Inflammatory cytokines in saliva: Early signs of metabolic disorders in chronic kidney disease. A controlled cross-sectional study
The aim of this study was to evaluate correlations between levels of cytokines in secreted stimulated saliva in patients with chronic kidney disease (CKD) and hyposalivation. Seventy patients with clearance <20 mL/min/1.73 m 2 were evaluated; 40 were predialysis, 21 hemodialysis, and 9 peritoneal...
Saved in:
| Published in | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics Vol. 110; no. 5; pp. 597 - 604 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York, NY
Mosby, Inc
01.11.2010
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1079-2104 1528-395X 1528-395X |
| DOI | 10.1016/j.tripleo.2010.07.007 |
Cover
| Abstract | The aim of this study was to evaluate correlations between levels of cytokines in secreted stimulated saliva in patients with chronic kidney disease (CKD) and hyposalivation.
Seventy patients with clearance <20 mL/min/1.73 m
2 were evaluated; 40 were predialysis, 21 hemodialysis, and 9 peritoneal dialysis, and they were matched with 70 control subjects. Salivary flow rate was measured and submandibular/sublingual saliva collected. Analyses were performed for whole protein content using a protein assay, and levels of tumor necrosis factor (TNF) α, interleukin (IL) 1β, γ-interferon (γ-INF), IL-6, IL-8, IL-10, monocyte chemotactic protein (MCP) 1, and soluble intercellular adhesion molecule (sICAM) 1, by using Luminex technology.
Patients with CKD had lower (
P = .03) stimulated salivary secretion rate and higher salivary whole protein concentration (
P = .002) than control subjects. Concentrations of IL-8 (
P = .03) and MCP-1 (
P = .002) were decreased and TNF-α/IL-10 (
P = .05) and IL-8/IL10 (
P = .03) ratios were decreased in CKD patients. CKD patients with low secretion levels of stimulated saliva expressed decreased levels of TNF-α (
P = .04), IL-1β (
P = .02), γ-INF (
P = .03), IL-6 (
P = .003), IL-8 (
P = .005), MCP-1 (
P = .006), and sICAM-1 (
P = .02).
Salivary cytokines and secretion rates are significantly decreased in CKD patients. Further research is necessary to understand operating mechanisms and clinical implications of the down-regulation of inflammatory markers in saliva. |
|---|---|
| AbstractList | The aim of this study was to evaluate correlations between levels of cytokines in secreted stimulated saliva in patients with chronic kidney disease (CKD) and hyposalivation.
Seventy patients with clearance <20 mL/min/1.73 m
2 were evaluated; 40 were predialysis, 21 hemodialysis, and 9 peritoneal dialysis, and they were matched with 70 control subjects. Salivary flow rate was measured and submandibular/sublingual saliva collected. Analyses were performed for whole protein content using a protein assay, and levels of tumor necrosis factor (TNF) α, interleukin (IL) 1β, γ-interferon (γ-INF), IL-6, IL-8, IL-10, monocyte chemotactic protein (MCP) 1, and soluble intercellular adhesion molecule (sICAM) 1, by using Luminex technology.
Patients with CKD had lower (
P = .03) stimulated salivary secretion rate and higher salivary whole protein concentration (
P = .002) than control subjects. Concentrations of IL-8 (
P = .03) and MCP-1 (
P = .002) were decreased and TNF-α/IL-10 (
P = .05) and IL-8/IL10 (
P = .03) ratios were decreased in CKD patients. CKD patients with low secretion levels of stimulated saliva expressed decreased levels of TNF-α (
P = .04), IL-1β (
P = .02), γ-INF (
P = .03), IL-6 (
P = .003), IL-8 (
P = .005), MCP-1 (
P = .006), and sICAM-1 (
P = .02).
Salivary cytokines and secretion rates are significantly decreased in CKD patients. Further research is necessary to understand operating mechanisms and clinical implications of the down-regulation of inflammatory markers in saliva. Objective The aim of this study was to evaluate correlations between levels of cytokines in secreted stimulated saliva in patients with chronic kidney disease (CKD) and hyposalivation. Study design Seventy patients with clearance <20 mL/min/1.73 m2 were evaluated; 40 were predialysis, 21 hemodialysis, and 9 peritoneal dialysis, and they were matched with 70 control subjects. Salivary flow rate was measured and submandibular/sublingual saliva collected. Analyses were performed for whole protein content using a protein assay, and levels of tumor necrosis factor (TNF) α, interleukin (IL) 1β, γ-interferon (γ-INF), IL-6, IL-8, IL-10, monocyte chemotactic protein (MCP) 1, and soluble intercellular adhesion molecule (sICAM) 1, by using Luminex technology. Results Patients with CKD had lower ( P = .03) stimulated salivary secretion rate and higher salivary whole protein concentration ( P = .002) than control subjects. Concentrations of IL-8 ( P = .03) and MCP-1 ( P = .002) were decreased and TNF-α/IL-10 ( P = .05) and IL-8/IL10 ( P = .03) ratios were decreased in CKD patients. CKD patients with low secretion levels of stimulated saliva expressed decreased levels of TNF-α ( P = .04), IL-1β ( P = .02), γ-INF ( P = .03), IL-6 ( P = .003), IL-8 ( P = .005), MCP-1 ( P = .006), and sICAM-1 ( P = .02). Conclusions Salivary cytokines and