A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis - Hughes, Michael R.; Anderson, Nicole; Maltby, Steven; Wong, Justin; Berberovic, Zorana; Birkenmeier, Connie S.; Haddon, D. James; Garcha, Kamal; Flenniken, Ann; Osborne, Lucy R.; Adamson, S. Lee; Rossant, Janet; et al. (Experimental hematology, 2011)
Keywords: Advanced Basic Science; Alkylating Agents - adverse effects; Alkylating Agents - pharmacology; Amino Acid Sequence; Animals; Ankyrins - genetics; Ankyrins - metabolism; Codon, Nonsense; Disease Models, Animal; Erythrocytes - metabolism; Ethylnitrosourea - adverse effects; Ethylnitrosourea - pharmacology; Female; Hematology, Oncology and Palliative Medicine; Humans; Male; Mice; Mice, Mutant Strains; Protein Binding; Sequence Deletion; Spherocytosis, Hereditary - chemically induced; Spherocytosis, Hereditary - genetics; Spherocytosis, Hereditary - metabolism