PAK4 signaling in health and disease: defining the PAK4–CREB axis

p21-Activated kinase 4 (PAK4), a member of the PAK family, regulates a wide range of cellular functions, including cell adhesion, migration, proliferation, and survival. Dysregulation of its expression and activity thus contributes to the development of diverse pathological conditions. PAK4 plays a...

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Bibliographic Details
Published inExperimental & molecular medicine Vol. 51; no. 2; pp. 1 - 9
Main Authors Won, So-Yoon, Park, Jung-Jin, Shin, Eun-Young, Kim, Eung-Gook
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.02.2019
Springer Nature B.V
Nature Publishing Group
생화학분자생물학회
Subjects
13
38
631/378/1934
631/80/86
692/308/1426
Animals
Antineoplastic drugs
Antitumor agents
Biomedical and Life Sciences
Biomedicine
Cell adhesion
Cell adhesion & migration
Cell migration
Cyclic AMP response element-binding protein
Cyclic AMP Response Element-Binding Protein - metabolism
Disease Susceptibility
Drug development
Embryogenesis
Humans
Medical Biochemistry
Melanins - biosynthesis
Mesenchyme
Metastases
Molecular Medicine
Neoplasms - etiology
Neoplasms - metabolism
Neoplasms - pathology
Neuroprotection
p21-activated kinase
p21-Activated Kinases - chemistry
p21-Activated Kinases - metabolism
Parkinson Disease - etiology
Parkinson Disease - metabolism
Parkinson's disease
Prostate cancer
Protein Binding
Protein Interaction Domains and Motifs
Review
Review Article
Signal Transduction
Stem Cells
Therapeutic applications
생화학
Online AccessGet full text
ISSN1226-3613
2092-6413
2092-6413
DOI10.1038/s12276-018-0204-0

Cover

Abstract p21-Activated kinase 4 (PAK4), a member of the PAK family, regulates a wide range of cellular functions, including cell adhesion, migration, proliferation, and survival. Dysregulation of its expression and activity thus contributes to the development of diverse pathological conditions. PAK4 plays a pivotal role in cancer progression by accelerating the epithelial–mesenchymal transition, invasion, and metastasis. Therefore, PAK4 is regarded as an attractive therapeutic target in diverse types of cancers, prompting the development of PAK4-specific inhibitors as anticancer drugs; however, these drugs have not yet been successful. PAK4 is essential for embryonic brain development and has a neuroprotective function. A long list of PAK4 effectors has been reported. Recently, the transcription factor CREB has emerged as a novel effector of PAK4. This finding has broad implications for the role of PAK4 in health and disease because CREB-mediated transcriptional reprogramming involves a wide range of genes. In this article, we review the PAK4 signaling pathways involved in prostate cancer, Parkinson’s disease, and melanogenesis, focusing in particular on the PAK4-CREB axis. Gene expression: The role of a regulatory enzyme in disease An enzyme that regulates an important controller of gene expression may offer a therapeutic target for cancer and other diseases. cAMP response element-binding protein (CREB) interacts with various other proteins to switch a myriad of target genes on and off in different cells. A review by Eung-Gook Kim, Eun-Young Shin and colleagues at Chungbuk National University, Cheongju, South Korea, explores the interplay between CREB and an enzyme called p21-activated kinase 4 (PAK4) in human health and disease. PAK4, for example, has been shown to promote CREB’s gene-activating function in prostate cancer, and PAK4 overexpression is a feature of numerous other tumor types. Disruptions in PAK4-mediated regulation of CREB activity have also been observed in neurons affected by Parkinson’s disease. The authors see strong clinical promise in further exploring the biology of the PAK4-CREB pathway.
AbstractList p21-Activated kinase 4 (PAK4), a member of the PAK family, regulates a wide range of cellular functions, including cell adhesion, migration, proliferation, and survival. Dysregulation of its expression and activity thus contributes to the development of diverse pathological conditions. PAK4 plays a pivotal role in cancer progression by accelerating the epithelial–mesenchymal transition, invasion, and metastasis. Therefore, PAK4 is regarded as an attractive therapeutic target in diverse types of cancers, prompting the development of PAK4-specific inhibitors as anticancer drugs; however, these drugs have not yet been successful. PAK4 is essential for embryonic brain development and has a neuroprotective function. A long list of PAK4 effectors has been reported. Recently, the transcription factor CREB has emerged as a novel effector of PAK4. This finding has broad implications for the role of PAK4 in health and disease because CREB-mediated transcriptional reprogramming involves a wide range of genes. In this article, we review the PAK4 signaling pathways involved in prostate cancer, Parkinson’s disease, and melanogenesis, focusing in particular on the PAK4-CREB axis.
