Surface-enhanced Raman spectroscopy of blood plasma and serum using Ag and Au nanoparticles: a systematic study

Surface-enhanced Raman spectroscopy (SERS) is a good candidate for the development of fast and easy-to-use diagnostic tools, possibly used on biofluids in point-of-care or screening tests. In particular, label-free SERS spectra of blood serum and plasma, two biofluids widely used in diagnostics, cou...

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Published in	Analytical and bioanalytical chemistry Vol. 406; no. 9-10; pp. 2355 - 2365
Main Authors	Bonifacio, Alois, Dalla Marta, Silvia, Spizzo, Riccardo, Cervo, Silvia, Steffan, Agostino, Colombatti, Alfonso, Sergo, Valter
Format	Journal Article
Language	English
Published	Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2014 Springer Springer Nature B.V
Subjects	Adult Age Factors Analysis Analytical Chemistry Anticoagulants Biobanks Biochemistry Biomarkers Bisphenol A Blood Blood Chemical Analysis Blood plasma blood serum Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science citrates Colloids Diagnostic software diagnostic techniques EDTA (chelating agent) Excitation Female Food Science Gold Gold - chemistry Gold compounds heparin Humans Laboratory Medicine Lasers Male Metabolism Metabolites Metal Nanoparticles - chemistry Monitoring/Environmental Analysis nanogold Nanoparticles Nanostructured materials Plasma Plasma - chemistry proteins Raman spectroscopy Research Paper screening Serums Silver Silver - chemistry Silver compounds Spectra Spectroscopy Spectrum analysis Spectrum Analysis, Raman - instrumentation Spectrum Analysis, Raman - methods Trace elements uric acid Wavelengths Young Adult Italy Nanoparticles Plasma Serum SERS Blood Surface-enhanced Raman spectroscopy
Online Access	Get full text
ISSN	1618-2642 1618-2650 1618-2650
DOI	10.1007/s00216-014-7622-1

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Abstract	Surface-enhanced Raman spectroscopy (SERS) is a good candidate for the development of fast and easy-to-use diagnostic tools, possibly used on biofluids in point-of-care or screening tests. In particular, label-free SERS spectra of blood serum and plasma, two biofluids widely used in diagnostics, could be used as a metabolic fingerprinting approach for biomarker discovery. This study aims at a systematic evaluation of SERS spectra of blood serum and plasma, using various Ag and Au aqueous colloids, as SERS substrates, in combination with three excitation lasers of different wavelengths, ranging from the visible to the near-infrared. The analysis of the SERS spectra collected from 20 healthy subjects under a variety of experimental conditions revealed that intense and repeatable spectra are quickly obtained only if proteins are filtered out from samples, and an excitation in the near-infrared is used in combination with Ag colloids. Moreover, common plasma anticoagulants such as EDTA and citrate are found to interfere with SERS spectra; accordingly, filtered serum or heparin plasma are the samples of choice, having identical SERS spectra. Most bands observed in SERS spectra of these biofluids are assigned to uric acid, a metabolite whose blood concentration depends on factors such as sex, age, therapeutic treatments, and various pathological conditions, suggesting that, even when the right experimental conditions are chosen, great care must be taken in designing studies with the purpose of developing diagnostic tests.
AbstractList	Surface-enhanced Raman spectroscopy (SERS) is a good candidate for the development of fast and easy-to-use diagnostic tools, possibly used on biofluids in point-of-care or screening tests. In particular, label-free SERS spectra of blood serum and plasma, two biofluids widely used in diagnostics, could be used as a metabolic fingerprinting approach for biomarker discovery. This study aims at a systematic evaluation of SERS spectra of blood serum and plasma, using various Ag and Au aqueous colloids, as SERS substrates, in combination with three excitation lasers of different wavelengths, ranging from the visible to the near-infrared. The analysis of the SERS spectra collected from 20 healthy subjects under a variety of experimental conditions revealed that intense and repeatable spectra are quickly obtained only if proteins are filtered out from samples, and an excitation in the near-infrared is used in combination with Ag colloids. Moreover, common plasma anticoagulants such as EDTA and citrate are found to interfere with SERS spectra; accordingly, filtered serum or heparin plasma are the samples of choice, having identical SERS spectra. Most bands observed in SERS spectra of these biofluids are assigned to uric acid, a metabolite whose blood concentration depends on factors such as sex, age, therapeutic treatments, and various pathological conditions, suggesting that, even when the right experimental conditions are chosen, great care must be taken in designing studies with the purpose of developing diagnostic tests. Surface-enhanced Raman spectroscopy (SERS) is a good candidate for the development of fast and easy-to-use diagnostic tools, possibly used on biofluids in point-of-care or screening tests. In particular, label-free SERS spectra of blood serum and plasma, two biofluids widely used in diagnostics, could be used as a metabolic fingerprinting approach for biomarker discovery. This study aims at a systematic evaluation of SERS spectra of blood serum and plasma, using various Ag and Au aqueous colloids, as SERS substrates, in combination with three excitation lasers of different wavelengths, ranging from the visible to the near-infrared. The analysis of the SERS spectra collected from 20 healthy