Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages
Increased circulating free fatty acids in subjects with type 2 diabetes may contribute to activation of macrophages, and thus the development of atherosclerosis. In this study, we investigated the effect of the saturated fatty acids (SFA) palmitate, stearate, myristate and laurate, and the unsaturat...
Saved in:
| Published in | Atherosclerosis Vol. 202; no. 2; pp. 382 - 393 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier Ireland Ltd
01.02.2009
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-9150 1879-1484 1879-1484 |
| DOI | 10.1016/j.atherosclerosis.2008.05.033 |
Cover
| Abstract | Increased circulating free fatty acids in subjects with type 2 diabetes may contribute to activation of macrophages, and thus the development of atherosclerosis. In this study, we investigated the effect of the saturated fatty acids (SFA) palmitate, stearate, myristate and laurate, and the unsaturated fatty acid linoleate, on the production of proinflammatory cytokines in phorbol ester-differentiated THP-1 cells, a model of human macrophages. Palmitate induced secretion and mRNA expression of TNF-α, IL-8 and IL-1β, and enhanced lipopolysaccharide (LPS)-induced IL-1β secretion. Proinflammatory cytokine secretion was also induced by stearate, but not by the shorter chain SFA, myristate and laurate, or linoleate. Triacsin C abolished the palmitate-induced cytokine secretion, suggesting that palmitate activation to palmitoyl-CoA is required for its effect. Palmitate-induced cytokine secretion was decreased by knockdown of serine palmitoyltransferase and mimicked by C
2-ceramide, indicating that ceramide is involved in palmitate-induced cytokine secretion. Palmitate phosphorylated p38 and JNK kinases, and blocking of these kinases with specific inhibitors diminished the palmitate-induced cytokine secretion. Palmitate also activated the AP-1 (c-Jun) transcription factor. Knockdown of MyD88 reduced the palmitate-induced IL-8, but not TNF-α or IL-1β secretion. In conclusion, our data suggest that the long-chain SFA induce proinflammatory cytokines in human macrophages
via pathways involving
de novo ceramide synthesis. This might contribute to the activation of macrophages in atherosclerotic plaques, especially in type 2 diabetes. |
|---|---|
| AbstractList | Increased circulating free fatty acids in subjects with type 2 diabetes may contribute to activation of macrophages, and thus the development of atherosclerosis. In this study, we investigated the effect of the saturated fatty acids (SFA) palmitate, stearate, myristate and laurate, and the unsaturated fatty acid linoleate, on the production of proinflammatory cytokines in phorbol ester-differentiated THP-1 cells, a model of human macrophages. Palmitate induced secretion and mRNA expression of TNF-alpha, IL-8 and IL-1 beta, and enhanced lipopolysaccharide (LPS)-induced IL-1 beta secretion. Proinflammatory cytokine secretion was also induced by stearate, but not by the shorter chain SFA, myristate and laurate, or linoleate. Triacsin C abolished the palmitate-induced cytokine secretion, suggesting that palmitate activation to palmitoyl-CoA is required for its effect. Palmitate-induced cytokine secretion was decreased by knockdown of serine palmitoyltransferase and mimicked by C(2)-ceramide, indicating that ceramide is involved in palmitate-induced cytokine secretion. Palmitate phosphorylated p38 and JNK kinases, and blocking of these kinases with specific inhibitors diminished the palmitate-induced cytokine secretion. Palmitate also activated the AP-1 (c-Jun) transcription factor. Knockdown of MyD88 reduced the palmitate-induced IL-8, but not TNF-alpha or IL-1 beta secretion. In conclusion, our data suggest that the long-chain SFA induce proinflammatory cytokines in human macrophages via pathways involving de novo ceramide synthesis. This might contribute to the activation of macrophages in atherosclerotic plaques, especially in type 2 diabetes. Increased circulating free fatty acids in subjects with type 2 diabetes may contribute to activation of macrophages, and thus the development of atherosclerosis. In this study, we investigated the effect of the saturated fatty acids (SFA) palmitate, stearate, myristate and laurate, and the unsaturated fatty acid linoleate, on the production of proinflammatory cytokines in phorbol ester-differentiated THP-1 cells, a model of human macrophages. Palmitate induced secretion and mRNA expression of TNF-α, IL-8 and IL-1β, and enhanced lipopolysaccharide (LPS)-induced IL-1β secretion. Proinflammatory cytokine secretion was also induced by stearate, but not by the shorter chain SFA, myristate and laurate, or linoleate. Triacsin C abolished the palmitate-induced cytokine secretion, suggesting that palmitate activation to palmitoyl-CoA is required for its effect. Palmitate-induced cytokine secretion was decreased by knockdown of serine palmitoyltransferase and mimicked by C 2-ceramide, indicating that ceramide is involved in palmitate-induced cytokine secretion. Palmitate phosphorylated p38 and JNK kinases, and blocking of these kinases with specific inhibitors diminished the palmitate-induced cytokine secretion. Palmitate also activated the AP-1 (c-Jun) transcription factor. Knockdown of MyD88 reduced the palmitate-induced IL-8, but not TNF-α or IL-1β secretion. In conclusion, our data suggest that the long-chain SFA induce proinflammatory cytokines in human macrophages via pathways involving de novo ceramide synthesis. This might contribute to the activation of macrophages in atherosclerotic plaques, especially in type 2 diabetes. Abstract Increased circulating free fatty acids in subjects with type 2 diabetes may contribute to activation of macrophages, and thus the development of atherosclerosis. In this study, we investigated the effect of the saturated fatty acids (SFA) palmitate, stearate, myristate and laurate, and the unsaturated fatty acid linoleate, on the production of proinflammatory cytokines in phorbol ester-differentiated THP-1 cells, a model of human macrophages. Palmitate induced secretion and mRNA expression of TNF-α, IL-8 and IL-1β, and enhanced lipopolysaccharide (LPS)-induced IL-1β secretion. Proinflammatory cytokine secretion was also induced by stearate, but not by the shorter chain SFA, myristate and laurate, or linoleate. Triacsin C abolished the palmitate-induced cytokine secretion, suggesting that palmitate activation to palmitoyl-CoA is required for its effect. Palmitate-induced cytokine secretion was decreased by knockdown of serine palmitoyltransferase and mimicked by C2 -ceramide, indicating that ceramide is involved in palmitate-induced cytokine secretion. Palmitate phosphorylated p38 and JNK kinases, and blocking of these kinases with specific inhibitors diminished the palmitate-induced cytokine secretion. Palmitate also activated the AP-1 (c-Jun) transcription factor. Knockdown of MyD88 reduced the palmitate-induced IL-8, but not TNF-α or IL-1β secretion. In conclusion, our data suggest that the long-chain SFA induce proinflammatory cytokines in human macrophages via pathways involving de novo ceramide synthesis. This might contribute to the