Gene expression: The role of a regulatory enzyme in disease An enzyme that regulates an important controller of gene expression may offer a therapeutic target for cancer and other diseases. cAMP response element-binding protein (CREB) interacts with various other proteins to switch a myriad of target genes on and off in different cells. A review by Eung-Gook Kim, Eun-Young Shin and colleagues at Chungbuk National University, Cheongju, South Korea, explores the interplay between CREB and an enzyme called p21-activated kinase 4 (PAK4) in human health and disease. PAK4, for example, has been shown to promote CREB’s gene-activating function in prostate cancer, and PAK4 overexpression is a feature of numerous other tumor types. Disruptions in PAK4-mediated regulation of CREB activity have also been observed in neurons affected by Parkinson’s disease. The authors see strong clinical promise in further exploring the biology of the PAK4-CREB pathway.
p21-Activated kinase 4 (PAK4), a member of the PAK family, regulates a wide range of cellular functions, including cell adhesion, migration, proliferation, and survival. Dysregulation of its expression and activity thus contributes to the development of diverse pathological conditions. PAK4 plays a pivotal role in cancer progression by accelerating the epithelial–mesenchymal transition, invasion, and metastasis. Therefore, PAK4 is regarded as an attractive therapeutic target in diverse types of cancers, prompting the development of PAK4-specific inhibitors as anticancer drugs; however, these drugs have not yet been successful. PAK4 is essential for embryonic brain development and has a neuroprotective function. A long list of PAK4 effectors has been reported. Recently, the transcription factor CREB has emerged as a novel effector of PAK4. This finding has broad implications for the role of PAK4 in health and disease because CREB-mediated transcriptional reprogramming involves a wide range of genes. In this article, we review the PAK4 signaling pathways involved in prostate cancer, Parkinson’s disease, and melanogenesis, focusing in particular on the PAK4-CREB axis.Gene expression: The role of a regulatory enzyme in diseaseAn enzyme that regulates an important controller of gene expression may offer a therapeutic target for cancer and other diseases. cAMP response element-binding protein (CREB) interacts with various other proteins to switch a myriad of target genes on and off in different cells. A review by Eung-Gook Kim, Eun-Young Shin and colleagues at Chungbuk National University, Cheongju, South Korea, explores the interplay between CREB and an enzyme called p21-activated kinase 4 (PAK4) in human health and disease. PAK4, for example, has been shown to promote CREB’s gene-activating function in prostate cancer, and PAK4 overexpression is a feature of numerous other tumor types. Disruptions in PAK4-mediated regulation of CREB activity have also been observed in neurons affected by Parkinson’s disease. The authors see strong clinical promise in further exploring the biology of the PAK4-CREB pathway.
p21-Activated kinase 4 (PAK4), a member of the PAK family, regulates a wide range of cellular functions, including cell adhesion, migration, proliferation, and survival. Dysregulation of its expression and activity thus contributes to the development of diverse pathological conditions. PAK4 plays a pivotal role in cancer progression by accelerating the epithelial–mesenchymal transition, invasion, and metastasis. Therefore, PAK4 is regarded as an attractive therapeutic target in diverse types of cancers, prompting the development of PAK4-specific inhibitors as anticancer drugs; however, these drugs have not yet been successful. PAK4 is essential for embryonic brain development and has a neuroprotective function. A long list of PAK4 effectors has been reported. Recently, the transcription factor CREB has emerged as a novel effector of PAK4. This finding has broad implications for the role of PAK4 in health and disease because CREB-mediated transcriptional reprogramming involves a wide range of genes. In this article, we review the PAK4 signaling pathways involved in prostate cancer, Parkinson’s disease, and melanogenesis, focusing in particular on the PAK4-CREB axis. An enzyme that regulates an important controller of gene expression may offer a therapeutic target for cancer and other diseases. cAMP response element-binding protein (CREB) interacts with various other proteins to switch a myriad of target genes on and off in different cells. A review by Eung-Gook Kim, Eun-Young Shin and colleagues at Chungbuk National University, Cheongju, South Korea, explores the interplay between CREB and an enzyme called p21-activated kinase 4 (PAK4) in human health and disease. PAK4, for example, has been shown to promote CREB’s gene-activating function in prostate cancer, and PAK4 overexpression is a feature of numerous other tumor types. Disruptions in PAK4-mediated regulation of CREB activity have also been observed in neurons affected by Parkinson’s disease. The authors see strong clinical promise in further exploring the biology of the PAK4-CREB pathway.