secretion rates are significantly decreased in CKD patients. Further research is necessary to understand operating mechanisms and clinical implications of the down-regulation of inflammatory markers in saliva. The aim of this study was to evaluate correlations between levels of cytokines in secreted stimulated saliva in patients with chronic kidney disease (CKD) and hyposalivation. Seventy patients with clearance <20 mL/min/1.73 m(2) were evaluated; 40 were predialysis, 21 hemodialysis, and 9 peritoneal dialysis, and they were matched with 70 control subjects. Salivary flow rate was measured and submandibular/sublingual saliva collected. Analyses were performed for whole protein content using a protein assay, and levels of tumor necrosis factor (TNF) α, interleukin (IL) 1β, γ-interferon (γ-INF), IL-6, IL-8, IL-10, monocyte chemotactic protein (MCP) 1, and soluble intercellular adhesion molecule (sICAM) 1, by using Luminex technology. Patients with CKD had lower (P = .03) stimulated salivary secretion rate and higher salivary whole protein concentration (P = .002) than control subjects. Concentrations of IL-8 (P = .03) and MCP-1 (P = .002) were decreased and TNF-α/IL-10 (P = .05) and IL-8/IL10 (P = .03) ratios were decreased in CKD patients. CKD patients with low secretion levels of stimulated saliva expressed decreased levels of TNF-α (P = .04), IL-1β (P = .02), γ-INF (P = .03), IL-6 (P = .003), IL-8 (P = .005), MCP-1 (P = .006), and sICAM-1 (P = .02). Salivary cytokines and secretion rates are significantly decreased in CKD patients. Further research is necessary to understand operating mechanisms and clinical implications of the down-regulation of inflammatory markers in saliva. The aim of this study was to evaluate correlations between levels of cytokines in secreted stimulated saliva in patients with chronic kidney disease (CKD) and hyposalivation. Study design: Seventy patients with clearance 20 mL/min/1.73 m super(2 were evaluated; 40 were predialysis, 21 hemodialysis, and 9 peritoneal dialysis, and they were matched with 70 control subjects. Salivary flow rate was measured and submandibular/sublingual saliva collected. Analyses were performed for whole protein content using a protein assay, and levels of tumor necrosis factor (TNF) alpha , interleukin (IL) 1 beta , gamma -interferon ( gamma -INF), IL-6, IL-8, IL-10, monocyte chemotactic protein (MCP) 1, and soluble intercellular adhesion molecule (sICAM) 1, by using Luminex technology. Results: Patients with CKD had lower (P = .03) stimulated salivary secretion rate and higher salivary whole protein concentration (P = .002) than control subjects. Concentrations of IL-8 (P = .03) and MCP-1 (P = .002) were decreased and TNF- alpha /IL-10 (P = .05) and IL-8/IL10 (P = .03) ratios were decreased in CKD patients. CKD patients with low secretion levels of stimulated saliva expressed decreased levels of TNF- alpha (P = .04), IL-1 beta (P = .02), gamma -INF (P = .03), IL-6 (P = .003), IL-8 (P = .005), MCP-1 (P = .006), and sICAM-1 (P = .02). Conclusions: Salivary cytokines and secretion rates are significantly decreased in CKD patients. Further research is necessary to understand operating mechanisms and clinical implications of the down-regulation of inflammatory markers in saliva.) The aim of this study was to evaluate correlations between levels of cytokines in secreted stimulated saliva in patients with chronic kidney disease (CKD) and hyposalivation.OBJECTIVEThe aim of this study was to evaluate correlations between levels of cytokines in secreted stimulated saliva in patients with chronic kidney disease (CKD) and hyposalivation.Seventy patients with clearance <20 mL/min/1.73 m(2) were evaluated; 40 were predialysis, 21 hemodialysis, and 9 peritoneal dialysis, and they were matched with 70 control subjects. Salivary flow rate was measured and submandibular/sublingual saliva collected. Analyses were performed for whole protein content using a protein assay, and levels of tumor necrosis factor (TNF) α, interleukin (IL) 1β, γ-interferon (γ-INF), IL-6, IL-8, IL-10, monocyte chemotactic protein (MCP) 1, and soluble intercellular adhesion molecule (sICAM) 1, by using Luminex technology.STUDY DESIGNSeventy patients with clearance <20 mL/min/1.73 m(2) were evaluated; 40 were predialysis, 21 hemodialysis, and 9 peritoneal dialysis, and they were matched with 70 control subjects. Salivary flow rate was measured and submandibular/sublingual saliva collected. Analyses were performed for whole protein content using a protein assay, and levels of tumor necrosis factor (TNF) α, interleukin (IL) 1β, γ-interferon (γ-INF), IL-6, IL-8, IL-10, monocyte chemotactic protein (MCP) 1, and soluble intercellular adhesion molecule (sICAM) 1, by using Luminex technology.Patients with CKD had lower (P = .03) stimulated salivary secretion rate and higher salivary whole protein concentration (P = .002) than control subjects. Concentrations of IL-8 (P = .03) and MCP-1 (P = .002) were decreased and TNF-α/IL-10 (P = .05) and IL-8/IL10 (P = .03) ratios were decreased in CKD patients. CKD patients with low secretion levels of stimulated saliva expressed