Myocardial T2 mapping reveals age- and sex-related differences in volunteers
Background T2 mapping indicates to be a sensitive method for detection of tissue oedema hidden beyond the detection limits of T2-weighted Cardiovascular Magnetic Resonance (CMR). However, due to variability of baseline T2 values in volunteers, reference values need to be defined. Therefore, the aim...
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| Published in | Journal of cardiovascular magnetic resonance Vol. 17; no. 1; p. 9 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
BioMed Central
06.02.2015
BioMed Central Ltd |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1097-6647 1532-429X 1532-429X |
| DOI | 10.1186/s12968-015-0118-0 |
Cover
| Abstract | Background
T2 mapping indicates to be a sensitive method for detection of tissue oedema hidden beyond the detection limits of T2-weighted Cardiovascular Magnetic Resonance (CMR). However, due to variability of baseline T2 values in volunteers, reference values need to be defined. Therefore, the aim of the study was to investigate the effects of age and sex on quantitative T2 mapping with a turbo gradient-spin-echo (GRASE) sequence at 1.5 T. For that reason, we studied sensitivity issues as well as technical and biological effects on GRASE-derived myocardial T2 maps. Furthermore, intra- and interobserver variability were calculated using data from a large volunteer group.
Methods
GRASE-derived multiecho images were analysed using dedicated software. After sequence optimization, validation and sensitivity measurements were performed in muscle phantoms
ex vivo
and
in vivo
. The optimized parameters were used to analyse CMR images of 74 volunteers of mixed sex and a wide range of age with typical prevalence of hypertension and diabetes. Myocardial T2 values were analysed globally and according to the 17 segment model. Strain-encoded (SENC) imaging was additionally performed to investigate possible effects of myocardial strain on global or segmental T2 values.
Results
Ex vivo
studies in muscle phantoms showed, that GRASE-derived T2 values were comparable to those acquired by a standard multiecho spinecho sequence but faster by a factor of 6. Besides that, T2 values reflected tissue water content. The
in vivo
measurements in volunteers revealed intra- and interobserver correlations with R
2
=0.91 and R
2
=0.94 as well as a coefficients of variation of 2.4% and 2.2%, respectively. While global T2 time significantly decreased towards the heart basis, female volunteers had significant higher T2 time irrespective of myocardial region. We found no correlation of segmental T2 values with maximal systolic, diastolic strain or heart rate. Interestingly, volunteers´ age was significantly correlated to T2 time while that was not the case for other coincident cardiovascular risk factors.
Conclusion
GRASE-derived T2 maps are highly reproducible. However, female sex and aging with typical prevalence of hypertension and diabetes were accompanied by increased myocardial T2 values. Thus, sex and age must be considered as influence factors when using GRASE in a diagnostic manner. |
|---|---|
| AbstractList | T2 mapping indicates to be a sensitive method for detection of tissue oedema hidden beyond the detection limits of T2-weighted Cardiovascular Magnetic Resonance (CMR). However, due to variability of baseline T2 values in volunteers, reference values need to be defined. Therefore, the aim of the study was to investigate the effects of age and sex on quantitative T2 mapping with a turbo gradient-spin-echo (GRASE) sequence at 1.5 T. For that reason, we studied sensitivity issues as well as technical and biological effects on GRASE-derived myocardial T2 maps. Furthermore, intra- and interobserver variability were calculated using data from a large volunteer group.BACKGROUNDT2 mapping indicates to be a sensitive method for detection of tissue oedema hidden beyond the detection limits of T2-weighted Cardiovascular Magnetic Resonance (CMR). However, due to variability of baseline T2 values in volunteers, reference values need to be defined. Therefore, the aim of the study was to investigate the effects of age and sex on quantitative T2 mapping with a turbo gradient-spin-echo (GRASE) sequence at 1.5 T. For that reason, we studied sensitivity issues as well as technical and biological effects on