p21-Activated kinase 4 (PAK4), a member of the PAK family, regulates a wide range of cellular functions, including cell adhesion, migration, proliferation, and survival. Dysregulation of its expression and activity thus contributes to the development of diverse pathological conditions. PAK4 plays a pivotal role in cancer progression by accelerating the epithelial–mesenchymal transition, invasion, and metastasis. Therefore, PAK4 is regarded as an attractive therapeutic target in diverse types of cancers, prompting the development of PAK4-specific inhibitors as anticancer drugs; however, these drugs have not yet been successful. PAK4 is essential for embryonic brain development and has a neuroprotective function. A long list of PAK4 effectors has been reported. Recently, the transcription factor CREB has emerged as a novel effector of PAK4. This finding has broad implications for the role of PAK4 in health and disease because CREB-mediated transcriptional reprogramming involves a wide range of genes. In this article, we review the PAK4 signaling pathways involved in prostate cancer, Parkinson’s disease, and melanogenesis, focusing in particular on the PAK4-CREB axis. KCI Citation Count: 0
p21-Activated kinase 4 (PAK4), a member of the PAK family, regulates a wide range of cellular functions, including cell adhesion, migration, proliferation, and survival. Dysregulation of its expression and activity thus contributes to the development of diverse pathological conditions. PAK4 plays a pivotal role in cancer progression by accelerating the epithelial-mesenchymal transition, invasion, and metastasis. Therefore, PAK4 is regarded as an attractive therapeutic target in diverse types of cancers, prompting the development of PAK4-specific inhibitors as anticancer drugs; however, these drugs have not yet been successful. PAK4 is essential for embryonic brain development and has a neuroprotective function. A long list of PAK4 effectors has been reported. Recently, the transcription factor CREB has emerged as a novel effector of PAK4. This finding has broad implications for the role of PAK4 in health and disease because CREB-mediated transcriptional reprogramming involves a wide range of genes. In this article, we review the PAK4 signaling pathways involved in prostate cancer, Parkinson's disease, and melanogenesis, focusing in particular on the PAK4-CREB axis.p21-Activated kinase 4 (PAK4), a member of the PAK family, regulates a wide range of cellular functions, including cell adhesion, migration, proliferation, and survival. Dysregulation of its expression and activity thus contributes to the development of diverse pathological conditions. PAK4 plays a pivotal role in cancer progression by accelerating the epithelial-mesenchymal transition, invasion, and metastasis. Therefore, PAK4 is regarded as an attractive therapeutic target in diverse types of cancers, prompting the development of PAK4-specific inhibitors as anticancer drugs; however, these drugs have not yet been successful. PAK4 is essential for embryonic brain development and has a neuroprotective function. A long list of PAK4 effectors has been reported. Recently, the transcription factor CREB has emerged as a novel effector of PAK4. This finding has broad implications for the role of PAK4 in health and disease because CREB-mediated transcriptional reprogramming involves a wide range of genes. In this article, we review the PAK4 signaling pathways involved in prostate cancer, Parkinson's disease, and melanogenesis, focusing in particular on the PAK4-CREB axis.
p21-Activated kinase 4 (PAK4), a member of the PAK family, regulates a wide range of cellular functions, including cell adhesion, migration, proliferation, and survival. Dysregulation of its expression and activity thus contributes to the development of diverse pathological conditions. PAK4 plays a pivotal role in cancer progression by accelerating the epithelial–mesenchymal transition, invasion, and metastasis. Therefore, PAK4 is regarded as an attractive therapeutic target in diverse types of cancers, prompting the development of PAK4-specific inhibitors as anticancer drugs; however, these drugs have not yet been successful. PAK4 is essential for embryonic brain development and has a neuroprotective function. A long list of PAK4 effectors has been reported. Recently, the transcription factor CREB has emerged as a novel effector of PAK4. This finding has broad implications for the role of PAK4 in health and disease because CREB-mediated transcriptional reprogramming involves a wide range of genes. In this article, we review the PAK4 signaling pathways involved in prostate cancer, Parkinson’s disease, and melanogenesis, focusing in particular on the PAK4-CREB axis. Gene expression: The role of a regulatory enzyme in disease An enzyme that regulates an important controller of gene expression may offer a therapeutic target for cancer and other diseases. cAMP response element-binding protein (CREB) interacts with various other proteins to switch a myriad of target genes on and off in different cells. A review by Eung-Gook Kim, Eun-Young Shin and colleagues at Chungbuk National University, Cheongju, South Korea, explores the interplay between CREB and an enzyme called p21-activated kinase 4 (PAK4) in human health and disease. PAK4, for example, has been shown to promote CREB’s gene-activating function in prostate cancer, and PAK4 overexpression is a feature of numerous other tumor types. Disruptions in PAK4-mediated regulation of CREB activity have also been observed in neurons affected by Parkinson’s disease. The authors see strong clinical promise in further exploring the biology of the PAK4-CREB pathway.
