-title: DNA Cell Biol.
– volume: 21
  start-page: 4923
  year: 2001
  end-page: 4930
  ident: bib58
  article-title: Energy hypometabolism in posterior cingulate cortex of Alzheimer's patients: superficial laminar cytochrome oxidase associated with disease duration
  publication-title: J. Neurosci.
– volume: 31
  start-page: 549
  year: 2010
  end-page: 566
  ident: bib23
  article-title: Neuronal gene expression in non-demented individuals with intermediate Alzheimer's disease neuropathology
  publication-title: Neurobiol. Aging
– volume: 98
  start-page: 3334
  year: 2001
  end-page: 3339
  ident: bib44
  article-title: Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: a foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 7
  start-page: 562
  year: 2012
  end-page: 578
  ident: bib56
  article-title: Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks
  publication-title: Nat. Protoc
– volume: 4
  start-page: P3
  year: 2003
  ident: bib10
  article-title: DAVID: database for annotation, visualization, and integrated discovery
  publication-title: Genome Biol
– volume: 62
  start-page: 493
  year: 2014
  end-page: 503
  ident: bib31
  article-title: Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microglia in vitro
  publication-title: Glia
– volume: 17
  start-page: 1046
  year: 1997
  end-page: 1054
  ident: bib27
  article-title: Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation
  publication-title: J. Neurosci.
– volume: 159
  start-page: 738
  year: 2002
  end-page: 745
  ident: bib2
  article-title: Longitudinal PET evaluation of cerebral metabolic decline in dementia: a potential outcome measure in Alzheimer's disease treatment studies
  publication-title: Am. J. Psychiatry
– volume: 334
  start-page: 752
  year: 1996
  end-page: 758
  ident: bib45
  article-title: Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E
  publication-title: N. Engl. J. Med
– volume: 4
  start-page: 3
  year: 2013
  ident: bib60
  article-title: MeCP2 modulates gene expression pathways in astrocytes
  publication-title: Mol. Autism
– volume: 489
  start-page: 391
  year: 2012
  end-page: 399
  ident: bib17
  article-title: An anatomically comprehensive atlas of the adult human brain transcriptome
  publication-title: Nature
– volume: 34
  start-page: 939
  year: 1984
  end-page: 944
  ident: bib29
  article-title: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
  publication-title: Neurology
– volume: 26
  start-page: 523
  year: 2003
  end-page: 530
  ident: bib32
  article-title: New roles for astrocytes: redefining the functional architecture of the brain
  publication-title: Trends Neurosci.
– volume: 103
  start-page: 17402
  year: 2006
  end-page: 17407
  ident: bib18
  article-title: Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target
  publication-title: Proc. Natl. Acad. Sci. U. S. A
– volume: 204
  start-page: 428
  year: 2004
  end-page: 437
  ident: bib38
  article-title: Astrocyte intermediate filaments in CNS pathologies and regeneration
  publication-title: J. Pathol.
– volume: 83
  start-page: 415
  year: 2008
  end-page: 423
  ident: bib15
  article-title: FASTKD2 nonsense mutation in an infantile mitochondrial encephalomyopathy associated with cytochrome c oxidase deficiency
  publication-title: Am. J. Hum. Genet
– volume: 32
  start-page: 1795
  year: 2011
  end-page: 1807
  ident: bib50
  article-title: Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype
  publication-title: Neurobiol. Aging
– volume: 281
  start-page: 29096
  year: 2006
  end-page: 29104
  ident: bib12
  article-title: Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP
  publication-title: J. Biol. Chem
– volume: 32
  start-page: 3
  year: 1977
  end-page: 12
  ident: bib21
  article-title: Patterns of astroglial hypertrophy and neuronal degeneration in the hippocampus of ages, memory-deficient rats
  publication-title: J. Gerontol.
