Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment
Cerebrovascular disease (CVD) and amyloid burden are the most frequent pathologies in subjects with cognitive impairment. However, the relationship between CVD, amyloid burden, and cognition are largely unknown. We aimed to evaluate whether CVD (lacunes, white matter hyperintensities, and microbleed...
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| Published in | Neurobiology of aging Vol. 35; no. 1; pp. 254 - 260 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.01.2014
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0197-4580 1558-1497 1558-1497 |
| DOI | 10.1016/j.neurobiolaging.2013.06.026 |
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| Abstract | Cerebrovascular disease (CVD) and amyloid burden are the most frequent pathologies in subjects with cognitive impairment. However, the relationship between CVD, amyloid burden, and cognition are largely unknown. We aimed to evaluate whether CVD (lacunes, white matter hyperintensities, and microbleeds) and amyloid burden (Pittsburgh compound B [PiB] retention ratio) contribute to cognitive impairment independently or interactively. We recruited 136 patients with subcortical vascular cognitive impairment who underwent magnetic resonance imaging, PiB–positron emission tomography, and neuropsychological testing. The number of lacunes was associated with memory, frontal dysfunctions, and disease severity. The volume of white matter hyperintensities and the PiB retention ratio were associated only with memory dysfunction. There was no direct correlation between CVD markers and PiB retention ratio except that the number of lacunes was negatively correlated with the PiB retention ratio. In addition, there were no interactive effects of CVD and PiB retention ratio on cognition. Our findings suggest that CVD and amyloid burden contribute independently and not interactively to specific patterns of cognitive dysfunction in patients with subcortical vascular cognitive impairment. |
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| AbstractList | Cerebrovascular disease (CVD) and amyloid burden are the most frequent pathologies in subjects with cognitive impairment. However, the relationship between CVD, amyloid burden, and cognition are largely unknown. We aimed to evaluate whether CVD (lacunes, white matter hyperintensities, and microbleeds) and amyloid burden (Pittsburgh compound B [PiB] retention ratio) contribute to cognitive impairment independently or interactively. We recruited 136 patients with subcortical vascular cognitive impairment who underwent magnetic resonance imaging, PiB–positron emission tomography, and neuropsychological testing. The number of lacunes was associated with memory, frontal dysfunctions, and disease severity. The volume of white matter hyperintensities and the PiB retention ratio were associated only with memory dysfunction. There was no direct correlation between CVD markers and PiB retention ratio except that the number of lacunes was negatively correlated with the PiB retention ratio. In addition, there were no interactive effects of CVD and PiB retention ratio on cognition. Our findings suggest that CVD and amyloid burden contribute independently and not interactively to specific patterns of cognitive dysfunction in patients with subcortical vascular cognitive impairment. Cerebrovascular disease (CVD) and amyloid burden are the most frequent pathologies in subjects with cognitive impairment. However, the relationship between CVD, amyloid burden, and cognition are largely unknown. We aimed to evaluate whether CVD (lacunes, white matter hyperintensities, and microbleeds) and amyloid burden (Pittsburgh compound B [PiB] retention ratio) contribute to cognitive impairment independently or interactively. We recruited 136 patients with subcortical vascular cognitive impairment who underwent magnetic resonance imaging, PiB-positron emission tomography, and neuropsychological testing. The number of lacunes was associated with memory, frontal dysfunctions, and disease severity. The volume of white matter hyperintensities and the PiB retention ratio were associated only with memory dysfunction. There was no direct correlation between CVD markers and PiB retention ratio except that the number of lacunes was negatively correlated with the PiB retention ratio. In addition, there were no interactive effects of CVD and PiB retention ratio on cognition. Our findings suggest that CVD and amyloid burden contribute independently and not interactively to specific patterns of cognitive dysfunction in patients with subcortical vascular cognitive impairment.Cerebrovascular disease (CVD) and amyloid burden are the most frequent pathologies in subjects with cognitive impairment. However, the relationship between CVD, amyloid burden, and cognition are largely unknown. We aimed to evaluate whether CVD (lacunes, white matter hyperintensities, and microbleeds) and amyloid burden (Pittsburgh compound B [PiB] retention ratio) contribute to cognitive impairment independently or interactively. We recruited 136 patients with subcortical vascular cognitive impairment who underwent magnetic resonance imaging, PiB-positron emission tomography, and neuropsychological testing. The number of lacunes was associated with memory, frontal dysfunctions, and disease severity. The volume of white matter hyperintensities and the PiB retention ratio were associated only with memory dysfunction. There was no direct correlation between CVD markers and PiB retention