Author Shin, Eun-Young
Kim, Eung-Gook
Park, Jung-Jin
Won, So-Yoon
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  surname: Won
  fullname: Won, So-Yoon
  organization: Department of Biochemistry, Chungbuk National University College of Medicine
– sequence: 2
  givenname: Jung-Jin
  surname: Park
  fullname: Park, Jung-Jin
  organization: Department of Biochemistry, Chungbuk National University College of Medicine
– sequence: 3
  givenname: Eun-Young
  surname: Shin
  fullname: Shin, Eun-Young
  email: eyshin@chungbuk.ac.kr
  organization: Department of Biochemistry, Chungbuk National University College of Medicine
– sequence: 4
  givenname: Eung-Gook
  surname: Kim
  fullname: Kim, Eung-Gook
  email: egkim@chungbuk.ac.kr
  organization: Department of Biochemistry, Chungbuk National University College of Medicine
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30755582$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1146/annurev.biochem.68.1.821
10.1016/j.stem.2013.10.003
10.1593/tlo.11145
10.1158/1535-7163.MCT-16-0205
10.1093/hmg/3.7.1069
10.1016/j.molmed.2006.07.008
10.18632/oncotarget.7721
10.1111/j.1600-0625.2009.00846.x
10.1016/j.neuron.2010.12.004
10.4049/jimmunol.1001829
10.1242/jcs.00080
10.1186/s13287-015-0103-4
10.1186/s13046-015-0165-2
10.1038/nature06128
10.1158/1078-0432.CCR-12-3433
10.1111/j.1751-1097.2007.00226.x
10.1083/jcb.144.6.1235
10.1038/onc.2012.255
10.1159/000132570
10.1038/34681
10.1016/j.celrep.2017.05.042
10.1158/1541-7786.MCR-12-0466
10.1111/jnc.13731
10.1152/physrev.00026.2013
10.1074/jbc.M115.697292
10.1038/jid.2014.548
10.1083/jcb.201501072
10.1038/nrm3072
10.1038/ng0894-509
10.1074/jbc.271.35.20997
10.1111/pcmr.12080
10.1186/s13000-015-0404-z
10.1111/j.1755-148X.2010.00800.x
10.1042/bj3410211
10.1126/stke.2001.94.pe1
10.1038/466S2a
10.1038/oncsis.2013.13
10.1101/gad.14.3.301
10.1111/pcmr.12596
10.1111/j.1755-148X.2010.00760.x
10.1242/jcs.01631
10.1038/nature09159
10.1016/j.cmet.2009.06.006
10.1128/MCB.23.21.7838-7848.2003
10.1038/35085068
10.1016/j.cell.2006.12.045
10.1158/1535-7163.MCT-15-0039
10.1038/onc.2011.294
10.1097/MPA.0000000000000276
10.1038/367040a0
10.1007/978-3-642-58591-3_6
10.1038/onc.2011.247
10.3233/JPD-130230
10.1016/j.cell.2011.02.013
10.1016/j.bbamcr.2011.11.013
10.1042/BC20070109
10.1074/jbc.273.49.32377
10.1016/j.cancergencyto.2009.03.017
10.1111/pcmr.12257
10.1016/S0002-9440(10)63260-9
10.1186/s13041-016-0230-6
10.1016/j.mrrev.2010.06.002
10.1242/dev.125.24.4969
10.1111/j.1471-4159.2007.04933.x
10.1074/jbc.273.29.17983
10.1016/0092-8674(88)90571-5
10.18632/oncotarget.13309
10.1007/s10103-018-2455-3
10.1111/j.1349-7006.2009.01252.x
10.1038/ng882
10.1073/pnas.1717437115
10.1111/jnc.12949
10.1038/nrc3645
10.1101/gad.14.2.158
10.1091/mbc.e05-09-0896
10.1128/MCB.21.10.3523-3533.2001
10.1038/srep42575
10.1038/jid.2012.270
10.1006/excr.2000.4803
10.1038/jid.2013.235
10.1158/1078-0432.CCR-08-1137
10.1126/scitranslmed.aaf1629
10.2174/156800910791208535
10.1016/j.neuropharm.2016.03.012
10.1038/nature22815
10.1016/j.ejmech.2016.09.049