– volume: 20
  start-page: 6
  year: 2006
  end-page: 15
  ident: bib54
  article-title: The role of biomarkers in clinical trials for Alzheimer disease
  publication-title: Alzheimer Dis. Assoc. Disord
– volume: 41
  start-page: 1094
  year: 2009
  end-page: 1099
  ident: bib20
  article-title: Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
  publication-title: Nat. Genet
– volume: 134
  start-page: 112
  year: 2008
  end-page: 123
  ident: bib34
  article-title: A mitochondrial protein compendium elucidates complex I disease biology
  publication-title: Cell
– volume: 27
  start-page: 75
  year: 2011
  end-page: 87
  ident: bib3
  article-title: Decreased proteolytic activity of the mitochondrial amyloid-beta degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondria
  publication-title: J. Alzheimers Dis
– volume: 8
  start-page: 150
  year: 2011
  ident: bib63
  article-title: The contribution of activated astrocytes to Abeta production: implications for Alzheimer's disease pathogenesis
  publication-title: J. Neuroinflammation
– volume: 83
  start-page: 415
  year: 2008
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib15
  article-title: FASTKD2 nonsense mutation in an infantile mitochondrial encephalomyopathy associated with cytochrome c oxidase deficiency
  publication-title: Am. J. Hum. Genet
  doi: 10.1016/j.ajhg.2008.08.009
– volume: 42
  start-page: 118
  year: 2011
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib5
  article-title: Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease
  publication-title: J. Chem. Neuroanat.
  doi: 10.1016/j.jchemneu.2011.06.007
– volume: 82
  start-page: 239
  year: 1991
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib6
  article-title: Neuropathological stageing of Alzheimer-related changes
  publication-title: Acta Neuropathol.
  doi: 10.1007/BF00308809
– volume: 33
  start-page: 240
  year: 2008
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib22
  article-title: Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set
  publication-title: Physiol. Genomics
  doi: 10.1152/physiolgenomics.00242.2007
– volume: 205
  start-page: 723
  year: 1979
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib48
  article-title: Metabolic mapping of functional activity in the hypothalamo-neurohypophysial system of the rat
  publication-title: Science
  doi: 10.1126/science.462184
– volume: 18
  start-page: 2269
  year: 2012
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib9
  article-title: Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs
  publication-title: RNA
  doi: 10.1261/rna.035600.112
– volume: 489
  start-page: 391
  year: 2012
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib17
  article-title: An anatomically comprehensive atlas of the adult human brain transcriptome
  publication-title: Nature
  doi: 10.1038/nature11405
– volume: 25
  start-page: 1105
  year: 2009
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib55
  article-title: TopHat: discovering splice junctions with RNA-Seq
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp120
– volume: 153
  start-page: 537
  year: 1978
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib14
  article-title: Hypertrophy of astroglial processes in the dentate gyrus of the senescent rat
  publication-title: Am. J. Anat.
  doi: 10.1002/aja.1001530405
– volume: 5
  start-page: re5
  year: 2012
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib42
  article-title: Pseudogenes: newly discovered players in human cancer
  publication-title: Sci. Signal
  doi: 10.1126/scisignal.2002858
– volume: 103
  start-page: 17402
  year: 2006
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib18
  article-title: Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target
  publication-title: Proc. Natl. Acad. Sci. U. S. A
  doi: 10.1073/pnas.0608396103
– volume: 11
  start-page: R106
  year: 2010
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib4
  article-title: Differential expression analysis for sequence count data
  publication-title: Genome Biol.
  doi: 10.1186/gb-2010-11-10-r106
– volume: 136
  start-page: 2510
  issue: Pt 8
  year: 2013
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib40
  article-title: Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology
  publication-title: Brain
  doi: 10.1093/brain/awt171
– volume: 35
  start-page: 1
  year: 2014
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib33
  article-title: Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice
  publication-title: Neurobiol. Aging
  doi: 10.1016/j.neurobiolaging.2013.07.008
– volume: 4
  start-page: 41
  year: 2009
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib28
  article-title: CD74 interacts with APP and suppresses the production of Abeta
  publication-title: Mol. Neurodegener.
  doi: 10.1186/1750-1326-4-41
– volume: 26
  start-page: 523
  year: 2003
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib32
  article-title: New roles for astrocytes: redefining the functional architecture of the brain
  publication-title: Trends Neurosci.
