Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states

Lateral hypothalamus (LH) neurons containing the neuropeptide hypocretin (HCRT; orexin) modulate affective components of arousal, but their relevant synaptic inputs remain poorly defined. Here we identified inputs onto LH neurons that originate from neuronal populations in the bed nuclei of stria te...

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Published inNature neuroscience Vol. 21; no. 8; pp. 1084 - 1095
Main Authors Giardino, William J., Eban-Rothschild, Ada, Christoffel, Daniel J., Li, Shi-Bin, Malenka, Robert C., de Lecea, Luis
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.08.2018
Nature Publishing Group
Subjects
13/1
14/19
631/378/1457/1284
631/378/3920
64/60
82/51
9/74
96/35
96/44
96/63
Amygdala
Amygdala (Brain)
Animal Genetics and Genomics
Animals
Arousal
Behavioral Sciences
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Brain research
Cholecystokinin
Cholecystokinin - physiology
Circuits
Conditioning, Operant - physiology
Corticotropin
Corticotropin-releasing hormone
Displays (Marketing)
Emotion regulation
Emotional behavior
Emotions - physiology
GABA
gamma-Aminobutyric Acid - physiology
Hypothalamic Area, Lateral - cytology
Hypothalamic Area, Lateral - physiology
Hypothalamus
Hypothalamus (lateral)
Luteinizing hormone
Male
Mice
Mice, Inbred C57BL
Nerve Net - cytology
Nerve Net - physiology
Neural circuitry
Neural networks
Neural Pathways - cytology
Neural Pathways - physiology
Neurobiology
Neurons
Neurons - physiology
Neuropeptides
Neuropeptides - metabolism
Neuropsychology
Neurosciences
Nuclei
Orexins
Orexins - metabolism
Orexins - physiology
Photic Stimulation
Physiological aspects
Physiological responses
Rodents
Self Stimulation
Septal Nuclei - cytology
Septal Nuclei - physiology
Stria terminalis
Subpopulations
γ-Aminobutyric acid
Online AccessGet full text
ISSN1097-6256
1546-1726
1546-1726
DOI10.1038/s41593-018-0198-x

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Abstract Lateral hypothalamus (LH) neurons containing the neuropeptide hypocretin (HCRT; orexin) modulate affective components of arousal, but their relevant synaptic inputs remain poorly defined. Here we identified inputs onto LH neurons that originate from neuronal populations in the bed nuclei of stria terminalis (BNST; a heterogeneous region of extended amygdala). We characterized two non-overlapping LH-projecting GABAergic BNST subpopulations that express distinct neuropeptides (corticotropin-releasing factor, CRF, and cholecystokinin, CCK). To functionally interrogate BNST→LH circuitry, we used tools for monitoring and manipulating neural activity with cell-type-specific resolution in freely behaving mice. We found that Crf -BNST and Cck -BNST neurons respectively provide abundant and sparse inputs onto Hcrt -LH neurons, display discrete physiological responses to salient stimuli, drive opposite emotionally valenced behaviors, and receive different proportions of inputs from upstream networks. Together, our data provide an advanced model for how parallel BNST→LH pathways promote divergent emotional states via connectivity patterns of genetically defined, circuit-specific neuronal subpopulations. Using genetically encoded physiological tools for monitoring, manipulating, and mapping discrete neural circuits, Giardino et al. characterize 2 discrete amygdala→hypothalamus pathways that promote opposite behavioral responses to emotional stimuli.
AbstractList Lateral hypothalamus (LH) neurons containing the neuropeptide hypocretin (HCRT; orexin) modulate affective components of arousal, but their relevant synaptic inputs remain poorly defined. Here we identified inputs onto LH neurons that originate from neuronal populations in the bed nuclei of stria terminalis (BNST; a heterogeneous region of extended amygdala). We characterized two non-overlapping LH-projecting GABAergic BNST subpopulations that express distinct neuropeptides (corticotropin-releasing factor, CRF, and cholecystokinin, CCK). To functionally interrogate BNST→LH circuitry, we used tools for monitoring and manipulating neural activity with cell-type-specific resolution in freely behaving mice. We found that Crf-BNST and Cck-BNST neurons respectively provide abundant and sparse inputs onto Hcrt-LH neurons, display discrete physiological responses to salient stimuli, drive opposite emotionally valenced behaviors, and receive different proportions of inputs from upstream networks. Together, our data provide an advanced model for how parallel BNST→LH pathways promote divergent emotional states via connectivity patterns of genetically defined, circuit-specific neuronal subpopulations.Lateral hypothalamus (LH) neurons containing the neuropeptide hypocretin (HCRT; orexin) modulate affective components of arousal, but their relevant synaptic inputs remain poorly defined. Here we identified inputs onto LH neurons that originate from neuronal populations in the bed nuclei of stria terminalis (BNST; a heterogeneous region of extended amygdala). We characterized two non-overlapping LH-projecting GABAergic BNST subpopulations that express distinct neuropeptides (corticotropin-releasing factor, CRF, and cholecystokinin, CCK). To functionally interrogate BNST→LH circuitry, we used tools for monitoring and manipulating neural activity with cell-type-specific resolution in freely behaving mice. We found that Crf-BNST and Cck-BNST neurons respectively provide abundant and sparse inputs onto Hcrt-LH neurons, display discrete physiological responses to salient stimuli, drive opposite emotionally valenced behaviors, and receive different proportions of inputs from upstream networks. Together, our data provide an advanced model for how parallel BNST→LH pathways promote divergent emotional states via connectivity patterns of genetically defined, circuit-specific neuronal subpopulations.
