Cessation of methotrexate and a small intestinal resection provide a good clinical course for a patient with a jejunum perforation induced by a methotrexate-associated lymphoproliferative disorder: a case report
Background Methotrexate (MTX) is a frequently used drug in the treatment of rheumatoid arthritis (RA), but occurrences of lymphoproliferative disorders (LPD) have been reported in patients undergoing an MTX regimen. Almost half of the patients with methotrexate-associated lymphoproliferative disorde...
Saved in:
| Published in | World journal of surgical oncology Vol. 19; no. 1; pp. 4 - 7 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
BioMed Central
02.01.2021
BioMed Central Ltd BMC |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1477-7819 1477-7819 |
| DOI | 10.1186/s12957-020-02114-0 |
Cover
| Abstract | Background
Methotrexate (MTX) is a frequently used drug in the treatment of rheumatoid arthritis (RA), but occurrences of lymphoproliferative disorders (LPD) have been reported in patients undergoing an MTX regimen. Almost half of the patients with methotrexate-associated lymphoproliferative disorders (MTX-LPD) have extranodal lesions; moreover, although extremely rare, digestive tract perforations resulting from the extranodal lesions of MTX-LPD have also been reported.
Case presentation
We describe the case of an 81-year-old woman with RA who had been prescribed MTX at 6 mg per week for the past 11 years. She was admitted to our hospital with occasional abdominal pain and was first diagnosed with enteritis. Her abdominal pain did not improve, and a computed tomography scan showed abdominal effusion and free air in the abdominal cavity. She was diagnosed with a digestive tract perforation and underwent emergency surgery. The perforation site was identified in the jejunum, and she underwent small intestinal resection around the perforated region. The pathological findings showed an ulcer in the jejunum and infiltration of large atypical lymphocytes around the perforated region. An immunohistochemical examination revealed the expression of a cluster of differentiation 20 and latent membrane protein 1. Considering the patient’s history of RA treated with MTX, she was diagnosed as having Epstein–Barr virus (EBV)-related MTX-LPD with a histological diagnosis of EBVMCU. MTX was discontinued after the surgery, and her soluble interleukin-2 receptor (sIL-2R) levels had returned to normal 1 year later. She has had a good course for the 2 years since surgery and remains asymptomatic with no recurrence of MTX-LPD, as confirmed by the sIL-2R levels.
Conclusion
We experienced a rare case of the jejunum perforation induced by MTX-LPD. Since only a few cases have been reported of a patient with small intestinal perforation induced by MTX-LPD, further research is necessary to evaluate the clinicopathological features of MTX-LPD. The patient had disease remission after surgery and by discontinuing MTX treatment; our case did not require chemotherapy. EBV-positive patients, especially those with a pathological presentation of EBVMCU, could have a higher likelihood of remission, which could have been a factor in the present case. |
|---|---|
| AbstractList | Background Methotrexate (MTX) is a frequently used drug in the treatment of rheumatoid arthritis (RA), but occurrences of lymphoproliferative disorders (LPD) have been reported in patients undergoing an MTX regimen. Almost half of the patients with methotrexate-associated lymphoproliferative disorders (MTX-LPD) have extranodal lesions; moreover, although extremely rare, digestive tract perforations resulting from the extranodal lesions of MTX-LPD have also been reported. Case presentation We describe the case of an 81-year-old woman with RA who had been prescribed MTX at 6 mg per week for the past 11 years. She was admitted to our hospital with occasional abdominal pain and was first diagnosed with enteritis. Her abdominal pain did not improve, and a computed tomography scan showed abdominal effusion and free air in the abdominal cavity. She was diagnosed with a digestive tract perforation and underwent emergency surgery. The perforation site was identified in the jejunum, and she underwent small intestinal resection around the perforated region. The pathological findings showed an ulcer in the jejunum and infiltration of large atypical lymphocytes around the perforated region. An immunohistochemical examination revealed the expression of a cluster of differentiation 20 and latent membrane protein 1. Considering the patient's history of RA treated with MTX, she was diagnosed as having Epstein-Barr virus (EBV)-related MTX-LPD with a histological diagnosis of EBVMCU. MTX was discontinued after the surgery, and her soluble interleukin-2 receptor (sIL-2R) levels had returned to normal 1 year later. She has had a good course for the 2 years since surgery and remains asymptomatic with no recurrence of MTX-LPD, as confirmed by the sIL-2R levels. Conclusion We experienced a rare case of the jejunum perforation induced by MTX-LPD. Since only a few cases have been reported of a patient with small intestinal perforation induced by MTX-LPD, further research is necessary to evaluate the clinicopathological features of MTX-LPD. The patient had disease remission after surgery and by discontinuing MTX treatment; our case did not require chemotherapy. EBV-positive patients, especially those with a pathological presentation of EBVMCU, could have a higher likelihood of remission, which could have been a factor in the present case. Keywords: Methotrexate, Lymphoproliferative disorder, Intestinal perforation, Jejunum, Epstein-Barr