磁共振弥散加权成像诊断移植肾急性排异的应用研究
R816.7; 目的:评估磁共振扩散加权成像(DWI)对肾脏移植术后移植肾急性排异诊断的应用价值.方法:选取首次行肾脏移植手术的患者69名,根据临床表现及病理穿刺结果,将患者分为排异组(ADCr,n=26例)和正常功能组(ADCn,n=43例).正常功能组在术后2～3周进行磁共振扫描,排异组在肾移植术后1个月内且肾脏穿刺活检前后5日内进行磁共振扫描.测量移植肾在不同扩散敏感梯度系数(b值=200、400、600、800、1 000 s/mm~2)时的的ADC值.两组数据比较采用t检验分析.结果:在不同b值取值时,排异组ADC值均较正常功能组有明显降低(P≤0.05).不同b值下的ROC曲线显示...
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| Published in | 浙江大学学报（医学版） Vol. 39; no. 2; pp. 163 - 167 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
浙江大学医学院,附属第二医院放射科,浙江,杭州,310009%浙江大学医学院,附属第一医院放射科,浙江,杭州,310003%浙江省肿瘤医院放射科,浙江,杭州,310022
2010
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1008-9292 |
| DOI | 10.3785/j.issn.1008-9292.2010.02.009 |
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| Abstract | R816.7; 目的:评估磁共振扩散加权成像(DWI)对肾脏移植术后移植肾急性排异诊断的应用价值.方法:选取首次行肾脏移植手术的患者69名,根据临床表现及病理穿刺结果,将患者分为排异组(ADCr,n=26例)和正常功能组(ADCn,n=43例).正常功能组在术后2～3周进行磁共振扫描,排异组在肾移植术后1个月内且肾脏穿刺活检前后5日内进行磁共振扫描.测量移植肾在不同扩散敏感梯度系数(b值=200、400、600、800、1 000 s/mm~2)时的的ADC值.两组数据比较采用t检验分析.结果:在不同b值取值时,排异组ADC值均较正常功能组有明显降低(P≤0.05).不同b值下的ROC曲线显示,当b取800 s/mm~2时,DWI诊断肾移植后急性排异的敏感度和特异度最高.结论:DWI可无创性早期诊断移植肾急性排异. |
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| AbstractList | R816.7; 目的:评估磁共振扩散加权成像(DWI)对肾脏移植术后移植肾急性排异诊断的应用价值.方法:选取首次行肾脏移植手术的患者69名,根据临床表现及病理穿刺结果,将患者分为排异组(ADCr,n=26例)和正常功能组(ADCn,n=43例).正常功能组在术后2～3周进行磁共振扫描,排异组在肾移植术后1个月内且肾脏穿刺活检前后5日内进行磁共振扫描.测量移植肾在不同扩散敏感梯度系数(b值=200、400、600、800、1 000 s/mm~2)时的的ADC值.两组数据比较采用t检验分析.结果:在不同b值取值时,排异组ADC值均较正常功能组有明显降低(P≤0.05).不同b值下的ROC曲线显示,当b取800 s/mm~2时,DWI诊断肾移植后急性排异的敏感度和特异度最高.结论:DWI可无创性早期诊断移植肾急性排异. |
| Abstract_FL | Objective: To evaluate the feasibility of MR diffusion-weighted imaging (DWI) in diagnosis of acute rejection after renal transplantation. Methods: Sixty-nine patients who underwent renal transplantation were enrolled in the study.According to the clinical features and renal biopsy,26 patients were designated in rejection group and 43 in non-rejection group.Patients in non-rejection group underwent MR DWI scan at 2 to 3 weeks after operation,and those in rejection group underwent scan at 5 d before or after renal biopsy.Then the apparent diffusion coefficient (ADC) values of transplanted kidneys were measured with high diffusion sensitivity gradient factors (b values). Results: Patients with acute rejection had significantly lower ADC (P≤0.05) than non-rejection patients with all the different b values (b=200,400,600,800,1 000 s/mm~2).The ROC curves showed that sensitivity and specificity were best when b value was 800 s/mm~2. Conclusion: DWI is a potential and reliable non-invasive method for the diagnosis of the acute rejection after renal transplantation. |
| Author | 许晶晶 张雷 张敏鸣 肖文波 |
| AuthorAffiliation | 浙江大学医学院,附属第二医院放射科,浙江,杭州,310009%浙江大学医学院,附属第一医院放射科,浙江,杭州,310003%浙江省肿瘤医院放射科,浙江,杭州,310022 |
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| Author_FL | XIAO Wen-bo XU Jing-jing ZHANG Lei ZHANG Min-ming |
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| DocumentTitle_FL | Value of diffusion-weighted MR imaging in diagnosis of acute rejection after renal transplantation |
| EndPage | 167 |
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| Keywords | Graft rejection/diag Diffusion-weighted imaging Rejection 磁共振成像/方法 Magnetic resonance imaging/methods 肾/病理学 肾移植/副作用 排异 Kidney transplantation/adveff 移植物排斥/诊断 扩散成像 |
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| Publisher | 浙江大学医学院,附属第二医院放射科,浙江,杭州,310009%浙江大学医学院,附属第一医院放射科,浙江,杭州,310003%浙江省肿瘤医院放射科,浙江,杭州,310022 |
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| Snippet | R816.7; 目的:评估磁共振扩散加权成像(DWI)对肾脏移植术后移植肾急性排异诊断的应用价值.方法:选取首次行肾脏移植手术的患者69名,根据临床表现及病理穿刺结果,将患者分为... |
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| Title | 磁共振弥散加权成像诊断移植肾急性排异的应用研究 |
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