Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels
Acid-sensing ion channels have important functions in physiology and pathology, but the molecular composition of acid-activated chloride channels had remained unclear. We now used a genome-wide siRNA screen to molecularly identify the widely expressed acid-sensitive outwardly-rectifying anion channe...
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| Published in | eLife Vol. 8 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
eLife Science Publications, Ltd
18.07.2019
eLife Sciences Publications Ltd eLife Sciences Publications, Ltd |
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| Online Access | Get full text |
| ISSN | 2050-084X 2050-084X |
| DOI | 10.7554/eLife.49187 |
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| Abstract | Acid-sensing ion channels have important functions in physiology and pathology, but the molecular composition of acid-activated chloride channels had remained unclear. We now used a genome-wide siRNA screen to molecularly identify the widely expressed acid-sensitive outwardly-rectifying anion channel PAORAC/ASOR. ASOR is formed by TMEM206 proteins which display two transmembrane domains (TMs) and are expressed at the plasma membrane. Ion permeation-changing mutations along the length of TM2 and at the end of TM1 suggest that these segments line ASOR’s pore. While not belonging to a gene family, TMEM206 has orthologs in probably all vertebrates. Currents from evolutionarily distant orthologs share activation by protons, a feature essential for ASOR’s role in acid-induced cell death. TMEM206 defines a novel class of ion channels. Its identification will help to understand its physiological roles and the diverse ways by which anion-selective pores can be formed. |
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| AbstractList | Acid-sensing ion channels have important functions in physiology and pathology, but the molecular composition of acid-activated chloride channels had remained unclear. We now used a genome-wide siRNA screen to molecularly identify the widely expressed acid-sensitive outwardly-rectifying anion channel PAORAC/ASOR. ASOR is formed by TMEM206 proteins which display two transmembrane domains (TMs) and are expressed at the plasma membrane. Ion permeation-changing mutations along the length of TM2 and at the end of TM1 suggest that these segments line ASOR's pore. While not belonging to a gene family, TMEM206 has orthologs in probably all vertebrates. Currents from evolutionarily distant orthologs share activation by protons, a feature essential for ASOR's role in acid-induced cell death. TMEM206 defines a novel class of ion channels. Its identification will help to understand its physiological roles and the diverse ways by which anion-selective pores can be formed. Acid-sensing ion channels have important functions in physiology and pathology, but the molecular composition of acid-activated chloride channels had remained unclear. We now used a genome-wide siRNA screen to molecularly identify the widely expressed acid-sensitive outwardly-rectifying anion channel PAORAC/ASOR. ASOR is formed by TMEM206 proteins which display two transmembrane domains (TMs) and are expressed at the plasma membrane. Ion permeation-changing mutations along the length of TM2 and at the end of TM1 suggest that these segments line ASOR's pore. While not belonging to a gene family, TMEM206 has orthologs in probably all vertebrates. Currents from evolutionarily distant orthologs share activation by protons, a feature essential for ASOR's role in acid-induced cell death. TMEM206 defines a novel class of ion channels. Its identification will help to understand its physiological roles and the diverse ways by which anion-selective pores can be formed.Acid-sensing ion channels have important functions in physiology and pathology, but