decreased levels of TNF-α (P = .04), IL-1β (P = .02), γ-INF (P = .03), IL-6 (P = .003), IL-8 (P = .005), MCP-1 (P = .006), and sICAM-1 (P = .02).RESULTSPatients with CKD had lower (P = .03) stimulated salivary secretion rate and higher salivary whole protein concentration (P = .002) than control subjects. Concentrations of IL-8 (P = .03) and MCP-1 (P = .002) were decreased and TNF-α/IL-10 (P = .05) and IL-8/IL10 (P = .03) ratios were decreased in CKD patients. CKD patients with low secretion levels of stimulated saliva expressed decreased levels of TNF-α (P = .04), IL-1β (P = .02), γ-INF (P = .03), IL-6 (P = .003), IL-8 (P = .005), MCP-1 (P = .006), and sICAM-1 (P = .02).Salivary cytokines and secretion rates are significantly decreased in CKD patients. Further research is necessary to understand operating mechanisms and clinical implications of the down-regulation of inflammatory markers in saliva.CONCLUSIONSSalivary cytokines and secretion rates are significantly decreased in CKD patients. Further research is necessary to understand operating mechanisms and clinical implications of the down-regulation of inflammatory markers in saliva. |
| Author | Lundahl, Joachim Thorman, Royne Yucel-Lindberg, Tülay Hylander, Britta |
| Author_xml | – sequence: 1 givenname: Royne surname: Thorman fullname: Thorman, Royne email: royne.thorman@ki.se organization: Department of Dental Medicine, Public Dental Service, Karolinska University Hospital, Karolinska Institutet, Solna, Sweden – sequence: 2 givenname: Joachim surname: Lundahl fullname: Lundahl, Joachim organization: Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Karolinska Institutet, Solna, Sweden – sequence: 3 givenname: Tülay surname: Yucel-Lindberg fullname: Yucel-Lindberg, Tülay organization: Division of Pediatric Dentistry, Department of Dental Medicine, Karolinska University Hospital, Karolinska Institutet, Solna, Sweden – sequence: 4 givenname: Britta surname: Hylander fullname: Hylander, Britta organization: Department of Nephrology, Karolinska University Hospital, Karolinska Institutet, Solna, Sweden |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23382777$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/20955949$$D View this record in MEDLINE/PubMed http://kipublications.ki.se/Default.aspx?queryparsed=id:121485119$$DView record from Swedish Publication Index |
| BookMark | eNqNkk1v1DAQhiNURD_gJ4B8QfSSxU7iOAEBqqoClSpxAKTerIk9Ae967cVOWuXKL8fpLkWqBOVka_zMK2vmOcz2nHeYZU8ZXTDK6pfLxRDMxqJfFDTVqFhQKh5kB4wXTV62_HIv3alo84LRaj87jHFJKa3Ltn2U7Re05byt2oPs57nrLazXMPgwETUNfmUcRmIciWDNFbwiZxDsRKL55iLxPVnjAJ23RhFtog8aww2tvgfvUnFltMNpfkOIuCAnRHk3BG8taqKCjzGPqAbjHVgSh1FPj7OHPdiIT3bnUfb1_dmX04_5xacP56cnF7mqKzrkjahZyXWtdcU6zUqoC4HQNxWUukfKa8p6aHkjoK8ZtqIGVF0BbVO3gKLryqMs3-bGa9yMndwEs4YwSQ9G7kqrdEPJq6bkReJfbPlN8D9GjINcm6jQWnDoxygFb8uC02omj_9JsqqueBp5wRL6bIeO3Rr17Sd-byQBz3cARAW2D-CUiX-4smwKIUTi-Ja7mWnA_hZhVM6GyKXcGSJnQyQVMhmS-l7f6VNmgHkfQwBj7-1-t-3GtKgrg0FGZdAp1CakrUrtzb0Jb-8kKGuSOGBXOGFc-jEkM9LMZCwklZ9nh2eFWbKXM3qZAt78PeA_PvALMP8HDw |
| CitedBy_id | crossref_primary_10_1016_j_ymeth_2013_04_005 crossref_primary_10_1016_j_archoralbio_2020_104709 crossref_primary_10_1016_j_bbi_2013_08_010 crossref_primary_10_1007_s11831_022_09866_w crossref_primary_10_1177_0300060518775563 crossref_primary_10_1007_s40620_022_01274_4 crossref_primary_10_1563_AAID_JOI_D_13_00188 crossref_primary_10_1016_j_animal_2022_100477 crossref_primary_10_1111_apm_13042 crossref_primary_10_3390_chemosensors10080294 crossref_primary_10_1016_j_archoralbio_2019_04_021 crossref_primary_10_1177_1535370216638770 crossref_primary_10_3389_fimmu_2021_725748 crossref_primary_10_1016_j_archoralbio_2015_09_008 crossref_primary_10_1111_jop_12021 crossref_primary_10_1093_ndt_gft401 crossref_primary_10_1016_j_cyto_2016_06_025 crossref_primary_10_1053_j_jrn_2024_07_007 crossref_primary_10_1667_RR13586_1 crossref_primary_10_1053_j_jrn_2012_08_006 crossref_primary_10_1590_0103_6440201902228 crossref_primary_10_1007_s00784_021_04218_7 crossref_primary_10_1007_s00784_020_03619_4 |
| Cites_doi | 10.1515/CCLM.2007.286 10.1093/oxfordjournals.bmb.a071272 10.1111/j.1365-2796.2007.01803.x 10.1159/000058394 10.1159/000014479 10.1053/j.arrt.2003.08.008 10.1093/cvr/cvp040 10.14219/jada.archive.2006.0181 10.4049/jimmunol.180.7.5130 10.1016/j.tripleo.2006.11.010 10.1111/j.1748-1716.1987.tb08223.x 10.1016/j.tripleo.2008.09.018 10.1371/journal.pone.0002535 10.1111/j.1542-4758.2006.00124.x 10.1093/jn/114.11.2010 10.1016/S1079-2104(99)70035-1 10.1159/000260369 10.1046/j.1523-1755.1999.00422.x 10.1016/0030-4220(77)90159-1 10.1046/j.1525-139X.2002.00083.x 10.1093/ndt/17.suppl_11.28 10.1016/j.archoralbio.2008.01.006 |
| ContentType | Journal Article |
| Copyright | 2010 Mosby, Inc. Mosby, Inc. 2015 INIST-CNRS Copyright © 2010 Mosby, Inc. All rights reserved. |
| Copyright_xml | – notice: 2010 Mosby, Inc. – notice: Mosby, Inc. – notice: 2015 INIST-CNRS – notice: Copyright © 2010 Mosby, Inc. All rights reserved. |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7T5 H94 7X8 ADTPV AOWAS |