ratio except that the number of lacunes was negatively correlated with the PiB retention ratio. In addition, there were no interactive effects of CVD and PiB retention ratio on cognition. Our findings suggest that CVD and amyloid burden contribute independently and not interactively to specific patterns of cognitive dysfunction in patients with subcortical vascular cognitive impairment. Abstract Cerebrovascular disease (CVD) and amyloid burden are the most frequent pathologies in subjects with cognitive impairment. However, the relationship between CVD, amyloid burden, and cognition are largely unknown. We aimed to evaluate whether CVD (lacunes, white matter hyperintensities, and microbleeds) and amyloid burden (Pittsburgh compound B [PiB] retention ratio) contribute to cognitive impairment independently or interactively. We recruited 136 patients with subcortical vascular cognitive impairment who underwent magnetic resonance imaging, PiB–positron emission tomography, and neuropsychological testing. The number of lacunes was associated with memory, frontal dysfunctions, and disease severity. The volume of white matter hyperintensities and the PiB retention ratio were associated only with memory dysfunction. There was no direct correlation between CVD markers and PiB retention ratio except that the number of lacunes was negatively correlated with the PiB retention ratio. In addition, there were no interactive effects of CVD and PiB retention ratio on cognition. Our findings suggest that CVD and amyloid burden contribute independently and not interactively to specific patterns of cognitive dysfunction in patients with subcortical vascular cognitive impairment. |
| Author | Shin, Ji Soo Kim, Jae Seung Ye, Byoung Seok Kim, Sook Hui Kim, Changsoo Kim, Hee Jin Ewers, Michael Yoon, Cindy W. Kim, Sung Tae Lee, Jong Min Lee, Kyung-Han Kim, Geon Ha Jeon, Seun Lee, Jae-Hong Noh, Young Cho, Hanna Oh, Seung Jun Kim, Chi Hun Choe, Yearn Seong Seo, Sang Won Werring, David J. Park, Jae-Hyun Na, Duk L. Weiner, Michael W. |
| AuthorAffiliation | e Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea i Pfizer Korea, Seoul, South Korea m Institute for Stroke and Dementia Research, Ludwig-Maximilians-University, Munich, Germany p Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea o Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA, USA a Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea k Department of Neurology, Gachon University Gil Medical Center, Incheon, South Korea n Department of Medicine, Radiology and Psychiatry, University of California, San Francisco, San Francisco, CA, USA j Department of Psychology, University of Cambridge, CB2 3EB, UK h Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea q Department of Brain Repair and Reh |
| AuthorAffiliation_xml | – name: j Department of Psychology, University of Cambridge, CB2 3EB, UK – name: k Department of Neurology, Gachon University Gil Medical Center, Incheon, South Korea – name: f Department of Biomedical Engineering, Hanyang University, Seoul, South Korea – name: l Department of Neurology, Inha University School of Medicine, Incheon, Korea – name: o Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA, USA – name: m Institute for Stroke and Dementia Research, Ludwig-Maximilians-University, Munich, Germany – name: n Department of Medicine, Radiology and Psychiatry, University of California, San Francisco, San Francisco, CA, USA – name: d Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, South Korea – name: q Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK – name: b Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, South Korea – name: p Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea – name: c Department of Neurology, Konkuk University Hospital, Konkuk University School of Medicine, Seoul, South Korea – name: g Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea – name: i Pfizer Korea, Seoul, South Korea – name: e Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea – name: a Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea – name: h Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23932881$$D View this record in MEDLINE/PubMed |
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| Keywords | White matter hyperintensity Microbleed Pittsburgh compound B Amyloid Cognition Lacune Cerebrovascular disease |
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| Snippet | Cerebrovascular disease (CVD) and amyloid burden are the most frequent pathologies in subjects with cognitive impairment. However, the relationship between... Abstract Cerebrovascular disease (CVD) and amyloid burden are the most frequent pathologies in subjects with cognitive impairment. However, the relationship... |
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| SubjectTerms | Aged Aged, 80 and over Amyloid Amyloid beta-Peptides - metabolism Aniline Compounds Brain - diagnostic imaging Brain - pathology Cerebrovascular disease Cerebrovascular Disorders - complications Cognition Cognition Disorders - diagnosis Cognition Disorders - etiology Cognition Disorders - metabolism Cognition Disorders - pathology Female Humans Internal Medicine Lacune Magnetic Resonance Imaging Male Memory Disorders - diagnosis Memory Disorders - etiology Memory Disorders - pathology Microbleed Neurology Neuropsychological Tests Pittsburgh compound B Positron-Emission Tomography Thiazoles White matter hyperintensity |
| Title | Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment |
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