  doi: 10.1016/j.tins.2003.08.008
– volume: 32
  start-page: 1795
  year: 2011
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib50
  article-title: Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype
  publication-title: Neurobiol. Aging
  doi: 10.1016/j.neurobiolaging.2011.04.013
– volume: 21
  start-page: 4923
  year: 2001
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib58
  article-title: Energy hypometabolism in posterior cingulate cortex of Alzheimer's patients: superficial laminar cytochrome oxidase associated with disease duration
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.21-13-04923.2001
– volume: 119
  start-page: 7
  year: 2010
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib52
  article-title: Astrocytes: biology and pathology
  publication-title: Acta Neuropathol.
  doi: 10.1007/s00401-009-0619-8
– volume: 8
  start-page: 150
  year: 2011
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib63
  article-title: The contribution of activated astrocytes to Abeta production: implications for Alzheimer's disease pathogenesis
  publication-title: J. Neuroinflammation
  doi: 10.1186/1742-2094-8-150
– volume: 52
  start-page: 289
  year: 2005
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib47
  article-title: Adult human subventricular, subgranular, and subpial zones contain astrocytes with a specialized intermediate filament cytoskeleton
  publication-title: Glia
  doi: 10.1002/glia.20243
– volume: 14
  start-page: 768
  year: 2011
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib53
  article-title: Induction of the mitochondrial NDUFA4L2 protein by HIF-1alpha decreases oxygen consumption by inhibiting complex I activity
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2011.10.008
– volume: 4
  start-page: P3
  year: 2003
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib10
  article-title: DAVID: database for annotation, visualization, and integrated discovery
  publication-title: Genome Biol
  doi: 10.1186/gb-2003-4-5-p3
– volume: 48
  start-page: 2868
  year: 2009
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib8
  article-title: Mammalian pitrilysin: substrate specificity and mitochondrial targeting
  publication-title: Biochemistry
  doi: 10.1021/bi8016125
– volume: 31
  start-page: 2287
  year: 2011
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib61
  article-title: A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2
  publication-title: Mol. Cell Biol
  doi: 10.1128/MCB.01381-10
– volume: 20
  start-page: 6
  year: 2006
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib54
  article-title: The role of biomarkers in clinical trials for Alzheimer disease
  publication-title: Alzheimer Dis. Assoc. Disord
  doi: 10.1097/01.wad.0000191420.61260.a8
– volume: 4
  year: 2005
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib62
  article-title: A general framework for weighted gene co-expression network analysis
  publication-title: Stat. Appl. Genet. Mol. Biol.
  doi: 10.2202/1544-6115.1128
– volume: 28
  start-page: 264
  year: 2008
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib7
  article-title: A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function
  publication-title: J. Neurosci
  doi: 10.1523/JNEUROSCI.4178-07.2008
– volume: 135
  start-page: 827
  year: 1989
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib36
  article-title: Astrocytes in Alzheimer's disease gray matter express alpha 1-antichymotrypsin mRNA
  publication-title: Am. J. Pathol.
– volume: 37
  start-page: 201
  year: 1996
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib41
  article-title: Diminished glucose transport and phosphorylation in Alzheimer's disease determined by dynamic FDG-PET
  publication-title: J. Nucl. Med.
– volume: 98
  start-page: 3334
  year: 2001
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib44
  article-title: Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: a foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.061509598
– volume: 25
  start-page: 1439
  year: 2000
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib11
  article-title: Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000)
  publication-title: Neurochem. Res.
  doi: 10.1023/A:1007677003387
– volume: 17
  start-page: 1046
  year: 1997
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib27
  article-title: Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.17-03-01046.1997
– volume: 62
  start-page: 493
  year: 2014
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib31
  article-title: Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microglia in vitro
  publication-title: Glia
  doi: 10.1002/glia.22619
– volume: 8
  start-page: 824
  year: 2013
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib19
  article-title: Immune players in the CNS: the astrocyte
  publication-title: J. Neuroimmune Pharmacol.