activation of macrophages in atherosclerotic plaques, especially in type 2 diabetes. Increased circulating free fatty acids in subjects with type 2 diabetes may contribute to activation of macrophages, and thus the development of atherosclerosis. In this study, we investigated the effect of the saturated fatty acids (SFA) palmitate, stearate, myristate and laurate, and the unsaturated fatty acid linoleate, on the production of proinflammatory cytokines in phorbol ester-differentiated THP-1 cells, a model of human macrophages. Palmitate induced secretion and mRNA expression of TNF-alpha, IL-8 and IL-1 beta, and enhanced lipopolysaccharide (LPS)-induced IL-1 beta secretion. Proinflammatory cytokine secretion was also induced by stearate, but not by the shorter chain SFA, myristate and laurate, or linoleate. Triacsin C abolished the palmitate-induced cytokine secretion, suggesting that palmitate activation to palmitoyl-CoA is required for its effect. Palmitate-induced cytokine secretion was decreased by knockdown of serine palmitoyltransferase and mimicked by C(2)-ceramide, indicating that ceramide is involved in palmitate-induced cytokine secretion. Palmitate phosphorylated p38 and JNK kinases, and blocking of these kinases with specific inhibitors diminished the palmitate-induced cytokine secretion. Palmitate also activated the AP-1 (c-Jun) transcription factor. Knockdown of MyD88 reduced the palmitate-induced IL-8, but not TNF-alpha or IL-1 beta secretion. In conclusion, our data suggest that the long-chain SFA induce proinflammatory cytokines in human macrophages via pathways involving de novo ceramide synthesis. This might contribute to the activation of macrophages in atherosclerotic plaques, especially in type 2 diabetes.Increased circulating free fatty acids in subjects with type 2 diabetes may contribute to activation of macrophages, and thus the development of atherosclerosis. In this study, we investigated the effect of the saturated fatty acids (SFA) palmitate, stearate, myristate and laurate, and the unsaturated fatty acid linoleate, on the production of proinflammatory cytokines in phorbol ester-differentiated THP-1 cells, a model of human macrophages. Palmitate induced secretion and mRNA expression of TNF-alpha, IL-8 and IL-1 beta, and enhanced lipopolysaccharide (LPS)-induced IL-1 beta secretion. Proinflammatory cytokine secretion was also induced by stearate, but not by the shorter chain SFA, myristate and laurate, or linoleate. Triacsin C abolished the palmitate-induced cytokine secretion, suggesting that palmitate activation to palmitoyl-CoA is required for its effect. Palmitate-induced cytokine secretion was decreased by knockdown of serine palmitoyltransferase and mimicked by C(2)-ceramide, indicating that ceramide is involved in palmitate-induced cytokine secretion. Palmitate phosphorylated p38 and JNK kinases, and blocking of these kinases with specific inhibitors diminished the palmitate-induced cytokine secretion. Palmitate also activated the AP-1 (c-Jun) transcription factor. Knockdown of MyD88 reduced the palmitate-induced IL-8, but not TNF-alpha or IL-1 beta secretion. In conclusion, our data suggest that the long-chain SFA induce proinflammatory cytokines in human macrophages via pathways involving de novo ceramide synthesis. This might contribute to the activation of macrophages in atherosclerotic plaques, especially in type 2 diabetes. |
| Author | Fogelstrand, Linda Wiklund, Olov Danielsson, Kristina Norén Håversen, Liliana |
| Author_xml | – sequence: 1 givenname: Liliana surname: Håversen fullname: Håversen, Liliana email: liliana.haversen@wlab.gu.se – sequence: 2 givenname: Kristina Norén surname: Danielsson fullname: Danielsson, Kristina Norén – sequence: 3 givenname: Linda surname: Fogelstrand fullname: Fogelstrand, Linda – sequence: 4 givenname: Olov surname: Wiklund fullname: Wiklund, Olov |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21146440$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/18599066$$D View this record in MEDLINE/PubMed https://gup.ub.gu.se/publication/109060$$DView record from Swedish Publication Index |
| BookMark | eNqVkl2L1DAUhousuB_6F6Q3613HpEnT9EJBhnVdWPBCvQ6n6elMZttkTNKV_ntTZlxhQFhvEkiePMk5by6zM-ssZtk1JStKqHi_W0HcondBD8towqokRK5ItSKMvcguqKybgnLJz7ILQkpaNLQi59llCDtCCK-pfJWdU1k1DRHiIlN3tpt0NM7mrs_33hnbDzCOEJ2fcz1H92Ashryd88HZTaG3YGweIE4eInZ5DzHOOWjThTxtbKcRbD6C9m6_hQ2G19nLHoaAb47zVfbj88339Zfi_uvt3frTfaEFk7Ho2lZ3wChpERrJauSykkLompV1I5juuWyhYZL3QnDKW8kq3pSyhoZXZVciu8qKgzf8wv3Uqr03I_hZOTBqM-1VWtpMKqCiJBVOEv_uwKeSf04YohpN0DgMYNFNQQkhecVolcC3R3BqR-yexH9amIDrIwBBw9B7sNqEJ66klAvOlxs_HLjUmxA89n9VRC3Rqp06iVYt0SpSqRRtOr8-Oa9NhCW56MEMz7bcHiyYwng06FXQBq3GznjUUXXOPNv08cSkB2NNasEDzhh2bvI2Ja6oCqUi6tvyGZe_SCQhjNMmCW7-LfiPh_wGXWv7uQ |
| CitedBy_id | crossref_primary_10_1002_jps_23057 crossref_primary_10_1194_jlr_M020941 crossref_primary_10_2527_jas_2012_5442 crossref_primary_10_3390_app11209762 crossref_primary_10_1007_s12013_010_9117_9 crossref_primary_10_1080_21655979_2021_1992333 crossref_primary_10_1016_j_atherosclerosis_2012_12_036 crossref_primary_10_1007_s00535_010_0218_4 crossref_primary_10_3389_fendo_2020_00351 crossref_primary_10_3390_biomedicines9050449 crossref_primary_10_3389_fpubh_2020_00476 crossref_primary_10_1002_mnfr_201400569 crossref_primary_10_1002_jcp_24013 crossref_primary_10_1536_ihj_19_059 crossref_primary_10_18097_PBMC20156101070 crossref_primary_10_1007_s00281_019_00748_1 crossref_primary_10_3390_biology11050701 crossref_primary_10_1016_j_plefa_2020_102236 crossref_primary_10_1186_s12944_024_02263_1 crossref_primary_10_1007_s40123_024_01079_7 crossref_primary_10_1007_s00394_018_1782_2 crossref_primary_10_1016_j_jnutbio_2014_07_008 crossref_primary_10_1016_j_bbalip_2019_158538 crossref_primary_10_1371_journal_pone_0068197 crossref_primary_10_3168_jds_2009_2876 crossref_primary_10_4137_CMT_S2370 crossref_primary_10_1021_acs_bioconjchem_2c00383 crossref_primary_10_1016_j_atherosclerosis_2016_04_021 crossref_primary_10_1007_s00018_019_03148_8 crossref_primary_10_1016_j_bbalip_2016_09_002 crossref_primary_10_1310_sci2303_188 crossref_primary_10_3390_ijms242015186 crossref_primary_10_1016_j_atherosclerosis_2009_09_004 crossref_primary_10_1016_j_mce_2014_06_010 crossref_primary_10_1155_2012_379024 crossref_primary_10_1007_s00125_011_2444_6 crossref_primary_10_1007_s11745_014_3971_y crossref_primary_10_1194_jlr_R050252 crossref_primary_10_4049_jimmunol_1302944 crossref_primary_10_1186_s12986_021_00540_9 crossref_primary_10_3389_fimmu_2017_00823 crossref_primary_10_3389_fphys_2018_00194 crossref_primary_10_1002_jssc_201000395 crossref_primary_10_1111_j_1600_065X_2012_01145_x crossref_primary_10_1038_cddis_2016_429 crossref_primary_10_1371_journal_pone_0193343 crossref_primary_10_1016_j_cellimm_2011_04_009 crossref_primary_10_1186_1476_511X_11_175 crossref_primary_10_1016_j_atherosclerosis_2009_10_032 crossref_primary_10_1017_S0007114509371676 crossref_primary_10_3746_jkfn_2012_41_2_283 crossref_primary_10_25040_aml2022_1_2_161 crossref_primary_10_1097_MOL_0b013e32832fa5c4 crossref_primary_10_1161_CIRCRESAHA_109_196261 crossref_primary_10_1016_j_bbalip_2010_07_007 crossref_primary_10_1155_2019_3560819 crossref_primary_10_1016_j_jaad_2015_02_1095 