Inside the biology of early T-cell precursor acute lymphoblastic leukemia: the perfect trick

Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a rare, distinct subtype of T-ALL characterized by genomic instability, a dismal prognosis and refractoriness to standard chemotherapy. Since its first description in 2009, the expanding knowledge of its intricate biology has led to th...

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Published inBiomarker research Vol. 9; no. 1; pp. 89 - 8
Main Authors Tarantini, Francesco, Cumbo, Cosimo, Anelli, Luisa, Zagaria, Antonella, Specchia, Giorgina, Musto, Pellegrino, Albano, Francesco
Format Journal Article
LanguageEnglish
Published London BioMed Central 20.12.2021
BioMed Central Ltd
BMC
Subjects
Acute lymphoblastic leukemia
Acute lymphocytic leukemia
Biology
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Chemotherapy
Cytokines
ETP-ALL biology
Gene expression
Genomic instability
Genomics
Hypotheses
Kinases
Leukemia
Lymphatic leukemia
Lymphocytes T
Lymphoid-myeloid potential
Molecular pathogenesis
Mutation
Pediatrics
Precision medicine
Prognosis
Review
Stem cell leukemia
Stem cells
T cell receptors
T cells
Transcription factors
Lymphoid-myeloid potential
Molecular pathogenesis
ETP-ALL biology
Online AccessGet full text
ISSN2050-7771
2050-7771
DOI10.1186/s40364-021-00347-z

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Abstract Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a rare, distinct subtype of T-ALL characterized by genomic instability, a dismal prognosis and refractoriness to standard chemotherapy. Since its first description in 2009, the expanding knowledge of its intricate biology has led to the definition of a stem cell leukemia with a combined lymphoid-myeloid potential: the perfect trick. Several studies in the last decade aimed to better characterize this new disease, but it was recognized as a distinct entity only in 2016. We review current insights into the biology of ETP-ALL and discuss the pathogenesis, genomic features and their impact on the clinical course in the precision medicine era today.
AbstractList Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a rare, distinct subtype of T-ALL characterized by genomic instability, a dismal prognosis and refractoriness to standard chemotherapy. Since its first description in 2009, the expanding knowledge of its intricate biology has led to the definition of a stem cell leukemia with a combined lymphoid-myeloid potential: the perfect trick. Several studies in the last decade aimed to better characterize this new disease, but it was recognized as a distinct entity only in 2016. We review current insights into the biology of ETP-ALL and discuss the pathogenesis, genomic features and their impact on the clinical course in the precision medicine era today.
Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a rare, distinct subtype of T-ALL characterized by genomic instability, a dismal prognosis and refractoriness to standard chemotherapy. Since its first description in 2009, the expanding knowledge of its intricate biology has led to the definition of a stem cell leukemia with a combined lymphoid-myeloid potential: the perfect trick. Several studies in the last decade aimed to better characterize this new disease, but it was recognized as a distinct entity only in 2016. We review current insights into the biology of ETP-ALL and discuss the pathogenesis, genomic features and their impact on the clinical course in the precision medicine era today.Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a rare, distinct subtype of T-ALL characterized by genomic instability, a dismal prognosis and refractoriness to standard chemotherapy. Since its first description in 2009, the expanding knowledge of its intricate biology has led to the definition of a stem cell leukemia with a combined lymphoid-myeloid potential: the perfect trick. Several studies in the last decade aimed to better characterize this new disease, but it was recognized as a distinct entity only in 2016. We review current insights into the biology of ETP-ALL and discuss the pathogenesis, genomic features and their impact on the clinical course in the precision medicine era today.
Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a rare, distinct subtype of T-ALL characterized by genomic instability, a dismal prognosis and refractoriness to standard chemotherapy. Since its first description in 2009, the expanding knowledge of its intricate biology has led to the definition of a stem cell leukemia with a combined lymphoid-myeloid potential: the perfect trick. Several studies in the last decade aimed to better characterize this new disease, but it was recognized as a distinct entity only in 2016. We review current insights into the biology of ETP-ALL and discuss the pathogenesis, genomic features and their impact on the clinical course in the precision medicine era today. Keywords: ETP-ALL biology, Lymphoid-myeloid potential, Molecular pathogenesis.
Abstract Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a rare, distinct subtype of T-ALL characterized by genomic instability, a dismal prognosis and refractoriness to standard chemotherapy. Since its first description in 2009, the expanding knowledge of its intricate biology has led to the definition of a stem cell leukemia with a combined lymphoid-myeloid potential: the perfect trick. Several studies in the last decade aimed to better characterize this new disease, but it was recognized as a distinct entity only in 2016. We review current insights into the biology of ETP-ALL and discuss the pathogenesis, genomic features and their impact on the clinical course in the precision medicine era today.