  doi: 10.1007/s11481-013-9480-6
– volume: 27
  start-page: 75
  year: 2011
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib3
  article-title: Decreased proteolytic activity of the mitochondrial amyloid-beta degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondria
  publication-title: J. Alzheimers Dis
  doi: 10.3233/JAD-2011-101716
– volume: 334
  start-page: 752
  year: 1996
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib45
  article-title: Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E
  publication-title: N. Engl. J. Med
  doi: 10.1056/NEJM199603213341202
– volume: 134
  start-page: 112
  year: 2008
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib34
  article-title: A mitochondrial protein compendium elucidates complex I disease biology
  publication-title: Cell
  doi: 10.1016/j.cell.2008.06.016
– volume: 4
  start-page: 3
  year: 2013
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib60
  article-title: MeCP2 modulates gene expression pathways in astrocytes
  publication-title: Mol. Autism
  doi: 10.1186/2040-2392-4-3
– volume: 6
  start-page: 50
  year: 1996
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib26
  article-title: Cellular bases of brain energy metabolism and their relevance to functional brain imaging: evidence for a prominent role of astrocytes
  publication-title: Cereb. Cortex
  doi: 10.1093/cercor/6.1.50
– volume: 204
  start-page: 428
  year: 2004
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib38
  article-title: Astrocyte intermediate filaments in CNS pathologies and regeneration
  publication-title: J. Pathol.
  doi: 10.1002/path.1645
– volume: 91
  start-page: 10625
  year: 1994
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib39
  article-title: Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.91.22.10625
– volume: 101
  start-page: 284
  year: 2004
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib46
  article-title: Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia
  publication-title: Proc. Natl. Acad. Sci. U. S. A
  doi: 10.1073/pnas.2635903100
– volume: 32
  start-page: 638
  year: 2009
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib51
  article-title: Molecular dissection of reactive astrogliosis and glial scar formation
  publication-title: Trends Neurosci.
  doi: 10.1016/j.tins.2009.08.002
– volume: 10
  start-page: 1567
  year: 1985
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib35
  article-title: Glial fibrillary acidic protein and Alzheimer's disease
  publication-title: Neurochem. Res.
  doi: 10.1007/BF00988599
– volume: 20
  start-page: 683
  year: 2001
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib25
  article-title: A gene expression profile of Alzheimer's disease
  publication-title: DNA Cell Biol.
  doi: 10.1089/10445490152717541
– volume: 159
  start-page: 738
  year: 2002
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib2
  article-title: Longitudinal PET evaluation of cerebral metabolic decline in dementia: a potential outcome measure in Alzheimer's disease treatment studies
  publication-title: Am. J. Psychiatry
  doi: 10.1176/appi.ajp.159.5.738
– volume: 7
  start-page: 562
  year: 2012
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib56
  article-title: Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks
  publication-title: Nat. Protoc
  doi: 10.1038/nprot.2012.016
– volume: 12
  start-page: 885
  year: 2002
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib59
  article-title: Pattern of organization of human mitochondrial pseudogenes in the nuclear genome
  publication-title: Genome Res.
  doi: 10.1101/gr.227202. Article published online before print in May 2002
– volume: 14
  start-page: S47
  issue: Suppl 1
  year: 2000
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib1
  article-title: Cell mediators of inflammation in the Alzheimer disease brain
  publication-title: Alzheimer Dis. Assoc. Disord.
  doi: 10.1097/00002093-200000001-00008
– volume: 57
  start-page: 339
  year: 2000
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib13
  article-title: Using serial registered brain magnetic resonance imaging to measure disease progression in Alzheimer disease: power calculations and estimates of sample size to detect treatment effects
  publication-title: Arch. Neurol.
  doi: 10.1001/archneur.57.3.339
– volume: 281
  start-page: 29096
  year: 2006
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib12
  article-title: Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP
  publication-title: J. Biol. Chem
  doi: 10.1074/jbc.M602532200
– volume: 41
  start-page: 1094
  year: 2009
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib20
  article-title: Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
  publication-title: Nat. Genet
  doi: 10.1038/ng.439
– volume: 105
  start-page: 4441
  year: 2008
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib24
  article-title: Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons
  publication-title: Proc. Natl. Acad. Sci. U. S. A
  doi: 10.1073/pnas.0709259105
– volume: 31
  start-page: 549
  year: 2010
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib23
  article-title: Neuronal gene expression in non-demented individuals with intermediate Alzheimer's disease neuropathology
  publication-title: Neurobiol. Aging
  doi: 10.1016/j.neurobiolaging.2008.05.013
– volume: 41
  start-page: 1088
  year: 2009
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib16
  article-title: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
  publication-title: Nat. Genet
  doi: 10.1038/ng.440
– volume: 32
  start-page: 3
  year: 1977
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib21
  article-title: Patterns of astroglial hypertrophy and neuronal degeneration in the hippocampus of ages, memory-deficient rats
  publication-title: J. Gerontol.