| DOI | 10.1016/j.tripleo.2010.07.007 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Immunology Abstracts AIDS and Cancer Research Abstracts MEDLINE - Academic SwePub SwePub Articles |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) AIDS and Cancer Research Abstracts Immunology Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE AIDS and Cancer Research Abstracts MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Dentistry |
| EISSN | 1528-395X |
| EndPage | 604 |
| ExternalDocumentID | oai_swepub_ki_se_548352 20955949 23382777 10_1016_j_tripleo_2010_07_007 S107921041000510X 1_s2_0_S107921041000510X |
| Genre | Journal Article Comparative Study |
| GroupedDBID | --- --K --M .1- .55 .FO .GJ .~1 0R~ 123 1B1 1CY 1P~ 1RT 1~. 1~5 3O- 4.4 4CK 4G. 53G 5VS 7-5 71M 8P~ AABNK AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQQT AAQXK AATTM AAWTL AAXKI AAXUO AAYWO ABFNM ABMAC ABOCM ABWVN ABXDB ACDAQ ACGFS ACIEU ACLOT ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADMUD ADNMO AEBSH AEIPS AEKER AEUPX AEVXI AFFNX AFPUW AFRHN AFTJW AFXIZ AGHFR AGQPQ AGUBO AGYEJ AIEXJ AIGII AIIUN AIKHN AITUG AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC C45 CAG COF CS3 DU5 EBS EFJIC EFKBS EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-Q HVGLF HZ~ IHE J1W KOM L7B M41 MJL MO0 N4W N9A O-L O9- OAUVE OBH OF. OHH OQ0 OVD OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SDF SDG SDP SEL SES SJN SSH SSZ T5K TEORI TWZ UCV UHS USG VVN X7M Z5R ZGI ZXP ZY1 ~HD AACTN AFCTW AFKWA AJOXV AMFUW PKN RIG ABLVK ABYKQ AHPSJ AJBFU LCYCR AAYXX CITATION AGCQF AGRNS IQODW CGR CUY CVF ECM EIF NPM 7T5 H94 7X8 ADTPV AOWAS |
| ID | FETCH-LOGICAL-c640t-876135d6dd41bd13a627eaf84a3dfe05601fa9587af61e976aecb2a9869ae7bb3 |
| IEDL.DBID | AIKHN |
| ISSN | 1079-2104 1528-395X |
| IngestDate | Mon Oct 20 03:26:13 EDT 2025 Sun Sep 28 05:24:41 EDT 2025 Sat Sep 27 16:52:33 EDT 2025 Wed Feb 19 01:47:35 EST 2025 Mon Jul 21 09:18:41 EDT 2025 Wed Oct 01 00:39:47 EDT 2025 Thu Apr 24 23:11:22 EDT 2025 Fri Feb 23 02:27:37 EST 2024 Sun Feb 23 10:19:51 EST 2025 Tue Oct 14 19:40:36 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Keywords | Kidney disease Metabolic disorder Urinary system disease Cross sectional study Renal failure Cytokine Early Chronic kidney disease Saliva |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 CC BY 4.0 Copyright © 2010 Mosby, Inc. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c640t-876135d6dd41bd13a627eaf84a3dfe05601fa9587af61e976aecb2a9869ae7bb3 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| PMID | 20955949 |
| PQID | 1464509521 |
| PQPubID | 23462 |
| PageCount | 8 |
| ParticipantIDs | swepub_primary_oai_swepub_ki_se_548352 proquest_miscellaneous_759325042 proquest_miscellaneous_1464509521 pubmed_primary_20955949 pascalfrancis_primary_23382777 crossref_primary_10_1016_j_tripleo_2010_07_007 crossref_citationtrail_10_1016_j_tripleo_2010_07_007 elsevier_sciencedirect_doi_10_1016_j_tripleo_2010_07_007 elsevier_clinicalkeyesjournals_1_s2_0_S107921041000510X elsevier_clinicalkey_doi_10_1016_j_tripleo_2010_07_007 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2010-11-01 |
| PublicationDateYYYYMMDD | 2010-11-01 |
| PublicationDate_xml | – month: 11 year: 2010 text: 2010-11-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | New York, NY |
| PublicationPlace_xml | – name: New York, NY – name: United States |
| PublicationTitle | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics |
| PublicationTitleAlternate | Oral Surg Oral Med Oral Pathol Oral Radiol Endod |
| PublicationYear | 2010 |
| Publisher | Mosby, Inc Elsevier |
| Publisher_xml | – name: Mosby, Inc – name: Elsevier |
| References | Barone, Bombardieri, Rosado, Morgan, Challacombe, De Vita (bib28) 2008; 180 Kalantar-Zadeh, Stenvinkel, Pillon, Kopple (bib2) 2003; 10 Thorman, Neovius, Hylander (bib10) 2008; 43 Tomas, Marinho, Limeres, Santos, Araujo, Diz (bib7) 2008; 53 Dhingra, Sharma, Arora, Slezak, Singal (bib19) 2009; 82 Kho, Lee, Chung, Kim (bib13) 1999; 88 Djoba Siawaya, Roberts, Babb, Black, Golakai, Stanley (bib29) 2008; 3 Aurer, Jorgicć-Srdjak, Plancak, Stavljenicć-Rukavina, Aurer-Kozelj (bib14) 2007; 29 Pecoits-Filho, Lindholm, Stenvinkel (bib4) 2002; 17 Stenvinkel, Alvestrand (bib3) 2002; 15 Buhlin, Baranay, Heimburger, Stenvinkel, Gustafsson (bib11) 2007; 5 Elmas, Lang, Kalsch, Hannak, Sueselbeck (bib17) 2007; 45 Cederholm, Persson, Andersson, Stenvinkel, Nordfors, Madden (bib26) 2007; 262 Nishida, Yamamoto, Tanaka, Kataoka, Kuboniwa, Nakayama (bib16) 2008; 9 von Bultzingslowen, Sollecito, Fox, Daniels, Jonsson, Lockhart (bib12) 2007; 103 Bayraktar, Kazancioglu, Bozfakioglu, Ecder, Yildiz, Ark (bib8) 2002; 91 Miller, King, Langub, Kryscio, Thomas (bib15) 2006; 137 Fletcher, Scopp, Hersh (bib27) 1977; 43 Stenvinkel, Heimburger, Paultre, Diczfalusy, Wang, Berglund (bib6) 1999; 55 Garcez, Limeres Posse, Carmona, Feijoo, Diz Dios (bib9) 2009; 107 Kalantar-Zadeh (bib18) 2006; 102 Jensen Kjeilen, Brodin, Aars, Berg (bib20) 1987; 131 Nederfors, Dahlof, Twetman (bib22) 1994; 102 Chisholm, Mason (bib21) 1975; 31 Korsrud, Brandtzaeg (bib23) 1980; 39 Kalantar-Zadeh, Balakrishnan (bib1) 2006; 10 Stenvinkel (bib5) 2001; 19 Ericsson, Hardwick (bib24) 1978; 12 Johansson, Ericson, Steen (bib25) 1984; 