the molecular composition of acid-activated chloride channels had remained unclear. We now used a genome-wide siRNA screen to molecularly identify the widely expressed acid-sensitive outwardly-rectifying anion channel PAORAC/ASOR. ASOR is formed by TMEM206 proteins which display two transmembrane domains (TMs) and are expressed at the plasma membrane. Ion permeation-changing mutations along the length of TM2 and at the end of TM1 suggest that these segments line ASOR's pore. While not belonging to a gene family, TMEM206 has orthologs in probably all vertebrates. Currents from evolutionarily distant orthologs share activation by protons, a feature essential for ASOR's role in acid-induced cell death. TMEM206 defines a novel class of ion channels. Its identification will help to understand its physiological roles and the diverse ways by which anion-selective pores can be formed. |
| Audience | Academic |
| Author | Lazarow, Katina von Kries, Jens Peter Blin, Sandy Jentsch, Thomas J Daubitz, Tony Ullrich, Florian |
| Author_xml | – sequence: 1 givenname: Florian orcidid: 0000-0002-1153-2040 surname: Ullrich fullname: Ullrich, Florian organization: Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany, Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin, Germany – sequence: 2 givenname: Sandy orcidid: 0000-0001-5762-5149 surname: Blin fullname: Blin, Sandy organization: Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany, Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin, Germany – sequence: 3 givenname: Katina surname: Lazarow fullname: Lazarow, Katina organization: Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany – sequence: 4 givenname: Tony surname: Daubitz fullname: Daubitz, Tony organization: Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany, Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin, Germany – sequence: 5 givenname: Jens Peter surname: von Kries fullname: von Kries, Jens Peter organization: Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany – sequence: 6 givenname: Thomas J orcidid: 0000-0002-3509-2553 surname: Jentsch fullname: Jentsch, Thomas J organization: Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany, Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin, Germany, NeuroCure Cluster of Excellence, Charité Universitätsmedizin, Berlin, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31318332$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1007/s00424-015-1786-1 10.1152/physrev.00022.2007 10.1016/j.exger.2010.09.005 10.1007/s00424-006-0193-z 10.1016/j.cell.2014.03.024 10.1038/nature07313 10.1038/378730a0 10.1152/ajpcell.00549.2002 10.1016/j.cell.2008.09.003 10.1126/science.aav9739 10.4161/chan.27748 10.1038/nature06907 10.1016/j.bbamem.2014.10.008 10.1038/ncomms1409 10.1016/0014-4827(88)90191-7 10.1038/s41568-018-0030-7 10.1152/ajpregu.1991.260.3.R581 10.1002/ar.23996 10.1007/s10555-018-09777-y 10.1038/386173a0 10.1113/jphysiol.2006.124719 10.1016/j.bbagen.2017.05.004 10.1016/0028-3908(96)00129-3 10.1038/nature03860 10.1016/S0092-8674(01)00206-9 10.1074/jbc.M301096200 10.1016/0076-6879(92)07008-c 10.1186/1744-8069-4-32 10.1529/biophysj.106.102319 10.1016/j.neuropharm.2014.12.016 10.1016/j.bbrc.2008.04.090 10.1016/j.cell.2014.01.011 10.1152/physrev.00029.2001 10.1038/nrn3529 10.1038/348510a0 10.1038/nature06163 10.1113/jphysiol.2005.089888 10.2174/138945012799201685 10.1007/s00424-013-1296-y 10.1073/pnas.95.14.8075 10.1152/physrev.00047.2017 10.1007/s00232-005-0800-5 10.1016/j.cell.2004.08.026 10.1126/science.1213760 10.1073/pnas.052692999 10.1152/ajprenal.1983.244.1.F89 10.1186/s13041-018-0369-4 10.1126/science.aau0236 10.1126/science.1163518 10.1016/j.bbrc.2013.01.090 10.1016/j.neuropharm.2014.12.010 10.1038/35042597 10.1152/ajpheart.00965.2005 10.1186/1475-2867-13-89 10.1111/bph.12521 10.1038/nm1668 10.1371/journal.pbio.0060013 10.1126/science.1252826 |