10.1038/s41388-018-0327-8
10.1021/acs.jafc.6b01785
10.1111/1523-1747.ep12395649
10.4161/cbt.7.11.6840
10.3389/fnana.2014.00159
10.1016/j.cellsig.2017.09.004
10.18632/oncotarget.9359
10.1371/journal.pgen.1004741
10.1016/S0960-9822(06)00052-2
10.1016/0960-7404(92)90088-3
10.1158/0008-5472.CAN-06-1996
10.1016/j.neuron.2014.08.049
10.1074/jbc.M100871200
10.3760/cma.j.issn.0366-6999.20130463
10.1101/cshperspect.a008029
10.5582/ddt.2016.01062
10.1042/BSR20130102
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References Zorov, Juhaszova, Sollott (CR61) 2014; 94
Ha, Boggon (CR6) 2018; 115
Bonaventure, Domingues, Larue (CR69) 2013; 26
Le Lay (CR105) 2009; 10
Almoguera (CR32) 1988; 53
Yu, Kanaan, Bae, Gabrielson (CR27) 2009; 193
Li (CR38) 2012; 1823
Horike (CR96) 2010; 23
Radu, Semenova, Kosoff, Chernoff (CR101) 2014; 14
Scherer, Kumar (CR102) 2010; 705
Grayson (CR51) 2010; 466
Tanner (CR54) 2003; 91
Yamada (CR84) 2013; 133
Chenette, Mitin, Der (CR5) 2006; 17
Qu (CR31) 2001; 21
Lazaro (CR57) 2014; 10
Huang (CR47) 2006; 66
Won (CR49) 2016; 8
Kim (CR63) 2016; 9
Park (CR30) 2018; 37
Pillaiyar, Manickam, Jung (CR94) 2017; 40
Taira, Nguyen, Be Tu, Tawata (CR100) 2016; 64
Bose, Beal (CR60) 2016; 139
Steven, Seliger (CR45) 2016; 7
Martin, Kim, Dawson, Dawson (CR59) 2014; 131
Zhu (CR17) 2012; 31
Danzer, Schnack, Sutcliffe, Hengerer, Gillardon (CR58) 2007; 103
Manser, Leung, Salihuddin, Zhao, Lim (CR1) 1994; 367
Nonaka (CR12) 2014; 84
Mills, Fishman, Rom, Dubin, Jacobson (CR34) 1995; 55
Thillai, Lam, Sarker, Wells (CR37) 2017; 8
Be (CR99) 2017; 10
Wen, Sakamoto, Miller (CR10) 2010; 185
Dentin (CR104) 2007; 449
Mayr, Montminy (CR9) 2001; 2
Dan, Kelly, Bernard, Minden (CR39) 2001; 276
Boughdady, Kinsella, Haboubi, Schofield (CR33) 1992; 1
Meylan, Halfon, Magistretti, Cardinaux (CR68) 2016; 107
Begum (CR28) 2009; 100
Garcia-Borron, Abdel-Malek, Jimenez-Cervantes (CR72) 2014; 27
Thommes, Lennartsson, Carlberg, Ronnstrand (CR91) 1999; 341
Davis (CR24) 2015; 14
Sasaki (CR66) 2011; 69
Sakamoto, Frank (CR46) 2009; 15
Warner, Schapira (CR55) 2003; 53
Ikeya, Takada (CR77) 1998; 125
Nobes, Hall (CR2) 1999; 144
DesMarais, Ghosh, Eddy, Condeelis (CR40) 2005; 118
Mujahid (CR97) 2017; 19
Tassabehji (CR75) 1994; 3
Dias, Junn, Mouradian (CR62) 2013; 3
Xue, Wang, Wang, Zhang (CR67) 2015; 67
Vershinin, Feldman, Chen, Levy (CR18) 2016; 291
Dart (CR42) 2015; 211
Altarejos, Montminy (CR65) 2011; 12
Lu, Katz, Gupta, Mayer (CR44) 1997; 7
Hachiya (CR87) 2004; 165
Mantamadiotis (CR64) 2002; 31
Brenner, Hearing (CR70) 2008; 84
Aboukameel (CR107) 2017; 16
Ahn (CR20) 2011; 4
Gu (CR95) 2012; 31
CR76
Manser, Lim (CR3) 1999; 22
Price (CR90) 1998; 273
Gnesutta, Minden (CR41) 2003; 23
Yeo, He, Baldwin, Nikfarjam (CR29) 2015; 44
Yun (CR85) 2015; 135
Hemesath, Price, Takemoto, Badalian, Fisher (CR89) 1998; 391
Bang (CR98) 2017; 30
Grabbe (CR86) 1994; 103
Hanahan, Weinberg (CR13) 2011; 144
Shi (CR78) 2015; 6
Tabusa, Brooks, Massey (CR14) 2013; 11
Sang (CR48) 2016; 7
Shaywitz, Greenberg (CR11) 1999; 68
Hughes, Newton, Liu, Read (CR74) 1994; 7
Dorsky, Raible, Moon (CR82) 2000; 14