GRASE-derived myocardial T2 maps. Furthermore, intra- and interobserver variability were calculated using data from a large volunteer group.GRASE-derived multiecho images were analysed using dedicated software. After sequence optimization, validation and sensitivity measurements were performed in muscle phantoms ex vivo and in vivo. The optimized parameters were used to analyse CMR images of 74 volunteers of mixed sex and a wide range of age with typical prevalence of hypertension and diabetes. Myocardial T2 values were analysed globally and according to the 17 segment model. Strain-encoded (SENC) imaging was additionally performed to investigate possible effects of myocardial strain on global or segmental T2 values.METHODSGRASE-derived multiecho images were analysed using dedicated software. After sequence optimization, validation and sensitivity measurements were performed in muscle phantoms ex vivo and in vivo. The optimized parameters were used to analyse CMR images of 74 volunteers of mixed sex and a wide range of age with typical prevalence of hypertension and diabetes. Myocardial T2 values were analysed globally and according to the 17 segment model. Strain-encoded (SENC) imaging was additionally performed to investigate possible effects of myocardial strain on global or segmental T2 values.Ex vivo studies in muscle phantoms showed, that GRASE-derived T2 values were comparable to those acquired by a standard multiecho spinecho sequence but faster by a factor of 6. Besides that, T2 values reflected tissue water content. The in vivo measurements in volunteers revealed intra- and interobserver correlations with R2=0.91 and R2=0.94 as well as a coefficients of variation of 2.4% and 2.2%, respectively. While global T2 time significantly decreased towards the heart basis, female volunteers had significant higher T2 time irrespective of myocardial region. We found no correlation of segmental T2 values with maximal systolic, diastolic strain or heart rate. Interestingly, volunteers´ age was significantly correlated to T2 time while that was not the case for other coincident cardiovascular risk factors.RESULTSEx vivo studies in muscle phantoms showed, that GRASE-derived T2 values were comparable to those acquired by a standard multiecho spinecho sequence but faster by a factor of 6. Besides that, T2 values reflected tissue water content. The in vivo measurements in volunteers revealed intra- and interobserver correlations with R2=0.91 and R2=0.94 as well as a coefficients of variation of 2.4% and 2.2%, respectively. While global T2 time significantly decreased towards the heart basis, female volunteers had significant higher T2 time irrespective of myocardial region. We found no correlation of segmental T2 values with maximal systolic, diastolic strain or heart rate. Interestingly, volunteers´ age was significantly correlated to T2 time while that was not the case for other coincident cardiovascular risk factors.GRASE-derived T2 maps are highly reproducible. However, female sex and aging with typical prevalence of hypertension and diabetes were accompanied by increased myocardial T2 values. Thus, sex and age must be considered as influence factors when using GRASE in a diagnostic manner.CONCLUSIONGRASE-derived T2 maps are highly reproducible. However, female sex and aging with typical prevalence of hypertension and diabetes were accompanied by increased myocardial T2 values. Thus, sex and age must be considered as influence factors when using GRASE in a diagnostic manner. Background: T2 mapping indicates to be a sensitive method for detection of tissue oedema hidden beyond the detection limits of T2-weighted Cardiovascular Magnetic Resonance (CMR). However, due to variability of baseline T2 values in volunteers, reference values need to be defined. Therefore, the aim of the study was to investigate the effects of age and sex on quantitative T2 mapping with a turbo gradient-spin-echo (GRASE) sequence at 1.5 T. For that reason, we studied sensitivity issues as well as technical and biological effects on GRASE-derived myocardial T2 maps. Furthermore, intra- and interobserver variability were calculated using data from a large volunteer group. Methods: GRASE-derived multiecho images were analysed using dedicated software. After sequence optimization, validation and sensitivity measurements were performed in muscle phantoms