Lateral hypothalamus (LH) neurons containing the neuropeptide hypocretin (Hcrt; orexin) modulate affective components of arousal, but their relevant synaptic inputs remain poorly defined. Here, we identified inputs onto LH neurons that originate from neuronal populations in the bed nuclei of stria terminalis (BNST; a heterogeneous region of extended amygdala). We characterized two non-overlapping LH-projecting GABAergic BNST subpopulations that express distinct neuropeptides (corticotropin-releasing factor; Crf, and cholecystokinin; Cck). To functionally interrogate BNST→LH circuitry, we used tools for monitoring and manipulating neural activity with cell-type-specific resolution in freely-behaving mice. We found that Crf-BNST and Cck-BNST neurons respectively provide abundant and sparse inputs onto Hcrt-LH neurons, display discrete physiological responses to salient stimuli, drive opposite emotionally valenced behaviors, and receive different proportions of inputs from upstream networks. Together, our data provide an advanced model for how parallel BNST->`LH pathways promote divergent emotional states via connectivity patterns of genetically defined, circuit-specific neuronal subpopulations.
Lateral hypothalamus (LH) neurons containing the neuropeptide hypocretin (HCRT; orexin) modulate affective components of arousal, but their relevant synaptic inputs remain poorly defined. Here we identified inputs onto LH neurons that originate from neuronal populations in the bed nuclei of stria terminalis (BNST; a heterogeneous region of extended amygdala). We characterized two non-overlapping LH-projecting GABAergic BNST subpopulations that express distinct neuropeptides (corticotropin-releasing factor, CRF, and cholecystokinin, CCK). To functionally interrogate BNST[right arrow]LH circuitry, we used tools for monitoring and manipulating neural activity with cell-type-specific resolution in freely behaving mice. We found that Crf-BNST and Cck-BNST neurons respectively provide abundant and sparse inputs onto Hcrt-LH neurons, display discrete physiological responses to salient stimuli, drive opposite emotionally valenced behaviors, and receive different proportions of inputs from upstream networks. Together, our data provide an advanced model for how parallel BNST[right arrow]LH pathways promote divergent emotional states via connectivity patterns of genetically defined, circuit-specific neuronal subpopulations.
Lateral hypothalamus (LH) neurons containing the neuropeptide hypocretin (HCRT; orexin) modulate affective components of arousal, but their relevant synaptic inputs remain poorly defined. Here we identified inputs onto LH neurons that originate from neuronal populations in the bed nuclei of stria terminalis (BNST; a heterogeneous region of extended amygdala). We characterized two non-overlapping LH-projecting GABAergic BNST subpopulations that express distinct neuropeptides (corticotropin-releasing factor, CRF, and cholecystokinin, CCK). To functionally interrogate BNST[right arrow]LH circuitry, we used tools for monitoring and manipulating neural activity with cell-type-specific resolution in freely behaving mice. We found that Crf-BNST and Cck-BNST neurons respectively provide abundant and sparse inputs onto Hcrt-LH neurons, display discrete physiological responses to salient stimuli, drive opposite emotionally valenced behaviors, and receive different proportions of inputs from upstream networks. Together, our data provide an advanced model for how parallel BNST[right arrow]LH pathways promote divergent emotional states via connectivity patterns of genetically defined, circuit-specific neuronal subpopulations. Using genetically encoded physiological tools for monitoring, manipulating, and mapping discrete neural circuits, Giardino et al. characterize 2 discrete amygdala[right arrow]hypothalamus pathways that promote opposite behavioral responses to emotional stimuli.
Lateral hypothalamus (LH) neurons containing the neuropeptide hypocretin (HCRT; orexin) modulate affective components of arousal, but their relevant synaptic inputs remain poorly defined. Here we identified inputs onto LH neurons that originate from neuronal populations in the bed nuclei of stria terminalis (BNST; a heterogeneous region of extended amygdala). We characterized two non-overlapping LH-projecting GABAergic BNST subpopulations that express distinct neuropeptides (corticotropin-releasing factor, CRF, and cholecystokinin, CCK). To functionally interrogate BNST→LH circuitry, we used tools for monitoring and manipulating neural activity with cell-type-specific resolution in freely behaving mice. We found that Crf-BNST and Cck-BNST neurons respectively provide abundant and sparse inputs onto Hcrt-LH neurons, display discrete physiological responses to salient stimuli, drive opposite emotionally valenced behaviors, and receive different proportions of inputs from upstream networks. Together, our data provide an advanced model for how parallel BNST→LH pathways promote divergent emotional states via connectivity patterns of genetically defined, circuit-specific neuronal subpopulations.
