Improved analysis of CRISPR fitness screens and reduced off-target effects with the BAGEL2 gene essentiality classifier - Kim, Eiru; Hart, Traver (Genome medicine, 2021)
Keywords: Algorithms; Analysis; Bayes Theorem; Bayesian analysis; Bioinformatics; Biomedical and Life Sciences; Biomedicine; Cancer; Cancer Research; Cell Line, Tumor; CRISPR; CRISPR-Cas Systems - genetics; Data Accuracy; Datasets; Deoxyribonucleic acid; DNA; Gene expression; Gene loci; Genes; Genes, Essential; Genetic aspects; Genetic screening; Genetic Testing; Genomes; Genomics; Human Genetics; Humans; Likelihood Functions; Medicine/Public Health; Metabolomics; Pipelines; Proteins; Regression Analysis; Reproductive fitness; Ribonucleic acid; RNA; Software; Systems Biology; Tumor suppressor genes