ex vivo and in vivo. The optimized parameters were used to analyse CMR images of 74 volunteers of mixed sex and a wide range of age with typical prevalence of hypertension and diabetes. Myocardial T2 values were analysed globally and according to the 17 segment model. Strain-encoded (SENC) imaging was additionally performed to investigate possible effects of myocardial strain on global or segmental T2 values. Results: Ex vivo studies in muscle phantoms showed, that GRASE-derived T2 values were comparable to those acquired by a standard multiecho spinecho sequence but faster by a factor of 6. Besides that, T2 values reflected tissue water content. The in vivo measurements in volunteers revealed intra- and interobserver correlations with R super(2)=0.91 and R super(2)=0.94 as well as a coefficients of variation of 2.4% and 2.2%, respectively. While global T2 time significantly decreased towards the heart basis, female volunteers had significant higher T2 time irrespective of myocardial region. We found no correlation of segmental T2 values with maximal systolic, diastolic strain or heart rate. Interestingly, volunteers age was significantly correlated to T2 time while that was not the case for other coincident cardiovascular risk factors. Conclusion: GRASE-derived T2 maps are highly reproducible. However, female sex and aging with typical prevalence of hypertension and diabetes were accompanied by increased myocardial T2 values. Thus, sex and age must be considered as influence factors when using GRASE in a diagnostic manner. Background T2 mapping indicates to be a sensitive method for detection of tissue oedema hidden beyond the detection limits of T2-weighted Cardiovascular Magnetic Resonance (CMR). However, due to variability of baseline T2 values in volunteers, reference values need to be defined. Therefore, the aim of the study was to investigate the effects of age and sex on quantitative T2 mapping with a turbo gradient-spin-echo (GRASE) sequence at 1.5 T. For that reason, we studied sensitivity issues as well as technical and biological effects on GRASE-derived myocardial T2 maps. Furthermore, intra- and interobserver variability were calculated using data from a large volunteer group. Methods GRASE-derived multiecho images were analysed using dedicated software. After sequence optimization, validation and sensitivity measurements were performed in muscle phantoms ex vivo and in vivo . The optimized parameters were used to analyse CMR images of 74 volunteers of mixed sex and a wide range of age with typical prevalence of hypertension and diabetes. Myocardial T2 values were analysed globally and according to the 17 segment model. Strain-encoded (SENC) imaging was additionally performed to investigate possible effects of myocardial strain on global or segmental T2 values. Results Ex vivo studies in muscle phantoms showed, that GRASE-derived T2 values were comparable to those acquired by a standard multiecho spinecho sequence but faster by a factor of 6. Besides that, T2 values reflected tissue water content. The in vivo measurements in volunteers revealed intra- and interobserver correlations with R 2 =0.91 and R 2 =0.94 as well as a coefficients of variation of 2.4% and 2.2%, respectively. While global T2 time significantly decreased towards the heart basis, female volunteers had significant higher T2 time irrespective of myocardial region. We found no correlation of segmental T2 values with maximal systolic, diastolic strain or heart rate. Interestingly, volunteers´ age was significantly correlated to T2 time while that was not the case for other coincident cardiovascular risk factors. Conclusion GRASE-derived T2 maps are highly reproducible. However, female sex and aging with typical prevalence of hypertension and diabetes were accompanied by increased myocardial T2 values. Thus, sex and age must be considered as influence factors when using GRASE in a diagnostic manner. Background T2 mapping indicates to be a sensitive method for detection of tissue oedema hidden beyond the detection limits of T2-weighted Cardiovascular Magnetic Resonance (CMR). However, due to variability of baseline T2 values in volunteers, reference values need to be defined. Therefore, the aim of the study was to investigate the effects of age and sex on quantitative T2 mapping with a turbo gradient-spin-echo (GRASE) sequence at 1.5 