OptiSelect and EnShap: Integrating machine learning and game theory for ischemic stroke prediction

• Published in: PloS one Vol. 20; no. 8; p. e0328967
• Main Authors: Chakraborty, Pritam, Bandyopadhyay, Anjan, Parui, Sricheta, Swain, Sujata, Banerjee, Partha Sarathy, Si, Tapas, Qin, Hong, Mallik, Saurav
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13.08.2025; Public Library of Science (PLoS)
• Subjects: Accuracy; Algorithms; Artificial intelligence; Brain research; Classification; Clinical medicine; Computer and Information Sciences; Datasets; Decision making; Decision Trees; Deep learning; Diagnosis; Ensemble learning; Feature selection; Game Theory; Health aspects; Humans; Innovations; Ischemia; Ischemic Stroke - diagnosis; Kernel functions; Learning algorithms; Logistic Models; Machine Learning; Medical prognosis; Medicine and Health Sciences; Mortality; Neural networks; Neural Networks, Computer; Patients; Performance evaluation; Physical Sciences; Predictions; Quantum physics; Regression analysis; Research and Analysis Methods; Risk assessment; Risk factors; Stroke; Stroke (Disease); Support Vector Machine; Support vector machines; India
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0328967

Stroke analysis using game theory and machine learning techniques. The study investigates the use of the Shapley value in predictive ischemic brain stroke analysis. Initially, preference algorithms identify the most important features in various machine learning models, including logistic regression, K-nearest neighbor, decision tree, support vector machine (linear kernel), support vector machine ( RBF kernel), neural networks, etc. For each sample, the top 3, 4, and 5 features are evaluated and selected to evaluate their performance. The Shapley value method was used to rank the models using their best four features based on their predictive capabilities. As a result, better-performing models were found. Afterward, ensemble machine learning methods were used to find the most accurate predictions using the top 5 models ranked by shapely value. The research demonstrates an impressive accuracy of 92.39%, surpassing other proposed models’ performance. This study highlights the utility of combining game theory and machine learning in Ischemic stroke prediction and the potential of ensemble learning methods to increase predictive accuracy in ischemic stroke analysis.