114 Aurer (10.1016/j.tripleo.2010.07.007_bib14) 2007; 29 Ericsson (10.1016/j.tripleo.2010.07.007_bib24) 1978; 12 von Bultzingslowen (10.1016/j.tripleo.2010.07.007_bib12) 2007; 103 Stenvinkel (10.1016/j.tripleo.2010.07.007_bib5) 2001; 19 Garcez (10.1016/j.tripleo.2010.07.007_bib9) 2009; 107 Nederfors (10.1016/j.tripleo.2010.07.007_bib22) 1994; 102 Miller (10.1016/j.tripleo.2010.07.007_bib15) 2006; 137 Thorman (10.1016/j.tripleo.2010.07.007_bib10) 2008; 43 Djoba Siawaya (10.1016/j.tripleo.2010.07.007_bib29) 2008; 3 Tomas (10.1016/j.tripleo.2010.07.007_bib7) 2008; 53 Elmas (10.1016/j.tripleo.2010.07.007_bib17) 2007; 45 Johansson (10.1016/j.tripleo.2010.07.007_bib25) 1984; 114 Kho (10.1016/j.tripleo.2010.07.007_bib13) 1999; 88 Nishida (10.1016/j.tripleo.2010.07.007_bib16) 2008; 9 Barone (10.1016/j.tripleo.2010.07.007_bib28) 2008; 180 Buhlin (10.1016/j.tripleo.2010.07.007_bib11) 2007; 5 Kalantar-Zadeh (10.1016/j.tripleo.2010.07.007_bib18) 2006; 102 Cederholm (10.1016/j.tripleo.2010.07.007_bib26) 2007; 262 Bayraktar (10.1016/j.tripleo.2010.07.007_bib8) 2002; 91 Chisholm (10.1016/j.tripleo.2010.07.007_bib21) 1975; 31 Stenvinkel (10.1016/j.tripleo.2010.07.007_bib6) 1999; 55 Fletcher (10.1016/j.tripleo.2010.07.007_bib27) 1977; 43 Dhingra (10.1016/j.tripleo.2010.07.007_bib19) 2009; 82 Kalantar-Zadeh (10.1016/j.tripleo.2010.07.007_bib1) 2006; 10 Korsrud (10.1016/j.tripleo.2010.07.007_bib23) 1980; 39 Kalantar-Zadeh (10.1016/j.tripleo.2010.07.007_bib2) 2003; 10 Stenvinkel (10.1016/j.tripleo.2010.07.007_bib3) 2002; 15 Jensen Kjeilen (10.1016/j.tripleo.2010.07.007_bib20) 1987; 131 Pecoits-Filho (10.1016/j.tripleo.2010.07.007_bib4) 2002; 17 |
| References_xml | – volume: 3 start-page: 1 year: 2008 end-page: 12 ident: bib29 article-title: An evaluation of commercial fluorescent bead-based luminex cytokine assays publication-title: PloS One – volume: 17 start-page: 28 year: 2002 end-page: 31 ident: bib4 article-title: The malnutrition, inflammation, and atherosclerosis (MIA) syndrome—the heart of the matter publication-title: Nephrol Dial Transplant – volume: 262 start-page: 215 year: 2007 end-page: 223 ident: bib26 article-title: Polymorphisms in cytokine genes influence long-term survival differently in elderly male and female patients publication-title: J Intern Med – volume: 88 start-page: 316 year: 1999 end-page: 319 ident: bib13 article-title: Oral manifestations and salivary flow rate, pH, and buffer capacity in patients with end-stage renal disease undergoing hemodialysis publication-title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod – volume: 29 start-page: 435 year: 2007 end-page: 439 ident: bib14 article-title: Proinflammatory factors in saliva as possible markers for periodontal disease publication-title: Coll Antropol – volume: 9 start-page: 229 year: 2008 end-page: 230 ident: bib16 article-title: Association between involuntary smoking and salivary markers related to periodontitis: a 2-year longitudinal study publication-title: J Periodont – volume: 31 start-page: 156 year: 1975 end-page: 158 ident: bib21 article-title: Salivary gland disease publication-title: Br Med Bull – volume: 39 start-page: 129 year: 1980 end-page: 140 ident: bib23 article-title: Quantitative immunohistochemistry of immunoglobulin- and J-chain–producing cells in human parotid and submandibular salivary glands publication-title: Immunology – volume: 103 start-page: 1 year: 2007 end-page: 15 ident: bib12 article-title: Salivary dysfunction associated with systemic diseases: systematic review and clinical management recommendations publication-title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod – volume: 53 start-page: 528 year: 2008 end-page: 532 ident: bib7 article-title: Changes in salivary composition in patients with renal failure publication-title: Arch Oral Biol – volume: 137 start-page: 322 year: 2006 end-page: 329 ident: bib15 article-title: Salivary biomarkers of existing periodontal disease: a cross-sectional study publication-title: J Am Dent Assoc – volume: 180 start-page: 5130 year: 2008 end-page: 5140 ident: bib28 article-title: CXCL13, CCL21, and CXCL12 expression in salivary glands of patients with Sjogren's syndrome and MALT lymphoma: association with reactive and malignant areas of lymphoid organization publication-title: J Immunol – volume: 55 start-page: 1899 year: 1999 end-page: 1911 ident: bib6 article-title: Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure publication-title: Kidney Int – volume: 102 start-page: 235 year: 1994 end-page: 237 ident: bib22 article-title: Effects of the beta-adrenoceptor antagonists atenolol and propranolol on human unstimulated whole saliva flow rate and protein composition publication-title: Scand J Dent Res – volume: 10 start-page: 315 year: 2006 end-page: 325 ident: bib1 article-title: The kidney disease wasting: inflammation, oxidative stress, and diet-gene interaction publication-title: Hemodial Int – volume: 19 start-page: 53 year: 2001 end-page: 61 ident: bib5 article-title: Inflammatory and atherosclerotic interactions in the depleted uremic patient publication-title: Blood Purif – volume: 15 start-page: 329 year: 2002 