T. For that reason, we studied sensitivity issues as well as technical and biological effects on GRASE-derived myocardial T2 maps. Furthermore, intra- and interobserver variability were calculated using data from a large volunteer group. Methods GRASE-derived multiecho images were analysed using dedicated software. After sequence optimization, validation and sensitivity measurements were performed in muscle phantoms ex vivo and in vivo. The optimized parameters were used to analyse CMR images of 74 volunteers of mixed sex and a wide range of age with typical prevalence of hypertension and diabetes. Myocardial T2 values were analysed globally and according to the 17 segment model. Strain-encoded (SENC) imaging was additionally performed to investigate possible effects of myocardial strain on global or segmental T2 values. Results Ex vivo studies in muscle phantoms showed, that GRASE-derived T2 values were comparable to those acquired by a standard multiecho spinecho sequence but faster by a factor of 6. Besides that, T2 values reflected tissue water content. The in vivo measurements in volunteers revealed intra- and interobserver correlations with R.sup.2=0.91 and R.sup.2=0.94 as well as a coefficients of variation of 2.4% and 2.2%, respectively. While global T2 time significantly decreased towards the heart basis, female volunteers had significant higher T2 time irrespective of myocardial region. We found no correlation of segmental T2 values with maximal systolic, diastolic strain or heart rate. Interestingly, volunteers´ age was significantly correlated to T2 time while that was not the case for other coincident cardiovascular risk factors. Conclusion GRASE-derived T2 maps are highly reproducible. However, female sex and aging with typical prevalence of hypertension and diabetes were accompanied by increased myocardial T2 values. Thus, sex and age must be considered as influence factors when using GRASE in a diagnostic manner. Keywords: Cardiovascular magnetic resonance, T2 mapping, Volunteer study, SENC T2 mapping indicates to be a sensitive method for detection of tissue oedema hidden beyond the detection limits of T2-weighted Cardiovascular Magnetic Resonance (CMR). However, due to variability of baseline T2 values in volunteers, reference values need to be defined. Therefore, the aim of the study was to investigate the effects of age and sex on quantitative T2 mapping with a turbo gradient-spin-echo (GRASE) sequence at 1.5 T. For that reason, we studied sensitivity issues as well as technical and biological effects on GRASE-derived myocardial T2 maps. Furthermore, intra- and interobserver variability were calculated using data from a large volunteer group. GRASE-derived multiecho images were analysed using dedicated software. After sequence optimization, validation and sensitivity measurements were performed in muscle phantoms ex vivo and in vivo. The optimized parameters were used to analyse CMR images of 74 volunteers of mixed sex and a wide range of age with typical prevalence of hypertension and diabetes. Myocardial T2 values were analysed globally and according to the 17 segment model. Strain-encoded (SENC) imaging was additionally performed to investigate possible effects of myocardial strain on global or segmental T2 values. Ex vivo studies in muscle phantoms showed, that GRASE-derived T2 values were comparable to those acquired by a standard multiecho spinecho sequence but faster by a factor of 6. Besides that, T2 values reflected tissue water content. The in vivo measurements in volunteers revealed intra- and interobserver correlations with R2=0.91 and R2=0.94 as well as a coefficients of variation of 2.4% and 2.2%, respectively. While global T2 time significantly decreased towards the heart basis, female volunteers had significant higher T2 time irrespective of myocardial region. We found no correlation of segmental T2 values with maximal systolic, diastolic strain or heart rate. Interestingly, volunteers´ age was significantly correlated to T2 time while that was not the case for other coincident cardiovascular risk factors. GRASE-derived T2 maps are highly reproducible. However, female sex and aging with typical prevalence of hypertension and diabetes were accompanied by increased myocardial T2 values. Thus, sex and age must be considered as influence factors when using GRASE in a diagnostic manner. T2 