  doi: 10.1093/geronj/32.1.3
– volume: 14
  start-page: 1590
  year: 1995
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib37
  article-title: Mice lacking glial fibrillary acidic protein display astrocytes devoid of intermediate filaments but develop and reproduce normally
  publication-title: Embo J
  doi: 10.1002/j.1460-2075.1995.tb07147.x
– volume: 6
  start-page: 35
  year: 2009
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib43
  article-title: Expression of complement system components during aging and amyloid deposition in APP transgenic mice
  publication-title: J. Neuroinflammation
  doi: 10.1186/1742-2094-6-35
– volume: 103
  start-page: 13606
  year: 2006
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib49
  article-title: Evolution of increased glia-neuron ratios in the human frontal cortex
  publication-title: Proc. Natl. Acad. Sci. U. S. A
  doi: 10.1073/pnas.0605843103
– volume: 34
  start-page: 939
  year: 1984
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib29
  article-title: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
  publication-title: Neurology
  doi: 10.1212/WNL.34.7.939
– volume: 16
  start-page: 877
  year: 1996
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib57
  article-title: Metabolic coupling between glia and neurons
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.16-03-00877.1996
– volume: 42
  start-page: 85
  year: 1997
  ident: 10.1016/j.neurobiolaging.2014.09.027_bib30
  article-title: Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.410420114
– reference: 16938869 - Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13606-11
– reference: 10714659 - Arch Neurol. 2000 Mar;57(3):339-44
– reference: 12734009 - Genome Biol. 2003;4(5):P3
– reference: 11425920 - J Neurosci. 2001 Jul 1;21(13):4923-30
– reference: 18771761 - Am J Hum Genet. 2008 Sep;83(3):415-23
– reference: 19734902 - Nat Genet. 2009 Oct;41(10):1088-93
– reference: 2817081 - Am J Pathol. 1989 Nov;135(5):827-34
– reference: 4088432 - Neurochem Res. 1985 Dec;10(12):1567-76
– reference: 18171944 - J Neurosci. 2008 Jan 2;28(1):264-78
– reference: 18572275 - Neurobiol Aging. 2010 Apr;31(4):549-66
– reference: 23351786 - Mol Autism. 2013 Jan 25;4(1):3
– reference: 19196155 - Biochemistry. 2009 Apr 7;48(13):2868-77
– reference: 23821340 - J Neuroimmune Pharmacol. 2013 Sep;8(4):824-39
– reference: 20012068 - Acta Neuropathol. 2010 Jan;119(1):7-35
– reference: 830730 - J Gerontol. 1977 Jan;32(1):3-12
– reference: 17090670 - Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17402-7
– reference: 20979621 - Genome Biol. 2010;11(10):R106
– reference: 8670638 - Cereb Cortex. 1996 Jan-Feb;6(1):50-61
– reference: 18270320 - Physiol Genomics. 2008 Apr 22;33(2):240-56
– reference: 24446231 - Glia. 2014 Apr;62(4):493-503
– reference: 11986126 - Am J Psychiatry. 2002 May;159(5):738-45
– reference: 727153 - Am J Anat. 1978 Dec;153(4):537-43
– reference: 23824488 - Brain. 2013 Aug;136(Pt 8):2510-26
– reference: 462184 - Science. 1979 Aug 17;205(4407):723-5
– reference: 8667045 - J Nucl Med. 1996 Feb;37(2):201-8
– reference: 22996553 - Nature. 2012 Sep 20;489(7416):391-9
– reference: 15495269 - J Pathol. 2004 Nov;204(4):428-37
– reference: 22100406 - Cell Metab. 2011 Dec 7;14(6):768-79
– reference: 1759558 - Acta Neuropathol. 1991;82(4):239-59
– reference: 14688411 - Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):284-9
– reference: 16849325 - J Biol Chem. 2006 Sep 29;281(39):29096-104
– reference: 18332434 - Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4441-6
– reference: 11788046 - DNA Cell Biol. 2001 Nov;20(11):683-95