subjects under a variety of experimental conditions revealed that intense and repeatable spectra are quickly obtained only if proteins are filtered out from samples, and an excitation in the near-infrared is used in combination with Ag colloids. Moreover, common plasma anticoagulants such as EDTA and citrate are found to interfere with SERS spectra; accordingly, filtered serum or heparin plasma are the samples of choice, having identical SERS spectra. Most bands observed in SERS spectra of these biofluids are assigned to uric acid, a metabolite whose blood concentration depends on factors such as sex, age, therapeutic treatments, and various pathological conditions, suggesting that, even when the right experimental conditions are chosen, great care must be taken in designing studies with the purpose of developing diagnostic tests.Surface-enhanced Raman spectroscopy (SERS) is a good candidate for the development of fast and easy-to-use diagnostic tools, possibly used on biofluids in point-of-care or screening tests. In particular, label-free SERS spectra of blood serum and plasma, two biofluids widely used in diagnostics, could be used as a metabolic fingerprinting approach for biomarker discovery. This study aims at a systematic evaluation of SERS spectra of blood serum and plasma, using various Ag and Au aqueous colloids, as SERS substrates, in combination with three excitation lasers of different wavelengths, ranging from the visible to the near-infrared. The analysis of the SERS spectra collected from 20 healthy subjects under a variety of experimental conditions revealed that intense and repeatable spectra are quickly obtained only if proteins are filtered out from samples, and an excitation in the near-infrared is used in combination with Ag colloids. Moreover, common plasma anticoagulants such as EDTA and citrate are found to interfere with SERS spectra; accordingly, filtered serum or heparin plasma are the samples of choice, having identical SERS spectra. Most bands observed in SERS spectra of these biofluids are assigned to uric acid, a metabolite whose blood concentration depends on factors such as sex, age, therapeutic treatments, and various pathological conditions, suggesting that, even when the right experimental conditions are chosen, great care must be taken in designing studies with the purpose of developing diagnostic tests. Surface-enhanced Raman spectroscopy (SERS) is a good candidate for the development of fast and easy-to-use diagnostic tools, possibly used on biofluids in point-of-care or screening tests. In particular, label-free SERS spectra of blood serum and plasma, two biofluids widely used in diagnostics, could be used as a metabolic fingerprinting approach for biomarker discovery. This study aims at a systematic evaluation of SERS spectra of blood serum and plasma, using various Ag and Au aqueous colloids, as SERS substrates, in combination with three excitation lasers of different wavelengths, ranging from the visible to the near-infrared. The analysis of the SERS spectra collected from 20 healthy subjects under a variety of experimental conditions revealed that intense and repeatable spectra are quickly obtained only if proteins are filtered out from samples, and an excitation in the near-infrared is used in combination with Ag colloids. Moreover, common plasma anticoagulants such as EDTA and citrate are found to interfere with SERS spectra; accordingly, filtered serum or heparin plasma are the samples of choice, having identical SERS spectra. Most bands observed in SERS spectra of these biofluids are assigned to uric acid, a metabolite whose blood concentration depends on factors such as sex, age, therapeutic treatments, and various pathological conditions, suggesting that, even when the right experimental conditions are chosen, great care must be taken in designing studies with the purpose of developing diagnostic tests. Keywords Surface-enhanced Raman spectroscopy * SERS * Blood * Plasma * Serum * Nanoparticles Issue Title: Trends and Critical Reviews/Bioimaging of trace elements in human lenses/FTIR spectroscopy for analyzing tears/Bisphenol A determination by fiber-optic sensors Surface-enhanced Raman spectroscopy (SERS) is a good candidate for the development of fast and easy-to-use diagnostic tools, possibly used on biofluids in point-of-care or screening tests. In particular, label-free SERS spectra of blood serum and plasma, two biofluids widely used in diagnostics, could be used as a metabolic fingerprinting approach for biomarker discovery. This study aims at a systematic evaluation of SERS spectra of blood serum and plasma, using various Ag and Au aqueous colloids, as SERS substrates, in combination with three excitation lasers of different wavelengths, ranging from the visible to the near-infrared. The analysis of the SERS spectra collected from 20 healthy subjects under a variety of experimental conditions revealed that intense and repeatable spectra are quickly obtained only if proteins are filtered out from samples, and an excitation in the near-infrared is used in combination with Ag colloids. Moreover, common plasma anticoagulants such as EDTA and citrate are found to interfere with SERS spectra; accordingly, filtered serum or heparin plasma are the samples of choice, having identical SERS spectra. Most bands observed in SERS spectra of these biofluids are assigned to uric acid, a metabolite whose blood concentration depends on factors such as sex, age, therapeutic treatments, and various pathological conditions, suggesting that, even when the right experimental conditions are chosen, great care must be taken in designing studies with the purpose of developing diagnostic tests.