virus, Case report, Epstein-Barr virus-positive mucocutaneous ulcer, EBVMCU Abstract Background Methotrexate (MTX) is a frequently used drug in the treatment of rheumatoid arthritis (RA), but occurrences of lymphoproliferative disorders (LPD) have been reported in patients undergoing an MTX regimen. Almost half of the patients with methotrexate-associated lymphoproliferative disorders (MTX-LPD) have extranodal lesions; moreover, although extremely rare, digestive tract perforations resulting from the extranodal lesions of MTX-LPD have also been reported. Case presentation We describe the case of an 81-year-old woman with RA who had been prescribed MTX at 6 mg per week for the past 11 years. She was admitted to our hospital with occasional abdominal pain and was first diagnosed with enteritis. Her abdominal pain did not improve, and a computed tomography scan showed abdominal effusion and free air in the abdominal cavity. She was diagnosed with a digestive tract perforation and underwent emergency surgery. The perforation site was identified in the jejunum, and she underwent small intestinal resection around the perforated region. The pathological findings showed an ulcer in the jejunum and infiltration of large atypical lymphocytes around the perforated region. An immunohistochemical examination revealed the expression of a cluster of differentiation 20 and latent membrane protein 1. Considering the patient’s history of RA treated with MTX, she was diagnosed as having Epstein–Barr virus (EBV)-related MTX-LPD with a histological diagnosis of EBVMCU. MTX was discontinued after the surgery, and her soluble interleukin-2 receptor (sIL-2R) levels had returned to normal 1 year later. She has had a good course for the 2 years since surgery and remains asymptomatic with no recurrence of MTX-LPD, as confirmed by the sIL-2R levels. Conclusion We experienced a rare case of the jejunum perforation induced by MTX-LPD. Since only a few cases have been reported of a patient with small intestinal perforation induced by MTX-LPD, further research is necessary to evaluate the clinicopathological features of MTX-LPD. The patient had disease remission after surgery and by discontinuing MTX treatment; our case did not require chemotherapy. EBV-positive patients, especially those with a pathological presentation of EBVMCU, could have a higher likelihood of remission, which could have been a factor in the present case. Methotrexate (MTX) is a frequently used drug in the treatment of rheumatoid arthritis (RA), but occurrences of lymphoproliferative disorders (LPD) have been reported in patients undergoing an MTX regimen. Almost half of the patients with methotrexate-associated lymphoproliferative disorders (MTX-LPD) have extranodal lesions; moreover, although extremely rare, digestive tract perforations resulting from the extranodal lesions of MTX-LPD have also been reported. We experienced a rare case of the jejunum perforation induced by MTX-LPD. Since only a few cases have been reported of a patient with small intestinal perforation induced by MTX-LPD, further research is necessary to evaluate the clinicopathological features of MTX-LPD. The patient had disease remission after surgery and by discontinuing MTX treatment; our case did not require chemotherapy. EBV-positive patients, especially those with a pathological presentation of EBVMCU, could have a higher likelihood of remission, which could have been a factor in the present case. Background Methotrexate (MTX) is a frequently used drug in the treatment of rheumatoid arthritis (RA), but occurrences of lymphoproliferative disorders (LPD) have been reported in patients undergoing an MTX regimen. Almost half of the patients with methotrexate-associated lymphoproliferative disorders (MTX-LPD) have extranodal lesions; moreover, although extremely rare, digestive tract perforations resulting from the extranodal lesions of MTX-LPD have also been reported. Case presentation We describe the case of an 81-year-old woman with RA who had been prescribed MTX at 6 mg per week for the past 11 years. She was admitted to our hospital with occasional abdominal pain and was first diagnosed with enteritis. Her abdominal pain did not improve, and a computed tomography scan showed abdominal effusion and free air in the abdominal cavity. She was diagnosed with a digestive tract perforation and underwent emergency surgery. The perforation site was identified in the jejunum, and she underwent small intestinal resection around the perforated region. The pathological findings showed an ulcer in the jejunum and infiltration of large atypical lymphocytes around the perforated region. An immunohistochemical examination revealed the expression of a cluster of differentiation 20 and latent membrane protein 1. Considering the patient’s history of RA treated with MTX, she was diagnosed as having Epstein–Barr virus (EBV)-related MTX-LPD with a histological diagnosis of EBVMCU. MTX was discontinued after the surgery, and her soluble interleukin-2 receptor (sIL-2R) levels had returned to normal 1 year later. She has had a good course for the 2 years since surgery and remains asymptomatic with no recurrence of MTX-LPD, as confirmed by the sIL-2R levels. Conclusion We experienced a rare case of the jejunum perforation induced by MTX-LPD. Since only a few cases have been reported of a patient with small intestinal perforation induced by MTX-LPD, further research is necessary to evaluate the clinicopathological features of MTX-LPD. The patient had disease remission after surgery and by discontinuing MTX treatment; our case did not require chemotherapy. EBV-positive