crossref_primary_10_1152_ajpendo_00076_2013 crossref_primary_10_1111_1753_0407_12073 crossref_primary_10_1111_j_1471_4159_2012_07660_x crossref_primary_10_18585_inabj_v3i3_148 crossref_primary_10_3390_biology10121318 crossref_primary_10_1152_physiol_00032_2009 crossref_primary_10_1016_j_bbrc_2015_03_137 crossref_primary_10_2152_jmi_56_88 crossref_primary_10_1530_JME_12_0166 crossref_primary_10_1016_j_acmx_2015_12_003 crossref_primary_10_1097_GME_0b013e318296431a crossref_primary_10_15406_jdmdc_2021_08_00216 crossref_primary_10_4049_jimmunol_1701552 crossref_primary_10_1155_2018_9601801 crossref_primary_10_3168_jds_2012_5382 crossref_primary_10_1016_j_bbadis_2018_06_021 crossref_primary_10_1530_JME_17_0062 crossref_primary_10_1016_j_jid_2018_03_1522 crossref_primary_10_1371_journal_pone_0195810 crossref_primary_10_1530_ERC_13_0227 crossref_primary_10_1016_j_plefa_2014_05_003 crossref_primary_10_1134_S1990750814030093 crossref_primary_10_1136_annrheumdis_2013_203755 crossref_primary_10_1016_j_ebiom_2020_103038 crossref_primary_10_1007_s11302_021_09791_w crossref_primary_10_1016_j_fsi_2013_07_004 crossref_primary_10_1016_j_plefa_2025_102667 crossref_primary_10_1074_jbc_M115_686709 crossref_primary_10_1016_j_cyto_2017_04_005 crossref_primary_10_1016_j_prostaglandins_2024_106873 crossref_primary_10_1111_imr_13360 crossref_primary_10_1016_j_retram_2016_08_001 crossref_primary_10_3168_jds_2011_5092 crossref_primary_10_1038_s41584_022_00776_6 crossref_primary_10_3390_molecules27010152 crossref_primary_10_1016_j_exer_2018_09_016 crossref_primary_10_1016_j_molimm_2016_12_009 crossref_primary_10_1111_are_15176 crossref_primary_10_1007_s00394_017_1456_5 crossref_primary_10_1186_1476_511X_11_115 crossref_primary_10_1007_s12031_013_0068_7 crossref_primary_10_1210_jc_2016_2732 crossref_primary_10_1007_s12011_017_1071_6 crossref_primary_10_1111_jne_12776 crossref_primary_10_1371_journal_pone_0159573 crossref_primary_10_3390_biology9110346 crossref_primary_10_3390_nu16091373 crossref_primary_10_1016_j_bcp_2014_08_013 crossref_primary_10_1016_j_bbalip_2018_01_009 crossref_primary_10_1002_jcp_25029 crossref_primary_10_1016_j_bbrc_2009_12_119 crossref_primary_10_3389_fimmu_2019_01807 crossref_primary_10_1007_s10620_011_1644_8 crossref_primary_10_1016_j_atherosclerosis_2009_01_010 crossref_primary_10_1016_j_neuroscience_2020_09_045 crossref_primary_10_1016_j_prostaglandins_2022_106622 crossref_primary_10_1016_j_cmet_2011_10_011 crossref_primary_10_3390_nu12123771 crossref_primary_10_1016_j_bbadis_2016_08_004 crossref_primary_10_1016_j_cbd_2018_12_007 crossref_primary_10_1111_1750_3841_13966 crossref_primary_10_1007_s12020_012_9676_1 crossref_primary_10_3233_NIB_170128 crossref_primary_10_1152_ajpendo_00187_2018 crossref_primary_10_1186_s12872_023_03690_1 crossref_primary_10_3390_ijms20174112 crossref_primary_10_1016_j_neurobiolaging_2012_05_017 crossref_primary_10_4049_jimmunol_0903475 crossref_primary_10_1002_ejlt_202000341 crossref_primary_10_1152_ajpheart_00137_2013 crossref_primary_10_1002_dmrr_2601 crossref_primary_10_1016_j_tem_2009_12_010 crossref_primary_10_1371_journal_pone_0029100 crossref_primary_10_1038_s41574_020_00464_z crossref_primary_10_1038_nri_2017_99 crossref_primary_10_5551_jat_28167 crossref_primary_10_1016_j_expneurol_2010_03_022 crossref_primary_10_3390_cells8091088 crossref_primary_10_20900_immunometab20200008 crossref_primary_10_1086_666828 crossref_primary_10_3390_microorganisms7110550 crossref_primary_10_3389_fcvm_2021_692184 crossref_primary_10_2337_db09_0848 crossref_primary_10_1186_1476_511X_11_30 crossref_primary_10_1513_AnnalsATS_201703_255AW crossref_primary_10_1002_mnfr_201200058 crossref_primary_10_1177_1352458517737372 crossref_primary_10_1016_j_bbih_2021_100298 crossref_primary_10_1007_s10103_017_2408_2 crossref_primary_10_1016_j_it_2021_07_005 crossref_primary_10_1038_srep32111 crossref_primary_10_3390_cells10071738 crossref_primary_10_1152_ajpendo_00515_2019 crossref_primary_10_3390_obesities4030020 crossref_primary_10_1080_19490976_2020_1730149 crossref_primary_10_1155_2014_479587 crossref_primary_10_3390_nu15051296 crossref_primary_10_1038_s41598_018_31926_0 crossref_primary_10_3390_nu16183215 crossref_primary_10_3389_fimmu_2022_820350 crossref_primary_10_2174_1566524020666200427102209 crossref_primary_10_1016_j_jaci_2020_08_013 crossref_primary_10_1007_s12035_017_0777_y crossref_primary_10_1016_j_aquaculture_2011_11_045 crossref_primary_10_1016_j_bbalip_2017_11_006 crossref_primary_10_1016_j_vph_2015_08_003 crossref_primary_10_1097_MOL_0b013e32832fa14d crossref_primary_10_1371_journal_pone_0075147 crossref_primary_10_1002_bem_20645 crossref_primary_10_1007_s11154_013_9274_4 crossref_primary_10_1177_1934578X1200701108 crossref_primary_10_3389_fendo_2020_00062 crossref_primary_10_1038_nm_2279 crossref_primary_10_1038_nri2925 crossref_primary_10_1071_RD17537 crossref_primary_10_1017_S0029665111001662 crossref_primary_10_1016_j_intimp_2014_08_002 crossref_primary_10_3168_jds_2021_20136 crossref_primary_10_3390_ph17121568 crossref_primary_10_1016_j_jtemb_2019_01_003 crossref_primary_10_1155_2022_4464180 crossref_primary_10_1016_j_addr_2021_113960 crossref_primary_10_1210_en_2009_0543 crossref_primary_10_1136_openhrt_2016_000467 crossref_primary_10_4049_jimmunol_1203074 crossref_primary_10_1007_s00125_014_3173_4 crossref_primary_10_1007_s12035_021_02328_7 |
| Cites_doi | 10.1089/10799900050116453 10.1128/MCB.13.11.6678 10.1016/S1054-8807(98)00033-7 10.1161/01.CIR.0000086014.80477.0D 10.1089/107999099313866 10.1016/0026-0495(93)90110-A 10.1074/jbc.M011695200 10.1152/ajpendo.2001.280.5.E745 10.1172/JCI118780 10.1128/MCB.13.10.6137 10.1016/S0021-9150(02)00371-4 10.1016/0092-8674(94)90380-8 10.1172/JCI0216450 10.1016/S0898-6568(00)00149-2 10.1074/jbc.M107873200 10.2174/1568010033484106 10.1016/S0008-8749(03)00006-6 10.2337/diabetes.53.12.3209 10.1016/S0959-437X(01)00258-1 10.1161/01.ATV.19.4.972 10.1093/jn/135.8.1841 10.1074/jbc.M312990200 10.1074/jbc.274.28.19559 10.1074/jbc.M311974200 10.1074/jbc.272.28.17795 10.1016/S0024-3205(00)00622-6 10.1056/NEJM199901143400207 10.1096/fj.01-0432com 10.1172/JCI28898 10.1074/jbc.M312692200 10.1046/j.1365-2362.2003.01181.x 10.1074/jbc.272.35.22173 10.1161/01.CIR.102.1.42 10.1046/j.1440-1711.2000.00875.x 10.1074/jbc.270.39.22689 10.1074/jbc.M513304200 10.1161/01.CIR.102.18.2180 10.1074/jbc.274.3.1767 10.1002/jlb.56.1.27 10.1016/j.bbrc.2005.07.123 10.1210/jc.83.8.2773 10.5551/jat1994.5.29 10.1074/jbc.M212307200 10.1016/S0005-2760(98)00145-3 10.1002/j.1460-2075.1996.tb00840.x 10.1016/j.abb.2003.08.020 10.1210/en.2004-1560 |
| ContentType | Journal Article |
| Copyright | 2008 Elsevier Ireland Ltd Elsevier Ireland Ltd 2009 INIST-CNRS |
| Copyright_xml | – notice: 2008 Elsevier Ireland Ltd – notice: Elsevier Ireland Ltd – notice: 2009 INIST-CNRS |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 ADTPV AOWAS F1U |
| DOI | 10.1016/j.atherosclerosis.2008.05.033 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic SwePub SwePub Articles SWEPUB Göteborgs universitet |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1879-1484 |
| EndPage | 393 |