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| Keywords | acidotoxicity naked mole rat PAC cell biology Cl- channel proton-activated ICl,H structural biology molecular biophysics human |
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| References | Voss (bib51) 2014; 344 Hartzell (bib20) 2008; 88 Huang (bib22) 2015; 94 Gillies (bib16) 2018; 18 Jentsch (bib27) 2007; 578 Drews (bib10) 2014; 171 Capurro (bib7) 2015; 1848 Li (bib32) 2011; 2 Ma (bib34) 2008; 371 Waldmann (bib52) 1997; 386 Yang (bib57) 2008; 455 Park (bib38) 2008; 6 Kato (bib29) 2013; 13 Nedergaard (bib35) 1991; 260 Husson (bib23) 2018; 11 Lingueglia (bib33) 1995; 378 Caputo (bib8) 2008; 322 Graves (bib17) 2008; 453 Jentsch (bib26) 2002; 82 Fu (bib14) 2013; 432 Capó-Aponte (bib6) 2005; 207 Funk (bib15) 2008; 4 Bengele (bib4) 1983; 244 Gründer (bib18) 2015; 94 Valinsky (bib50) 2017; 1861 Qiu (bib40) 2014; 157 Eigenbrod (bib12) 2019; 364 Smith (bib47) 2011; 334 Holmgren (bib21) 1996; 35 Edrey (bib11) 2011; 46 Arosio (bib1) 2007; 93 Scheel (bib44) 2005; 436 Sun (bib48) 2002; 99 Wang (bib53) 2007; 454 Neher (bib36) 1992; 207 Thews (bib49) 2019; 38 Baconguis (bib3) 2014; 156 Yamamoto (bib56) 2006; 290 Lambert (bib31) 2005; 567 Schroeder (bib45) 2008; 134 Jasti (bib24) 2007; 449 Piwon (bib39) 2000; 408 Nobles (bib37) 2004; 287 Browe (bib5) 2018 Auzanneau (bib2) 2003; 278 Chu (bib9) 2012; 13 Sato-Numata (bib43) 2016; 468 Xiong (bib55) 2004; 118 Günther (bib19) 1998; 95 Yang (bib58) 2019; 364 Jentsch (bib28) 2018; 98 Sato-Numata (bib42) 2014; 8 Wemmie (bib54) 2013; 14 Sato-Numata (bib41) 2013; 465 Jentsch (bib25) 1990; 348 Kornak (bib30) 2001; 104 Friese (bib13) 2007; 13 Silver (bib46) 1988; 175 |
| References_xml | – volume: 468 start-page: 795 year: 2016 ident: bib43 article-title: Distinct pharmacological and molecular properties of the acid-sensitive outwardly rectifying (ASOR) anion channel from those of the volume-sensitive outwardly rectifying (VSOR) anion channel publication-title: Pflügers Archiv - European Journal of Physiology doi: 10.1007/s00424-015-1786-1 – volume: 88 start-page: 639 year: 2008 ident: bib20 article-title: Molecular physiology of bestrophins: multifunctional membrane proteins linked to Best disease and other retinopathies publication-title: Physiological Reviews doi: 10.1152/physrev.00022.2007 – volume: 46 start-page: 116 year: 2011 ident: bib11 article-title: Endocrine function and neurobiology of the longest-living rodent, the naked mole-rat publication-title: Experimental Gerontology doi: 10.1016/j.exger.2010.09.005 – volume: 454 start-page: 223 year: 2007 ident: bib53 article-title: Role of acid-sensitive outwardly rectifying anion channels in acidosis-induced cell death in human epithelial cells publication-title: Pflügers Archiv - European Journal of Physiology doi: 10.1007/s00424-006-0193-z – volume: 157 start-page: 447 year: 2014 ident: bib40 article-title: SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel publication-title: Cell doi: 10.1016/j.cell.2014.03.024 – volume: 455 start-page: 1210 year: 2008 ident: bib57 article-title: TMEM16A confers receptor-activated calcium-dependent chloride conductance publication-title: Nature doi: 10.1038/nature07313 – volume: 378 start-page: 730 year: 1995 ident: bib33 article-title: Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel publication-title: Nature doi: 10.1038/378730a0 – volume: 287 start-page: C1426 year: 2004 ident: bib37 article-title: Extracellular acidification elicits a chloride current that shares characteristics with ICl(swell) publication-title: American Journal of Physiology. Cell Physiology doi: 10.1152/ajpcell.00549.2002 – volume: 134 start-page: 1019 year: 2008 ident: bib45 article-title: Expression cloning of TMEM16A as a calcium-activated chloride channel subunit publication-title: Cell doi: 10.1016/j.cell.2008.09.003 – volume: 364 