patients, especially those with a pathological presentation of EBVMCU, could have a higher likelihood of remission, which could have been a factor in the present case. Methotrexate (MTX) is a frequently used drug in the treatment of rheumatoid arthritis (RA), but occurrences of lymphoproliferative disorders (LPD) have been reported in patients undergoing an MTX regimen. Almost half of the patients with methotrexate-associated lymphoproliferative disorders (MTX-LPD) have extranodal lesions; moreover, although extremely rare, digestive tract perforations resulting from the extranodal lesions of MTX-LPD have also been reported. We describe the case of an 81-year-old woman with RA who had been prescribed MTX at 6 mg per week for the past 11 years. She was admitted to our hospital with occasional abdominal pain and was first diagnosed with enteritis. Her abdominal pain did not improve, and a computed tomography scan showed abdominal effusion and free air in the abdominal cavity. She was diagnosed with a digestive tract perforation and underwent emergency surgery. The perforation site was identified in the jejunum, and she underwent small intestinal resection around the perforated region. The pathological findings showed an ulcer in the jejunum and infiltration of large atypical lymphocytes around the perforated region. An immunohistochemical examination revealed the expression of a cluster of differentiation 20 and latent membrane protein 1. Considering the patient's history of RA treated with MTX, she was diagnosed as having Epstein-Barr virus (EBV)-related MTX-LPD with a histological diagnosis of EBVMCU. MTX was discontinued after the surgery, and her soluble interleukin-2 receptor (sIL-2R) levels had returned to normal 1 year later. She has had a good course for the 2 years since surgery and remains asymptomatic with no recurrence of MTX-LPD, as confirmed by the sIL-2R levels. We experienced a rare case of the jejunum perforation induced by MTX-LPD. Since only a few cases have been reported of a patient with small intestinal perforation induced by MTX-LPD, further research is necessary to evaluate the clinicopathological features of MTX-LPD. The patient had disease remission after surgery and by discontinuing MTX treatment; our case did not require chemotherapy. EBV-positive patients, especially those with a pathological presentation of EBVMCU, could have a higher likelihood of remission, which could have been a factor in the present case. Methotrexate (MTX) is a frequently used drug in the treatment of rheumatoid arthritis (RA), but occurrences of lymphoproliferative disorders (LPD) have been reported in patients undergoing an MTX regimen. Almost half of the patients with methotrexate-associated lymphoproliferative disorders (MTX-LPD) have extranodal lesions; moreover, although extremely rare, digestive tract perforations resulting from the extranodal lesions of MTX-LPD have also been reported.BACKGROUNDMethotrexate (MTX) is a frequently used drug in the treatment of rheumatoid arthritis (RA), but occurrences of lymphoproliferative disorders (LPD) have been reported in patients undergoing an MTX regimen. Almost half of the patients with methotrexate-associated lymphoproliferative disorders (MTX-LPD) have extranodal lesions; moreover, although extremely rare, digestive tract perforations resulting from the extranodal lesions of MTX-LPD have also been reported.We describe the case of an 81-year-old woman with RA who had been prescribed MTX at 6 mg per week for the past 11 years. She was admitted to our hospital with occasional abdominal pain and was first diagnosed with enteritis. Her abdominal pain did not improve, and a computed tomography scan showed abdominal effusion and free air in the abdominal cavity. She was diagnosed with a digestive tract perforation and underwent emergency surgery. The perforation site was identified in the jejunum, and she underwent small intestinal resection around the perforated region. The pathological findings showed an ulcer in the jejunum and infiltration of large atypical lymphocytes around the perforated region. An immunohistochemical examination revealed the expression of a cluster of differentiation 20 and latent membrane protein 1. Considering the patient's history of RA treated with MTX, she was diagnosed as having Epstein-Barr virus (EBV)-related MTX-LPD with a histological diagnosis of EBVMCU. MTX was discontinued after the surgery, and her soluble interleukin-2 receptor (sIL-2R) levels had returned to normal 1 year later. She has had a good course for the 2 years since surgery and remains asymptomatic with no recurrence of MTX-LPD, as confirmed by the sIL-2R levels.CASE PRESENTATIONWe describe the case of an 81-year-old woman with RA who had been prescribed MTX at 6 mg per week for the past 11 years. She was admitted to our hospital with occasional abdominal pain and was first diagnosed with enteritis. Her abdominal pain did not improve, and a computed tomography scan showed abdominal effusion and free air in the abdominal cavity. She was diagnosed with a digestive tract perforation and underwent emergency surgery. The perforation site was identified in the jejunum, and she underwent small intestinal resection around the perforated region. The pathological findings showed an ulcer in the jejunum and infiltration of large atypical lymphocytes around the perforated region. An immunohistochemical examination revealed the expression of a cluster of differentiation 20 and latent membrane protein 1. Considering the patient's history of RA treated with MTX, she was diagnosed as having Epstein-Barr virus (EBV)-related MTX-LPD with a