| ExternalDocumentID | oai_gup_ub_gu_se_109060 18599066 21146440 10_1016_j_atherosclerosis_2008_05_033 S0021915008003419 1_s2_0_S0021915008003419 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K --M .1- .55 .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 23N 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AABNK AAEDT AAEDW AAFWJ AAIKJ AAKOC AALRI AAOAW AAQFI AATTM AAXKI AAXUO AAYWO ABBQC ABFNM ABJNI ABLJU ABMAC ABMZM ABOCM ABXDB ACDAQ ACGFS ACIEU ACIUM ACRLP ACVFH ADBBV ADCNI ADEZE AEBSH AEIPS AEKER AENEX AEUPX AEVXI AEXQZ AFFNX AFJKZ AFPUW AFRHN AFTJW AFXIZ AGCQF AGHFR AGUBO AGYEJ AHHHB AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 EBS EFJIC EFKBS EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEB HMK HMO HVGLF HZ~ IHE J1W J5H K-O KOM L7B M27 M41 MO0 N9A O-L O9- OAUVE OA~ OK1 OL0 OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SAE SCC SDF SDG SDP SEL SES SEW SPCBC SSH SSZ T5K WUQ X7M Z5R ZGI ZXP ~G- ~KM AACTN AFCTW AFKWA AJOXV AMFUW NCXOZ RIG 0SF AAIAV ABLVK ABYKQ AHPSJ AJBFU EFLBG LCYCR ZA5 AAYXX ACLOT CITATION ~HD AGRNS IQODW CGR CUY CVF ECM EIF NPM 7X8 ADTPV AOWAS F1U |
| ID | FETCH-LOGICAL-c638t-dbbcda310bea9837e485866c7327963cf48ba9384f66414b83549287a9452d2e3 |
| IEDL.DBID | .~1 |
| ISSN | 0021-9150 1879-1484 |
| IngestDate | Tue Sep 09 23:05:31 EDT 2025 Fri Sep 05 12:13:33 EDT 2025 Mon Jul 21 05:58:43 EDT 2025 Mon Jul 21 09:12:00 EDT 2025 Wed Oct 01 04:59:49 EDT 2025 Thu Apr 24 22:55:24 EDT 2025 Fri Feb 23 02:28:06 EST 2024 Sun Feb 23 10:19:16 EST 2025 Tue Aug 26 17:44:27 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | Serine palmitoyltransferase Palmitate Atherosclerosis Stearate Ceramide Diabetes Proinflammatory cytokines Macrophages Endocrinopathy Human Long chain Diabetes mellitus Serine Cytokine Sphingolipid Lipids Cardiovascular disease Vascular disease Saturated fatty acid Aminoacid Macrophage |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c638t-dbbcda310bea9837e485866c7327963cf48ba9384f66414b83549287a9452d2e3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 18599066 |
| PQID | 66845315 |
| PQPubID | 23479 |
| PageCount | 12 |
| ParticipantIDs | swepub_primary_oai_gup_ub_gu_se_109060 proquest_miscellaneous_66845315 pubmed_primary_18599066 pascalfrancis_primary_21146440 crossref_primary_10_1016_j_atherosclerosis_2008_05_033 crossref_citationtrail_10_1016_j_atherosclerosis_2008_05_033 elsevier_sciencedirect_doi_10_1016_j_atherosclerosis_2008_05_033 elsevier_clinicalkeyesjournals_1_s2_0_S0021915008003419 elsevier_clinicalkey_doi_10_1016_j_atherosclerosis_2008_05_033 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2009-02-01 |
| PublicationDateYYYYMMDD | 2009-02-01 |
| PublicationDate_xml | – month: 02 year: 2009 text: 2009-02-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | Amsterdam |
| PublicationPlace_xml | – name: Amsterdam – name: Ireland |
| PublicationTitle | Atherosclerosis |
| PublicationTitleAlternate | Atherosclerosis |
| PublicationYear | 2009 |
| Publisher | Elsevier Ireland Ltd Elsevier |
| Publisher_xml | – name: Elsevier Ireland Ltd – name: Elsevier |
| References | Cipollone, Iezzi, Fazia (bib8) 2003; 108 Gray, Chandra, Clay (bib24) 1993; 13 Hwang (bib38) 2001; 15 Kern, Ranganathan, Li, Wood, Ranganathan (bib6) 2001; 280 Dolgachev, Farooqui, Kulaeva (bib33) 2004; 279 Clausell, Kalil, Biolo, Molossi, Azevedo (bib10) 1999; 8 Frayn, Coppack, Humphreys, Clark, Evans (bib12) 1993; 42 Gable, Han, Monaghan (bib36) 2002; 277 Haversen, Ohlsson, Hahn-Zoric, Hanson, Mattsby-Baltzer (bib32) 2002; 220 Rolli, Kotlyarov, Sakamoto, Gaestel, Neininger (bib27) 1999; 274 Jove, Planavila, Laguna, Vazquez-Carrera (bib40) 2005; 146 Perry, Hannun (bib43) 1998; 1436 Staiger, Staiger, Stefan (bib16) 2004; 53 Brenner, Koppenhoefer, Weinstock (bib44) 1997; 272 Newell, Deisseroth, Lopez-Berestein (bib21) 1994; 5 Yip, Facchini, Reaven (bib1) 1998; 83 Lee, Zhao, Youn (bib41) 2004; 279 Festa, D’Agostino, Howard (bib2) 2000; 102 Auron, Webb (bib23) 1994; 5 Svensson, Camejo, Cabre (bib48) 2003; 33 Chavez, Summers (bib34) 2003; 419 Yudkin, Stehouwer, Emeis, Coppack (bib3) 1999; 19 Ito, Ikeda (bib47) 2003; 2 Roebuck (bib18) 1999; 19 Weston, Davis (bib25) 2002; 12 Fukumoto, Naito, Asano, Aramaki (bib9) 1998; 5 Ohlsson, Englund, Karlsson (bib31) 1996; 98 Ross (bib7) 1999; 340 Yao, Mackman, Edgington, Fan (bib20) 1997; 272 Guha, Mackman (bib42) 2001; 13 Pickup, Chusney, Thomas, Burt (bib5) 2000; 67 Lee, Sohn, Rhee, Hwang (bib14) 2001; 276 Shi, Kokoeva, Inouye (bib39) 2006; 116 Senn (bib45) 2006; 281 Kunsch, Rosen (bib19) 1993; 13 Westwick, Bielawska, Dbaibo, Hannun, Brenner (bib29) 1995; 270 Bejaoui, Uchida, Yasuda (bib35) 2002; 110 Chavez, Knotts, Wang (bib28) 2003; 278 Stollenwerk, Lindholm, Porn-Ares (bib46) 2005; 335 Ajuwon, Spurlock (bib17) 2005; 135 Leinonen, Hurt-Camejo, Wiklund (bib4) 2003; 166 Weigert, Brodbeck, Staiger (bib15) 2004; 279 Moreno, Murcia, Palacios (bib11) 2000; 102 de Pablo, Alvarez de Cienfuegos (bib13) 2000; 78 Diaz, Lopez-Berestein (bib22) 2000; 20 Tan, Rouse, Zhang (bib26) 1996; 15 Derijard, Hibi, Wu (bib37) 1994; 76 MacKichan, DeFranco (bib30) 1999; 274 Festa (10.1016/j.atherosclerosis.2008.05.033_bib2) 2000; 102 Kern (10.1016/j.atherosclerosis.2008.05.033_bib6) 2001; 280 Moreno (10.1016/j.atherosclerosis.2008.05.033_bib11) 2000; 102 Ohlsson (10.1016/j.atherosclerosis.2008.05.033_bib31) 1996; 98 Diaz (10.1016/j.atherosclerosis.2008.05.033_bib22) 2000; 20 Rolli (10.1016/j.atherosclerosis.2008.05.033_bib27) 1999; 274 Auron (10.1016/j.atherosclerosis.2008.05.033_bib23) 1994; 5 Dolgachev (10.1016/j.atherosclerosis.2008.05.033_bib33) 2004; 279 Svensson (10.1016/j.atherosclerosis.2008.05.033_bib48) 2003; 33 Tan (10.1016/j.atherosclerosis.2008.05.033_bib26) 1996; 15 Stollenwerk (10.1016/j.atherosclerosis.2008.05.033_bib46) 2005; 335 Weston (10.1016/j.atherosclerosis.2008.05.033_bib25) 2002; 12 Pickup (10.1016/j.atherosclerosis.2008.05.033_bib5) 2000; 67 de Pablo (10.1016/j.atherosclerosis.2008.05.033_bib13) 2000; 78 Hwang (10.1016/j.atherosclerosis.2008.05.033_bib38) 2001; 15 Chavez (10.1016/j.atherosclerosis.2008.05.033_bib34) 2003; 419 Cipollone (10.1016/j.atherosclerosis.2008.05.033_bib8) 2003; 108 Westwick (10.1016/j.atherosclerosis.2008.05.033_bib29) 1995; 270 Gray (10.1016/j.atherosclerosis.2008.05.033_bib24) 1993; 13 Frayn (10.1016/j.atherosclerosis.2008.05.033_bib12) 1993; 42 Kunsch (10.1016/j.atherosclerosis.2008.05.033_bib19) 1993; 13 Shi (10.1016/j.atherosclerosis.2008.05.033_bib39) 2006; 116 Yao (10.1016/j.atherosclerosis.2008.05.033_bib20) 1997; 272 Chavez (10.1016/j.atherosclerosis.2008.05.033_bib28) 2003; 278 Derijard (10.1016/j.atherosclerosis.2008.05.033_bib37) 1994; 76 Perry (10.1016/j.atherosclerosis.2008.05.033_bib43) 1998; 1436 Lee (10.1016/j.atherosclerosis.2008.05.033_bib14) 2001; 276 Yudkin (10.1016/j.atherosclerosis.2008.05.033_bib3) 1999; 19 Haversen (10.1016/j.atherosclerosis.2008.05.033_bib32) 2002; 220 Clausell (10.1016/j.atherosclerosis.2008.05.033_bib10) 1999; 8 Jove (10.1016/j.atherosclerosis.2008.05.033_bib40) 2005; 146 Brenner (10.1016/j.atherosclerosis.2008.05.033_bib44) 1997; 272 Staiger (10.1016/j.atherosclerosis.2008.05.033_bib16) 2004; 53 MacKichan (10.1016/j.atherosclerosis.2008.05.033_bib30) 1999; 274 Ito (10.1016/j.atherosclerosis.2008.05.033_bib47) 2003; 2 Bejaoui (10.1016/j.atherosclerosis.2008.05.033_bib35) 2002; 110 Ross (10.1016/j.atherosclerosis.2008.05.033_bib7) 1999; 340 Fukumoto (10.1016/j.atherosclerosis.2008.05.033_bib9) 1998; 5 Ajuwon (10.1016/j.atherosclerosis.2008.05.033_bib17) 2005; 135 Leinonen (10.1016/j.atherosclerosis.2008.05.033_bib4) 2003; 166 Roebuck (10.1016/j.atherosclerosis.2008.05.033_bib18) 1999; 19 Lee (10.1016/j.atherosclerosis.2008.05.033_bib41) 2004; 279 Weigert (10.1016/j.atherosclerosis.2008.05.033_bib15) 2004; 279 Senn (10.1016/j.atherosclerosis.2008.05.033_bib45) 2006; 281 Guha (10.1016/j.atherosclerosis.2008.05.033_bib42) 2001; 13 Newell (10.1016/j.atherosclerosis.2008.05.033_bib21) 1994; 5 Gable (10.1016/j.atherosclerosis.2008.05.033_bib36) 2002; 277 Yip (10.1016/j.atherosclerosis.2008.05.033_bib1) 1998; 83 |
