Characterizing longitudinal white matter development during early childhood

Post-mortem studies have shown the maturation of the brain’s myelinated white matter, crucial for efficient and coordinated brain communication, follows a nonlinear spatio-temporal pattern that corresponds with the onset and refinement of cognitive functions and behaviors. Unfortunately, investigati...

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Published in	Brain Structure and Function Vol. 220; no. 4; pp. 1921 - 1933
Main Authors	Dean, Douglas C., O’Muircheartaigh, Jonathan, Dirks, Holly, Waskiewicz, Nicole, Walker, Lindsay, Doernberg, Ellen, Piryatinsky, Irene, Deoni, Sean C. L.
Format	Journal Article
Language	English
Published	Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2015 Springer Nature B.V
Subjects	Age Factors Biomedical and Life Sciences Biomedicine Brain Brain Mapping Cell Biology Child Child development Child Development - physiology Child, Preschool Cognition Female Humans Imaging, Three-Dimensional Infant Longitudinal Studies Magnetic Resonance Imaging Male Neurology Neuropsychological Tests Neurosciences NMR Nuclear magnetic resonance Original Original Article Sex Characteristics White Matter - growth & development White matter development Myelin water fraction Magnetic resonance imaging Brain development
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ISSN	1863-2653 1863-2661 1863-2661 0340-2061
DOI	10.1007/s00429-014-0763-3