histological diagnosis of EBVMCU. MTX was discontinued after the surgery, and her soluble interleukin-2 receptor (sIL-2R) levels had returned to normal 1 year later. She has had a good course for the 2 years since surgery and remains asymptomatic with no recurrence of MTX-LPD, as confirmed by the sIL-2R levels.We experienced a rare case of the jejunum perforation induced by MTX-LPD. Since only a few cases have been reported of a patient with small intestinal perforation induced by MTX-LPD, further research is necessary to evaluate the clinicopathological features of MTX-LPD. The patient had disease remission after surgery and by discontinuing MTX treatment; our case did not require chemotherapy. EBV-positive patients, especially those with a pathological presentation of EBVMCU, could have a higher likelihood of remission, which could have been a factor in the present case.CONCLUSIONWe experienced a rare case of the jejunum perforation induced by MTX-LPD. Since only a few cases have been reported of a patient with small intestinal perforation induced by MTX-LPD, further research is necessary to evaluate the clinicopathological features of MTX-LPD. The patient had disease remission after surgery and by discontinuing MTX treatment; our case did not require chemotherapy. EBV-positive patients, especially those with a pathological presentation of EBVMCU, could have a higher likelihood of remission, which could have been a factor in the present case. Background Methotrexate (MTX) is a frequently used drug in the treatment of rheumatoid arthritis (RA), but occurrences of lymphoproliferative disorders (LPD) have been reported in patients undergoing an MTX regimen. Almost half of the patients with methotrexate-associated lymphoproliferative disorders (MTX-LPD) have extranodal lesions; moreover, although extremely rare, digestive tract perforations resulting from the extranodal lesions of MTX-LPD have also been reported. Case presentation We describe the case of an 81-year-old woman with RA who had been prescribed MTX at 6 mg per week for the past 11 years. She was admitted to our hospital with occasional abdominal pain and was first diagnosed with enteritis. Her abdominal pain did not improve, and a computed tomography scan showed abdominal effusion and free air in the abdominal cavity. She was diagnosed with a digestive tract perforation and underwent emergency surgery. The perforation site was identified in the jejunum, and she underwent small intestinal resection around the perforated region. The pathological findings showed an ulcer in the jejunum and infiltration of large atypical lymphocytes around the perforated region. An immunohistochemical examination revealed the expression of a cluster of differentiation 20 and latent membrane protein 1. Considering the patient’s history of RA treated with MTX, she was diagnosed as having Epstein–Barr virus (EBV)-related MTX-LPD with a histological diagnosis of EBVMCU. MTX was discontinued after the surgery, and her soluble interleukin-2 receptor (sIL-2R) levels had returned to normal 1 year later. She has had a good course for the 2 years since surgery and remains asymptomatic with no recurrence of MTX-LPD, as confirmed by the sIL-2R levels. Conclusion We experienced a rare case of the jejunum perforation induced by MTX-LPD. Since only a few cases have been reported of a patient with small intestinal perforation induced by MTX-LPD, further research is necessary to evaluate the clinicopathological features of MTX-LPD. The patient had disease remission after surgery and by discontinuing MTX treatment; our case did not require chemotherapy. EBV-positive patients, especially those with a pathological presentation of EBVMCU, could have a higher likelihood of remission, which could have been a factor in the present case. |
| ArticleNumber | 4 |
| Audience | Academic |
| Author | Aoyanagi, Nobuyoshi Ono, Hayato Shimizu, Atsushi Endo, Daisuke Nagai, Takeshi Kumazawa, Keigo Sumiya, Ryusuke Nomura, Masahiro |
| Author_xml | – sequence: 1 givenname: Masahiro surname: Nomura fullname: Nomura, Masahiro organization: Department of Surgery, Kohnodai Hospital, National Center for Global Health and Medicine – sequence: 2 givenname: Ryusuke orcidid: 0000-0002-2464-6717 surname: Sumiya fullname: Sumiya, Ryusuke email: rsumiya@hosp.ncgm.go.jp organization: Department of Surgery, Kohnodai Hospital, National Center for Global Health and Medicine – sequence: 3 givenname: Hayato surname: Ono fullname: Ono, Hayato organization: Department of Surgery, Kohnodai Hospital, National Center for Global Health and Medicine – sequence: 4 givenname: Takeshi surname: Nagai fullname: Nagai, Takeshi organization: Department of Surgery, Kohnodai Hospital, National Center for Global Health and Medicine – sequence: 5 givenname: Keigo surname: Kumazawa fullname: Kumazawa, Keigo organization: Department of Surgery, Kohnodai Hospital, National Center for Global Health and Medicine – sequence: 6 givenname: Atsushi surname: Shimizu fullname: Shimizu, Atsushi organization: Department of Surgery, Kohnodai Hospital, National Center for Global Health and Medicine – sequence: 7 givenname: Daisuke surname: Endo fullname: Endo, Daisuke organization: Department of Surgery, Kohnodai Hospital, National Center for Global Health and Medicine – sequence: 8 givenname: Nobuyoshi surname: Aoyanagi fullname: Aoyanagi, Nobuyoshi organization: Department of Surgery, Kohnodai Hospital, National Center for Global Health and Medicine |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33388058$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNUl1rFDEUHaRibfUP-CABQXyZmvlMxgehFD8KBV_0OWSSm90smWRMZlr3d_qHvLtb290iRYZhMsk5596cc0-yIx88ZNmrgp4VBW_fp6LsGpbTkuJbFHVOn2TPi5qxnPGiO9pbH2cnKa0oLauqqZ5lx1VVcU4b_jz7fQEpyckGT4IhA0zLMEX4JScg0msiSRqkc8T6CdJkvXQkQgK1JYwxXFuNQLIIQRPlrLcKESrMMQExIeLRiOLgJ3JjpyX-rmA1-3kgI0Q83xW2Xs8KNOnXCNhvIZcpBWVxpYlbD-MyYElnDWyI10C0TSFqiB-QpySWjDCGOL3InhrpEry8_Z5mPz5_-n7xNb_69uXy4vwqV23Fp7zUvZEgy7bgUMmmYmgK5YxLXdSKdbQGULoqay4566DsOiQ0JRRt0Zmml6Y6zS53ujrIlRijHWRciyCt2G6EuBAyTlY5EJLWbVkZI5lktWmB96bjnekrVeuedg1qVTut2Y9yfYOe3wkWVGziFru4BcYttnELiqyPO9Y49wNohUZH6Q5aOTzxdikW4VowxvCmHAXe3QrE8HPGiMVgkwLnpIcwJ1HWrKGI6zbQNw-gK8wZJ2KL4rxpClbeoxYSr229wSyl2oiK87ahTdPStkPU2T9Q-GgYrMIpNxb3Dwhv9whLkG5apuDmzfykQ-DrfUfurPg78QgodwAVQ0oRzP_5zB-QlJ22w4t9W_c49TbYhHX8AuK9bY-w_gC7Szjz |