ArticleNumber 89
Audience Academic
Author Zagaria, Antonella
Albano, Francesco
Anelli, Luisa
Cumbo, Cosimo
Musto, Pellegrino
Tarantini, Francesco
Specchia, Giorgina
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Cites_doi 10.1016/j.immuni.2004.05.004
10.1177/2040620720929475
10.1038/s41375-020-0869-y
10.2147/OTT.S312494
10.1038/nature06839
10.1084/jem.20050146
10.1038/bcj.2011.49
10.1182/blood-2016-03-643544
10.1182/blood-2014-05-574566
10.1084/jem.20112239
10.1016/j.leukres.2013.06.010
10.1016/j.ccell.2018.01.006
10.1182/blood-2015-08-661702
10.1111/bjh.12882
10.1038/ni.2255
10.1182/blood-2004-10-3900
10.1016/j.leukres.2019.01.003
10.1016/S1535-6108(02)00018-1
10.1182/blood.2020010510
10.1182/blood-2012-11-465138
10.1016/S1470-2045(08)70314-0
10.1182/blood-2011-03-343947
10.1038/nature06840
10.1111/ejh.12238
10.3390/ijms22094502
10.1111/ijlh.12942
10.1182/blood.V104.11.3371.3371
10.1182/blood-2016-08-733196
10.1016/j.celrep.2016.01.064
10.1158/2159-8290.CD-14-0353
10.1111/j.1365-2141.2011.08955.x
10.1182/blood-2004-08-3087
10.1084/jem.20122727
10.3324/haematol.2013.090233
10.1182/blood-2014-06-580480
10.1016/j.immuni.2007.05.009
10.1002/ajh.26144
10.1172/JCI147898
10.1038/s41467-021-24044-5
10.1371/journal.pone.0053190
10.1038/ng.3909
10.1038/s41588-020-0602-9
10.1101/mcs.a000539
10.1182/blood-2012-09-458570
10.1111/bjh.15960
10.1186/s13045-015-0229-y
10.1016/j.ccr.2011.02.008
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Issue 1
Keywords Lymphoid-myeloid potential
Molecular pathogenesis
ETP-ALL biology
Language English
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References JJ Bell (347_CR7) 2008; 452
T Ni Chonghaile (347_CR42) 2014; 4
347_CR45
347_CR5
LM Treanor (347_CR11) 2014; 211
E Danis (347_CR18) 2016; 14
AA Ferrando (347_CR46) 2002; 1
K Patrick (347_CR4) 2014; 166
A Chopra (347_CR23) 2014; 92
347_CR51
N Jain (347_CR3) 2016; 127
347_CR54
347_CR15
347_CR16
A Kloetgen (347_CR55) 2020; 52
347_CR17
L Fransecky (347_CR41) 2016; 9
347_CR9
347_CR56
H Döhner (347_CR39) 2017; 129
S Peirs (347_CR43) 2014; 124
A Allen (347_CR53) 2013; 37
O Castaneda Puglianini (347_CR52) 2020; 11
KE Berquam-Vrieze (347_CR10) 2011; 118
H Wada (347_CR8) 2008; 452
Y Li (347_CR12) 2021; 131
T Inukai (347_CR22) 2012; 156
H Khogeer (347_CR24) 2019; 186
347_CR20
SL Maude (347_CR13) 2015; 125
P Wang (347_CR21) 2018; 97
B Knoechel (347_CR35) 2015; 1
MP McCormack (347_CR14) 2013; 122
A Kumar (347_CR40) 2019; 78
G Balciunaite (347_CR49) 2005; 105
347_CR19
M Neumann (347_CR6) 2013; 121
K Morita (347_CR27) 2021; 96
HA Hou (347_CR32) 2020; 27
S Garg (347_CR25) 2019; 41
347_CR30
C Benz (347_CR50) 2005; 202
DA Arber (347_CR47) 2016; 127
HE Porritt (347_CR48) 2004; 20
L Zuurbier (347_CR28) 2014; 99
D Di Giacomo (347_CR29) 2021; 19
347_CR38
347_CR33
A Bhandoola (347_CR26) 2007; 26
347_CR34
347_CR36
E Coustan-Smith (347_CR1) 2009; 10
P Vlierberghe (347_CR37) 2011; 208
J Soulier (347_CR44) 2005; 106
J Mao (347_CR2) 2021; 14
Y Liu (347_CR31) 2017; 49
References_xml – volume: 97
  start-page: 0
  year: 2018
  ident: 347_CR21
  publication-title: Med (United States)
– volume: 20
  start-page: 735
  year: 2004
  ident: 347_CR48
  publication-title: Immunity
  doi: 10.1016/j.immuni.2004.05.004
– volume: 11
  start-page: 204062072092947
  year: 2020
  ident: 347_CR52
  publication-title: Ther Adv Hematol
  doi: 10.1177/2040620720929475