mapping indicates to be a sensitive method for detection of tissue oedema hidden beyond the detection limits of T2-weighted Cardiovascular Magnetic Resonance (CMR). However, due to variability of baseline T2 values in volunteers, reference values need to be defined. Therefore, the aim of the study was to investigate the effects of age and sex on quantitative T2 mapping with a turbo gradient-spin-echo (GRASE) sequence at 1.5 T. For that reason, we studied sensitivity issues as well as technical and biological effects on GRASE-derived myocardial T2 maps. Furthermore, intra- and interobserver variability were calculated using data from a large volunteer group. GRASE-derived multiecho images were analysed using dedicated software. After sequence optimization, validation and sensitivity measurements were performed in muscle phantoms ex vivo and in vivo. The optimized parameters were used to analyse CMR images of 74 volunteers of mixed sex and a wide range of age with typical prevalence of hypertension and diabetes. Myocardial T2 values were analysed globally and according to the 17 segment model. Strain-encoded (SENC) imaging was additionally performed to investigate possible effects of myocardial strain on global or segmental T2 values. Ex vivo studies in muscle phantoms showed, that GRASE-derived T2 values were comparable to those acquired by a standard multiecho spinecho sequence but faster by a factor of 6. Besides that, T2 values reflected tissue water content. The in vivo measurements in volunteers revealed intra- and interobserver correlations with R.sup.2=0.91 and R.sup.2=0.94 as well as a coefficients of variation of 2.4% and 2.2%, respectively. While global T2 time significantly decreased towards the heart basis, female volunteers had significant higher T2 time irrespective of myocardial region. We found no correlation of segmental T2 values with maximal systolic, diastolic strain or heart rate. Interestingly, volunteers´ age was significantly correlated to T2 time while that was not the case for other coincident cardiovascular risk factors. GRASE-derived T2 maps are highly reproducible. However, female sex and aging with typical prevalence of hypertension and diabetes were accompanied by increased myocardial T2 values. Thus, sex and age must be considered as influence factors when using GRASE in a diagnostic manner. |
| ArticleNumber | 9 |
| Audience | Academic |
| Author | Haberkorn, Sebastian Westenfeld, Ralf Bönner, Florian Schnackenburg, Bernhard Range, Felix Butzbach, Britta Kelm, Malte Neizel-Wittke, Mirja Janzarik, Niko Jacoby, Christoph Flögel, Ulrich Spieker, Maximilian |
| Author_xml | – sequence: 1 givenname: Florian surname: Bönner fullname: Bönner, Florian email: Florian.Boenner@med.uni-duesseldorf.de organization: Department of Cardiology, Pulmonology and Vascular Medicine, Heinrich Heine University, Medical Faculty – sequence: 2 givenname: Niko surname: Janzarik fullname: Janzarik, Niko organization: Department of Cardiology, Pulmonology and Vascular Medicine, Heinrich Heine University, Medical Faculty – sequence: 3 givenname: Christoph surname: Jacoby fullname: Jacoby, Christoph organization: Department of Cardiology, Pulmonology and Vascular Medicine, Heinrich Heine University, Medical Faculty, Department of Molecular Cardiology, Heinrich Heine University, Medical Faculty – sequence: 4 givenname: Maximilian surname: Spieker fullname: Spieker, Maximilian organization: Department of Cardiology, Pulmonology and Vascular Medicine, Heinrich Heine University, Medical Faculty – sequence: 5 givenname: Bernhard surname: Schnackenburg fullname: Schnackenburg, Bernhard organization: Philips Healthcare – sequence: 6 givenname: Felix surname: Range fullname: Range, Felix organization: Department of Cardiology, Pulmonology and Vascular Medicine, Heinrich Heine University, Medical Faculty – sequence: 7 givenname: Britta surname: Butzbach fullname: Butzbach, Britta organization: Department of Cardiology, Pulmonology and Vascular Medicine, Heinrich Heine University, Medical Faculty – sequence: 8 givenname: Sebastian surname: Haberkorn fullname: Haberkorn, Sebastian organization: Department of Cardiology, Pulmonology and Vascular Medicine, Heinrich Heine University, Medical Faculty – sequence: 9 givenname: Ralf surname: Westenfeld fullname: Westenfeld, Ralf organization: Department of Cardiology, Pulmonology