Kim (CR23) 2008; 29
Xiao, Li, Mitton, Ikeda, Sakamoto (CR50) 2010; 10
Han (CR79) 2018; 33
Chen (CR25) 2008; 7
Galisteo, Chernoff, Su, Skolnik, Schlessinger (CR43) 1996; 271
Recasens, Dehay (CR56) 2014; 8
CR16
Cai (CR22) 2015; 34
Park (CR21) 2013; 32
Fernandez (CR103) 2009; 18
Kravitz (CR53) 2010; 466
Davis (CR26) 2013; 19
Wen (CR88) 2013; 126
Arias-Romero, Chernoff (CR4) 2008; 100
Wells, Abo, Ridley (CR15) 2002; 115
Xu (CR93) 2000; 255
Wu (CR92) 2000; 14
Cui (CR71) 2007; 128
Bellei, Pitisci, Catricala, Larue, Picardo (CR81) 2011; 24
King (CR35) 2017; 7
Asati, Mahapatra, Bharti (CR106) 2017; 125
Du, Montminy (CR7) 1998; 273
Choi (CR80) 2013; 13
Kim, Lee, Lee (CR83) 2013; 133
Wong, Chen, Karantza, Minden (CR19) 2013; 2
Levy, Khaled, Fisher (CR73) 2006; 12
Shu, Wu, Sun, Chi, Wang (CR36) 2015; 10
Finkbeiner (CR8) 2001; 2001
Sulzer (CR52) 2017; 546
T Mantamadiotis (204_CR64) 2002; 31
AE Hughes (204_CR74) 1994; 7
DF Lazaro (204_CR57) 2014; 10
R Cui (204_CR71) 2007; 128
X Xiao (204_CR50) 2010; 10
M Wu (204_CR92) 2000; 14
LE Wong (204_CR19) 2013; 2
SJ Davis (204_CR26) 2013; 19
A Bose (204_CR60) 2016; 139
Z Vershinin (204_CR18) 2016; 291
CY Yun (204_CR85) 2015; 135
K Du (204_CR7) 1998; 273
DB Zorov (204_CR61) 2014; 94
M Sang (204_CR48) 2016; 7
N Mujahid (204_CR97) 2017; 19
EM Meylan (204_CR68) 2016; 107
D Scherer (204_CR102) 2010; 705
S Bang (204_CR98) 2017; 30
J Le Lay (204_CR105) 2009; 10
B Mayr (204_CR9) 2001; 2
M Nonaka (204_CR12) 2014; 84
JH Kim (204_CR23) 2008; 29
RI Dorsky (204_CR82) 2000; 14
H Kim (204_CR63) 2016; 9
E Manser (204_CR1) 1994; 367
G Zhu (204_CR17) 2012; 31
JC Garcia-Borron (204_CR72) 2014; 27
M Tassabehji (204_CR75) 1994; 3
M Brenner (204_CR70) 2008; 84
V Dias (204_CR62) 2013; 3
S Chen (204_CR25) 2008; 7
TJ Hemesath (204_CR89) 1998; 391
V Asati (204_CR106) 2017; 125
S Finkbeiner (204_CR8) 2001; 2001
A Begum (204_CR28) 2009; 100
ML Galisteo (204_CR43) 1996; 271
204_CR76
M Radu (204_CR101) 2014; 14
B Bellei (204_CR81) 2011; 24
CD Nobes (204_CR2) 1999; 144
JJ Park (204_CR30) 2018; 37
D Yeo (204_CR29) 2015; 44
TuPT Be (204_CR99) 2017; 10
MH Park (204_CR21) 2013; 32
K Thillai (204_CR37) 2017; 8
S Cai (204_CR22) 2015; 34
SJ Davis (204_CR24) 2015; 14
I Martin (204_CR59) 2014; 131
AJ Shaywitz (204_CR11) 1999; 68
ZC Xue (204_CR67) 2015; 67
AV Kravitz (204_CR53) 2010; 466
CM Wells (204_CR15) 2002; 115
H Tabusa (204_CR14) 2013; 11
YS Choi (204_CR80) 2013; 13
T Sasaki (204_CR66) 2011; 69
XR Shu (204_CR36) 2015; 10
L Han (204_CR79) 2018; 33
JY Kim (204_CR83) 2013; 133
W Yu (204_CR27) 2009; 193
LE Arias-Romero (204_CR4) 2008; 100
T Pillaiyar (204_CR94) 2017; 40
204_CR16
KM Sakamoto (204_CR46) 2009; 15
C Levy (204_CR73) 2006; 12
TT Warner (204_CR55) 2003; 53
J Qu (204_CR31) 2001; 21
W Lu (204_CR44) 1997; 7
T Yamada (204_CR84) 2013; 133
A Aboukameel (204_CR107) 2017; 16
M Ikeya (204_CR77) 1998; 125
V DesMarais (204_CR40) 2005; 118
Y Gu (204_CR95) 2012; 31
EJ Chenette (204_CR5) 2006; 17
AE Dart (204_CR42) 2015; 211
BH Ha (204_CR6) 2018; 115
C Almoguera (204_CR32) 1988; 53
IS Boughdady (204_CR33) 1992; 1