end-page: 337 ident: bib3 article-title: Inflammation in end-stage renal disease: sources, consequences, and therapy publication-title: Semin Dial – volume: 91 start-page: 210 year: 2002 end-page: 214 ident: bib8 article-title: Stimulated salivary flow rate in chronic hemodialysis patients publication-title: Nephron – volume: 114 start-page: 2010 year: 1984 end-page: 2020 ident: bib25 article-title: Studies of the effect of diet on saliva secretion and caries development: the effect of fasting on saliva composition of female subjects publication-title: J Nutr – volume: 5 start-page: 235 year: 2007 end-page: 244 ident: bib11 article-title: Oral health and pro-inflammatory status in end-stage renal disease patients publication-title: Oral Health Prev Dent – volume: 82 start-page: 59 year: 2009 end-page: 66 ident: bib19 article-title: IL-10 attenuates TNF-alpha–induced NF-kappa B pathway activation and cardiomyocyte apoptosis publication-title: Cardiovasc Res – volume: 10 start-page: 155 year: 2003 end-page: 169 ident: bib2 article-title: Inflammation and nutrition in renal insufficiency publication-title: Adv Ren Replace Ther – volume: 43 start-page: 1 year: 2008 end-page: 6 ident: bib10 article-title: Clinical findings in oral health during progression of chronic kidney disease to end-stage renal disease in a Swedish population publication-title: Scand J Urol Nephrol – volume: 102 start-page: 59 year: 2006 end-page: 60 ident: bib18 article-title: The latest addition to the inflammatory homeboys in chronic kidney disease: interleukin-8 publication-title: Nephron – volume: 131 start-page: 169 year: 1987 end-page: 175 ident: bib20 article-title: Parotid salivary flow in response to mechanical and gustatory stimulation in man publication-title: Acta Physiol Scand – volume: 43 start-page: 218 year: 1977 end-page: 226 ident: bib27 article-title: Oral manifestations of secondary hyperparathyroidism related to long-term hemodialysis therapy publication-title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod – volume: 45 start-page: 1360 year: 2007 end-page: 1365 ident: bib17 article-title: High plasma levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) and interleukin-8 (IL-8) characterize patients prone to ventricular fibrillation complicating myocardial infarction publication-title: Clin Chem Lab Med – volume: 12 start-page: 94 year: 1978 ident: bib24 article-title: Individual diagnosis, prognosis and counselling for caries prevention publication-title: Caries Res – volume: 107 start-page: 224 year: 2009 end-page: 228 ident: bib9 article-title: Oral health status of patients with a mild decrease in glomerular filtration rate publication-title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod – volume: 5 start-page: 235 year: 2007 ident: 10.1016/j.tripleo.2010.07.007_bib11 article-title: Oral health and pro-inflammatory status in end-stage renal disease patients publication-title: Oral Health Prev Dent – volume: 45 start-page: 1360 year: 2007 ident: 10.1016/j.tripleo.2010.07.007_bib17 article-title: High plasma levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) and interleukin-8 (IL-8) characterize patients prone to ventricular fibrillation complicating myocardial infarction publication-title: Clin Chem Lab Med doi: 10.1515/CCLM.2007.286 – volume: 31 start-page: 156 year: 1975 ident: 10.1016/j.tripleo.2010.07.007_bib21 article-title: Salivary gland disease publication-title: Br Med Bull doi: 10.1093/oxfordjournals.bmb.a071272 – volume: 262 start-page: 215 year: 2007 ident: 10.1016/j.tripleo.2010.07.007_bib26 article-title: Polymorphisms in cytokine genes influence long-term survival differently in elderly male and female patients publication-title: J Intern Med doi: 10.1111/j.1365-2796.2007.01803.x – volume: 91 start-page: 210 year: 2002 ident: 10.1016/j.tripleo.2010.07.007_bib8 article-title: Stimulated salivary flow rate in chronic hemodialysis patients publication-title: Nephron doi: 10.1159/000058394 – volume: 19 start-page: 53 year: 2001 ident: 10.1016/j.tripleo.2010.07.007_bib5 article-title: Inflammatory and atherosclerotic interactions in the depleted uremic patient publication-title: Blood Purif doi: 10.1159/000014479 – volume: 102 start-page: 59 year: 2006 ident: 10.1016/j.tripleo.2010.07.007_bib18 article-title: The latest addition to the inflammatory homeboys in chronic kidney disease: interleukin-8 publication-title: Nephron – volume: 10 start-page: 155 year: 2003 ident: 10.1016/j.tripleo.2010.07.007_bib2 article-title: Inflammation and nutrition in renal insufficiency publication-title: Adv Ren Replace Ther doi: 10.1053/j.arrt.2003.08.008 – volume: 9 start-page: 229 year: 2008 ident: 10.1016/j.tripleo.2010.07.007_bib16 article-title: Association between involuntary smoking and salivary markers related to periodontitis: a 2-year longitudinal study publication-title: J Periodont – volume: 82 start-page: 59 year: 2009 ident: 10.1016/j.tripleo.2010.07.007_bib19 article-title: IL-10 attenuates TNF-alpha–induced NF-kappa B pathway activation and cardiomyocyte apoptosis publication-title: Cardiovasc Res doi: 10.1093/cvr/cvp040 – volume: 29 start-page: 