From mild cognitive impairment to subjective cognitive decline: conceptual and methodological evolution

• Published in: Neuropsychiatric disease and treatment Vol. 13; pp. 491 - 498
• Main Authors: Cheng, Yu-Wen, Chen, Ta-Fu, Chiu, Ming-Jang
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2017; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Aging; Alzheimer's disease; Alzheimer’s disease (AD); Atrophy; Biomarkers; Cognition; Cognition & reasoning; Cognitive ability; Dementia; Drug development; Drug therapy; Elderly; Health aspects; Medical imaging; Memory; mild cognitive impairment (MCI); Neurology; Neuropathology; Older people; Pathology; Population; preclinical Alzheimer’s disease; Review; Risk factors; subjective cognitive decline (SCD); Taiwan; mild cognitive impairment; subjective cognitive decline; Alzheimer’s disease; preclinical Alzheimer’s disease
• ISSN: 1178-2021; 1176-6328; 1178-2021
• DOI: 10.2147/NDT.S123428

Identification of subjects at the early stages of Alzheimer's disease (AD) is fundamental for drug development and possible intervention or prevention of cognitive decline. The concept of mild cognitive impairment (MCI) evolved during the past two decades to define subjects at the transitional stage between normal aging and dementia. Evidence from cross-sectional and longitudinal studies has shown that MCI is associated with an increased risk of positive AD biomarkers and an increased annual conversion rate of 5%-17% to AD. The presence of AD biomarkers in subjects with MCI was associated with an even higher risk of progression to dementia. However, earlier clinical trials for pharmacotherapy in subjects with MCI were disappointing. To extend the spectrum of AD to an earlier stage before MCI, subjective cognitive decline (SCD) was introduced and was defined as self-reported cognitive decline before the deficits could be detected by cognitive tests. Subjects with SCD have an increased risk of underlying AD pathology. However, SCD can also develop secondary to other heterogeneous etiologies, including other neurodegenerative and psychiatric diseases, personality traits, physical conditions, and medication use. Several clinical and biomarker features were proposed to predict risk of conversion to AD in subjects with SCD. Further longitudinal studies are needed to support the validity of these high-risk features.