| CitedBy_id | crossref_primary_10_3390_cancers13184578 crossref_primary_10_1016_j_ajoms_2021_08_012 crossref_primary_10_3390_cancers13153815 crossref_primary_10_1136_bcr_2023_257148 crossref_primary_10_1186_s13256_024_04730_w crossref_primary_10_3390_jcm11164915 crossref_primary_10_1007_s40278_021_90027_x crossref_primary_10_7759_cureus_30936 |
| Cites_doi | 10.1056/NEJM199004053221404 10.3748/wjg.v20.i29.9990 10.1016/j.tranon.2020.100911 10.5387/fms.2017-23 10.1097/PAS.0000000000001271 10.1002/rmv.1816 10.1007/s12325-017-0612-x 10.3960/jslrt.18039 10.1097/00000478-200301000-00003 10.3109/14397595.2013.878016 10.3960/jslrt.19007 10.1007/s10637-010-9505-4 10.1093/annonc/mdt188 10.1111/cas.13249 10.3960/jslrt.19014 10.1200/JCO.1996.14.6.1943 10.3960/jslrt.19028 10.1186/s40164-016-0042-5 10.1111/ejh.12116 10.1007/s12032-008-9069-8 10.5833/jjgs.2018.0084 10.3748/wjg.v18.i16.1871 10.1007/s00296-017-3764-8 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2021 COPYRIGHT 2021 BioMed Central Ltd. 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: The Author(s) 2021 – notice: COPYRIGHT 2021 BioMed Central Ltd. – notice: 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QL 7QO 7X7 7XB 88E 8FD 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR C1K CCPQU DWQXO FR3 FYUFA GHDGH K9. M0S M1P P64 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 5PM ADTOC UNPAY DOA |
| DOI | 10.1186/s12957-020-02114-0 |
| DatabaseName | Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Technology Research Database Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central Environmental Sciences and Pollution Management ProQuest One ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni) Medical Database Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) Unpaywall for CDI: Periodical Content Unpaywall DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database Technology Research Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central China Environmental Sciences and Pollution Management ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Publicly Available Content Database MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: C6C name: Springer Nature OA Free Journals url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 5 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1477-7819 |
| EndPage | 7 |
| ExternalDocumentID | oai_doaj_org_article_a04623ffa7a74f6e8bf989fb3c4db095 10.1186/s12957-020-02114-0 PMC7778788 A650556069 33388058 10_1186_s12957_020_02114_0 |
| Genre | Journal Article Case Reports |
| GeographicLocations | Japan |
| GeographicLocations_xml | – name: Japan |
| GroupedDBID | --- 0R~ 29R 2WC 53G 5VS 7X7 88E 8FI 8FJ AAFWJ AAJSJ AASML ABDBF ABUWG ACGFO ACGFS ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ ADUKV AEAQA AENEX AFKRA AFPKN AFRAH AHBYD AHMBA AHYZX ALMA_UNASSIGNED_HOLDINGS AMKLP AMTXH AOIJS BAPOH BAWUL BCNDV BENPR BFQNJ BMC BPHCQ BVXVI C6C CCPQU CS3 DIK DU5 E3Z EBD EBLON EBS ESX F5P FYUFA GROUPED_DOAJ GX1 HMCUK IAO IHR IHW INH INR ITC KQ8 M1P M48 M~E O5R O5S OK1 OVT P2P PGMZT PHGZM PHGZT PIMPY PJZUB PPXIY PQQKQ PROAC PSQYO PUEGO RBZ RNS ROL RPM RSV SMD SOJ TR2 TUS UKHRP W2D WOQ WOW XSB ~8M AAYXX CITATION ALIPV CGR CUY CVF ECM EIF NPM PMFND 3V. 7QL 7QO 7XB 8FD 8FK AZQEC C1K DWQXO FR3 K9. P64 PKEHL PQEST PQUKI PRINS 7X8 5PM 2VQ 4.4 ADTOC AHSBF EJD H13 HYE IPNFZ RIG UNPAY |
| ID | FETCH-LOGICAL-c638t-2dbfaea2618e3a5373380878ad14c7904eecd3248a879e2992db52e1619f5baf3 |
| IEDL.DBID | M48 |
| ISSN | 1477-7819 |
| IngestDate | Wed Aug 27 01:30:29 EDT 2025 Wed Aug 20 00:09:19 EDT 2025 Tue Sep 30 16:02:54 EDT 2025 Fri Sep 05 11:07:15 EDT 2025 Fri Jul 25 20:44:11 EDT 2025 Tue Jun 17 20:42:59 EDT 2025 Tue Jun 10 20:23:58 EDT 2025 Thu May 22 21:21:16 EDT 2025 Thu Apr 03 07:09:42 EDT 2025 Wed Oct 01 03:02:16 EDT 2025 Thu Apr 24 23:09:17 EDT 2025 Sat Sep 06 07:30:30 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Case report Lymphoproliferative disorder Jejunum Epstein–Barr virus-positive mucocutaneous ulcer Methotrexate Intestinal perforation Epstein–Barr virus EBVMCU |
| Language | English |
| License | Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. cc-by |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c638t-2dbfaea2618e3a5373380878ad14c7904eecd3248a879e2992db52e1619f5baf3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Report-3 ObjectType-Case Study-4 ObjectType-Case Study-2 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 |
| ORCID | 0000-0002-2464-6717 |
| OpenAccessLink | https://doaj.org/article/a04623ffa7a74f6e8bf989fb3c4db095 |
| PMID | 33388058 |
| PQID | 2478855172 |
| PQPubID | 42870 |
| PageCount | 7 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_a04623ffa7a74f6e8bf989fb3c4db095 unpaywall_primary_10_1186_s12957_020_02114_0 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7778788 proquest_miscellaneous_2475088398 proquest_journals_2478855172 gale_infotracmisc_A650556069 gale_infotracacademiconefile_A650556069 gale_healthsolutions_A650556069 pubmed_primary_33388058 crossref_primary_10_1186_s12957_020_02114_0 crossref_citationtrail_10_1186_s12957_020_02114_0 springer_journals_10_1186_s12957_020_02114_0 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2021-01-02 |