– reference: 8994059 - J Neurosci. 1997 Feb 1;17(3):1046-54
– reference: 21750375 - J Alzheimers Dis. 2011;27(1):75-87
– reference: 22990117 - Sci Signal. 2012;5(242):re5
– reference: 22047170 - J Neuroinflammation. 2011;8:150
– reference: 21444724 - Mol Cell Biol. 2011 Jun;31(11):2287-98
– reference: 23097428 - RNA. 2012 Dec;18(12):2269-76
– reference: 23954174 - Neurobiol Aging. 2014 Jan;35(1):1-14
– reference: 16001427 - Glia. 2005 Dec;52(4):289-300
– reference: 19734903 - Nat Genet. 2009 Oct;41(10):1094-9
– reference: 16646834 - Stat Appl Genet Mol Biol. 2005;4:Article17
– reference: 7737111 - EMBO J. 1995 Apr 18;14(8):1590-8
– reference: 11248079 - Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3334-9
– reference: 21756998 - J Chem Neuroanat. 2011 Oct;42(2):118-26
– reference: 19917141 - J Neuroinflammation. 2009;6:35
– reference: 11059815 - Neurochem Res. 2000 Oct;25(9-10):1439-51
– reference: 9225689 - Ann Neurol. 1997 Jul;42(1):85-94
– reference: 12045142 - Genome Res. 2002 Jun;12(6):885-93
– reference: 6610841 - Neurology. 1984 Jul;34(7):939-44
– reference: 14522144 - Trends Neurosci. 2003 Oct;26(10):523-30
– reference: 19289445 - Bioinformatics. 2009 May 1;25(9):1105-11
– reference: 19782411 - Trends Neurosci. 2009 Dec;32(12):638-47
– reference: 10850730 - Alzheimer Dis Assoc Disord. 2000;14 Suppl 1:S47-53
– reference: 8592548 - N Engl J Med. 1996 Mar 21;334(12):752-8
– reference: 16493230 - Alzheimer Dis Assoc Disord. 2006 Jan-Mar;20(1):6-15
– reference: 19849849 - Mol Neurodegener. 2009 Oct 22;4:41
– reference: 21705112 - Neurobiol Aging. 2011 Oct;32(10):1795-807
– reference: 18614015 - Cell. 2008 Jul 11;134(1):112-23
– reference: 7938003 - Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10625-9
– reference: 22383036 - Nat Protoc. 2012 Mar;7(3):562-78
– reference: 8558256 - J Neurosci. 1996 Feb 1;16(3):877-85
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Snippet Alzheimer's disease (AD) is characterized by deficits in cerebral metabolic rates of glucose in the posterior cingulate (PC) and precuneus in AD subjects, and...
Abstract Alzheimer's disease (AD) is characterized by deficits in cerebral metabolic rates of glucose in the posterior cingulate (PC) and precuneus in AD...
Alzheimer’s disease (AD) is characterized by deficits in cerebral metabolic rates of glucose in the posterior cingulate (PC) and precuneus in AD subjects, and...
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SubjectTerms Aged
Aged, 80 and over
Alzheimer Disease - genetics
Alzheimer Disease - immunology
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Alzheimer's disease
Amyloid beta-Peptides - genetics
Amyloid beta-Peptides - metabolism
Antigens, Differentiation, B-Lymphocyte - physiology
Astrocytes
Astrocytes - immunology
Astrocytes - metabolism
Brain - cytology
Brain - immunology
Clusterin - physiology
Complement C3 - physiology
Electron Transport Complex IV - genetics
Electron Transport Complex IV - metabolism
Energy Metabolism - genetics
Female
Gene Expression - genetics
Histocompatibility Antigens Class II - physiology
Humans
Immune response
Immunity, Cellular - genetics
Internal Medicine
Male
Mitochondria
Mitochondria - genetics
Mitochondria - metabolism
Neurology
Posterior cingulate
Protein-Serine-Threonine Kinases - genetics
Protein-Serine-Threonine Kinases - metabolism
RNA sequencing
Sequence Analysis, RNA
tRNA Methyltransferases - genetics
tRNA Methyltransferases - metabolism
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Title Alzheimer's disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes
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