– ident: 347_CR36
  doi: 10.1038/s41375-020-0869-y
– volume: 14
  start-page: 3795
  year: 2021
  ident: 347_CR2
  publication-title: Onco Targets Ther
  doi: 10.2147/OTT.S312494
– volume: 452
  start-page: 768
  year: 2008
  ident: 347_CR8
  publication-title: Nature
  doi: 10.1038/nature06839
– volume: 202
  start-page: 21
  year: 2005
  ident: 347_CR50
  publication-title: J Exp Med
  doi: 10.1084/jem.20050146
– ident: 347_CR33
  doi: 10.1038/bcj.2011.49
– volume: 127
  start-page: 2391
  year: 2016
  ident: 347_CR47
  publication-title: Blood.
  doi: 10.1182/blood-2016-03-643544
– volume: 124
  start-page: 3738
  year: 2014
  ident: 347_CR43
  publication-title: Blood
  doi: 10.1182/blood-2014-05-574566
– volume: 208
  start-page: 2571
  year: 2011
  ident: 347_CR37
  publication-title: J Exp Med
  doi: 10.1084/jem.20112239
– ident: 347_CR30
  doi: 10.1016/j.leukres.2013.06.010
– ident: 347_CR16
  doi: 10.1016/j.ccell.2018.01.006
– volume: 127
  start-page: 1863
  year: 2016
  ident: 347_CR3
  publication-title: Blood
  doi: 10.1182/blood-2015-08-661702
– volume: 166
  start-page: 421
  year: 2014
  ident: 347_CR4
  publication-title: Br J Haematol
  doi: 10.1111/bjh.12882
– ident: 347_CR51
  doi: 10.1038/ni.2255
– ident: 347_CR15
– volume: 106
  start-page: 274
  year: 2005
  ident: 347_CR44
  publication-title: Blood
  doi: 10.1182/blood-2004-10-3900
– volume: 78
  start-page: 3
  year: 2019
  ident: 347_CR40
  publication-title: Leuk Res. Elsevier
  doi: 10.1016/j.leukres.2019.01.003
– volume: 1
  start-page: 75
  year: 2002
  ident: 347_CR46
  publication-title: Cancer Cell
  doi: 10.1016/S1535-6108(02)00018-1
– ident: 347_CR38
  doi: 10.1016/j.leukres.2019.01.003
– volume: 19
  start-page: blood.202001051
  year: 2021
  ident: 347_CR29
  publication-title: Blood
  doi: 10.1182/blood.2020010510
– volume: 121
  start-page: 4749
  year: 2013
  ident: 347_CR6
  publication-title: Blood
  doi: 10.1182/blood-2012-11-465138
– volume: 10
  start-page: 147
  year: 2009
  ident: 347_CR1
  publication-title: Lancet Oncol
  doi: 10.1016/S1470-2045(08)70314-0
– volume: 118
  start-page: 4646
  year: 2011
  ident: 347_CR10
  publication-title: Blood
  doi: 10.1182/blood-2011-03-343947
– volume: 452
  start-page: 764
  year: 2008
  ident: 347_CR7
  publication-title: Nature
  doi: 10.1038/nature06840
– volume: 92
  start-page: 211
  year: 2014
  ident: 347_CR23
  publication-title: Eur J Haematol
  doi: 10.1111/ejh.12238
– ident: 347_CR9
– ident: 347_CR54
  doi: 10.3390/ijms22094502
– ident: 347_CR19
  doi: 10.1016/j.ccell.2018.01.006
– volume: 41
  start-page: e32
  year: 2019
  ident: 347_CR25
  publication-title: Int J Lab Hematol
  doi: 10.1111/ijlh.12942
– ident: 347_CR34
  doi: 10.1182/blood.V104.11.3371.3371
– volume: 129
  start-page: 424
  year: 2017
  ident: 347_CR39
  publication-title: Blood
  doi: 10.1182/blood-2016-08-733196
– ident: 347_CR5
– ident: 347_CR17
  doi: 10.1016/j.celrep.2016.01.064
– volume: 4
  start-page: 1074
  year: 2014
  ident: 347_CR42
  publication-title: Cancer Discov
  doi: 10.1158/2159-8290.CD-14-0353
– volume: 156
  start-page: 358
  year: 2012
  ident: 347_CR22
  publication-title: Br J Haematol
  doi: 10.1111/j.1365-2141.2011.08955.x
– volume: 105
  start-page: 1930
  year: 2005
  ident: 347_CR49
  publication-title: Blood
  doi: 10.1182/blood-2004-08-3087