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Abstract	Post-mortem studies have shown the maturation of the brain’s myelinated white matter, crucial for efficient and coordinated brain communication, follows a nonlinear spatio-temporal pattern that corresponds with the onset and refinement of cognitive functions and behaviors. Unfortunately, investigation of myelination in vivo is challenging and, thus, little is known about the normative pattern of myelination, or its association with functional development. Using a novel quantitative magnetic resonance imaging technique sensitive to myelin we examined longitudinal white matter development in 108 typically developing children ranging in age from 2.5 months to 5.5 years. Using nonlinear mixed effects modeling, we provide the first in vivo longitudinal description of myelin water fraction development. Moreover, we show distinct male and female developmental patterns, and demonstrate significant relationships between myelin content and measures of cognitive function. These findings advance a new understanding of healthy brain development and provide a foundation from which to assess atypical development.
AbstractList	Post-mortem studies have shown the maturation of the brain’s myelinated white matter, crucial for efficient and coordinated brain communication, follows a nonlinear spatio-temporal pattern that corresponds with the onset and refinement of cognitive functions and behaviors. Unfortunately, investigation of myelination in vivo is challenging and, thus, little is known about the normative pattern of myelination, or its association with functional development. Using a novel quantitative magnetic resonance imaging technique sensitive to myelin we examined longitudinal white matter development in 108 typically developing children ranging in age from 2.5 months to 5.5 years. Using nonlinear mixed effects modeling, we provide the first in vivo longitudinal description of myelin water fraction development. Moreover, we show distinct male and female developmental patterns, and demonstrate significant relationships between myelin content and measures of cognitive function. These findings advance a new understanding of healthy brain development and provide a foundation from which to assess atypical development. Post-mortem studies have shown the maturation of the brain's myelinated white matter, crucial for efficient and coordinated brain communication, follows a nonlinear spatio-temporal pattern that corresponds with the onset and refinement of cognitive functions and behaviors. Unfortunately, investigation of myelination in vivo is challenging and, thus, little is known about the normative pattern of myelination, or its association with functional development. Using a novel quantitative magnetic resonance imaging technique sensitive to myelin we examined longitudinal white matter development in 108 typically developing children ranging in age from 2.5 months to 5.5 years. Using nonlinear mixed effects modeling, we provide the first in vivo longitudinal description of myelin water fraction development. Moreover, we show distinct male and female developmental patterns, and demonstrate significant relationships between myelin content and measures of cognitive function. These findings advance a new understanding of healthy brain development and provide a foundation from which to assess atypical development.Post-mortem studies have shown the maturation of the brain's myelinated white matter, crucial for efficient and coordinated brain communication, follows a nonlinear spatio-temporal pattern that corresponds with the onset and refinement of cognitive functions and behaviors. Unfortunately, investigation of myelination in vivo is challenging and, thus, little is known about the normative pattern of myelination, or its association with functional development. Using a novel quantitative magnetic resonance imaging technique sensitive to myelin we examined longitudinal white matter development in 108 typically developing children ranging in age from 2.5 months to 5.5 years. Using nonlinear mixed effects modeling, we provide the first in vivo longitudinal description of myelin water fraction development. Moreover, we show distinct male and female developmental patterns, and demonstrate significant relationships between myelin content and measures of cognitive function. These findings advance a new understanding of healthy brain development and provide a foundation from which to assess atypical development. Post-mortem studies have shown the maturation of the brain's myelinated white matter, crucial for efficient and coordinated brain communication, follows a nonlinear spatio-temporal pattern that corresponds with the onset and refinement of cognitive functions and behaviors. Unfortunately, investigation of myelination in vivo is challenging and, thus, little is known about the normative pattern of myelination, or its association with functional development. Using a novel quantitative magnetic resonance imaging technique sensitive to myelin we examined longitudinal white matter development in 108 typically developing children ranging in age from 2.5 months to 5.5 years. Using nonlinear mixed effects modeling, we provide the first in vivo longitudinal description of myelin water fraction development. Moreover, we show distinct male and female developmental patterns, and demonstrate significant relationships between myelin content and measures of cognitive function. These findings advance a new understanding of healthy brain development and provide a foundation from which to assess atypical development. Post-mortem studies have shown the maturation of the brain’s myelinated white matter, crucial for efficient and coordinated brain communication, follows a nonlinear spatio-temporal pattern that corresponds with the onset and refinement of cognitive functions and behaviors. Unfortunately, investigation of myelination in vivo is challenging and, thus, little is known about the normative pattern of myelination, or its association with functional development. Using a novel quantitative magnetic resonance imaging technique sensitive to myelin we examined longitudinal white matter development in 108 typically developing children ranging in age from 2.5 months to 5.5 years. Using nonlinear mixed effects modeling, we provide the first in vivo longitudinal description of myelin water fraction development. Moreover, we show distinct male and female developmental patterns, and demonstrate significant relationships between myelin content and measures of cognitive function. These findings advance a new understanding of healthy brain development and provide a foundation from which to assess atypical development.
Author	Dirks, Holly Walker, Lindsay Piryatinsky, Irene Deoni, Sean C. L. Dean, Douglas C. Doernberg, Ellen O’Muircheartaigh, Jonathan Waskiewicz, Nicole
Author_xml	– sequence: 1 givenname: Douglas C. surname: Dean fullname: Dean, Douglas C. email: douglas_dean_iii@brown.edu organization: Advanced Baby Imaging Laboratory, School of Engineering, Brown University – sequence: 2 givenname: Jonathan surname: O’Muircheartaigh fullname: O’Muircheartaigh, Jonathan organization: Advanced Baby Imaging Laboratory, School of Engineering, Brown University, Department of Neuroimaging, King’s College London, Institute of Psychiatry – sequence: 3 givenname: Holly surname: Dirks fullname: Dirks, Holly organization: Advanced Baby Imaging Laboratory, School of Engineering, Brown University – sequence: 4 givenname: Nicole surname: Waskiewicz fullname: Waskiewicz, Nicole organization: Advanced Baby Imaging Laboratory, School of Engineering, Brown University – sequence: 5 givenname: Lindsay surname: Walker fullname: Walker, Lindsay organization: Advanced Baby Imaging Laboratory, School of Engineering, Brown University – sequence: 6 givenname: Ellen surname: Doernberg fullname: Doernberg, Ellen organization: Advanced Baby Imaging Laboratory, School of Engineering, Brown University – sequence: 7 givenname: Irene surname: Piryatinsky fullname: Piryatinsky, Irene organization: Advanced Baby Imaging Laboratory, School of Engineering, Brown University – sequence: 8 givenname: Sean C. L. surname: Deoni fullname: Deoni, Sean C. L. organization: Advanced Baby Imaging Laboratory, School of Engineering, Brown University
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/24710623$$D View this record in MEDLINE/PubMed
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Snippet	Post-mortem studies have shown the maturation of the brain’s myelinated white matter, crucial for efficient and coordinated brain communication, follows a... Post-mortem studies have shown the maturation of the brain's myelinated white matter, crucial for efficient and coordinated brain communication, follows a... Post-mortem studies have shown the maturation of the brain’s myelinated white matter, crucial for efficient and coordinated brain communication, follows a...
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StartPage	1921
SubjectTerms	Age Factors Biomedical and Life Sciences Biomedicine Brain Brain Mapping Cell Biology Child Child development Child Development - physiology Child, Preschool Cognition Female Humans Imaging, Three-Dimensional Infant Longitudinal Studies Magnetic Resonance Imaging Male Neurology Neuropsychological Tests Neurosciences NMR Nuclear magnetic resonance Original Original Article Sex Characteristics White Matter - growth & development
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Title	Characterizing longitudinal white matter development during early childhood
URI	https://link.springer.com/article/10.1007/s00429-014-0763-3 https://www.ncbi.nlm.nih.gov/pubmed/24710623 https://www.proquest.com/docview/1691224788 https://www.proquest.com/docview/1691598512 https://www.proquest.com/docview/1705070102 https://pubmed.ncbi.nlm.nih.gov/PMC4481335
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