| References_xml | – volume: 278 start-page: 10297 year: 2003 end-page: 10303 ident: bib28 article-title: A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids publication-title: J Biol Chem – volume: 335 start-page: 603 year: 2005 end-page: 608 ident: bib46 article-title: Very low-density lipoprotein induces interleukin-1beta expression in macrophages publication-title: Biochem Biophys Res Commun – volume: 146 start-page: 3087 year: 2005 end-page: 3095 ident: bib40 article-title: Palmitate-induced interleukin 6 production is mediated by protein kinase C and nuclear-factor kappaB activation and leads to glucose transporter 4 down-regulation in skeletal muscle cells publication-title: Endocrinology – volume: 220 start-page: 83 year: 2002 end-page: 95 ident: bib32 article-title: Lactoferrin down-regulates the LPS-induced cytokine production in monocytic cells via NF-kappa B publication-title: Cell Immunol – volume: 5 start-page: 29 year: 1998 end-page: 35 ident: bib9 article-title: Immunohistochemical and morphometric evaluations of coronary atherosclerotic plaques associated with myocardial infarction and diabetes mellitus publication-title: J Atheroscler Thromb – volume: 83 start-page: 2773 year: 1998 end-page: 2776 ident: bib1 article-title: Resistance to insulin-mediated glucose disposal as a predictor of cardiovascular disease publication-title: J Clin Endocrinol Metab – volume: 78 start-page: 31 year: 2000 end-page: 39 ident: bib13 article-title: Modulatory effects of dietary lipids on immune system functions publication-title: Immunol Cell Biol – volume: 116 start-page: 3015 year: 2006 end-page: 3025 ident: bib39 article-title: TLR4 links innate immunity and fatty acid-induced insulin resistance publication-title: J Clin Invest – volume: 272 start-page: 17795 year: 1997 end-page: 17801 ident: bib20 article-title: Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells. Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors publication-title: J Biol Chem – volume: 270 start-page: 22689 year: 1995 end-page: 22692 ident: bib29 article-title: Ceramide activates the stress-activated protein kinases publication-title: J Biol Chem – volume: 42 start-page: 504 year: 1993 end-page: 510 ident: bib12 article-title: Periprandial regulation of lipid metabolism in insulin-treated diabetes mellitus publication-title: Metabolism – volume: 274 start-page: 19559 year: 1999 end-page: 19564 ident: bib27 article-title: Stress-induced stimulation of early growth response gene-1 by p38/stress-activated protein kinase 2 is mediated by a cAMP-responsive promoter element in a MAPKAP kinase 2-independent manner publication-title: J Biol Chem – volume: 102 start-page: 2180 year: 2000 end-page: 2184 ident: bib11 article-title: Coronary composition and macrophage infiltration in atherectomy specimens from patients with diabetes mellitus publication-title: Circulation – volume: 76 start-page: 1025 year: 1994 end-page: 1037 ident: bib37 article-title: JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain publication-title: Cell – volume: 2 start-page: 257 year: 2003 end-page: 265 ident: bib47 article-title: Inflammatory cytokines and cardiovascular disease publication-title: Curr Drug Targets Inflamm Allergy – volume: 8 start-page: 145 year: 1999 end-page: 151 ident: bib10 article-title: Increased expression of tumor necrosis factor-alpha in diabetic macrovasculopathy publication-title: Cardiovasc Pathol – volume: 279 start-page: 23942 year: 2004 end-page: 23952 ident: bib15 article-title: Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB publication-title: J Biol Chem – volume: 13 start-page: 85 year: 2001 end-page: 94 ident: bib42 article-title: LPS induction of gene expression in human monocytes publication-title: Cell Signal – volume: 110 start-page: 1301 year: 2002 end-page: 1308 ident: bib35 article-title: Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis publication-title: J Clin Invest – volume: 419 start-page: 101 year: 2003 end-page: 109 ident: bib34 article-title: Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes publication-title: Arch Biochem Biophys – volume: 33 start-page: 464 year: 2003 end-page: 471 ident: bib48 article-title: Fatty acids modulate the effect of darglitazone on macrophage CD36 expression publication-title: Eur J Clin Invest – volume: 98 start-page: 78 year: 1996 end-page: 89 ident: bib31 article-title: Oxidized low density lipoprotein inhibits lipopolysaccharide-induced binding of nuclear factor-kappaB to DNA and the subsequent expression of tumor necrosis factor-alpha and interleukin-1beta in macrophages publication-title: J Clin Invest – volume: 276 start-page: 16683 year: 2001 end-page: 16689 ident: bib14 article-title: Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4 publication-title: J Biol Chem – volume: 15 start-page: 4629 year: 1996 end-page: 4642 ident: bib26 article-title: FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2 publication-title: EMBO J – volume: 277 start-page: 10194 year: 2002 end-page: 10200 ident: bib36 article-title: Mutations in the yeast LCB1 and LCB2 genes, including those corresponding to the hereditary sensory neuropathy type I mutations, dominantly inactivate serine palmitoyltransferase publication-title: J Biol Chem – volume: 279 start-page: 16971 year: 2004 end-page: 16979 ident: bib41 article-title: Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1 publication-title: J Biol Chem – volume: 135 start-page: 1841 year: 2005 end-page: 1846 ident: bib17 article-title: Palmitate Activates the NF-{kappa}B transcription factor and induces IL-6 and TNF{alpha} expression in 3T3-L1 adipocytes publication-title: J Nutr – volume: 19 start-page: 429 year: 1999 end-page: 438 ident: bib18 article-title: Regulation of interleukin-8 gene expression publication-title: J Interf Cytokine Res – volume: 279 start-page: 23238 year: 2004 end-page: 23249 ident: bib33 article-title: De novo ceramide accumulation due to inhibition of its conversion to complex sphingolipids in apoptotic photosensitized cells publication-title: J Biol Chem – volume: 166 start-page: 387 year: 2003 end-page: 394 ident: bib4 article-title: Insulin resistance and adiposity correlate with acute-phase reaction and soluble cell adhesion molecules in type 2 diabetes publication-title: Atherosclerosis – volume: 5 start-page: 573 year: 1994 end-page: 592 ident: bib23 article-title: Interleukin-1: a gene