start-page: 395 year: 2019 ident: bib58 article-title: PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel publication-title: Science doi: 10.1126/science.aav9739 – volume: 8 start-page: 278 year: 2014 ident: bib42 article-title: Temperature sensitivity of acid-sensitive outwardly rectifying (ASOR) anion channels in cortical neurons is involved in hypothermic neuroprotection against acidotoxic necrosis publication-title: Channels doi: 10.4161/chan.27748 – volume: 453 start-page: 788 year: 2008 ident: bib17 article-title: The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes publication-title: Nature doi: 10.1038/nature06907 – volume: 1848 start-page: 105 year: 2015 ident: bib7 article-title: Functional analysis of acid-activated cl− channels: properties and mechanisms of regulation publication-title: Biochimica Et Biophysica Acta (BBA) - Biomembranes doi: 10.1016/j.bbamem.2014.10.008 – volume: 2 year: 2011 ident: bib32 article-title: Outlines of the pore in open and closed conformations describe the gating mechanism of ASIC1 publication-title: Nature Communications doi: 10.1038/ncomms1409 – volume: 175 start-page: 266 year: 1988 ident: bib46 article-title: Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts publication-title: Experimental Cell Research doi: 10.1016/0014-4827(88)90191-7 – volume: 18 start-page: 576 year: 2018 ident: bib16 article-title: Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow publication-title: Nature Reviews Cancer doi: 10.1038/s41568-018-0030-7 – volume: 260 start-page: R581 year: 1991 ident: bib35 article-title: Dynamics of interstitial and intracellular pH in evolving brain infarct publication-title: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology doi: 10.1152/ajpregu.1991.260.3.R581 – year: 2018 ident: bib5 article-title: Naked Mole-Rats: blind, naked, and feeling no pain publication-title: The Anatomical Record doi: 10.1002/ar.23996 – volume: 38 start-page: 113 year: 2019 ident: bib49 article-title: Tumor pH and metastasis: a malignant process beyond hypoxia publication-title: Cancer and Metastasis Reviews doi: 10.1007/s10555-018-09777-y – volume: 386 start-page: 173 year: 1997 ident: bib52 article-title: A proton-gated cation channel involved in acid-sensing publication-title: Nature doi: 10.1038/386173a0 – volume: 578 start-page: 633 year: 2007 ident: bib27 article-title: Chloride and the endosomal-lysosomal pathway: emerging roles of CLC chloride transporters publication-title: The Journal of Physiology doi: 10.1113/jphysiol.2006.124719 – volume: 1861 start-page: 2007 year: 2017 ident: bib50 article-title: Characterization of constitutive and acid-induced outwardly rectifying chloride currents in immortalized mouse distal tubular cells publication-title: Biochimica Et Biophysica Acta (BBA) - General Subjects doi: 10.1016/j.bbagen.2017.05.004 – volume: 35 start-page: 797 year: 1996 ident: bib21 article-title: On the use of thiol-modifying agents to determine channel topology publication-title: Neuropharmacology doi: 10.1016/0028-3908(96)00129-3 – volume: 436 start-page: 424 year: 2005 ident: bib44 article-title: Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins publication-title: Nature doi: 10.1038/nature03860 – volume: 104 start-page: 205 year: 2001 ident: bib30 article-title: Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man publication-title: Cell doi: 10.1016/S0092-8674(01)00206-9 – volume: 278 start-page: 19230 year: 2003 ident: bib2 article-title: A novel voltage-dependent chloride current activated by extracellular acidic pH in cultured rat Sertoli cells publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M301096200 – volume: 207 start-page: 123 year: 1992 ident: bib36 article-title: Correction for liquid junction potentials in patch clamp experiments publication-title: Methods in Enzymology doi: 10.1016/0076-6879(92)07008-c – volume: 4 