N Gnesutta (204_CR41) 2003; 23
JY Altarejos (204_CR65) 2011; 12
R Dentin (204_CR104) 2007; 449
W Xu (204_CR93) 2000; 255
A Recasens (204_CR56) 2014; 8
H King (204_CR35) 2017; 7
D Hanahan (204_CR13) 2011; 144
M Grayson (204_CR51) 2010; 466
N Horike (204_CR96) 2010; 23
CM Tanner (204_CR54) 2003; 91
J Grabbe (204_CR86) 1994; 103
WC Huang (204_CR47) 2006; 66
NE Mills (204_CR34) 1995; 55
ER Price (204_CR90) 1998; 273
J Bonaventure (204_CR69) 2013; 26
LP Fernandez (204_CR103) 2009; 18
C Dan (204_CR39) 2001; 276
SY Won (204_CR49) 2016; 8
K Thommes (204_CR91) 1999; 341
D Sulzer (204_CR52) 2017; 546
E Manser (204_CR3) 1999; 22
A Steven (204_CR45) 2016; 7
KM Danzer (204_CR58) 2007; 103
Y Shi (204_CR78) 2015; 6
A Hachiya (204_CR87) 2004; 165
AY Wen (204_CR10) 2010; 185
N Taira (204_CR100) 2016; 64
HK Ahn (204_CR20) 2011; 4
Y Li (204_CR38) 2012; 1823
GD Wen (204_CR88) 2013; 126
References_xml – volume: 68
  start-page: 821
  year: 1999
  end-page: 861
  ident: CR11
  article-title: CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals
  publication-title: Annu. Rev. Biochem.
  doi: 10.1146/annurev.biochem.68.1.821
– volume: 13
  start-page: 720
  year: 2013
  end-page: 733
  ident: CR80
  article-title: Distinct functions for Wnt/beta-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2013.10.003
– volume: 4
  start-page: 345
  year: 2011
  end-page: 349
  ident: CR20
  article-title: P21-activated kinase 4 overexpression in metastatic gastric cancer patients
  publication-title: Transl. Oncol.
  doi: 10.1593/tlo.11145
– volume: 16
  start-page: 76
  year: 2017
  end-page: 87
  ident: CR107
  article-title: Novel p21-activated kinase 4 (PAK4) allosteric modulators overcome drug resistance and stemness in pancreatic ductal adenocarcinoma
  publication-title: Mol. Cancer Ther.
  doi: 10.1158/1535-7163.MCT-16-0205
– volume: 3
  start-page: 1069
  year: 1994
  end-page: 1074
  ident: CR75
  article-title: PAX3 gene structure and mutations: close analogies between Waardenburg syndrome and the Splotch mouse
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/3.7.1069
– volume: 67
  start-page: 155
  year: 2015
  end-page: 162
  ident: CR67
  article-title: CREB-regulated transcription coactivator 1: important roles in neurodegenerative disorders
  publication-title: Sheng Li Xue Bao
– volume: 12
  start-page: 406
  year: 2006
  end-page: 414
  ident: CR73
  article-title: MITF: master regulator of melanocyte development and melanoma oncogene
  publication-title: Trends Mol. Med.
  doi: 10.1016/j.molmed.2006.07.008
– ident: CR16
– volume: 7
  start-page: 35454
  year: 2016
  end-page: 35465
  ident: CR45
  article-title: Control of CREB expression in tumors: from molecular mechanisms and signal transduction pathways to therapeutic target
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.7721
– volume: 91
  start-page: 133
  year: 2003
  end-page: 142
  ident: CR54
  article-title: Is the cause of Parkinson’s disease environmental or hereditary? Evidence from twin studies
  publication-title: Adv. Neurol.