– volume: 211
  start-page: 701
  year: 2014
  ident: 347_CR11
  publication-title: J Exp Med
  doi: 10.1084/jem.20122727
– volume: 99
  start-page: 94
  year: 2014
  ident: 347_CR28
  publication-title: Haematologica
  doi: 10.3324/haematol.2013.090233
– volume: 27
  start-page: 1
  year: 2020
  ident: 347_CR32
  publication-title: J Biomed Sci. Journal of Biomedical Science
– volume: 125
  start-page: 1759
  year: 2015
  ident: 347_CR13
  publication-title: Blood
  doi: 10.1182/blood-2014-06-580480
– volume: 26
  start-page: 678
  year: 2007
  ident: 347_CR26
  publication-title: Immunity
  doi: 10.1016/j.immuni.2007.05.009
– volume: 96
  start-page: 589
  year: 2021
  ident: 347_CR27
  publication-title: Am J Hematol
  doi: 10.1002/ajh.26144
– volume: 131
  start-page: e147898
  issue: 17
  year: 2021
  ident: 347_CR12
  publication-title: J Clin Invest
  doi: 10.1172/JCI147898
– ident: 347_CR56
  doi: 10.1038/s41467-021-24044-5
– ident: 347_CR20
  doi: 10.1371/journal.pone.0053190
– volume: 49
  start-page: 1211
  year: 2017
  ident: 347_CR31
  publication-title: Nat Genet. Nature Publishing Group
  doi: 10.1038/ng.3909
– volume: 52
  start-page: 388
  issue: 4
  year: 2020
  ident: 347_CR55
  publication-title: Nat Genet
  doi: 10.1038/s41588-020-0602-9
– volume: 14
  start-page: 1953
  year: 2016
  ident: 347_CR18
  publication-title: Cell Rep. The Authors
  doi: 10.1016/j.celrep.2016.01.064
– volume: 37
  start-page: 1027
  year: 2013
  ident: 347_CR53
  publication-title: Leuk Res. Elsevier Ltd
  doi: 10.1016/j.leukres.2013.06.010
– volume: 1
  start-page: a000539
  year: 2015
  ident: 347_CR35
  publication-title: Mol Case Stud
  doi: 10.1101/mcs.a000539
– volume: 122
  start-page: 2093
  year: 2013
  ident: 347_CR14
  publication-title: Blood
  doi: 10.1182/blood-2012-09-458570
– volume: 186
  start-page: 538
  year: 2019
  ident: 347_CR24
  publication-title: Br J Haematol
  doi: 10.1111/bjh.15960
– volume: 9
  start-page: 1
  year: 2016
  ident: 347_CR41
  publication-title: J Hematol Oncol. Journal of Hematology & Oncology
  doi: 10.1186/s13045-015-0229-y
– ident: 347_CR45
  doi: 10.1016/j.ccr.2011.02.008
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Snippet Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a rare, distinct subtype of T-ALL characterized by genomic instability, a dismal prognosis and...
Abstract Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a rare, distinct subtype of T-ALL characterized by genomic instability, a dismal...
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SubjectTerms Acute lymphoblastic leukemia
Acute lymphocytic leukemia
Biology
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Chemotherapy
Cytokines
ETP-ALL biology
Gene expression
Genomic instability
Genomics
Hypotheses
Kinases
Leukemia
Lymphatic leukemia
Lymphocytes T
Lymphoid-myeloid potential
Molecular pathogenesis
Mutation
Pediatrics
Precision medicine
Prognosis
Review
Stem cell leukemia
Stem cells
T cell receptors
T cells
Transcription factors
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Title Inside the biology of early T-cell precursor acute lymphoblastic leukemia: the perfect trick
URI https://link.springer.com/article/10.1186/s40364-021-00347-z
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Volume 9
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