Lateral hypothalamus (LH) neurons containing the neuropeptide hypocretin (HCRT; orexin) modulate affective components of arousal, but their relevant synaptic inputs remain poorly defined. Here we identified inputs onto LH neurons that originate from neuronal populations in the bed nuclei of stria terminalis (BNST; a heterogeneous region of extended amygdala). We characterized two non-overlapping LH-projecting GABAergic BNST subpopulations that express distinct neuropeptides (corticotropin-releasing factor, CRF, and cholecystokinin, CCK). To functionally interrogate BNST→LH circuitry, we used tools for monitoring and manipulating neural activity with cell-type-specific resolution in freely behaving mice. We found that Crf -BNST and Cck -BNST neurons respectively provide abundant and sparse inputs onto Hcrt -LH neurons, display discrete physiological responses to salient stimuli, drive opposite emotionally valenced behaviors, and receive different proportions of inputs from upstream networks. Together, our data provide an advanced model for how parallel BNST→LH pathways promote divergent emotional states via connectivity patterns of genetically defined, circuit-specific neuronal subpopulations. Using genetically encoded physiological tools for monitoring, manipulating, and mapping discrete neural circuits, Giardino et al. characterize 2 discrete amygdala→hypothalamus pathways that promote opposite behavioral responses to emotional stimuli.
Audience Academic
Author de Lecea, Luis
Li, Shi-Bin
Eban-Rothschild, Ada
Christoffel, Daniel J.
Malenka, Robert C.
Giardino, William J.
AuthorAffiliation 1 Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, USA 94305
2 Current address: Department of Psychology, University of Michigan, Ann Arbor, MI, USA 48109
AuthorAffiliation_xml – name: 1 Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, USA 94305
– name: 2 Current address: Department of Psychology, University of Michigan, Ann Arbor, MI, USA 48109
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  givenname: William J.
  orcidid: 0000-0001-7474-7914
  surname: Giardino
  fullname: Giardino, William J.
  organization: Department of Psychiatry & Behavioral Sciences, Stanford University
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  givenname: Ada
  orcidid: 0000-0001-5816-1315
  surname: Eban-Rothschild
  fullname: Eban-Rothschild, Ada
  organization: Department of Psychiatry & Behavioral Sciences, Stanford University, Department of Psychology, University of Michigan
– sequence: 3
  givenname: Daniel J.
  orcidid: 0000-0002-6303-5134
  surname: Christoffel
  fullname: Christoffel, Daniel J.
  organization: Department of Psychiatry & Behavioral Sciences, Stanford University
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  givenname: Shi-Bin
  surname: Li
  fullname: Li, Shi-Bin
  organization: Department of Psychiatry & Behavioral Sciences, Stanford University
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  surname: Malenka
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  orcidid: 0000-0002-8921-5942
  surname: de Lecea
  fullname: de Lecea, Luis
  email: llecea@stanford.edu
  organization: Department of Psychiatry & Behavioral Sciences, Stanford University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30038273$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/j.neuron.2009.12.001
10.1523/JNEUROSCI.18-23-09996.1998
10.1016/j.pnpbp.2009.06.021
10.1016/j.neuron.2005.03.010
10.1016/j.cell.2014.05.017
10.1523/JNEUROSCI.20-20-07760.2000
10.1002/cne.901780204
10.1016/j.celrep.2014.12.040
10.1007/7854_2016_58
10.1016/S0092-8674(00)80949-6
10.1016/0969-8051(94)90080-9
10.1038/nn.4487
10.1038/mp.2016.218
10.1038/nature19318
10.1073/pnas.1011756107
10.1073/pnas.0700293104
10.1111/ejn.13636
10.1016/S0092-8674(00)81965-0
10.1016/j.conb.2014.07.006
10.1038/nature12041
10.1038/tp.2016.293
10.1523/JNEUROSCI.1193-05.2005
10.1038/nrn2192
10.1016/j.cmet.2009.06.011
10.1038/ncomms11395
10.1523/JNEUROSCI.3459-04.2004
10.1038/mp.2016.1
10.1073/pnas.0507480102
10.1523/JNEUROSCI.6096-08.2009
10.1523/JNEUROSCI.5924-08.2009
10.1111/bph.12639
10.1038/nn.4346
10.1111/j.1460-9568.2011.07808.x
10.1038/nn.3972
10.1002/cne.20002
10.1073/pnas.95.1.322
10.1016/j.cell.2015.01.003
10.1016/j.neuropharm.2011.10.003
10.1111/acer.12076
10.1126/science.1241812
10.1016/j.cub.2016.07.013
10.1002/cne.23954
10.1038/ncomms7266
10.1073/pnas.1315542111
10.1002/cne.902800409
10.2174/1570159X11311020002
10.1038/ncomms11937
10.1038/nature12018
10.1016/0006-8993(82)90272-4
10.1016/j.celrep.2017.01.030
10.1038/nn.4377
10.1016/j.conb.2017.04.010
10.1073/pnas.0906593106
ContentType Journal Article
Copyright The Author(s) 2018
COPYRIGHT 2018 Nature Publishing Group
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AUTHOR CONTRIBUTIONS
W.J.G. and L.d.L. conceived and designed the studies. W.J.G. and A.E.-R. and D.J.C. and S.-B. L. performed experiments. W.J.G. and D.J.C. analyzed data. R.C.M. provided equipment and resources, W.J.G. wrote the manuscript with contributions from A.E.-R., D.J.C., and L.d.L.
