A functionally impaired missense variant identified in French Canadian families implicates FANCI as a candidate ovarian cancer-predisposing gene - Fierheller, Caitlin T.; Guitton-Sert, Laure; Alenezi, Wejdan M.; Revil, Timothée; Oros, Kathleen K.; Gao, Yuandi; Bedard, Karine; Arcand, Suzanna L.; Serruya, Corinne; Behl, Supriya; Meunier, Liliane; Fleury, Hubert; et al. (Genome medicine, 2021)
Keywords: Age; Biobanks; Bioinformatics; Biomedical and Life Sciences; Biomedicine; BRCA1 protein; BRCA1 Protein - genetics; BRCA2 protein; BRCA2 Protein - genetics; Breast cancer; Breast Neoplasms - ethnology; Breast Neoplasms - genetics; Canada; Cancer; Cancer Research; Cancer-predisposing gene; Cisplatin; Consortia; Deoxyribonucleic acid; DNA; DNA damage; DNA microarrays; DNA repair; DNA sequencing; Epithelial cells; Fallopian tube; Families & family life; Family; Family medical history; FANCI; Fanconi Anemia Complementation Group Proteins - genetics; Fanconi's anemia; Female; Females; Genealogy; Genes; Genetic aspects; Genetic drift; Genetic Predisposition to Disease; Genetic research; Homologous recombination; Human Genetics; Humans; Investigations; Localization; Male; Medicine/Public Health; Metabolomics; Monosaccharides; Ovarian cancer; Ovarian Neoplasms - ethnology; Ovarian Neoplasms - genetics; Population; Population genetics; Prevention; Protein arrays; Protein expression; Ribose; Sugars; Systems Biology; Tissue microarray; Tumor cell lines; Whole exome sequencing; Canada; Quebec Canada; Whole exome sequencing; Hereditary cancer; Cancer-predisposing gene; Tissue microarray; Protein expression; Familial aggregation of cancer; Fanconi anaemia pathway; DNA repair; Ovarian cancer; FANCI