and Vascular Medicine, Heinrich Heine University, Medical Faculty – sequence: 10 givenname: Mirja surname: Neizel-Wittke fullname: Neizel-Wittke, Mirja organization: Department of Cardiology, Pulmonology and Vascular Medicine, Heinrich Heine University, Medical Faculty – sequence: 11 givenname: Ulrich surname: Flögel fullname: Flögel, Ulrich organization: Department of Molecular Cardiology, Heinrich Heine University, Medical Faculty, CARID (Cardiovascular Research Institute Düsseldorf) – sequence: 12 givenname: Malte surname: Kelm fullname: Kelm, Malte organization: Department of Cardiology, Pulmonology and Vascular Medicine, Heinrich Heine University, Medical Faculty, CARID (Cardiovascular Research Institute Düsseldorf) |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25656484$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.2214/AJR.05.0442 10.1002/mrm.24139 10.1161/CIRCIMAGING.111.967836 10.1002/jmri.21612 10.1089/ars.2011.4179 10.1016/j.jcmg.2012.06.010 10.1016/S0735-1097(00)01196-7 10.1002/mrm.1910230110 10.2214/AJR.07.2031 10.1378/chest.127.1.143 10.1186/1532-429X-15-53 10.1016/0730-725X(93)90070-T 10.1007/s00395-014-0430-0 10.1161/CIRCIMAGING.112.973222 10.1253/circj.CJ-10-0196 10.1016/0002-9149(83)90093-0 10.1002/jmri.20681 10.1152/jappl.1997.83.3.904 10.1161/01.CIR.0000048893.62841.F7 10.1186/1532-429X-15-27 10.1016/j.neuroimage.2012.06.064 10.1161/hc0402.102975 10.1161/01.CIR.0000127428.10985.C6 10.1002/mrm.25125 10.1161/CIRCIMAGING.113.001541 10.1007/s00424-013-1232-1 10.1016/j.ejrad.2011.06.041 10.1186/1532-429X-15-103 10.1093/eurheartj/ehn207 10.1038/nrcardio.2010.124 |
| ContentType | Journal Article |
| Copyright | Bönner et al.; licensee BioMed Central. 2015 COPYRIGHT 2015 BioMed Central Ltd. |
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| Keywords | SENC Cardiovascular magnetic resonance T2 mapping Volunteer study |
| Language | English |
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| References | Dai (10.1186/s12968-015-0118-0_bib16) 2012; 16 Lakatta (10.1186/s12968-015-0118-0_bib29) 2003; 107 Marie (10.1186/s12968-015-0118-0_bib10) 2001; 37 Hardy (10.1186/s12968-015-0118-0_bib24) 1997; 83 Boxt (10.1186/s12968-015-0118-0_bib1) 1993; 11 Mavrogeni (10.1186/s12968-015-0118-0_bib26) 2005; 127 Zhang (10.1186/s12968-015-0118-0_bib20) 2015; 73 Prasloski (10.1186/s12968-015-0118-0_bib18) 2012; 63 Neizel (10.1186/s12968-015-0118-0_bib22) 2009; 29 Regitz-Zagrosek (10.1186/s12968-015-0118-0_bib17) 2010; 74 Imbriaco (10.1186/s12968-015-0118-0_bib9) 2007; 188 Wittnich (10.1186/s12968-015-0118-0_bib27) 2013; 465 Higgins (10.1186/s12968-015-0118-0_bib2) 1983; 52 Scholz (10.1186/s12968-015-0118-0_bib5) 1992; 23 von Knobelsdorff-Brenkenhoff (10.1186/s12968-015-0118-0_bib23) 2013; 15 Raza (10.1186/s12968-015-0118-0_bib19) 2012; 81 Kali (10.1186/s12968-015-0118-0_bib6) 2014; 7 Nyman (10.1186/s12968-015-0118-0_bib30) 2013; 15 van der Meer (10.1186/s12968-015-0118-0_bib31) 2008; 29 He (10.1186/s12968-015-0118-0_bib25) 2006; 24 Zia (10.1186/s12968-015-0118-0_bib15) 2012; 5 van Heeswijk (10.1186/s12968-015-0118-0_bib13) 2012; 5 Thavendiranathan (10.1186/s12968-015-0118-0_bib12) 2012; 5 Giri (10.1186/s12968-015-0118-0_bib11) 2012; 68 Gouya (10.1186/s12968-015-0118-0_bib8) 2008; 190 Abdel-Aty (10.1186/s12968-015-0118-0_bib3) 2004; 109 Wince (10.1186/s12968-015-0118-0_bib4) 2010; 7 Hassan (10.1186/s12968-015-0118-0_bib28) 2013; 7 Bonner (10.1186/s12968-015-0118-0_bib7) 2014; 109 Wassmuth (10.1186/s12968-015-0118-0_bib14) 2013; 15 Cerqueira (10.1186/s12968-015-0118-0_bib21) 2002; 105 |
| References_xml | – volume: 188 start-page: 850 year: 2007 ident: 10.1186/s12968-015-0118-0_bib9 article-title: MRI characterization of myocardial tissue in patients with Fabry's disease publication-title: AJR Am J Roentgenol doi: 10.2214/AJR.05.0442 – volume: 68 start-page: 1570 year: 2012 ident: 10.1186/s12968-015-0118-0_bib11 article-title: Myocardial T(2) mapping with respiratory navigator and automatic nonrigid motion correction publication-title: Magn Reson Med doi: 10.1002/mrm.24139 – volume: 5 start-page: 102 year: 2012 ident: 10.1186/s12968-015-0118-0_bib12 article-title: Improved detection of myocardial involvement in acute inflammatory cardiomyopathies using T2 mapping publication-title: Circ Cardiovasc Imaging doi: 10.1161/CIRCIMAGING.111.967836 – volume: 29 start-page: 99 year: 2009 ident: 