| PublicationDateYYYYMMDD | 2021-01-02 |
| PublicationDate_xml | – month: 01 year: 2021 text: 2021-01-02 day: 02 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | World journal of surgical oncology |
| PublicationTitleAbbrev | World J Surg Onc |
| PublicationTitleAlternate | World J Surg Oncol |
| PublicationYear | 2021 |
| Publisher | BioMed Central BioMed Central Ltd BMC |
| Publisher_xml | – name: BioMed Central – name: BioMed Central Ltd – name: BMC |
| References | TK Roberts (2114_CR24) 2016; 5 S Takanashi (2114_CR5) 2017; 37 CJ Houldcroft (2114_CR6) 2015; 25 S Oe (2114_CR4) 2020; 53 Y Gion (2114_CR3) 2017; 108 G Salles (2114_CR10) 2017; 34 M Tokuhira (2114_CR14) 2018; 59 E Jantuan (2114_CR26) 2020; 14 Y Hoshida (2114_CR18) 2007; 34 Y Yoshida (2114_CR1) 2014; 24 R Vaidya (2114_CR13) 2013; 24 T Ikeda (2114_CR25) 2019; 59 E Lecarpentier (2114_CR11) 2011; 29 E Salloum (2114_CR17) 1996; 14 S Saito (2114_CR22) 2019; 59 HJ Freeman (2114_CR8) 2014; 20 D Kurita (2114_CR15) 2019; 43 S Momose (2114_CR21) 2019; 59 T Oyama (2114_CR23) 2003; 27 R Rizzi (2114_CR20) 2008; 26 SH Swerdlow (2114_CR2) 2017 MS Klempner (2114_CR12) 1990; 322 LW Wang (2114_CR7) 2017; 91 HJ Freeman (2114_CR9) 2012; 18 E Suzuki (2114_CR16) 2018; 64 A Ichikawa (2114_CR19) 2013; 91 |
| References_xml | – volume-title: World Health Organization classification of tumours of haematopoietic and lymphoid tissues. Revised 4th ed year: 2017 ident: 2114_CR2 – volume: 322 start-page: 959 year: 1990 ident: 2114_CR12 publication-title: N Engl J Med. doi: 10.1056/NEJM199004053221404 – volume: 20 start-page: 9990 year: 2014 ident: 2114_CR8 publication-title: World J Gastroenterol. doi: 10.3748/wjg.v20.i29.9990 – volume: 14 start-page: 100911 year: 2020 ident: 2114_CR26 publication-title: Transl Oncol. doi: 10.1016/j.tranon.2020.100911 – volume: 64 start-page: 82 year: 2018 ident: 2114_CR16 publication-title: Fukushima J Med Sci. doi: 10.5387/fms.2017-23 – volume: 43 start-page: 869 year: 2019 ident: 2114_CR15 publication-title: Am J Surg Pathol. doi: 10.1097/PAS.0000000000001271 – volume: 25 start-page: 71 year: 2015 ident: 2114_CR6 publication-title: Rev Med Virol. doi: 10.1002/rmv.1816 – volume: 91 start-page: e01718 year: 2017 ident: 2114_CR7 publication-title: J Virol. – volume: 34 start-page: 2232 year: 2017 ident: 2114_CR10 publication-title: Adv Ther. doi: 10.1007/s12325-017-0612-x – volume: 59 start-page: 64 year: 2019 ident: 2114_CR25 publication-title: J Clin Exp Hematop. doi: 10.3960/jslrt.18039 – volume: 34 start-page: 322 year: 2007 ident: 2114_CR18 publication-title: J Rheumatol. – volume: 27 start-page: 16 year: 2003 ident: 2114_CR23 publication-title: Am J Surg Pathol. doi: 10.1097/00000478-200301000-00003 – volume: 24 start-page: 763 year: 2014 ident: 2114_CR1 publication-title: Mod Rheumatol. doi: 10.3109/14397595.2013.878016 – volume: 59 start-page: 72 year: 2018 ident: 2114_CR14 publication-title: J Clin Exp Hematop. doi: 10.3960/jslrt.19007 – volume: 29 start-page: 1500 year: 2011 ident: 2114_CR11 publication-title: Invest New Drugs. doi: 10.1007/s10637-010-9505-4 – volume: 24 start-page: 2439 year: 2013 ident: 2114_CR13 publication-title: Ann Oncol. doi: 10.1093/annonc/mdt188 – volume: 108 start-page: 1271 year: 2017 ident: 2114_CR3 publication-title: Cancer Sci. doi: 10.1111/cas.13249 – volume: 59 start-page: 48 year: 2019 ident: 2114_CR21 publication-title: J Clin Exp Hematop. doi: 10.3960/jslrt.19014 – volume: 14 start-page: 1943 year: 1996 ident: 2114_CR17 publication-title: J Clin Oncol. doi: 10.1200/JCO.1996.14.6.1943 – volume: 59 start-page: 145 year: 2019 ident: 2114_CR22 publication-title: J Clin Exp Hematop. doi: 10.3960/jslrt.19028 – volume: 5 start-page: 13 year: 2016 ident: 2114_CR24 publication-title: Exp Hematol Oncol. doi: 10.1186/s40164-016-0042-5 – volume: 91 start-page: 20 year: 2013 ident: 2114_CR19 publication-title: Eur J Haematol. doi: 10.1111/ejh.12116 – volume: 26 start-page: 1 year: 2008 ident: 2114_CR20 publication-title: Med Oncol. doi: 10.1007/s12032-008-9069-8 – volume: 53 start-page: 239 year: 2020 ident: 2114_CR4 publication-title: Jpn J Gastroenterol Surg. doi: 10.5833/jjgs.2018.0084 – volume: 18 start-page: 1871 year: 2012 ident: 2114_CR9 publication-title: World J Gastroenterol. doi: 10.3748/wjg.v18.i16.1871 – volume: 37 start-page: 1629 year: 2017 ident: 2114_CR5 publication-title: Rheumatol Int. doi: 10.1007/s00296-017-3764-8 |
| SSID | ssj0023353 |
| Score | 2.278577 |
| Snippet | Background
Methotrexate (MTX) is a frequently used drug in the treatment of rheumatoid arthritis (RA), but occurrences of lymphoproliferative disorders (LPD)... Methotrexate (MTX) is a frequently used drug in the treatment of rheumatoid arthritis (RA), but occurrences of lymphoproliferative disorders (LPD) have been... Background Methotrexate (MTX) is a frequently used drug in the treatment of rheumatoid arthritis (RA), but occurrences of lymphoproliferative disorders (LPD)... Abstract Background Methotrexate (MTX) is a frequently used drug in the treatment of rheumatoid arthritis (RA), but occurrences of lymphoproliferative... |
| SourceID | doaj unpaywall pubmedcentral proquest gale pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 4 |