expression system regulated at multiple levels publication-title: Eur Cytokine Netw – volume: 340 start-page: 115 year: 1999 end-page: 126 ident: bib7 article-title: Atherosclerosis—an inflammatory disease publication-title: N Engl J Med – volume: 20 start-page: 741 year: 2000 end-page: 748 ident: bib22 article-title: A distinct element involved in lipopolysaccharide activation of the tumor necrosis factor-alpha promoter in monocytes publication-title: J Interf Cytokine Res – volume: 67 start-page: 291 year: 2000 end-page: 300 ident: bib5 article-title: Plasma interleukin-6, tumour necrosis factor alpha and blood cytokine production in type 2 diabetes publication-title: Life Sci – volume: 5 start-page: 27 year: 1994 end-page: 35 ident: bib21 article-title: Interaction of nuclear proteins with an AP-1/CRE-like promoter sequence in the human TNF-alpha gene publication-title: J Leukoc Biol – volume: 1436 start-page: 233 year: 1998 end-page: 243 ident: bib43 article-title: The role of ceramide in cell signaling publication-title: Biochim Biophys Acta – volume: 19 start-page: 972 year: 1999 end-page: 978 ident: bib3 article-title: C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? publication-title: Arterioscler Thromb Vasc Biol – volume: 280 start-page: E745 year: 2001 end-page: E751 ident: bib6 article-title: Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance publication-title: Am J Physiol Endocrinol Metab – volume: 272 start-page: 22173 year: 1997 end-page: 22181 ident: bib44 article-title: Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153 publication-title: J Biol Chem – volume: 13 start-page: 6137 year: 1993 end-page: 6146 ident: bib19 article-title: NF-kappa B subunit-specific regulation of the interleukin-8 promoter publication-title: Mol Cell Biol – volume: 12 start-page: 14 year: 2002 end-page: 21 ident: bib25 article-title: The JNK signal transduction pathway publication-title: Curr Opin Genet Dev – volume: 274 start-page: 1767 year: 1999 end-page: 1775 ident: bib30 article-title: Role of ceramide in lipopolysaccharide (LPS)-induced signalling LPS increases ceramide rather than acting as a structural homolog publication-title: J Biol Chem – volume: 15 start-page: 2556 year: 2001 end-page: 2564 ident: bib38 article-title: Modulation of the expression of cyclooxygenase-2 by fatty acids mediated through toll-like receptor 4-derived signaling pathways publication-title: FASEB J – volume: 53 start-page: 3209 year: 2004 end-page: 3216 ident: bib16 article-title: Palmitate-induced interleukin-6 expression in human coronary artery endothelial cells publication-title: Diabetes – volume: 13 start-page: 6678 year: 1993 end-page: 6689 ident: bib24 article-title: A CRE/ATF-like site in the upstream regulatory sequence of the human interleukin 1 beta gene is necessary for induction in U937 and THP-1 monocytic cell lines publication-title: Mol Cell Biol – volume: 102 start-page: 42 year: 2000 end-page: 47 ident: bib2 article-title: Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS) publication-title: Circulation – volume: 108 start-page: 1070 year: 2003 end-page: 1077 ident: bib8 article-title: The receptor RAGE as a progression factor amplifying arachidonate-dependent inflammatory and proteolytic response in human atherosclerotic plaques: role of glycemic control publication-title: Circulation – volume: 281 start-page: 26865 year: 2006 end-page: 26875 ident: bib45 article-title: Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes publication-title: J Biol Chem – volume: 20 start-page: 741 year: 2000 ident: 10.1016/j.atherosclerosis.2008.05.033_bib22 article-title: A distinct element involved in lipopolysaccharide activation of the tumor necrosis factor-alpha promoter in monocytes publication-title: J Interf Cytokine Res doi: 10.1089/10799900050116453 – volume: 13 start-page: 6678 year: 1993 ident: 10.1016/j.atherosclerosis.2008.05.033_bib24 article-title: A CRE/ATF-like site in the upstream regulatory sequence of the human interleukin 1 beta gene is necessary for induction in U937 and THP-1 monocytic cell lines publication-title: Mol Cell Biol doi: 10.1128/MCB.13.11.6678 – volume: 8 start-page: 145 year: 1999 ident: 10.1016/j.atherosclerosis.2008.05.033_bib10 article-title: Increased expression of tumor necrosis factor-alpha in diabetic macrovasculopathy publication-title: Cardiovasc Pathol doi: 10.1016/S1054-8807(98)00033-7 – volume: 108 start-page: 1070 year: 2003 ident: 10.1016/j.atherosclerosis.2008.05.033_bib8 article-title: The receptor RAGE as a progression factor amplifying arachidonate-dependent inflammatory and proteolytic response in human atherosclerotic plaques: role of glycemic control publication-title: Circulation doi: 10.1161/01.CIR.0000086014.80477.0D – volume: 19 start-page: 429 year: 1999 ident: 10.1016/j.atherosclerosis.2008.05.033_bib18 article-title: Regulation of interleukin-8 gene expression publication-title: J Interf Cytokine Res doi: 10.1089/107999099313866 – volume: 42 start-page: 504 year: 1993 ident: 10.1016/j.atherosclerosis.2008.05.033_bib12 article-title: Periprandial regulation of lipid metabolism in insulin-treated diabetes mellitus publication-title: Metabolism doi: 10.1016/0026-0495(93)90110-A – volume: 276 start-page: 16683 year: 2001 ident: 10.1016/j.atherosclerosis.2008.05.033_bib14 article-title: Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4 publication-title: J Biol Chem doi: 10.1074/jbc.M011695200 – volume: 280 start-page: E745 year: 2001 ident: 10.1016/j.atherosclerosis.2008.05.033_bib6 article-title: Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.2001.280.5.E745 – volume: 98 start-page: 78 year: 1996 ident: 10.1016/j.atherosclerosis.2008.05.033_bib31 article-title: Oxidized low density lipoprotein inhibits lipopolysaccharide-induced binding of nuclear factor-kappaB to DNA and the subsequent expression of tumor necrosis factor-alpha and interleukin-1beta in macrophages publication-title: J Clin Invest doi: 10.1172/JCI118780 – volume: 13 start-page: 6137 year: 1993 ident: 10.1016/j.atherosclerosis.2008.05.033_bib19 article-title: NF-kappa B subunit-specific regulation of the interleukin-8 promoter publication-title: Mol Cell Biol doi: 10.1128/MCB.13.10.6137 – volume: 166 start-page: 387 year: 2003 ident: 10.1016/j.atherosclerosis.2008.05.033_bib4 article-title: Insulin resistance and adiposity correlate with acute-phase reaction and soluble cell adhesion molecules in type 2 diabetes publication-title: Atherosclerosis doi: 10.1016/S0021-9150(02)00371-4 – volume: 76 start-page: 1025 year: 1994 ident: 10.1016/j.atherosclerosis.2008.05.033_bib37 article-title: JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain publication-title: Cell doi: 10.1016/0092-8674(94)90380-8 – volume: 110 start-page: 1301 year: 2002 ident: 10.1016/j.atherosclerosis.2008.05.033_bib35 article-title: Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis publication-title: J Clin Invest doi: 10.1172/JCI0216450 – volume: 13 start-page: 85 year: 2001 ident: 10.1016/j.atherosclerosis.2008.05.033_bib42 article-title: LPS induction of gene expression in human monocytes publication-title: Cell Signal doi: 10.1016/S0898-6568(00)00149-2 – volume: 277 start-page: 