10.1186/s12968-015-0118-0_bib22 article-title: Strain-encoded (SENC) magnetic resonance imaging to evaluate regional heterogeneity of myocardial strain in healthy volunteers: comparison with conventional tagging publication-title: J Magn Reson Imaging doi: 10.1002/jmri.21612 – volume: 16 start-page: 1492 year: 2012 ident: 10.1186/s12968-015-0118-0_bib16 article-title: Cardiac aging: from molecular mechanisms to significance in human health and disease publication-title: Antioxid Redox Signal doi: 10.1089/ars.2011.4179 – volume: 5 start-page: 1231 year: 2012 ident: 10.1186/s12968-015-0118-0_bib13 article-title: Free-breathing 3 T magnetic resonance T2-mapping of the heart publication-title: JACC Cardiovasc Imaging doi: 10.1016/j.jcmg.2012.06.010 – volume: 37 start-page: 825 year: 2001 ident: 10.1186/s12968-015-0118-0_bib10 article-title: Detection and prediction of acute heart transplant rejection with the myocardial T2 determination provided by a black-blood magnetic resonance imaging sequence publication-title: J Am Coll Cardiol doi: 10.1016/S0735-1097(00)01196-7 – volume: 23 start-page: 89 year: 1992 ident: 10.1186/s12968-015-0118-0_bib5 article-title: NMR relaxation times in acute myocardial infarction: relative influence of changes in tissue water and fat content publication-title: Magn Reson Med doi: 10.1002/mrm.1910230110 – volume: 190 start-page: 1576 year: 2008 ident: 10.1186/s12968-015-0118-0_bib8 article-title: Rapidly reversible myocardial edema in patients with acromegaly: assessment with ultrafast T2 mapping in a single-breath-hold MRI sequence publication-title: AJR Am J Roentgenol doi: 10.2214/AJR.07.2031 – volume: 127 start-page: 143 year: 2005 ident: 10.1186/s12968-015-0118-0_bib26 article-title: Cardiac and sternocleidomastoid muscle involvement in Duchenne muscular dystrophy: an MRI study publication-title: Chest doi: 10.1378/chest.127.1.143 – volume: 15 start-page: 53 year: 2013 ident: 10.1186/s12968-015-0118-0_bib23 article-title: Myocardial T1 and T2 mapping at 3 T: reference values, influencing factors and implications publication-title: J Cardiovasc Magn Reson doi: 10.1186/1532-429X-15-53 – volume: 11 start-page: 375 year: 1993 ident: 10.1186/s12968-015-0118-0_bib1 article-title: Estimation of myocardial water content using transverse relaxation time from dual spin-echo magnetic resonance imaging publication-title: Magn Reson Imaging doi: 10.1016/0730-725X(93)90070-T – volume: 109 start-page: 430 year: 2014 ident: 10.1186/s12968-015-0118-0_bib7 article-title: Multifunctional MR monitoring of the healing process after myocardial infarction publication-title: Basic Res Cardiol doi: 10.1007/s00395-014-0430-0 – volume: 5 start-page: 566 year: 2012 ident: 10.1186/s12968-015-0118-0_bib15 article-title: Characterizing myocardial edema and hemorrhage using quantitative T2 and T2* mapping at multiple time intervals post ST-segment elevation myocardial infarction publication-title: Circ Cardiovasc Imaging doi: 10.1161/CIRCIMAGING.112.973222 – volume: 74 start-page: 1265 year: 2010 ident: 10.1186/s12968-015-0118-0_bib17 article-title: Sex and gender differences in myocardial hypertrophy and heart failure publication-title: Circ J doi: 10.1253/circj.CJ-10-0196 – volume: 7 start-page: 47 year: 2013 ident: 10.1186/s12968-015-0118-0_bib28 article-title: Effect of exercise training and anabolic androgenic steroids on hemodynamics, glycogen content, angiogenesis and apoptosis of cardiac muscle in adult male rats publication-title: Int J Health Sci (Qassim) – volume: 52 start-page: 184 year: 1983 ident: 10.1186/s12968-015-0118-0_bib2 article-title: Nuclear magnetic resonance imaging of acute myocardial infarction in dogs: alterations in magnetic relaxation times publication-title: Am J Cardiol doi: 10.1016/0002-9149(83)90093-0 – volume: 24 start-page: 580 year: 2006 ident: 10.1186/s12968-015-0118-0_bib25 article-title: Development of a novel optimized breathhold technique for myocardial T2 measurement in thalassemia publication-title: J Magn Reson Imaging doi: 10.1002/jmri.20681 – volume: 83 start-page: 904 year: 1997 ident: 10.1186/s12968-015-0118-0_bib24 article-title: Measurement of magnetic resonance T2 for physiological experiments publication-title: J Appl Physiol (1985) doi: 10.1152/jappl.1997.83.3.904 – volume: 107 start-page: 346 year: 2003 ident: 10.1186/s12968-015-0118-0_bib29 