Immunoselective Cell Growth Inhibition by Antibody-Adriamycin Conjugates Targeting c-erbB-2 Product on Human Cancer Cells
Monoclonal antibodies targeting c-erbB-2 protooncogene product p185 were conjugated with adriamycin via a pH-sensitive spacer. The resultant antibody-adriamycin conjugates showed immunoselective binding, internalization and cytotoxicity to p185-positive human breast cancer cell SKBr-3 and gastric ca...
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| Published in | Biological & pharmaceutical bulletin Vol. 18; no. 9; pp. 1279 - 1282 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Tokyo
The Pharmaceutical Society of Japan
1995
Maruzen Japan Science and Technology Agency |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0918-6158 1347-5215 |
| DOI | 10.1248/bpb.18.1279 |
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| Abstract | Monoclonal antibodies targeting c-erbB-2 protooncogene product p185 were conjugated with adriamycin via a pH-sensitive spacer. The resultant antibody-adriamycin conjugates showed immunoselective binding, internalization and cytotoxicity to p185-positive human breast cancer cell SKBr-3 and gastric cancer cell MKN-7, but not to normal human lymphocytes. |
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| AbstractList | Monoclonal antibodies targeting c-erbB-2 protooncogene product p185 were conjugated with adriamycin via a pH-sensitive spacer. The resultant antibody-adriamycin conjugates showed immunoselective binding, internalization and cytotoxicity to p185-positive human breast cancer cell SKBr-3 and gastric cancer cell MKN-7, but not to normal human lymphocytes.Monoclonal antibodies targeting c-erbB-2 protooncogene product p185 were conjugated with adriamycin via a pH-sensitive spacer. The resultant antibody-adriamycin conjugates showed immunoselective binding, internalization and cytotoxicity to p185-positive human breast cancer cell SKBr-3 and gastric cancer cell MKN-7, but not to normal human lymphocytes. Monoclonal antibodies targeting c-erbB-2 protooncogene product p185 were conjugated with adriamycin via a pH-sensitive spacer. The resultant antibody-adriamycin conjugates showed immunoselective binding, internalization and cytotoxicity to p185-positive human breast cancer cell SKBr-3 and gastric cancer cell MKN-7, but not to normal human lymphocytes. |
| Author | SUZUKI, Shinya TANAKA, Megumi HASHIMOTO, Yoshiyuki MASUKO, Takashi |
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| Copyright | The Pharmaceutical Society of Japan 1996 INIST-CNRS Copyright Japan Science and Technology Agency 1995 |
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| Keywords | Antineoplastic agent Human Cytotoxicity Monoclonal antibody Immunoconjugate In vitro Target Cell line C-Onc gene Internalization Anthracyclins Chemical uptake Tumor cell Protooncogene |
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| References | 5) Shen W.C., Ryser H.J.P., Biochim. Biophys. Acta, 102, 1048-1054 (1981). 3) Masuko T., Sugahara K., Kozono M., Otsuki T., Akiyama T., Yamamoto T., Toyoshima K., Hashimoto Y., Jpn. J. Cancer Res., 80, 10-14 (1989). 2) Di Fiorre P.P., Segatto O., Aaronson S.A., Methods Enzymol., 198, 272-277 (1991). 4) Hashimoto Y., Masuko T., Yagita H., Endoh N., Kanazawa J., Tazawa J., Jpn. J. Cancer Res., 74, 818-821 (1983). 1) Speth P.A., Van Hoesel Q.G., Haanen C., Clin. Pharmacokinet, 15, 15-31 (1988). |
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| SubjectTerms | adriamycin Antibiotics, Antineoplastic - pharmacology Antineoplastic agents Biological and medical sciences Cell Division - drug effects Chemotherapy Doxorubicin - pharmacology Humans Immunotoxins - pharmacokinetics Immunotoxins - pharmacology internalization Medical sciences monoclonal antibody Neoplasms - pathology Neoplasms - therapy Pharmacology. Drug treatments Receptor, ErbB-2 - analysis Receptor, ErbB-2 - immunology Tumor Cells, Cultured |
| Title | Immunoselective Cell Growth Inhibition by Antibody-Adriamycin Conjugates Targeting c-erbB-2 Product on Human Cancer Cells |
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