435 year: 2007 ident: 10.1016/j.tripleo.2010.07.007_bib14 article-title: Proinflammatory factors in saliva as possible markers for periodontal disease publication-title: Coll Antropol – volume: 137 start-page: 322 year: 2006 ident: 10.1016/j.tripleo.2010.07.007_bib15 article-title: Salivary biomarkers of existing periodontal disease: a cross-sectional study publication-title: J Am Dent Assoc doi: 10.14219/jada.archive.2006.0181 – volume: 39 start-page: 129 year: 1980 ident: 10.1016/j.tripleo.2010.07.007_bib23 article-title: Quantitative immunohistochemistry of immunoglobulin- and J-chain–producing cells in human parotid and submandibular salivary glands publication-title: Immunology – volume: 180 start-page: 5130 year: 2008 ident: 10.1016/j.tripleo.2010.07.007_bib28 article-title: CXCL13, CCL21, and CXCL12 expression in salivary glands of patients with Sjogren's syndrome and MALT lymphoma: association with reactive and malignant areas of lymphoid organization publication-title: J Immunol doi: 10.4049/jimmunol.180.7.5130 – volume: 103 start-page: 1 year: 2007 ident: 10.1016/j.tripleo.2010.07.007_bib12 article-title: Salivary dysfunction associated with systemic diseases: systematic review and clinical management recommendations publication-title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod doi: 10.1016/j.tripleo.2006.11.010 – volume: 43 start-page: 1 year: 2008 ident: 10.1016/j.tripleo.2010.07.007_bib10 article-title: Clinical findings in oral health during progression of chronic kidney disease to end-stage renal disease in a Swedish population publication-title: Scand J Urol Nephrol – volume: 131 start-page: 169 year: 1987 ident: 10.1016/j.tripleo.2010.07.007_bib20 article-title: Parotid salivary flow in response to mechanical and gustatory stimulation in man publication-title: Acta Physiol Scand doi: 10.1111/j.1748-1716.1987.tb08223.x – volume: 102 start-page: 235 year: 1994 ident: 10.1016/j.tripleo.2010.07.007_bib22 article-title: Effects of the beta-adrenoceptor antagonists atenolol and propranolol on human unstimulated whole saliva flow rate and protein composition publication-title: Scand J Dent Res – volume: 107 start-page: 224 year: 2009 ident: 10.1016/j.tripleo.2010.07.007_bib9 article-title: Oral health status of patients with a mild decrease in glomerular filtration rate publication-title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod doi: 10.1016/j.tripleo.2008.09.018 – volume: 3 start-page: 1 year: 2008 ident: 10.1016/j.tripleo.2010.07.007_bib29 article-title: An evaluation of commercial fluorescent bead-based luminex cytokine assays publication-title: PloS One doi: 10.1371/journal.pone.0002535 – volume: 10 start-page: 315 year: 2006 ident: 10.1016/j.tripleo.2010.07.007_bib1 article-title: The kidney disease wasting: inflammation, oxidative stress, and diet-gene interaction publication-title: Hemodial Int doi: 10.1111/j.1542-4758.2006.00124.x – volume: 114 start-page: 2010 year: 1984 ident: 10.1016/j.tripleo.2010.07.007_bib25 article-title: Studies of the effect of diet on saliva secretion and caries development: the effect of fasting on saliva composition of female subjects publication-title: J Nutr doi: 10.1093/jn/114.11.2010 – volume: 88 start-page: 316 year: 1999 ident: 10.1016/j.tripleo.2010.07.007_bib13 article-title: Oral manifestations and salivary flow rate, pH, and buffer capacity in patients with end-stage renal disease undergoing hemodialysis publication-title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod doi: 10.1016/S1079-2104(99)70035-1 – volume: 12 start-page: 94 year: 1978 ident: 10.1016/j.tripleo.2010.07.007_bib24 article-title: Individual diagnosis, prognosis and counselling for caries prevention publication-title: Caries Res doi: 10.1159/000260369 – volume: 55 start-page: 1899 year: 1999 ident: 10.1016/j.tripleo.2010.07.007_bib6 article-title: Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure publication-title: Kidney Int doi: 10.1046/j.1523-1755.1999.00422.x – volume: 43 start-page: 218 year: 1977 ident: 10.1016/j.tripleo.2010.07.007_bib27 article-title: Oral manifestations of secondary hyperparathyroidism related to long-term hemodialysis therapy publication-title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod doi: 10.1016/0030-4220(77)90159-1 – volume: 15 start-page: 329 year: 2002 ident: 10.1016/j.tripleo.2010.07.007_bib3 article-title: Inflammation in end-stage renal disease: sources, consequences, and therapy publication-title: Semin Dial doi: 10.1046/j.1525-139X.2002.00083.x – volume: 17 start-page: 28 year: 2002 ident: 10.1016/j.tripleo.2010.07.007_bib4 article-title: The malnutrition, inflammation, and atherosclerosis (MIA) syndrome—the heart of the matter publication-title: Nephrol Dial Transplant doi: 10.1093/ndt/17.suppl_11.28 – volume: 53 start-page: 528 year: 2008 ident: 10.1016/j.tripleo.2010.07.007_bib7 article-title: Changes in salivary composition in patients with renal failure publication-title: Arch Oral Biol doi: 10.1016/j.archoralbio.2008.01.006 |
| SSID | ssj0006399 |
| Score | 1.8996651 |