ORCID 0000-0001-5816-1315
0000-0002-6303-5134
0000-0001-7474-7914
0000-0002-8921-5942
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References Sakurai (CR15) 2005; 46
Füzesi, Daviu, Wamsteeker Cusulin, Bonin, Bains (CR38) 2016; 7
Leinninger (CR45) 2009; 10
Nieh (CR2) 2015; 160
Hata (CR11) 2011; 34
Bender, Holschbach, Stöcklin (CR51) 1994; 21
Baimel, Lau, Qiao, Borgland (CR44) 2017; 18
Giardino, de Lecea (CR6) 2014; 29
Sakurai (CR4) 1998; 92
Winrow (CR28) 2012; 62
Crestani (CR30) 2013; 11
Winsky-Sommerer (CR17) 2004; 24
Bonnavion, Jackson, Carter, de Lecea (CR27) 2015; 6
Nguyen, Dela Cruz, Sun, Holmes, Xu (CR46) 2016; 524
Krettek, Price (CR32) 1978; 178
Armbruster, Li, Pausch, Herlitze, Roth (CR24) 2007; 104
Radley, Gosselink, Sawchenko (CR33) 2009; 29
de Lecea (CR3) 1998; 95
McHenry (CR37) 2017; 20
Lin (CR40) 2010; 65
Dong, Swanson (CR35) 2004; 471
González (CR43) 2016; 26
Li, Giardino, de Lecea (CR7) 2017; 33
González, Iordanidou, Strom, Adamantidis, Burdakov (CR14) 2016; 7
Unger (CR50) 2015; 10
Eban-Rothschild, Giardino, de Lecea (CR42) 2017; 44
Gunaydin (CR22) 2014; 157
Eban-Rothschild, Rothschild, Giardino, Jones, de Lecea (CR26) 2016; 19
Marcinkiewcz (CR21) 2016; 537
Zhang, Aravanis, Adamantidis, de Lecea, Deisseroth (CR23) 2007; 8
Muschamp (CR13) 2014; 111
Poulin, Arbour, Laforest, Drolet (CR47) 2009; 33
Baimel (CR5) 2015; 172
Wall, Wickersham, Cetin, De La Parra, Callaway (CR25) 2010; 107
Kim (CR18) 2013; 496
Lebow, Chen (CR19) 2016; 21
McCarthy (CR48) 2017; 46
Giardino, Ryabinin (CR54) 2013; 37
Lin (CR41) 1999; 98
Tsujino (CR16) 2005; 25
Mazzone (CR39) 2018; 23
Weller, Smith (CR34) 1982; 232
Giardino (CR53) 2017; 7
Pleil (CR36) 2015; 18
CR29
Ju, Swanson (CR31) 1989; 280
Boutrel (CR10) 2005; 102
Bourgin (CR8) 2000; 20
Peyron (CR9) 1998; 18
Jennings (CR20) 2013; 496
Guettier (CR52) 2009; 106
Jennings, Rizzi, Stamatakis, Ung, Stuber (CR1) 2013; 341
Borgland (CR12) 2009; 29
Shemesh (CR49) 2016; 19
EK Unger (198_CR50) 2015; 10
198_CR29
KL Weller (198_CR34) 1982; 232
JA McHenry (198_CR37) 2017; 20
EH Nieh (198_CR2) 2015; 160
WJ Giardino (198_CR6) 2014; 29
T Sakurai (198_CR15) 2005; 46
T Füzesi (198_CR38) 2016; 7
JA González (198_CR43) 2016; 26
N Tsujino (198_CR16) 2005; 25
KE Pleil (198_CR36) 2015; 18
WJ Giardino (198_CR53) 2017; 7
SL Borgland (198_CR12) 2009; 29
JM Guettier (198_CR52) 2009; 106
LA Gunaydin (198_CR22) 2014; 157
EA McCarthy (198_CR48) 2017; 46
P Bonnavion (198_CR27) 2015; 6
CC Crestani (198_CR30) 2013; 11
C Peyron (198_CR9) 1998; 18
SY Kim (198_CR18) 2013; 496
R Winsky-Sommerer (198_CR17) 2004; 24
T Hata (198_CR11) 2011; 34
L Lin (198_CR41) 1999; 98
JF Poulin (198_CR47) 2009; 33
C Baimel (198_CR44) 2017; 18
Y Shemesh (198_CR49) 2016; 19
JH Jennings (198_CR20) 2013; 496
JW Muschamp (198_CR13) 2014; 111
C Baimel (198_CR5) 2015; 172
B Boutrel (198_CR10) 2005; 102
CM Mazzone (198_CR39) 2018; 23
AQ Nguyen (198_CR46) 2016; 524
NR Wall (198_CR25) 2010; 107
JE Krettek (198_CR32) 1978; 178
L Lecea de (198_CR3) 1998; 95
HW Dong (198_CR35) 2004; 471
P Bourgin (198_CR8) 2000; 20
JJ Radley (198_CR33) 2009; 29
WJ Giardino (198_CR54) 2013; 37
BN Armbruster (198_CR24) 2007; 104
GM Leinninger (198_CR45) 2009; 10
CA Marcinkiewcz (198_CR21) 2016; 537
F Zhang (198_CR23) 2007; 8
MA Lebow (198_CR19) 2016; 21
G Ju (198_CR31) 1989; 280
JH Jennings (198_CR1) 2013; 341
JA González (198_CR14) 2016; 7
CJ Winrow (198_CR28) 2012; 62
T Sakurai (198_CR4) 1998; 92
A Eban-Rothschild (198_CR42) 2017; 44
D Bender (198_CR51) 1994; 21
CW Lin (198_CR40) 2010; 65
SB Li (198_CR7) 2017; 33
A Eban-Rothschild (198_CR26) 2016; 19
References_xml – volume: 65
  start-page: 32
  year: 2010
  end-page: 39
  ident: CR40
  article-title: Genetically increased cell-intrinsic excitability enhances neuronal integration into adult brain circuits
  publication-title: Neuron
  doi: 10.1016/j.neuron.2009.12.001
– volume: 18
  start-page: 9996
  year: 1998
  end-page: 10015
  ident: CR9