10194 year: 2002 ident: 10.1016/j.atherosclerosis.2008.05.033_bib36 article-title: Mutations in the yeast LCB1 and LCB2 genes, including those corresponding to the hereditary sensory neuropathy type I mutations, dominantly inactivate serine palmitoyltransferase publication-title: J Biol Chem doi: 10.1074/jbc.M107873200 – volume: 2 start-page: 257 year: 2003 ident: 10.1016/j.atherosclerosis.2008.05.033_bib47 article-title: Inflammatory cytokines and cardiovascular disease publication-title: Curr Drug Targets Inflamm Allergy doi: 10.2174/1568010033484106 – volume: 220 start-page: 83 year: 2002 ident: 10.1016/j.atherosclerosis.2008.05.033_bib32 article-title: Lactoferrin down-regulates the LPS-induced cytokine production in monocytic cells via NF-kappa B publication-title: Cell Immunol doi: 10.1016/S0008-8749(03)00006-6 – volume: 53 start-page: 3209 year: 2004 ident: 10.1016/j.atherosclerosis.2008.05.033_bib16 article-title: Palmitate-induced interleukin-6 expression in human coronary artery endothelial cells publication-title: Diabetes doi: 10.2337/diabetes.53.12.3209 – volume: 12 start-page: 14 year: 2002 ident: 10.1016/j.atherosclerosis.2008.05.033_bib25 article-title: The JNK signal transduction pathway publication-title: Curr Opin Genet Dev doi: 10.1016/S0959-437X(01)00258-1 – volume: 19 start-page: 972 year: 1999 ident: 10.1016/j.atherosclerosis.2008.05.033_bib3 article-title: C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.19.4.972 – volume: 135 start-page: 1841 year: 2005 ident: 10.1016/j.atherosclerosis.2008.05.033_bib17 article-title: Palmitate Activates the NF-{kappa}B transcription factor and induces IL-6 and TNF{alpha} expression in 3T3-L1 adipocytes publication-title: J Nutr doi: 10.1093/jn/135.8.1841 – volume: 279 start-page: 16971 year: 2004 ident: 10.1016/j.atherosclerosis.2008.05.033_bib41 article-title: Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1 publication-title: J Biol Chem doi: 10.1074/jbc.M312990200 – volume: 274 start-page: 19559 year: 1999 ident: 10.1016/j.atherosclerosis.2008.05.033_bib27 article-title: Stress-induced stimulation of early growth response gene-1 by p38/stress-activated protein kinase 2 is mediated by a cAMP-responsive promoter element in a MAPKAP kinase 2-independent manner publication-title: J Biol Chem doi: 10.1074/jbc.274.28.19559 – volume: 279 start-page: 23238 year: 2004 ident: 10.1016/j.atherosclerosis.2008.05.033_bib33 article-title: De novo ceramide accumulation due to inhibition of its conversion to complex sphingolipids in apoptotic photosensitized cells publication-title: J Biol Chem doi: 10.1074/jbc.M311974200 – volume: 272 start-page: 17795 year: 1997 ident: 10.1016/j.atherosclerosis.2008.05.033_bib20 article-title: Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells. Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors publication-title: J Biol Chem doi: 10.1074/jbc.272.28.17795 – volume: 67 start-page: 291 year: 2000 ident: 10.1016/j.atherosclerosis.2008.05.033_bib5 article-title: Plasma interleukin-6, tumour necrosis factor alpha and blood cytokine production in type 2 diabetes publication-title: Life Sci doi: 10.1016/S0024-3205(00)00622-6 – volume: 340 start-page: 115 year: 1999 ident: 10.1016/j.atherosclerosis.2008.05.033_bib7 article-title: Atherosclerosis—an inflammatory disease publication-title: N Engl J Med doi: 10.1056/NEJM199901143400207 – volume: 15 start-page: 2556 year: 2001 ident: 10.1016/j.atherosclerosis.2008.05.033_bib38 article-title: Modulation of the expression of cyclooxygenase-2 by fatty acids mediated through toll-like receptor 4-derived signaling pathways publication-title: FASEB J doi: 10.1096/fj.01-0432com – volume: 116 start-page: 3015 year: 2006 ident: 10.1016/j.atherosclerosis.2008.05.033_bib39 article-title: TLR4 links innate immunity and fatty acid-induced insulin resistance publication-title: J Clin Invest doi: 10.1172/JCI28898 – volume: 279 start-page: 23942 year: 2004 ident: 10.1016/j.atherosclerosis.2008.05.033_bib15 article-title: Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB publication-title: J Biol Chem doi: 10.1074/jbc.M312692200 – volume: 33 start-page: 464 year: 2003 ident: 10.1016/j.atherosclerosis.2008.05.033_bib48 article-title: Fatty acids modulate the effect of darglitazone on macrophage CD36 expression publication-title: Eur J Clin Invest doi: 10.1046/j.1365-2362.2003.01181.x – volume: 272 start-page: 22173 year: 1997 ident: 10.1016/j.atherosclerosis.2008.05.033_bib44 article-title: Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153 publication-title: J Biol Chem doi: 10.1074/jbc.272.35.22173 – volume: 102 start-page: 42 year: 2000 ident: 10.1016/j.atherosclerosis.2008.05.033_bib2 article-title: Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS) publication-title: Circulation doi: 10.1161/01.CIR.102.1.42 – volume: 78 start-page: 31 year: 2000 ident: 10.1016/j.atherosclerosis.2008.05.033_bib13 article-title: Modulatory effects of dietary lipids on immune system functions publication-title: Immunol Cell Biol doi: 10.1046/j.1440-1711.2000.00875.x – volume: 270 start-page: 22689 year: 1995 ident: 10.1016/j.atherosclerosis.2008.05.033_bib29 article-title: Ceramide activates the stress-activated protein kinases publication-title: J Biol Chem doi: 10.1074/jbc.270.39.22689 – volume: 281 start-page: 26865 year: 2006 ident: 10.1016/j.atherosclerosis.2008.05.033_bib45 article-title: Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes publication-title: J Biol Chem doi: 10.1074/jbc.M513304200 – volume: 102 start-page: 2180 year: 2000 ident: 10.1016/j.atherosclerosis.2008.05.033_bib11 article-title: Coronary composition and macrophage infiltration in atherectomy specimens from patients with diabetes mellitus publication-title: Circulation doi: 10.1161/01.CIR.102.18.2180 – volume: 274 start-page: 1767 year: 1999 ident: 10.1016/j.atherosclerosis.2008.05.033_bib30 article-title: Role of ceramide in lipopolysaccharide (LPS)-induced signalling LPS increases ceramide rather than acting as a structural homolog publication-title: J Biol Chem doi: 10.1074/jbc.274.3.1767 – volume: 5 start-page: 27 year: 1994 ident: 10.1016/j.atherosclerosis.2008.05.033_bib21 article-title: Interaction of nuclear proteins with an AP-1/CRE-like promoter sequence in the human TNF-alpha gene publication-title: J Leukoc Biol doi: 10.1002/jlb.56.1.27 – volume: 335 start-page: 603 year: 2005 ident: 10.1016/j.atherosclerosis.2008.05.033_bib46 article-title: Very low-density lipoprotein induces interleukin-1beta expression in macrophages publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2005.07.123 – volume: 83 start-page: 2773 year: 1998 ident: 10.1016/j.atherosclerosis.2008.05.033_bib1 article-title: Resistance to insulin-mediated glucose disposal as a predictor of cardiovascular disease publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.83.8.2773 – volume: 5 start-page: 29 year: 1998 ident: 10.1016/j.atherosclerosis.2008.05.033_bib9 article-title: Immunohistochemical and morphometric evaluations of coronary atherosclerotic plaques associated with myocardial infarction and diabetes mellitus publication-title: J Atheroscler Thromb doi: 10.5551/jat1994.5.29 – volume: 278 start-page: 10297 