| SubjectTerms | Abdomen Aged, 80 and over Antigens Arthritis Cancer therapies Care and treatment Case Report Case studies Chemotherapy Complications and side effects Computed tomography Disorders DNA methylation Drug dosages Effusion Enteritis Epstein-Barr virus Epstein-Barr Virus Infections Female Gastrointestinal tract Health services Herpesvirus 4, Human Hospitals Humans Immunoproliferative diseases Injuries Interleukin 2 Intestinal perforation Intestinal Perforation - surgery Intestine Intestines Jejunum Jejunum - surgery Latent membrane protein 1 Lesions Lymphocytes Lymphoma Lymphoproliferative disorder Lymphoproliferative Disorders Medical prognosis Medicine Medicine & Public Health Melanoma Membrane proteins Metastasis Methotrexate Methotrexate - adverse effects Monoclonal antibodies Neoplasm Recurrence, Local Pain Patients Perforation Prognosis Proteins Remission Rheumatoid arthritis Small intestine Surgery Surgical Oncology Tumors Ulcers |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQDzwOiDeBAkZC4kCjZmM7driViqpCKicq9WY5sQ1U22TV3RXs7-QPMWM7YQNS4cBhD7szzsbOeB7xzDeEvFKVNfjJJXjzOa-syGtb2HxWgm0xRnAfTvBPPlbHp_zDmTjbavWFOWERHjgu3L7B6knmvZFGcl851fha1b5hLbcN-AeofcGMDcFUCrUYE2wokVHV_hKsmpA5hkpg02Y8LyZmKKD1_6mTt4zS7wmT46npLXJj3S3M5puZz7cM09Edcjt5lPQgzuQuuea6e-T6STozv09-HGKXE1x_2nsaOkavLt138DGp6Sw1dHkBV6WIGwHbHS-FFUmh3IGmOj1g-tz3lg5llLTtMfeDgsMLpATNSvGVLnw9d-frbn1BFyFxPv4xBP4gQpY2G2DYvoXcJPEA4nwDktUvsI2QdxGQnNoEDvoWxrVgcGk843hATo_efzo8zlMrh7yFDb7KS9t44wyEa8oxI5iEyLhQUhk7462sC-5ca8G3U0bJ2oGJhAGidOCO1l40xrOHZKfrO_eYUNYwJkuIVCteh_aXCDhTOMWt9wiNk5HZ8GR1m3DOsd3GXId4R1U6SoMGadBBGnSRkTfjmEVE-biS-x0KzMiJCN3hB5BbneRW_01uM_ICxU3HctdRz-gDcJkFuKFVnZHXgQM1DUygNalgApYBMbsmnLsTTtAQ7ZQ8iLROGmqpS-ybAO6yLDPyciTjSMy661y_Djzov7NaZeRR3AHjpBlDGCEBFDnZG5NVmVK6r18CfrmUYCUUjNwbdtGv27pq1ffGnfYPD-nJ_3hIT8nNEnOY8JVbuUt2Vpdr9wyc0FXzPOibn62ehMQ priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELagSDwOiDeBAkZC4kCtJnESO1xQqagqpHKi0t4sJ7YL1TZZ9iHY38kfYsZxshuQVhz2sOtx1nbmaXu-IeSNLIzGDxPgzbOsMDkrTWxYkoJt0TrPnD_BP_tSnJ5nnyf5JGy4LcK1yl4nekVt2hr3yA9TxHkH8y7SD7MfDKtG4elqKKFxndxIwFVBrhaTTcDFec77RBlZHC7AtuWCYcAEli3JWDwyRh6z_1_NvGWa_r42OZyd3iG3Vs1Mr3_q6XTLPJ3cI3eDX0mPOka4T67Z5gG5eRZOzh-S38dY6wTfAm0d9XWjl3P7CzxNqhtDNV1cwVMpokeA0OOjMC_JJz3QkK0HRBdta2ifTEnrFm-AUHB7oSkAtFLc2IWvl_Zy1ayu6Mxfn-_-GMJ_YCRDqzUQbA-B6cAk0DhdA3-1Mywm5GwHS05NgAh9D_1qMLu0O-l4RM5PPn09PmWhoAOrQcyXLDWV01ZD0CYt1zkXEB_HUkhtkqwWZZxZWxvw8KSWorRgKKFDnlpwSkuXV9rxx2SvaRv7lFBecS5SiFeLrPRFMBF2JrYyM84hQE5Ekv7NqjqgnWPRjanyUY8sVMcNCrhBeW5QcUTeDX1mHdbHTuqPyDADJeJ0-x_a-YUKYq805v5y57TQInOFlZWDsbqK15mpwLuNyCtkN9UlvQ7aRh2B45yDM1qUEXnrKVDfwARqHdImYBkQuWtEuT-iBD1Rj5t7llZBTy3URqoi8npoxp54966x7crToBfPSxmRJ50EDJPmHMGEcmgRI9kYrcq4pfn-zaOYCwG2QkLPg16KNsPateoHg6T9x0t6tnvSz8ntFO8o4ZZauk_2lvOVfQFO5rJ66TXJH8X3e10 priority: 102 providerName: ProQuest – databaseName: Springer Nature OA Free Journals dbid: C6C link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1bb9MwFLbQkLg8IO4EBhgJiQcW0cZJ7PA2KqYJaTwxaW-WE9vA1CXV2gr2O_lDfMdxQwNogoc-tD52HftcY5_vMPZSldbQJ5Xw5tO8tEVa2YlNpxlsizFF7sMJ_tHH8vA4_3BSnESYHMqF2T6_n6ryzRL2qJApBTmwRtM8RXh-tYDipet7s3I2BFdCFGKTFPPXfiPDE_D5_9TCW2bo9yuSwznpTXZ93S7MxTczn2-ZooPb7Fb0Ifl-v-l32BXX3mXXjuIp-T32Y0Z1TWjFeed5qBG9Onff4VVy01pu-PIMo3JCioCA01CUgxQSHHjMzAPR566zfJM4yZuObntwuLhoimCsnF7i4uupO1236zO-CFfl-z9GqA-msby-AMH2FFITGQKN8wvwUregwkHe9RDk3EY40Lfo18DE8v5U4z47Pnj_aXaYxuINaQORXqWZrb1xBgGacsIUQiIWniipjJ3mjawmuXONhTenjJKVg1FEhyJzcEArX9TGiwdsp-1a94hxUQshM8SmZV6FgpcEMTNxKrfeExhOwqabndVNRDanAhtzHSIcVeqeGzS4QQdu0JOEvR76LHpcj0up3xHDDJSEyR1-AKvqKOLaUJ6v8N5II3NfOlV7zNXXosltDU82Yc-J3XSf4DpoFr0PJ7mA41lWCXsVKEi34AEaE1MksAyE0jWi3B1RQic04-YNS-uok5Y6o0oJcJBllrAXQzP1pHt2revWgYY8dlGphD3sJWB4aCEIOKhAixzJxmhVxi3t1y8BsVxK2AWFnnsbKfo1rctWfW-QtH_YpMf_N_oTdiOj-0n0Oi3bZTur87V7CgdzVT8LmuUnvXl0DQ priority: 102 providerName: Springer Nature |
| Title | Cessation of methotrexate and a small intestinal resection provide a good clinical course for a patient with a jejunum perforation induced by a methotrexate-associated lymphoproliferative disorder: a case report |
| URI | https://link.springer.com/article/10.1186/s12957-020-02114-0 https://www.ncbi.nlm.nih.gov/pubmed/33388058 https://www.proquest.com/docview/2478855172 https://www.proquest.com/docview/2475088398 https://pubmed.ncbi.nlm.nih.gov/PMC7778788 https://wjso.biomedcentral.com/track/pdf/10.1186/s12957-020-02114-0 https://doaj.org/article/a04623ffa7a74f6e8bf989fb3c4db095 |
| UnpaywallVersion | publishedVersion |
| Volume | 19 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVADU databaseName: BioMedCentral customDbUrl: eissn: 1477-7819 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0023353 issn: 1477-7819 databaseCode: RBZ dateStart: 20030101 isFulltext: true titleUrlDefault: https://www.biomedcentral.com/search/ providerName: BioMedCentral – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1477-7819 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0023353 issn: 1477-7819 databaseCode: KQ8 dateStart: 20030101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1477-7819 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0023353 issn: 1477-7819 databaseCode: KQ8 dateStart: 20030201 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1477-7819 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0023353 issn: 1477-7819 databaseCode: DOA dateStart: 20030101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVEBS databaseName: Academic Search Ultimate - eBooks customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn eissn: 1477-7819 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0023353 issn: 1477-7819 databaseCode: ABDBF dateStart: 20090101 isFulltext: true titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn providerName: EBSCOhost – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1477-7819 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0023353 