  article-title: Neurons containing hypocretin (orexin) project to multiple neuronal systems
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.18-23-09996.1998
– volume: 33
  start-page: 1356
  year: 2009
  end-page: 1365
  ident: CR47
  article-title: Neuroanatomical characterization of endogenous opioids in the bed nucleus of the stria terminalis
  publication-title: Prog. Neuropsychopharmacol. Biol. Psychiatry
  doi: 10.1016/j.pnpbp.2009.06.021
– volume: 46
  start-page: 297
  year: 2005
  end-page: 308
  ident: CR15
  article-title: Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice
  publication-title: Neuron
  doi: 10.1016/j.neuron.2005.03.010
– volume: 157
  start-page: 1535
  year: 2014
  end-page: 1551
  ident: CR22
  article-title: Natural neural projection dynamics underlying social behavior
  publication-title: Cell
  doi: 10.1016/j.cell.2014.05.017
– volume: 20
  start-page: 7760
  year: 2000
  end-page: 7765
  ident: CR8
  article-title: Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.20-20-07760.2000
– volume: 178
  start-page: 225
  year: 1978
  end-page: 254
  ident: CR32
  article-title: Amygdaloid projections to subcortical structures within the basal forebrain and brainstem in the rat and cat
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.901780204
– volume: 10
  start-page: 453
  year: 2015
  end-page: 462
  ident: CR50
  article-title: Medial amygdalar aromatase neurons regulate aggression in both sexes
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2014.12.040
– ident: CR29
– volume: 33
  start-page: 93
  year: 2017
  end-page: 104
  ident: CR7
  article-title: Hypocretins and arousal
  publication-title: Curr. Top. Behav. Neurosci.
  doi: 10.1007/7854_2016_58
– volume: 92
  start-page: 573
  year: 1998
  end-page: 585
  ident: CR4
  article-title: Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80949-6
– volume: 21
  start-page: 921
  year: 1994
  end-page: 925
  ident: CR51
  article-title: Synthesis of n.c.a. carbon-11 labelled clozapine and its major metabolite clozapine- -oxide and comparison of their biodistribution in mice
  publication-title: Nucl. Med. Biol.
  doi: 10.1016/0969-8051(94)90080-9
– volume: 20
  start-page: 449
  year: 2017
  end-page: 458
  ident: CR37
  article-title: Hormonal gain control of a medial preoptic area social reward circuit
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4487
– volume: 23
  start-page: 143
  year: 2018
  end-page: 153
  ident: CR39
  article-title: Acute engagement of Gq-mediated signaling in the bed nucleus of the stria terminalis induces anxiety-like behavior
  publication-title: Mol. Psychiatry
  doi: 10.1038/mp.2016.218
– volume: 537
  start-page: 97
  year: 2016
  end-page: 101
  ident: CR21
  article-title: Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala
  publication-title: Nature
  doi: 10.1038/nature19318
– volume: 107
  start-page: 21848
  year: 2010
  end-page: 21853
  ident: CR25
  article-title: Monosynaptic circuit tracing in vivo through Cre-dependent targeting and complementation of modified rabies virus
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1011756107
– volume: 104
  start-page: 5163
  year: 2007
  end-page: 5168
  ident: CR24
  article-title: Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0700293104
– volume: 46
  start-page: 2035
  year: 2017
  end-page: 2046
  ident: CR48
  article-title: DREADD-induced silencing of the medial amygdala reduces the preference for male pheromones and the expression of lordosis in estrous female mice
  publication-title: Eur. J. Neurosci.
  doi: 10.1111/ejn.13636
– volume: 98
  start-page: 365
  year: 1999
  end-page: 376
  ident: CR41
  article-title: The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81965-0
– volume: 29
  start-page: 103
  year: 2014
  end-page: 108
  ident: CR6
  article-title: Hypocretin (orexin) neuromodulation of stress and reward pathways
  publication-title: Curr. Opin. Neurobiol.
