Engineered microbial biosensors based on bacterial two-component systems as synthetic biotechnology platforms in bioremediation and biorefinery

Two-component regulatory systems (TCRSs) mediate cellular response by coupling sensing and regulatory mechanisms. TCRSs are comprised of a histidine kinase (HK), which serves as a sensor, and a response regulator, which regulates expression of the effector gene after being phosphorylated by HK. Usin...

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Published inMicrobial cell factories Vol. 16; no. 1; pp. 62 - 10
Main Authors Ravikumar, Sambandam, Baylon, Mary Grace, Park, Si Jae, Choi, Jong-il
Format Journal Article
LanguageEnglish
Published London BioMed Central 14.04.2017
BioMed Central Ltd
BMC
Subjects
Adsorption
Analysis
Applied Microbiology
Bacteria
Biodegradation, Environmental
Biomass
Biorefineries
Biorefinery
Bioremediation
Biosensing Techniques
Biosensor
Biosensors
Biotechnology
Chemistry
Chemistry and Materials Science
Contamination
E coli
Enzymes
Enzymology
Gene expression
Gene Expression Regulation
Genetic circuit
Genetic Engineering
Histidine
Histidine kinase
Histidine Kinase - genetics
Histidine Kinase - metabolism
Kinases
Metabolic Engineering
Microbial Genetics and Genomics
Microbiology
Microorganisms
Proteins
Refining
Regulatory mechanisms (biology)
Review
Signal Transduction
Transcription Factors - genetics
Transcription Factors - metabolism
Transmitters
Two-component regulatory system
Biorefinery
Two-component regulatory system
Bioremediation
Biosensor
Genetic circuit
Online AccessGet full text
ISSN1475-2859
1475-2859
DOI10.1186/s12934-017-0675-z

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Abstract Two-component regulatory systems (TCRSs) mediate cellular response by coupling sensing and regulatory mechanisms. TCRSs are comprised of a histidine kinase (HK), which serves as a sensor, and a response regulator, which regulates expression of the effector gene after being phosphorylated by HK. Using these attributes, bacterial TCRSs can be engineered to design microbial systems for different applications. This review focuses on the current advances in TCRS-based biosensors and on the design of microbial systems for bioremediation and their potential application in biorefinery.
AbstractList Two-component regulatory systems (TCRSs) mediate cellular response by coupling sensing and regulatory mechanisms. TCRSs are comprised of a histidine kinase (HK), which serves as a sensor, and a response regulator, which regulates expression of the effector gene after being phosphorylated by HK. Using these attributes, bacterial TCRSs can be engineered to design microbial systems for different applications. This review focuses on the current advances in TCRS-based biosensors and on the design of microbial systems for bioremediation and their potential application in biorefinery.
Abstract Two-component regulatory systems (TCRSs) mediate cellular response by coupling sensing and regulatory mechanisms. TCRSs are comprised of a histidine kinase (HK), which serves as a sensor, and a response regulator, which regulates expression of the effector gene after being phosphorylated by HK. Using these attributes, bacterial TCRSs can be engineered to design microbial systems for different applications. This review focuses on the current advances in TCRS-based biosensors and on the design of microbial systems for bioremediation and their potential application in biorefinery.
Two-component regulatory systems (TCRSs) mediate cellular response by coupling sensing and regulatory mechanisms. TCRSs are comprised of a histidine kinase (HK), which serves as a sensor, and a response regulator, which regulates expression of the effector gene after being phosphorylated by HK. Using these attributes, bacterial TCRSs can be engineered to design microbial systems for different applications. This review focuses on the current advances in TCRS-based biosensors and on the design of microbial systems for bioremediation and their potential application in biorefinery.Two-component regulatory systems (TCRSs) mediate cellular response by coupling sensing and regulatory mechanisms. TCRSs are comprised of a histidine kinase (HK), which serves as a sensor, and a response regulator, which regulates expression of the effector gene after being phosphorylated by HK. Using these attributes, bacterial TCRSs can be engineered to design microbial systems for different applications. This review focuses on the current advances in TCRS-based biosensors and on the design of microbial systems for bioremediation and their potential application in biorefinery.
Two-component regulatory systems (TCRSs) mediate cellular response by coupling sensing and regulatory mechanisms. TCRSs are comprised of a histidine kinase (HK), which serves as a sensor, and a response regulator, which regulates expression of the effector gene after being phosphorylated by HK. Using these attributes, bacterial TCRSs can be engineered to design microbial systems for different applications. This review focuses on the current advances in TCRS-based biosensors and on the design of microbial systems for bioremediation and their potential application in biorefinery. Keywords: Two-component regulatory system, Biosensor, Bioremediation, Genetic circuit, Biorefinery
ArticleNumber 62
Audience Academic
Author Ravikumar, Sambandam
Baylon, Mary Grace
Choi, Jong-il
Park, Si Jae
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  surname: Choi
  fullname: Choi, Jong-il
  email: choiji01@jnu.ac.kr
  organization: Biomolecules Engineering Lab, Department of Biotechnology and Bioengineering, Chonnam National University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28410609$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords Biorefinery
Two-component regulatory system
Bioremediation
Biosensor
Genetic circuit
Language English
License Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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SecondaryResourceType review_article
Snippet Two-component regulatory systems (TCRSs) mediate cellular response by coupling sensing and regulatory mechanisms. TCRSs are comprised of a histidine kinase...
Abstract Two-component regulatory systems (TCRSs) mediate cellular response by coupling sensing and regulatory mechanisms. TCRSs are comprised of a histidine...
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pubmed
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SourceType Open Website
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Publisher
StartPage 62
SubjectTerms Adsorption
Analysis
Applied Microbiology
Bacteria
Biodegradation, Environmental
Biomass
Biorefineries
Biorefinery
Bioremediation
Biosensing Techniques
Biosensor
Biosensors
Biotechnology
Chemistry
Chemistry and Materials Science
Contamination
E coli
Enzymes
Enzymology
Gene expression
Gene Expression Regulation
Genetic circuit
Genetic Engineering
Histidine
Histidine kinase
Histidine Kinase - genetics
Histidine Kinase - metabolism
Kinases
Metabolic Engineering
Microbial Genetics and Genomics
Microbiology
Microorganisms
Proteins
Refining
Regulatory mechanisms (biology)
Review
Signal Transduction
Transcription Factors - genetics
Transcription Factors - metabolism
Transmitters
Two-component regulatory system
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Title Engineered microbial biosensors based on bacterial two-component systems as synthetic biotechnology platforms in bioremediation and biorefinery
URI https://link.springer.com/article/10.1186/s12934-017-0675-z
https://www.ncbi.nlm.nih.gov/pubmed/28410609
https://www.proquest.com/docview/1895834544
https://www.proquest.com/docview/1888679309
https://pubmed.ncbi.nlm.nih.gov/PMC5391612
https://doaj.org/article/b7f30fb855174e3285aabf9ec191a4a1
Volume 16
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