issn: 1477-7819 databaseCode: DIK dateStart: 20030101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 1477-7819 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0023353 issn: 1477-7819 databaseCode: GX1 dateStart: 0 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1477-7819 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0023353 issn: 1477-7819 databaseCode: M~E dateStart: 20030101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 1477-7819 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0023353 issn: 1477-7819 databaseCode: RPM dateStart: 20030101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1477-7819 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0023353 issn: 1477-7819 databaseCode: 7X7 dateStart: 20090101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: http://www.proquest.com/pqcentral?accountid=15518 eissn: 1477-7819 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0023353 issn: 1477-7819 databaseCode: BENPR dateStart: 20090101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVFZP databaseName: Scholars Portal: Open Access Journals [open access] customDbUrl: eissn: 1477-7819 dateEnd: 20250131 omitProxy: true ssIdentifier: ssj0023353 issn: 1477-7819 databaseCode: M48 dateStart: 20030701 isFulltext: true titleUrlDefault: http://journals.scholarsportal.info providerName: Scholars Portal – providerCode: PRVAVX databaseName: Springer Nature HAS Fully OA customDbUrl: eissn: 1477-7819 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0023353 issn: 1477-7819 databaseCode: AAJSJ dateStart: 20031201 isFulltext: true titleUrlDefault: https://www.springernature.com providerName: Springer Nature – providerCode: PRVAVX databaseName: Springer Nature OA Free Journals customDbUrl: eissn: 1477-7819 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0023353 issn: 1477-7819 databaseCode: C6C dateStart: 20031201 isFulltext: true titleUrlDefault: http://www.springeropen.com/ providerName: Springer Nature |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1bb9MwFLbGJnF5QNwpjGIkJB5YoI2d2EFCaK02TUid0ESliRfLie2xqUtKL2L9nfwhznEuNDBVPLRS6uPUsc819vkOIa9lbDR-AgHefMBjEwWJ6ZmgH4Jt0Trizu_gj47jozH_fBqdbpG63FE1gfNrQzusJzWeTd5d_Vh9AoH_6AVexu_nYLMiEWAgBBarzwMI4XfAMoXI5SPe7CqEjHlUyj4XIhBgCuskmmvv0TJUHs__X629Zrb-PlLZ7KveIbeW-VSvfurJZM10Hd4jdyufk-6XTHKfbNn8Abk5qnbVH5JfQ6yDgitEC0d9TenFzF6BF0p1bqim80u4K0VkCVAIeCvMWfIJEbTK5AOis6IwtE60pFmBp0MouMTQVIG3UnzpC5cX9mKZLy_p1B-tL__4PDfAZIamKyBYH0KgKwaCxskKeK-YYqEhZ0vIcmoq-NAP0C8Dk0zLXZBHZHx48HV4FFTFHoIMVMAiCE3qtNUQ0EnLdMQExM49KaQ2fZ6JpMetzQx4f1JLkVgwotAhCi04rImLUu3YY7KdF7l9SihLGRMhxLIxT3yBTISk6VnJjXMIntMh_XplVVYhoWNBjonyEZGMVckNCrhBeW5QvQ552_SZljggG6kHyDANJWJ4-x-K2ZmqVILSmBfMnNNCC-5iK1MHY3Upy7hJwfPtkJfIbqpMiG00kdoHpzoCRzVOOuSNp0DpgAfIdJVSAdOAqF4tyt0WJeiQrN1cs7SqRVCFWFkBHGoRdsirphl74rm83BZLT4MePktkhzwpJaB5aMYQaCiCFtGSjdastFvy8-8e4VwIsCMSeu7VUvRnWJtmfa-RtP9YpGeb5-Q5uR3i-SV83Rbuku3FbGlfgAO6SLvkhjgVXbIzODj-cgJXw3jY9S9zul7fwPfJ4NtvUiiFdQ |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LbxMxELZKkSgcEG8ChRoJxIGuull717tICJVCldKmp1bKzXjXdmmV7oY8VPKn-DP8IWa8j2RBirj0kEPisePHeB625xtCXseRVvjxBFjzHo906CXa1143AN2iVMitu8HvH0e9U_51EA7WyK86FgafVdYy0QlqXWR4Rr4TIM47qHcRfBz98DBrFN6u1ik0SrY4NPMrcNkmHw4-w_q-CYL9Lyd7Pa_KKuBlwGtTL9CpVUaB5xAbpkImwEnzYxEr3eWZSHxuTKbBzIhVLBID0hoqhIEByyixYaosg3ZvkJuc-Ryx-sVg4eAxFrI6MCeOdiagS0PhoYMGmrTLPb-l_FyOgH81wZIq_PuZZnNXe4dszPKRml-p4XBJHe7fI3crO5bulox3n6yZ_AG51a9u6h-S33uYWwVXnRaWujzV07H5CZYtVbmmik4uoVWKaBUgZLApjINyQRa0ig4EorOi0LQO3qRZgS9OKJjZUFQBwlI8SIavF-Zils8u6cg91y__-DzXwLiapnMgWO6CpyqmhMLhHPi5GGHyImtKGHSqK0jS91AvAzVPy5uVR-T0Wpb6MVnPi9w8JZSljIkA_OOIJy7pJsLc-Cbm2loE5OmQbr2yMqvQ1THJx1A6LyuOZMkNErhBOm6Qfoe8a-qMSmyRldSfkGEaSsQFdz8U4zNZiRmpMNaYWauEEtxGJk4t9NWmLOM6BWu6Q7aQ3WQZZNtIN7kLhnoIxm-UdMhbR4HyDQaQqSpMA6YBkcJalJstSpBLWbu4ZmlZycWJXOziDnnVFGNNfOuXm2LmaNBrYEncIU_KHdAMmjEELwqhRLT2RmtW2iX5-XeHmi4E6KYYam7Xu2jRrVWzvt3stP9YpGerB71FNnon_SN5dHB8-JzcDvB9FB7nBZtkfTqemRdg4E7Tl06qUPLtusXYHw-IuCE |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwELfQJg14QHwTGMxISDywaG0cxw5vZTCNwiYkmLQ3y4ntsalLqn4I-nfyD3HnOKEBNMFDH9o7u45957uLfb8j5IXMjMZPLMCbj9PM8Dg3AxMPE7AtWvPU-RP8o-Ps8CQdn_LTtSx-f9u9PZJschoQpala7E2Na1RcZntzsFJcxBj6gI0apjEE7ZuS5xmEX5uj0fjzuAu6GOOsTZb5a8ueQfK4_X_uzmvm6ferk9356U1yfVlN9eqbnkzWTNTBbXIr-JZ01AjDHXLNVnfJ1lE4Pb9HfuxjvRNcCVo76mtHL2b2O3ibVFeGajq_hF4pIkiA4mNXmJvkEx9oyNgDprO6NrRNqKRljbdAKLi-QAogrRRf7sLXC3uxrJaXdOqv0Dd_fF4ZECZDixUwrA8h1kFQgDhZgYzVUywo5GwDTU5NgAl9De1KML20Oe24T04O3n3ZP4xDUYe4BFVfxIkpnLYaAjdpmeZMQIw8kEJqM0xLkQ9Sa0sDXp7UUuQWjCU04IkFxzR3vNCOPSAbVV3ZR4SygjGRQMyapbkvhInQMwMrU-McguREZNiurCoD4jkW3pgoH_nITDXSoEAalJcGNYjIq67NtMH7uJL7DQpMx4lY3f6Henamguorjfm_zDkttEhdZmXhYKyuYGVqCvBwI7KD4qaaxNdux1EjcJ45OKRZHpGXngP3HHiAUofUCZgGRO_qcW73OGGvKPvkVqRV2KvmKsEKCuA4iyQizzsytsT7d5Wtl54HPXmWy4g8bDSge2jGEFCIA0X0dKM3K31Kdf7VI5kLAfZCQsvdVot-DeuqWd_tNO0fFunx__W-Q7Y-vT1QH98ff3hCbiR4hQnfuCXbZGMxW9qn4IMuimdhm_kJ4LyAuA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cessation+of+methotrexate+and+a+small+intestinal+resection+provide+a+good+clinical+course+for+a+patient+with+a+jejunum+perforation+induced+by+a+methotrexate-associated+lymphoproliferative+disorder%3A+a+case+report&rft.jtitle=World+journal+of+surgical+oncology&rft.au=Nomura%2C+Masahiro&rft.au=Sumiya%2C+Ryusuke&rft.au=Ono%2C+Hayato&rft.au=Nagai%2C+Takeshi&rft.date=2021-01-02&rft.pub=BioMed+Central+Ltd&rft.issn=1477-7819&rft.eissn=1477-7819&rft.volume=19&rft.issue=1&rft_id=info:doi/10.1186%2Fs12957-020-02114-0&rft.externalDocID=A650556069 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1477-7819&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1477-7819&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1477-7819&client=summon |