Audience	Academic
Author	Steffan, Agostino Bonifacio, Alois Colombatti, Alfonso Cervo, Silvia Spizzo, Riccardo Sergo, Valter Dalla Marta, Silvia
Author_xml	– sequence: 1 givenname: Alois surname: Bonifacio fullname: Bonifacio, Alois email: abonifacio@units.it organization: Centre of Excellence for Nanostructured Materials and Department of Engineering and Architecture, University of Trieste – sequence: 2 givenname: Silvia surname: Dalla Marta fullname: Dalla Marta, Silvia organization: Centre of Excellence for Nanostructured Materials and Department of Engineering and Architecture, University of Trieste – sequence: 3 givenname: Riccardo surname: Spizzo fullname: Spizzo, Riccardo organization: Division of Experim. Oncology 2, CRO Aviano, National Cancer Institute – sequence: 4 givenname: Silvia surname: Cervo fullname: Cervo, Silvia organization: CRO-Biobank, CRO Aviano, National Cancer Institute – sequence: 5 givenname: Agostino surname: Steffan fullname: Steffan, Agostino organization: CRO-Biobank, CRO Aviano, National Cancer Institute – sequence: 6 givenname: Alfonso surname: Colombatti fullname: Colombatti, Alfonso organization: Division of Experim. Oncology 2, CRO Aviano, National Cancer Institute, Centre of Excellence MAT Department of Medical and Biological Science, University of Udine – sequence: 7 givenname: Valter surname: Sergo fullname: Sergo, Valter organization: Centre of Excellence for Nanostructured Materials and Department of Engineering and Architecture, University of Trieste
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/24493335$$D View this record in MEDLINE/PubMed
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Keywords	Nanoparticles Plasma Serum SERS Blood Surface-enhanced Raman spectroscopy
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10.1016/j.bios.2010.03.033 – year: 2002 ident: CR37 publication-title: Clinical laboratory medicine – year: 2013 ident: CR21 publication-title: R: a language and environment for statistical computing – volume: 86 start-page: 3391 year: 1982 end-page: 3395 ident: CR15 article-title: Adsorption and surface-enhanced Raman of dyes on silver and gold sols publication-title: J Phys Chem doi: 10.1021/j100214a025 – volume: 10 start-page: 031108 year: 2005 end-page: 03110810 ident: CR24 article-title: Comparison of mid-infrared and Raman spectroscopy in the quantitative analysis of serum publication-title: J Biomed Opt doi: 10.1117/1.1911847 – volume: 6 start-page: 113 year: 2011 end-page: 124 ident: CR26 article-title: Electromagnetic enhancement effect caused by aggregation on SERS-active gold nanoparticles publication-title: Plasmonics doi: 10.1007/s11468-010-9176-1 – volume: 1 start-page: 696 year: 2010 end-page: 703 ident: CR25 article-title: Understanding the SERS effects of single silver 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Snippet	Surface-enhanced Raman spectroscopy (SERS) is a good candidate for the development of fast and easy-to-use diagnostic tools, possibly used on biofluids in... Issue Title: Trends and Critical Reviews/Bioimaging of trace elements in human lenses/FTIR spectroscopy for analyzing tears/Bisphenol A determination by...
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SubjectTerms	Adult Age Factors Analysis Analytical Chemistry Anticoagulants Biobanks Biochemistry Biomarkers Bisphenol A Blood Blood Chemical Analysis Blood plasma blood serum Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science citrates Colloids Diagnostic software diagnostic techniques EDTA (chelating agent) Excitation Female Food Science Gold Gold - chemistry Gold compounds heparin Humans Laboratory Medicine Lasers Male Metabolism Metabolites Metal Nanoparticles - chemistry Monitoring/Environmental Analysis nanogold Nanoparticles Nanostructured materials Plasma Plasma - chemistry proteins Raman spectroscopy Research Paper screening Serums Silver Silver - chemistry Silver compounds Spectra Spectroscopy Spectrum analysis Spectrum Analysis, Raman - instrumentation Spectrum Analysis, Raman - methods Trace elements uric acid Wavelengths Young Adult
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Title	Surface-enhanced Raman spectroscopy of blood plasma and serum using Ag and Au nanoparticles: a systematic study
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