year: 2008 ident: bib15 article-title: Modulation of chloride homeostasis by inflammatory mediators in dorsal root ganglion neurons publication-title: Molecular Pain doi: 10.1186/1744-8069-4-32 – volume: 93 start-page: 232 year: 2007 ident: bib1 article-title: Spectroscopic and structural study of proton and halide ion cooperative binding to gfp publication-title: Biophysical Journal doi: 10.1529/biophysj.106.102319 – volume: 94 start-page: 9 year: 2015 ident: bib18 article-title: Biophysical properties of acid-sensing ion channels (ASICs) publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2014.12.016 – volume: 371 start-page: 437 year: 2008 ident: bib34 article-title: A proton-activated, outwardly rectifying chloride channel in human umbilical vein endothelial cells publication-title: Biochemical and Biophysical Research Communications doi: 10.1016/j.bbrc.2008.04.090 – volume: 156 start-page: 717 year: 2014 ident: bib3 article-title: X-ray structure of acid-sensing ion channel 1-snake toxin complex reveals open state of a Na+-selective channel publication-title: Cell doi: 10.1016/j.cell.2014.01.011 – volume: 82 start-page: 503 year: 2002 ident: bib26 article-title: Molecular structure and physiological function of chloride channels publication-title: Physiological Reviews doi: 10.1152/physrev.00029.2001 – volume: 14 start-page: 461 year: 2013 ident: bib54 article-title: Acid-sensing ion channels in pain and disease publication-title: Nature Reviews Neuroscience doi: 10.1038/nrn3529 – volume: 348 start-page: 510 year: 1990 ident: bib25 article-title: Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes publication-title: Nature doi: 10.1038/348510a0 – volume: 449 start-page: 316 year: 2007 ident: bib24 article-title: Structure of acid-sensing ion channel 1 at 1.9 Å resolution and low pH publication-title: Nature doi: 10.1038/nature06163 – volume: 567 start-page: 191 year: 2005 ident: bib31 article-title: Characterization of a proton-activated, outwardly rectifying anion channel publication-title: The Journal of Physiology doi: 10.1113/jphysiol.2005.089888 – volume: 13 start-page: 263 year: 2012 ident: bib9 article-title: Physiological and pathological functions of acid-sensing ion channels in the central nervous system publication-title: Current Drug Targets doi: 10.2174/138945012799201685 – volume: 465 start-page: 1535 year: 2013 ident: bib41 article-title: Acid-sensitive outwardly rectifying (ASOR) anion channels in human epithelial cells are highly sensitive to temperature and independent of ClC-3 publication-title: Pflügers Archiv - European Journal of Physiology doi: 10.1007/s00424-013-1296-y – volume: 95 start-page: 8075 year: 1998 ident: bib19 article-title: ClC-5, the chloride channel mutated in Dent's disease, colocalizes with the proton pump in endocytotically active kidney cells publication-title: PNAS doi: 10.1073/pnas.95.14.8075 – volume: 98 start-page: 1493 year: 2018 ident: bib28 article-title: CLC chloride channels and transporters: structure, function, physiology, and disease publication-title: Physiological Reviews doi: 10.1152/physrev.00047.2017 – volume: 207 start-page: 11 year: 2005 ident: bib6 article-title: Characterization of regulatory volume behavior by fluorescence quenching in human corneal epithelial cells publication-title: Journal of Membrane Biology doi: 10.1007/s00232-005-0800-5 – volume: 118 start-page: 687 year: 2004 ident: bib55 article-title: Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels publication-title: Cell doi: 10.1016/j.cell.2004.08.026 – volume: 334 start-page: 1557 year: 2011 ident: bib47 article-title: The molecular basis of acid insensitivity in the African naked mole-rat publication-title: Science doi: 10.1126/science.1213760 – volume: 99 start-page: 4008 year: 2002 ident: bib48 article-title: The vitelliform macular dystrophy protein defines a new family of