year: 2003 ident: 10.1016/j.atherosclerosis.2008.05.033_bib28 article-title: A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids publication-title: J Biol Chem doi: 10.1074/jbc.M212307200 – volume: 1436 start-page: 233 year: 1998 ident: 10.1016/j.atherosclerosis.2008.05.033_bib43 article-title: The role of ceramide in cell signaling publication-title: Biochim Biophys Acta doi: 10.1016/S0005-2760(98)00145-3 – volume: 5 start-page: 573 year: 1994 ident: 10.1016/j.atherosclerosis.2008.05.033_bib23 article-title: Interleukin-1: a gene expression system regulated at multiple levels publication-title: Eur Cytokine Netw – volume: 15 start-page: 4629 year: 1996 ident: 10.1016/j.atherosclerosis.2008.05.033_bib26 article-title: FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2 publication-title: EMBO J doi: 10.1002/j.1460-2075.1996.tb00840.x – volume: 419 start-page: 101 year: 2003 ident: 10.1016/j.atherosclerosis.2008.05.033_bib34 article-title: Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes publication-title: Arch Biochem Biophys doi: 10.1016/j.abb.2003.08.020 – volume: 146 start-page: 3087 year: 2005 ident: 10.1016/j.atherosclerosis.2008.05.033_bib40 article-title: Palmitate-induced interleukin 6 production is mediated by protein kinase C and nuclear-factor kappaB activation and leads to glucose transporter 4 down-regulation in skeletal muscle cells publication-title: Endocrinology doi: 10.1210/en.2004-1560 |
| SSID | ssj0004718 |
| Score | 2.3855593 |
| Snippet | Increased circulating free fatty acids in subjects with type 2 diabetes may contribute to activation of macrophages, and thus the development of... Abstract Increased circulating free fatty acids in subjects with type 2 diabetes may contribute to activation of macrophages, and thus the development of... |
| SourceID | swepub proquest pubmed pascalfrancis crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 382 |
| SubjectTerms | Atherosclerosis Atherosclerosis (general aspects, experimental research) Biological and medical sciences biosynthesis Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Cardiovascular system Cell Line Cell Line, Tumor Ceramide Ceramides Ceramides - biosynthesis Cytokines Cytokines - genetics Cytokines - metabolism Cytokines - secretion cytology Dermatologi och venereologi Dermatology and Venereal Diseases Diabetes drug effects Fatty Acids Fatty Acids - pharmacology genetics Humans Interleukin-1beta Interleukin-1beta - genetics Interleukin-1beta - metabolism Interleukin-1beta - secretion Interleukin-8 Interleukin-8 - genetics Interleukin-8 - metabolism Interleukin-8 - secretion JNK Mitogen-Activated Protein Kinases JNK Mitogen-Activated Protein Kinases - metabolism Lauric Acids Lauric Acids - pharmacology Leukemia Linoleic Acid Linoleic Acid - pharmacology Macrophages Medical sciences Messenger metabolism Microbiology in the Medical Area Mikrobiologi inom det medicinska området Monocytes Monocytes - cytology Monocytes - drug effects Monocytes - physiology Myeloid Differentiation Factor 88 Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - metabolism Myristic Acid Myristic Acid - pharmacology p38 Mitogen-Activated Protein Kinases p38 Mitogen-Activated Protein Kinases - metabolism Palmitate Palmitic Acid Palmitic Acid - pharmacology Palmitoyl Coenzyme A Palmitoyl Coenzyme A - metabolism pharmacology Pharmacology. Drug treatments physiology Proinflammatory cytokines RNA RNA, Messenger - metabolism RNA, Small Interfering secretion Serine palmitoyltransferase Small Interfering Stearate Stearic Acids Stearic Acids - pharmacology Transcription Factor AP-1 Transcription Factor AP-1 - metabolism Tumor Tumor Necrosis Factor-alpha Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - secretion Vasodilator agents. Cerebral vasodilators |
| Title | Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0021915008003419 https://www.clinicalkey.es/playcontent/1-s2.0-S0021915008003419 https://dx.doi.org/10.1016/j.atherosclerosis.2008.05.033 https://www.ncbi.nlm.nih.gov/pubmed/18599066 https://www.proquest.com/docview/66845315 https://gup.ub.gu.se/publication/109060 |
| Volume | 202 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Complete Freedom Collection [SCCMFC] customDbUrl: eissn: 1879-1484 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0004718 issn: 0021-9150 databaseCode: ACRLP dateStart: 19950106 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection customDbUrl: eissn: 1879-1484 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0004718 issn: 0021-9150 databaseCode: .~1 dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals [SCFCJ] customDbUrl: eissn: 1879-1484 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0004718 issn: 0021-9150 databaseCode: AIKHN dateStart: 19950106 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVLSH databaseName: Elsevier Journals customDbUrl: mediaType: online eissn: 1879-1484 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0004718 issn: 0021-9150 databaseCode: AKRWK dateStart: 19700101 isFulltext: true providerName: Library Specific Holdings |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Na9wwEB1CAqFQSvrttN3q0PbmxGvLWhlCaQgN25bm1EBuQpKljdvEXiLvYS_97RnZ8i5JU0jpxQfbGiNpZvRkvZkBeKc1V0WZZ3EuGY9xxddxUVgZaysNNzJRVnfZPk_Y9JR-PcvPNuBoiIXxtMrg-3uf3nnrcGc_jOb-vKp8jC9aG-IZj3l8VjIfwU6Zp_Xt_V7TPLzz7Wke49i_vQ3v1xyvDmQ1DkXitXKBWpnvJVn2t3Xq4Vw6HD3bl724C5feSjraLVTHO_AoIExy2HfiMWyY-glsfw9n6E9B-GodXTQDaSxBuahjqBaX3XE70cu2-eWp8EQtyUVTz2J9LquaOJ8AFHFpSaxs2yWRuiodwQddkT9yKX0psHN0Tu4ZnB5__nE0jUOZhVij8bVxqZQuJcI8ZWSB-1VDec4Z05MsnaB5aku5kkXGqWWMjqnyv4oK3GjJguZpmZrsOWzWTW1eAtGIH5QdFwZxIG5MuTLcJjazhmUoKikjOBgGVeiQg9yXwrgQA9nsp7g1J6FOZi5wTiJgq-bzPhnHfRt-HGZQDBGn6CMFLhv3FTC5S4BxweKdGAuXikT8oZURfFq1vKHY__Lx0Q2lW_U99SHllCYRvB20UKB38Ec-sjbNwgnGOEUvm0fwolfO9bjxHIEIYxF86LV19cQnHJ8t5gJvzRbCGU9SSFiy-_8deQUP-sM4zwZ6DZvt1cK8QUzXqlFntCPYOvzybXpyDcfqUgw |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB6VrVSQEOJNeLQ-ALfQbOJ4HQkhqopqS9s9tVJvlu3Y24U2WeHsYf8948TZVUuRirjk4MgT2Z75_DmeB8B7rbkqyjyLc8l4jDu-jovCylhbabiRibK6zfY5YeMz-v08P9-A_T4WxrtVBuzvML1F69CyG2Zzdz6b-RhftDbkM57z-Kxk92CT5ojJA9jcOzwaT9bhkaNhB8jeGwE7bMGHtZtXy7Nqh1LxOXPBuzL_lGTZ37aqh3PpcAJtV_niNmp6I-9ou1cdPIZHgWSSvW4cT2DDVE9h6yRcoz8D4Qt2tAENpLYE5aKaoWZctTfuRC-b-qf3hidqSS7rahrrCzmriPM5QJGalsTKplkSqWelI_iirfNHrqSvBnaB-OSew9nBt9P9cRwqLcQa7a-JS6V0KZHpKSMLPLIaynPOmB5l6QgtVFvKlSwyTi1jdEiV_1tU4FlLFjRPy9RkL2BQ1ZV5BUQjhVB2WBikgng25cpwm9jMGpahqKSM4HM_qUKHNOS-Gsal6P3NfogbaxJKZeYC1yQCtuo-7_Jx3LXjl34FRR90ijApcOe4q4DRbQKMC0bvxFC4VCTiD8WM4Ouq5zXd_pePb19TutXYUx9VTmkSwU6vhQIBwt_6yMrUCycY4xSBNo_gZaec63njOXIRxiL42Gnr6o3POT5dzAU2TRfCGe-nkLDk9f8PZAfuj09PjsXx4eToDTzo7ua8c9BbGDS_FuYdUrxGbQcT_g0O6lS3 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Induction+of+proinflammatory+cytokines+by+long-chain+saturated+fatty+acids+in+human+macrophages&rft.jtitle=Atherosclerosis&rft.au=H%C3%A5versen%2C+Liliana&rft.au=Danielsson%2C+Kristina+Nor%C3%A9n&rft.au=Fogelstrand%2C+Linda&rft.au=Wiklund%2C+Olov&rft.date=2009-02-01&rft.issn=1879-1484&rft.eissn=1879-1484&rft.volume=202&rft.issue=2&rft.spage=382&rft_id=info:doi/10.1016%2Fj.atherosclerosis.2008.05.033&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F00219150%2FS0021915009X0002X%2Fcov150h.gif |