  doi: 10.1016/j.conb.2014.07.006
– volume: 496
  start-page: 224
  year: 2013
  end-page: 228
  ident: CR20
  article-title: Distinct extended amygdala circuits for divergent motivational states
  publication-title: Nature
  doi: 10.1038/nature12041
– volume: 7
  year: 2017
  ident: CR53
  article-title: Control of chronic excessive alcohol drinking by genetic manipulation of the Edinger-Westphal nucleus urocortin-1 neuropeptide system
  publication-title: Transl. Psychiatry
  doi: 10.1038/tp.2016.293
– volume: 25
  start-page: 7459
  year: 2005
  end-page: 7469
  ident: CR16
  article-title: Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1193-05.2005
– volume: 8
  start-page: 577
  year: 2007
  end-page: 581
  ident: CR23
  article-title: Circuit-breakers: optical technologies for probing neural signals and systems
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn2192
– volume: 10
  start-page: 89
  year: 2009
  end-page: 98
  ident: CR45
  article-title: Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2009.06.011
– volume: 7
  year: 2016
  ident: CR14
  article-title: Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin networks
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms11395
– volume: 24
  start-page: 11439
  year: 2004
  end-page: 11448
  ident: CR17
  article-title: Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.3459-04.2004
– volume: 21
  start-page: 450
  year: 2016
  end-page: 463
  ident: CR19
  article-title: Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders
  publication-title: Mol. Psychiatry
  doi: 10.1038/mp.2016.1
– volume: 102
  start-page: 19168
  year: 2005
  end-page: 19173
  ident: CR10
  article-title: Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0507480102
– volume: 29
  start-page: 11215
  year: 2009
  end-page: 11225
  ident: CR12
  article-title: Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.6096-08.2009
– volume: 29
  start-page: 7330
  year: 2009
  end-page: 7340
  ident: CR33
  article-title: A discrete GABAergic relay mediates medial prefrontal cortical inhibition of the neuroendocrine stress response
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.5924-08.2009
– volume: 172
  start-page: 334
  year: 2015
  end-page: 348
  ident: CR5
  article-title: Orexin/hypocretin role in reward: implications for opioid and other addictions
  publication-title: Br. J. Pharmacol.
  doi: 10.1111/bph.12639
– volume: 19
  start-page: 1489
  year: 2016
  end-page: 1496
  ident: CR49
  article-title: Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4346
– volume: 34
  start-page: 816
  year: 2011
  end-page: 826
  ident: CR11
  article-title: Intra-ventral tegmental area or intracerebroventricular orexin-A increases the intra-cranial self-stimulation threshold via activation of the corticotropin-releasing factor system in rats
  publication-title: Eur. J. Neurosci.
  doi: 10.1111/j.1460-9568.2011.07808.x
– volume: 18
  start-page: 545
  year: 2015
  end-page: 552
  ident: CR36
  article-title: NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.3972
– volume: 471
  start-page: 396
  year: 2004
  end-page: 433
  ident: CR35
  article-title: Projections from bed nuclei of the stria terminalis, posterior division: implications for cerebral hemisphere regulation of defensive and reproductive behaviors
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.20002
– volume: 95
  start-page: 322
  year: 1998
  end-page: 327
  ident: CR3
  article-title: The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.95.1.322
– volume: 160
  start-page: 528
  year: 2015
  end-page: 541
  ident: CR2
  article-title: Decoding neural circuits that control compulsive sucrose seeking
  publication-title: Cell
  doi: 10.1016/j.cell.2015.01.003
– volume: 62
  start-page: 978
  year: 2012
  end-page: 987
  ident: CR28
  article-title: Pharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomnia
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2011.10.003
– volume: 37
  start-page: 1161
  year: 2013
  end-page: 1170
  ident: CR54
  article-title: CRF1 receptor signaling regulates food and fluid intake in the drinking-in-the-dark model of binge alcohol consumption
  publication-title: Alcohol. Clin. Exp. Res.
  doi: 10.1111/acer.12076
– volume: 341
  start-page: 1517
  year: 2013
  end-page: 1521
  ident: CR1
  article-title: The inhibitory circuit architecture of the lateral hypothalamus orchestrates feeding
  publication-title: Science
  doi: 10.1126/science.1241812
– volume: 26
  start-page: 2486
  year: 2016
  end-page: 2491
  ident: CR43
  article-title: Inhibitory interplay between orexin neurons and eating
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2016.07.013
– volume: 524
  start-page: 2379
  year: 2016
  end-page: 2399
  ident: CR46
  article-title: Genetic cell targeting uncovers specific neuronal types and distinct subregions in the bed nucleus of the stria terminalis
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.23954
– volume: 6
  year: 2015
  ident: CR27
  article-title: Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regulates stress responses
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms7266
– volume: 111
  start-page: E1648
  year: 2014
  end-page: E1655
  ident: CR13
  article-title: Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1315542111
– volume: 280
  start-page: 587
  year: 1989
  end-page: 602
  ident: CR31
  article-title: Studies on the cellular architecture of the bed nuclei of the stria terminalis in the rat: I. Cytoarchitecture
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.902800409
– volume: 11
  start-page: 141
  year: 2013
  end-page: 159
  ident: CR30
  article-title: Mechanisms in the bed nucleus of the stria terminalis involved in control of autonomic and neuroendocrine functions: a review
  publication-title: Curr. Neuropharmacol.
