Functional neuroimaging in subjective cognitive decline: current status and a research path forward

Subjective cognitive decline is a putative precursor to dementia marked by perceived worsening of cognitive function without overt performance issues on neuropsychological assessment. Although healthy older adults with subjective cognitive decline may function normally, perceived worsening may indic...

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Published inAlzheimer's research & therapy Vol. 12; no. 1; pp. 23 - 18
Main Authors Viviano, Raymond P., Damoiseaux, Jessica S.
Format Journal Article
LanguageEnglish
Published London BioMed Central 09.03.2020
BioMed Central Ltd
BMC
Subjects
Aging
Alzheimer's disease
Biomedical and Life Sciences
Biomedicine
Brain - diagnostic imaging
Brain - physiopathology
Brain research
Cognitive ability
Cognitive Dysfunction - diagnostic imaging
Cognitive Dysfunction - physiopathology
Connectivity
Dementia
Diseases
Displays (Marketing)
Elderly
Etiology (Medicine)
Executive function
Functional neuroimaging
Functional Neuroimaging - methods
Geriatric cognitive disorders
Geriatric Psychiatry
Geriatrics/Gerontology
Humans
Medical imaging
Medical research
Memory
Nervous system diseases
Neurodegeneration
Neurodegenerative diseases
Neuroimaging
Neurology
Neurophysiology
Neurosciences
Older people
Perceptions
Physiological aspects
Review
Signal processing
Subject Cognitive Decline
Subjective cognitive decline
United States
Functional neuroimaging
Connectivity
Subjective cognitive decline
Online AccessGet full text
ISSN1758-9193
1758-9193
DOI10.1186/s13195-020-00591-9