article-title: Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part II: the aging heart in health: links to heart disease publication-title: Circulation doi: 10.1161/01.CIR.0000048893.62841.F7 – volume: 15 start-page: 27 year: 2013 ident: 10.1186/s12968-015-0118-0_bib14 article-title: Variability and homogeneity of cardiovascular magnetic resonance myocardial T2-mapping in volunteers compared to patients with edema publication-title: J Cardiovasc Magn Reson doi: 10.1186/1532-429X-15-27 – volume: 63 start-page: 533 year: 2012 ident: 10.1186/s12968-015-0118-0_bib18 article-title: Rapid whole cerebrum myelin water imaging using a 3D GRASE sequence publication-title: Neuroimage doi: 10.1016/j.neuroimage.2012.06.064 – volume: 105 start-page: 539 year: 2002 ident: 10.1186/s12968-015-0118-0_bib21 article-title: Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association publication-title: Circulation doi: 10.1161/hc0402.102975 – volume: 109 start-page: 2411 year: 2004 ident: 10.1186/s12968-015-0118-0_bib3 article-title: Delayed enhancement and T2-weighted cardiovascular magnetic resonance imaging differentiate acute from chronic myocardial infarction publication-title: Circulation doi: 10.1161/01.CIR.0000127428.10985.C6 – volume: 73 start-page: 223 year: 2015 ident: 10.1186/s12968-015-0118-0_bib20 article-title: Comparison of myelin water fraction from multiecho T decay curve and steady-state methods publication-title: Magn Reson Med doi: 10.1002/mrm.25125 – volume: 7 start-page: 471 year: 2014 ident: 10.1186/s12968-015-0118-0_bib6 article-title: Determination of location, size and transmurality of chronic myocardial infarction without exogenous contrast media using cardiac magnetic resonance imaging at 3T publication-title: Circ Cardiovasc Imaging doi: 10.1161/CIRCIMAGING.113.001541 – volume: 465 start-page: 719 year: 2013 ident: 10.1186/s12968-015-0118-0_bib27 article-title: Sex differences in myocardial metabolism and cardiac function: an emerging concept publication-title: Pflugers Arch doi: 10.1007/s00424-013-1232-1 – volume: 81 start-page: e536 year: 2012 ident: 10.1186/s12968-015-0118-0_bib19 article-title: Assessment of colorectal hepatic metastases by quantitative T2 relaxation time publication-title: Eur J Radiol doi: 10.1016/j.ejrad.2011.06.041 – volume: 15 start-page: 103 year: 2013 ident: 10.1186/s12968-015-0118-0_bib30 article-title: Cardiac steatosis and left ventricular function in men with metabolic syndrome publication-title: J Cardiovasc Magn Reson doi: 10.1186/1532-429X-15-103 – volume: 29 start-page: 1516 year: 2008 ident: 10.1186/s12968-015-0118-0_bib31 article-title: The ageing male heart: myocardial triglyceride content as independent predictor of diastolic function publication-title: Eur Heart J doi: 10.1093/eurheartj/ehn207 – volume: 7 start-page: 547 year: 2010 ident: 10.1186/s12968-015-0118-0_bib4 article-title: Molecular imaging: T2-weighted CMR of the area at risk–a risky business? publication-title: Nat Rev Cardiol doi: 10.1038/nrcardio.2010.124 |
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T2 mapping indicates to be a sensitive method for detection of tissue oedema hidden beyond the detection limits of T2-weighted Cardiovascular... T2 mapping indicates to be a sensitive method for detection of tissue oedema hidden beyond the detection limits of T2-weighted Cardiovascular Magnetic... Background T2 mapping indicates to be a sensitive method for detection of tissue oedema hidden beyond the detection limits of T2-weighted Cardiovascular... Background: T2 mapping indicates to be a sensitive method for detection of tissue oedema hidden beyond the detection limits of T2-weighted Cardiovascular... |
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| SubjectTerms | Adult Age Age Factors Angiology Biomedical materials Cardiology Complications and side effects Correlation Diagnosis Female Heart beat Humans Hypertension Image Enhancement - methods Imaging Magnetic resonance Magnetic Resonance Imaging, Cine - methods Male Mapping Mathematical models Medicine Medicine & Public Health Middle Aged Myocardial Contraction Myocardium - pathology Phantoms, Imaging Radiology Risk factors Sex Sex Factors Surgical implants |
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| Title | Myocardial T2 mapping reveals age- and sex-related differences in volunteers |
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