  doi: 10.2174/1570159X11311020002
– volume: 7
  year: 2016
  ident: CR38
  article-title: Hypothalamic CRH neurons orchestrate complex behaviours after stress
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms11937
– volume: 496
  start-page: 219
  year: 2013
  end-page: 223
  ident: CR18
  article-title: Diverging neural pathways assemble a behavioural state from separable features in anxiety
  publication-title: Nature
  doi: 10.1038/nature12018
– volume: 232
  start-page: 255
  year: 1982
  end-page: 270
  ident: CR34
  article-title: Afferent connections to the bed nucleus of the stria terminalis
  publication-title: Brain Res.
  doi: 10.1016/0006-8993(82)90272-4
– volume: 18
  start-page: 1346
  year: 2017
  end-page: 1355
  ident: CR44
  article-title: Projection-target-defined effects of orexin and dynorphin on VTA dopamine neurons
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2017.01.030
– volume: 19
  start-page: 1356
  year: 2016
  end-page: 1366
  ident: CR26
  article-title: VTA dopaminergic neurons regulate ethologically relevant sleep-wake behaviors
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4377
– volume: 44
  start-page: 132
  year: 2017
  end-page: 138
  ident: CR42
  article-title: To sleep or not to sleep: neuronal and ecological insights
  publication-title: Curr. Opin. Neurobiol.
  doi: 10.1016/j.conb.2017.04.010
– volume: 106
  start-page: 19197
  year: 2009
  end-page: 19202
  ident: CR52
  article-title: A chemical-genetic approach to study G protein regulation of beta cell function in vivo
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0906593106
– volume: 496
  start-page: 224
  year: 2013
  ident: 198_CR20
  publication-title: Nature
  doi: 10.1038/nature12041
– volume: 44
  start-page: 132
  year: 2017
  ident: 198_CR42
  publication-title: Curr. Opin. Neurobiol.
  doi: 10.1016/j.conb.2017.04.010
– volume: 157
  start-page: 1535
  year: 2014
  ident: 198_CR22
  publication-title: Cell
  doi: 10.1016/j.cell.2014.05.017
– volume: 62
  start-page: 978
  year: 2012
  ident: 198_CR28
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2011.10.003
– volume: 20
  start-page: 7760
  year: 2000
  ident: 198_CR8
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.20-20-07760.2000
– volume: 102
  start-page: 19168
  year: 2005
  ident: 198_CR10
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0507480102
– volume: 341
  start-page: 1517
  year: 2013
  ident: 198_CR1
  publication-title: Science
  doi: 10.1126/science.1241812
– volume: 21
  start-page: 450
  year: 2016
  ident: 198_CR19
  publication-title: Mol. Psychiatry
  doi: 10.1038/mp.2016.1
– volume: 18
  start-page: 9996
  year: 1998
  ident: 198_CR9
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.18-23-09996.1998
– volume: 7
  year: 2017
  ident: 198_CR53
  publication-title: Transl. Psychiatry
  doi: 10.1038/tp.2016.293
– volume: 25
  start-page: 7459
  year: 2005
  ident: 198_CR16
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1193-05.2005
– volume: 21
  start-page: 921
  year: 1994
  ident: 198_CR51
  publication-title: Nucl. Med. Biol.
  doi: 10.1016/0969-8051(94)90080-9
– volume: 34
  start-page: 816
  year: 2011
  ident: 198_CR11
  publication-title: Eur. J. Neurosci.
  doi: 10.1111/j.1460-9568.2011.07808.x
– volume: 19
  start-page: 1356
  year: 2016
  ident: 198_CR26
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4377
– volume: 95
  start-page: 322
  year: 1998
  ident: 198_CR3
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.95.1.322
– volume: 11
  start-page: 141
  year: 2013
  ident: 198_CR30
  publication-title: Curr. Neuropharmacol.
  doi: 10.2174/1570159X11311020002
– volume: 471
  start-page: 396
  year: 2004
  ident: 198_CR35
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.20002
– ident: 198_CR29
– volume: 23
  start-page: 143
  year: 2018
  ident: 198_CR39
  publication-title: Mol. Psychiatry
  doi: 10.1038/mp.2016.218
– volume: 33
  start-page: 93
  year: 2017
  ident: 198_CR7
  publication-title: Curr. Top. Behav. Neurosci.
  doi: 10.1007/7854_2016_58
– volume: 20
  start-page: 449
  year: 2017
  ident: 198_CR37
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4487
– volume: 98
  start-page: 365
  year: 1999
  ident: 198_CR41
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81965-0
– volume: 92
  start-page: 573
  year: 1998
  ident: 198_CR4
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80949-6
– volume: 524
  start-page: 2379
  year: 2016
  ident: 198_CR46
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.23954
– volume: 18
  start-page: 545
  year: 2015
  ident: 198_CR36
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.3972
– volume: 232
  start-page: 255
  year: 1982
  ident: 198_CR34
  publication-title: Brain Res.
  doi: 10.1016/0006-8993(82)90272-4
– volume: 26
  start-page: 2486
  year: 2016
  ident: 198_CR43
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2016.07.013
– volume: 10
  start-page: 89
  year: 2009
  ident: 198_CR45
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2009.06.011
– volume: 6
  year: 2015
  ident: 198_CR27
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms7266
– volume: 10
  start-page: 453
  year: 2015
  ident: 198_CR50
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2014.12.040
– volume: 29
  start-page: 103
  year: 2014
  ident: 198_CR6
  publication-title: Curr. Opin. Neurobiol.