chloride channels publication-title: PNAS doi: 10.1073/pnas.052692999 – volume: 244 start-page: F89 year: 1983 ident: bib4 article-title: Effect of respiratory acidosis on acidification by the medullary collecting duct publication-title: American Journal of Physiology-Renal Physiology doi: 10.1152/ajprenal.1983.244.1.F89 – volume: 11 year: 2018 ident: bib23 article-title: Naked mole-rat cortical neurons are resistant to acid-induced cell death publication-title: Molecular Brain doi: 10.1186/s13041-018-0369-4 – volume: 364 start-page: 852 year: 2019 ident: bib12 article-title: Rapid molecular evolution of pain insensitivity in multiple African rodents publication-title: Science doi: 10.1126/science.aau0236 – volume: 322 start-page: 590 year: 2008 ident: bib8 article-title: TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity publication-title: Science doi: 10.1126/science.1163518 – volume: 432 start-page: 701 year: 2013 ident: bib14 article-title: Extracellular acidic pH-activated, outward rectifying chloride currents can be regulated by reactive oxygen species in human THP-1 monocytes publication-title: Biochemical and Biophysical Research Communications doi: 10.1016/j.bbrc.2013.01.090 – volume: 94 start-page: 42 year: 2015 ident: bib22 article-title: Two aspects of ASIC function: synaptic plasticity and neuronal injury publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2014.12.010 – volume: 408 start-page: 369 year: 2000 ident: bib39 article-title: ClC-5 Cl- channel disruption impairs endocytosis in a mouse model for Dent's disease publication-title: Nature doi: 10.1038/35042597 – volume: 290 start-page: H1905 year: 2006 ident: bib56 article-title: Acidic extracellular pH-activated outwardly rectifying chloride current in mammalian cardiac myocytes publication-title: American Journal of Physiology-Heart and Circulatory Physiology doi: 10.1152/ajpheart.00965.2005 – volume: 13 year: 2013 ident: bib29 article-title: Acidic extracellular microenvironment and cancer publication-title: Cancer Cell International doi: 10.1186/1475-2867-13-89 – volume: 171 start-page: 1019 year: 2014 ident: bib10 article-title: Structural requirements of steroidal agonists of transient receptor potential melastatin 3 (TRPM3) cation channels publication-title: British Journal of Pharmacology doi: 10.1111/bph.12521 – volume: 13 start-page: 1483 year: 2007 ident: bib13 article-title: Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system publication-title: Nature Medicine doi: 10.1038/nm1668 – volume: 6 year: 2008 ident: bib38 article-title: Selective inflammatory pain insensitivity in the African naked mole-rat (Heterocephalus glaber) publication-title: PLOS Biology doi: 10.1371/journal.pbio.0060013 – volume: 344 start-page: 634 year: 2014 ident: bib51 article-title: Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC publication-title: Science doi: 10.1126/science.1252826 |
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| SubjectTerms | Acidification Acidity acidotoxicity Acids Acids - metabolism Animals Anions - metabolism Apoptosis Cell Biology Cell death Cell Death - genetics Cell Membrane - genetics Cell Membrane - metabolism Cell membranes Channel pores Chloride Chloride channels Chloride Channels - chemistry Chloride Channels - genetics Chloride Channels - metabolism Chlorides - metabolism Cl- channel Genetic screening Genome, Human - genetics Genomes Genomics HeLa Cells Humans Hydrogen-Ion Concentration ICl,H Identification and classification Ion channels Membrane proteins naked mole rat Novels PAC Physiological aspects Proteins proton-activated Protons RNA siRNA Sodium channels Structural Biology and Molecular Biophysics Transmembrane domains |
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| Title | Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels |
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