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Abstract Subjective cognitive decline is a putative precursor to dementia marked by perceived worsening of cognitive function without overt performance issues on neuropsychological assessment. Although healthy older adults with subjective cognitive decline may function normally, perceived worsening may indicate incipient dementia and predict future deterioration. Therefore, the experience of decline represents a possible entry point for clinical intervention. However, intervention requires a physical manifestation of neuroabnormality to both corroborate incipient dementia and to target clinically. While some individuals with subjective cognitive decline may harbor pathophysiology for specific neurodegenerative disorders, many do not display clear indicators. Thus, disorder-agnostic brain measures could be useful to track the trajectory of decline, and functional neuroimaging in particular may be sensitive to detect incipient dementia and have the ability to track disease-related change when the underlying disease etiology remains unclear. Therefore, in this review, we discuss functional neuroimaging studies of subjective cognitive decline and possible reconciliations to inconsistent findings. We conclude by proposing a functional model where noisy signal propagation and inefficient signal processing across whole-brain networks may lead to the subjective experience of decline and discuss future research directions guided by this model.
AbstractList Subjective cognitive decline is a putative precursor to dementia marked by perceived worsening of cognitive function without overt performance issues on neuropsychological assessment. Although healthy older adults with subjective cognitive decline may function normally, perceived worsening may indicate incipient dementia and predict future deterioration. Therefore, the experience of decline represents a possible entry point for clinical intervention. However, intervention requires a physical manifestation of neuroabnormality to both corroborate incipient dementia and to target clinically. While some individuals with subjective cognitive decline may harbor pathophysiology for specific neurodegenerative disorders, many do not display clear indicators. Thus, disorder-agnostic brain measures could be useful to track the trajectory of decline, and functional neuroimaging in particular may be sensitive to detect incipient dementia and have the ability to track disease-related change when the underlying disease etiology remains unclear. Therefore, in this review, we discuss functional neuroimaging studies of subjective cognitive decline and possible reconciliations to inconsistent findings. We conclude by proposing a functional model where noisy signal propagation and inefficient signal processing across whole-brain networks may lead to the subjective experience of decline and discuss future research directions guided by this model.
Abstract Subjective cognitive decline is a putative precursor to dementia marked by perceived worsening of cognitive function without overt performance issues on neuropsychological assessment. Although healthy older adults with subjective cognitive decline may function normally, perceived worsening may indicate incipient dementia and predict future deterioration. Therefore, the experience of decline represents a possible entry point for clinical intervention. However, intervention requires a physical manifestation of neuroabnormality to both corroborate incipient dementia and to target clinically. While some individuals with subjective cognitive decline may harbor pathophysiology for specific neurodegenerative disorders, many do not display clear indicators. Thus, disorder-agnostic brain measures could be useful to track the trajectory of decline, and functional neuroimaging in particular may be sensitive to detect incipient dementia and have the ability to track disease-related change when the underlying disease etiology remains unclear. Therefore, in this review, we discuss functional neuroimaging studies of subjective cognitive decline and possible reconciliations to inconsistent findings. We conclude by proposing a functional model where noisy signal propagation and inefficient signal processing across whole-brain networks may lead to the subjective experience of decline and discuss future research directions guided by this model.
Subjective cognitive decline is a putative precursor to dementia marked by perceived worsening of cognitive function without overt performance issues on neuropsychological assessment. Although healthy older adults with subjective cognitive decline may function normally, perceived worsening may indicate incipient dementia and predict future deterioration. Therefore, the experience of decline represents a possible entry point for clinical intervention. However, intervention requires a physical manifestation of neuroabnormality to both corroborate incipient dementia and to target clinically. While some individuals with subjective cognitive decline may harbor pathophysiology for specific neurodegenerative disorders, many do not display clear indicators. Thus, disorder-agnostic brain measures could be useful to track the trajectory of decline, and functional neuroimaging in particular may be sensitive to detect incipient dementia and have the ability to track disease-related change when the underlying disease etiology remains unclear. Therefore, in this review, we discuss functional neuroimaging studies of subjective cognitive decline and possible reconciliations to inconsistent findings. We conclude by proposing a functional model where noisy signal propagation and inefficient signal processing across whole-brain networks may lead to the subjective experience of decline and discuss future research directions guided by this model.Subjective cognitive decline is a putative precursor to dementia marked by perceived worsening of cognitive function without overt performance issues on neuropsychological assessment. Although healthy older adults with subjective cognitive decline may function normally, perceived worsening may indicate incipient dementia and predict future deterioration. Therefore, the experience of decline represents a possible entry point for clinical intervention. However, intervention requires a physical manifestation of neuroabnormality to both corroborate incipient dementia and to target clinically. While some individuals with subjective cognitive decline may harbor pathophysiology for specific neurodegenerative disorders, many do not display clear indicators. Thus, disorder-agnostic brain measures could be useful to track the trajectory of decline, and functional neuroimaging in particular may be sensitive to detect incipient dementia and have the ability to track disease-related change when the underlying disease etiology remains unclear. Therefore, in this review, we discuss functional neuroimaging studies of subjective cognitive decline and possible reconciliations to inconsistent findings. We conclude by proposing a functional model where noisy signal propagation and inefficient signal processing across whole-brain networks may lead to the subjective experience of decline and discuss future research directions guided by this model.
Subjective cognitive decline is a putative precursor to dementia marked by perceived worsening of cognitive function without overt performance issues on neuropsychological assessment. Although healthy older adults with subjective cognitive decline may function normally, perceived worsening may indicate incipient dementia and predict future deterioration. Therefore, the experience of decline represents a possible entry point for clinical intervention. However, intervention requires a physical manifestation of neuroabnormality to both corroborate incipient dementia and to target clinically. While some individuals with subjective cognitive decline may harbor pathophysiology for specific neurodegenerative disorders, many do not display clear indicators. Thus, disorder-agnostic brain measures could be useful to track the trajectory of decline, and functional neuroimaging in particular may be sensitive to detect incipient dementia and have the ability to track disease-related change when the underlying disease etiology remains unclear. Therefore, in this review, we discuss functional neuroimaging studies of subjective cognitive decline and possible reconciliations to inconsistent findings. We conclude by proposing a functional model where noisy signal propagation and inefficient signal processing across whole-brain networks may lead to the subjective experience of decline and discuss future research directions guided by this model. Keywords: Subjective cognitive decline, Functional neuroimaging, Connectivity
ArticleNumber 23
Audience Academic
Author Viviano, Raymond P.
Damoiseaux, Jessica S.
Author_xml – sequence: 1
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  surname: Viviano
  fullname: Viviano, Raymond P.
  organization: Department of Psychology, Wayne State University, Institute of Gerontology, Wayne State University
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  surname: Damoiseaux
  fullname: Damoiseaux, Jessica S.
  email: damoiseaux@wayne.edu
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Issue 1
Keywords Functional neuroimaging
Connectivity
Subjective cognitive decline
Language English
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Snippet Subjective cognitive decline is a putative precursor to dementia marked by perceived worsening of cognitive function without overt performance issues on...
Abstract Subjective cognitive decline is a putative precursor to dementia marked by perceived worsening of cognitive function without overt performance issues...
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SubjectTerms Aging
Alzheimer's disease
Biomedical and Life Sciences
Biomedicine
Brain - diagnostic imaging
Brain - physiopathology
Brain research
Cognitive ability
Cognitive Dysfunction - diagnostic imaging
Cognitive Dysfunction - physiopathology
Connectivity
Dementia
Diseases
Displays (Marketing)
Elderly
Etiology (Medicine)
Executive function
Functional neuroimaging
Functional Neuroimaging - methods
Geriatric cognitive disorders
Geriatric Psychiatry
Geriatrics/Gerontology
Humans
Medical imaging
Medical research
Memory
Nervous system diseases
Neurodegeneration
Neurodegenerative diseases
Neuroimaging
Neurology
Neurophysiology
Neurosciences
Older people
Perceptions
Physiological aspects
Review
Signal processing
Subject Cognitive Decline
Subjective cognitive decline
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Title Functional neuroimaging in subjective cognitive decline: current status and a research path forward
URI https://link.springer.com/article/10.1186/s13195-020-00591-9
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Volume 12
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