  doi: 10.1016/j.conb.2014.07.006
– volume: 29
  start-page: 11215
  year: 2009
  ident: 198_CR12
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.6096-08.2009
– volume: 537
  start-page: 97
  year: 2016
  ident: 198_CR21
  publication-title: Nature
  doi: 10.1038/nature19318
– volume: 33
  start-page: 1356
  year: 2009
  ident: 198_CR47
  publication-title: Prog. Neuropsychopharmacol. Biol. Psychiatry
  doi: 10.1016/j.pnpbp.2009.06.021
– volume: 160
  start-page: 528
  year: 2015
  ident: 198_CR2
  publication-title: Cell
  doi: 10.1016/j.cell.2015.01.003
– volume: 172
  start-page: 334
  year: 2015
  ident: 198_CR5
  publication-title: Br. J. Pharmacol.
  doi: 10.1111/bph.12639
– volume: 18
  start-page: 1346
  year: 2017
  ident: 198_CR44
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2017.01.030
– volume: 19
  start-page: 1489
  year: 2016
  ident: 198_CR49
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4346
– volume: 37
  start-page: 1161
  year: 2013
  ident: 198_CR54
  publication-title: Alcohol. Clin. Exp. Res.
  doi: 10.1111/acer.12076
– volume: 106
  start-page: 19197
  year: 2009
  ident: 198_CR52
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0906593106
– volume: 107
  start-page: 21848
  year: 2010
  ident: 198_CR25
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1011756107
– volume: 178
  start-page: 225
  year: 1978
  ident: 198_CR32
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.901780204
– volume: 7
  year: 2016
  ident: 198_CR38
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms11937
– volume: 496
  start-page: 219
  year: 2013
  ident: 198_CR18
  publication-title: Nature
  doi: 10.1038/nature12018
– volume: 280
  start-page: 587
  year: 1989
  ident: 198_CR31
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.902800409
– volume: 111
  start-page: E1648
  year: 2014
  ident: 198_CR13
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1315542111
– volume: 46
  start-page: 2035
  year: 2017
  ident: 198_CR48
  publication-title: Eur. J. Neurosci.
  doi: 10.1111/ejn.13636
– volume: 24
  start-page: 11439
  year: 2004
  ident: 198_CR17
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.3459-04.2004
– volume: 65
  start-page: 32
  year: 2010
  ident: 198_CR40
  publication-title: Neuron
  doi: 10.1016/j.neuron.2009.12.001
– volume: 46
  start-page: 297
  year: 2005
  ident: 198_CR15
  publication-title: Neuron
  doi: 10.1016/j.neuron.2005.03.010
– volume: 7
  year: 2016
  ident: 198_CR14
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms11395
– volume: 104
  start-page: 5163
  year: 2007
  ident: 198_CR24
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0700293104
– volume: 8
  start-page: 577
  year: 2007
  ident: 198_CR23
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn2192
– volume: 29
  start-page: 7330
  year: 2009
  ident: 198_CR33
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.5924-08.2009
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Snippet Lateral hypothalamus (LH) neurons containing the neuropeptide hypocretin (HCRT; orexin) modulate affective components of arousal, but their relevant synaptic...
Lateral hypothalamus (LH) neurons containing the neuropeptide hypocretin (Hcrt; orexin) modulate affective components of arousal, but their relevant synaptic...
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SubjectTerms 13/1
14/19
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82/51
9/74
96/35
96/44
96/63
Amygdala
Amygdala (Brain)
Animal Genetics and Genomics
Animals
Arousal
Behavioral Sciences
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Brain research
Cholecystokinin
Cholecystokinin - physiology
Circuits
Conditioning, Operant - physiology
Corticotropin
Corticotropin-releasing hormone
Displays (Marketing)
Emotion regulation
Emotional behavior
Emotions - physiology
GABA
gamma-Aminobutyric Acid - physiology
Hypothalamic Area, Lateral - cytology
Hypothalamic Area, Lateral - physiology
Hypothalamus
Hypothalamus (lateral)
Luteinizing hormone
Male
Mice
Mice, Inbred C57BL
Nerve Net - cytology
Nerve Net - physiology
Neural circuitry
Neural networks
Neural Pathways - cytology
Neural Pathways - physiology
Neurobiology
Neurons
Neurons - physiology
Neuropeptides
Neuropeptides - metabolism
Neuropsychology
Neurosciences
Nuclei
Orexins
Orexins - metabolism
Orexins - physiology
Photic Stimulation
Physiological aspects
Physiological responses
Rodents
Self Stimulation
Septal Nuclei - cytology
Septal Nuclei - physiology
Stria terminalis
Subpopulations
γ-Aminobutyric acid
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Title Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states
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https://www.ncbi.nlm.nih.gov/pubmed/30038273
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https://pubmed.ncbi.nlm.nih.gov/PMC6095688
https://www.ncbi.nlm.nih.gov/pmc/articles/6095688
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