| Snippet | The aim of this study was to evaluate correlations between levels of cytokines in secreted stimulated saliva in patients with chronic kidney disease (CKD) and... Objective The aim of this study was to evaluate correlations between levels of cytokines in secreted stimulated saliva in patients with chronic kidney disease... |
| SourceID | swepub proquest pubmed pascalfrancis crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 597 |
| SubjectTerms | Biological and medical sciences Case-Control Studies Cell adhesion molecules Chemokine CCL2 - analysis Cross-Sectional Studies Cytokines - analysis Dental Caries - metabolism Female Humans Inflammation Mediators - analysis Intercellular Adhesion Molecule-1 - analysis Interferon-gamma - analysis Interleukin-10 - analysis Interleukin-1beta - analysis Interleukin-6 - analysis Interleukin-8 - analysis Kidneys Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Otorhinolaryngology. Stomatology Periapical Diseases - metabolism Periodontitis - metabolism Peritoneal Dialysis Renal Dialysis Renal failure Renal Insufficiency, Chronic - metabolism Renal Insufficiency, Chronic - therapy Saliva - chemistry Saliva - immunology Saliva - secretion Salivary Proteins and Peptides - analysis Secretory Rate - physiology Sublingual Gland - secretion Submandibular Gland - secretion Surgery Tumor Necrosis Factor-alpha - analysis Urinary system involvement in other diseases. Miscellaneous Xerostomia - metabolism |
| Title | Inflammatory cytokines in saliva: Early signs of metabolic disorders in chronic kidney disease. A controlled cross-sectional study |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S107921041000510X https://www.clinicalkey.es/playcontent/1-s2.0-S107921041000510X https://dx.doi.org/10.1016/j.tripleo.2010.07.007 https://www.ncbi.nlm.nih.gov/pubmed/20955949 https://www.proquest.com/docview/1464509521 https://www.proquest.com/docview/759325042 http://kipublications.ki.se/Default.aspx?queryparsed=id:121485119 |
| Volume | 110 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Complete Freedom Collection [SCCMFC] customDbUrl: eissn: 1528-395X dateEnd: 20111231 omitProxy: true ssIdentifier: ssj0006399 issn: 1079-2104 databaseCode: ACRLP dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals [SCFCJ] customDbUrl: eissn: 1528-395X dateEnd: 20111231 omitProxy: true ssIdentifier: ssj0006399 issn: 1079-2104 databaseCode: AIKHN dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Science Direct customDbUrl: eissn: 1528-395X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0006399 issn: 1079-2104 databaseCode: .~1 dateStart: 0 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVLSH databaseName: Elsevier Journals customDbUrl: mediaType: online eissn: 1528-395X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0006399 issn: 1079-2104 databaseCode: AKRWK dateStart: 19950101 isFulltext: true providerName: Library Specific Holdings |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB612wNICPEs4bEyEuKW3TycOOG2KlRbVvQAVOzNcmJbSnebrJr00AsHfjljx9mq0KqI00ZZjxLb4_FM5pvPAO8SqSMMZUs_TwLtU1bimssUGsM8FKmmiWa2wvvLcTo_oZ-XyXIHDoZaGAOrdLa_t-nWWrs7Uzea001VTb9h4JJjwEJD64cEy13Yw_0ny0awNztazI-3Btlswj30MPeNwFUhz_R00p2bD9qNA3kZPkN22xb1YCNaHDjdn3hxk0v6B9-o3aMOH8FD51ySWf_-j2FH1U_g3kcDCDJnuj2FX0e1RhU4s6l1Ul52zcrA3klVk1aYpNAHYhmPiYF1tKTR5Ex1qCbrqiTS8XTa1mXPqUtWlazVJXFpngmZEYd9XytJbPf81oK9zHtZKttncHL46fvB3HenMPhlSoPOmMswTmQqJQ0LGcYijZgSOqMilloFJqLTIk8yJnQaKvRuhCqLSORZmgvFiiJ-DqO6qdULICVGc4WKGbYPaSiVSNG-SIbqkkUFXnhAh4HnpaMoNydlrPmARTvlbr64mS8emOQ5ik22Ypueo-MugXSYVT4UoKLJ5LiL3CXIbhJUrVv4LQ95G_GA_6WcHmRbyWv6_S8PHV9TvG0fozjOIsawwdtBEzkaB5PxEbVqLloT11H0CNFF84Dc0oYl6MInaLs92O-1-OoBlp-Q5h6879V6-48hJXe3VnilOAa-6Mq__P9evoL7Fphhyzxfw6g7v1Bv0N_rijHsTn6GY7eqze_i64_FbxkVWiY |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwELYoPVCpQvQdCtSVqt6ym4cTJ70hKFpa4FKQ9mY5sS2FXZIVCQcuPfSXd8ZxdkULouotSmaU2B6PZzKfPxPyKVEmglS29PMkMD7jJcy5TIMzzEOZGpYYbnd4n56lkwv2bZpM18jBsBcGYZXO9_c-3Xprd2fsenO8qKrxD0hcckhYWGjjkGD6hDxlScQxAxv9XOE8cAnugYe5j-KrbTzjy1F3jb-zGwfxQjZD_tAC9XwhW-g20593cV9A-gfbqF2hjrbIpgst6X7_9S_Imq5fko1DhAPhiW6vyK_j2oABXNnCOi1vu2aGoHda1bSVWBL6Qi3fMUVQR0sbQ690B0Yyr0qqHEunlS57Rl06q1Stb6kr8ozoPnXI97lW1DbPby3UC7_LEtm-JhdHX88PJr47g8EvUxZ06CzDOFGpUiwsVBjLNOJamozJWBkdYD5nZJ5kXJo01BDbSF0WkcyzNJeaF0X8hqzXTa3fEVpCLlfomIN8yEKlZQreRXEwliwq4MIjbOh4UTqCcjwnYy4GJNqlcOMlcLxEgKVzUBst1RY9Q8djCukwqmLYfgoOU8Aa8pgiv09Rt27atyIUbSQC8ZdpeiRbat6x7n956d4dw1u2MYrjDKwdBD4OlijANWC9R9a6uWkxq2MQD0KA5hH6gAxPIIBPwHN75G1vxasXWHZClnvkc2_WyydISe5uzeBKC0h7IZDf_v9WfiAbk_PTE3FyfPb9PXlmIRp2w-cOWe-ub_QuRH5dsWdn9m9CwVlL |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Inflammatory+cytokines+in+saliva%3A+early+signs+of+metabolic+disorders+in+chronic+kidney+disease.+A+controlled+cross-sectional+study&rft.jtitle=Oral+surgery%2C+oral+medicine%2C+oral+pathology%2C+oral+radiology+and+endodontics&rft.au=Thorman%2C+Royne&rft.au=Lundahl%2C+Joachim&rft.au=Yucel-Lindberg%2C+T%C3%BClay&rft.au=Hylander%2C+Britta&rft.date=2010-11-01&rft.eissn=1528-395X&rft.volume=110&rft.issue=5&rft.spage=597&rft_id=info:doi/10.1016%2Fj.tripleo.2010.07.007&rft_id=info%3Apmid%2F20955949&rft.externalDocID=20955949 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F10792104%2FS1079210410X00105%2Fcov150h.gif |