– volume: 18
  start-page: 634
  year: 2009
  end-page: 642
  ident: CR103
  article-title: Pigmentation-related genes and their implication in malignant melanoma susceptibility
  publication-title: Exp. Dermatol.
  doi: 10.1111/j.1600-0625.2009.00846.x
– volume: 69
  start-page: 106
  year: 2011
  end-page: 119
  ident: CR66
  article-title: SIK2 is a key regulator for neuronal survival after ischemia via TORC1-CREB
  publication-title: Neuron
  doi: 10.1016/j.neuron.2010.12.004
– volume: 185
  start-page: 6413
  year: 2010
  end-page: 6419
  ident: CR10
  article-title: The role of the transcription factor CREB in immune function
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1001829
– volume: 115
  start-page: 3947
  year: 2002
  end-page: 3956
  ident: CR15
  article-title: PAK4 is activated via PI3K in HGF-stimulated epithelial cells
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.00080
– volume: 6
  start-page: 120
  year: 2015
  ident: CR78
  article-title: Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately
  publication-title: Stem Cell Res. Ther.
  doi: 10.1186/s13287-015-0103-4
– volume: 34
  start-page: 48
  year: 2015
  ident: CR22
  article-title: Overexpression of P21-activated kinase 4 is associated with poor prognosis in non-small cell lung cancer and promotes migration and invasion
  publication-title: J. Exp. Clin. Cancer Res.
  doi: 10.1186/s13046-015-0165-2
– volume: 449
  start-page: 366
  year: 2007
  end-page: 369
  ident: CR104
  article-title: Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2
  publication-title: Nature
  doi: 10.1038/nature06128
– volume: 19
  start-page: 1411
  year: 2013
  end-page: 1421
  ident: CR26
  article-title: Functional analysis of genes in regions commonly amplified in high-grade serous and endometrioid ovarian cancer
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-12-3433
– volume: 84
  start-page: 539
  year: 2008
  end-page: 549
  ident: CR70
  article-title: The protective role of melanin against UV damage in human skin
  publication-title: Photochem. Photobiol.
  doi: 10.1111/j.1751-1097.2007.00226.x
– volume: 144
  start-page: 1235
  year: 1999
  end-page: 1244
  ident: CR2
  article-title: Rho GTPases control polarity, protrusion, and adhesion during cell movement
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.144.6.1235
– volume: 32
  start-page: 2475
  year: 2013
  end-page: 2482
  ident: CR21
  article-title: p21-Activated kinase 4 promotes prostate cancer progression through CREB
  publication-title: Oncogene
  doi: 10.1038/onc.2012.255
– volume: 29
  start-page: 41
  year: 2008
  end-page: 49
  ident: CR23
  article-title: Gene expression profiles in gallbladder cancer: the close genetic similarity seen for early and advanced gallbladder cancers may explain the poor prognosis
  publication-title: Tumour Biol.
  doi: 10.1159/000132570
– volume: 55
  start-page: 1444
  year: 1995
  end-page: 1447
  ident: CR34
  article-title: Increased prevalence of K-ras oncogene mutations in lung adenocarcinoma
  publication-title: Cancer Res.
– volume: 391
  start-page: 298
  year: 1998
  end-page: 301
  ident: CR89
  article-title: MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes
  publication-title: Nature
  doi: 10.1038/34681
– volume: 19
  start-page: 2177
  year: 2017
  end-page: 2184
  ident: CR97
  article-title: A UV-independent topical small-molecule approach for melanin production in human skin
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2017.05.042
– volume: 11
  start-page: 109
  year: 2013
  end-page: 121
  ident: CR14
  article-title: Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling
  publication-title: Mol. Cancer Res.
  doi: 10.1158/1541-7786.MCR-12-0466
– volume: 139
  start-page: 216
  issue: Suppl 1
  year: 2016
  end-page: 231
  ident: CR60
  article-title: Mitochondrial dysfunction in Parkinson’s disease
  publication-title: J. Neurochem.
  doi: 10.1111/jnc.13731
– volume: 94
  start-page: 909
  year: 2014
  end-page: 950
  ident: CR61
  article-title: Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00026.2013
– volume: 291
  start-page: 6786
  year: 2016
  end-page: 6795
  ident: CR18
  article-title: PAK4 methylation by SETD6 promotes the activation of the Wnt/beta-catenin pathway
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M115.697292
– volume: 135
  start-page: 1385
  year: 2015
  end-page: 1394
  ident: CR85
  article-title: p21-activated kinase 4 critically regulates melanogenesis via activation of the CREB/MITF and beta-catenin/MITF pathways
  publication-title: J. Invest. Dermatol.
  doi: 10.1038/jid.2014.548
– volume: 211
  start-page: 863
  year: 2015
  end-page: 879
  ident: CR42
  article-title: PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201501072
– volume: 12
  start-page: 141
  year: 2011
  end-page: 151
  ident: CR65
  article-title: CREB and the CRTC co-activators: sensors for hormonal and metabolic signals
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3072
– volume: 7
  start-page: 509
  year: 1994
  end-page: 512
  ident: CR74
  article-title: A gene for Waardenburg syndrome type 2 maps close to the human homologue of the microphthalmia gene at chromosome 3p12-p14.1
  publication-title: Nat. Genet.
  doi: 10.1038/ng0894-509
– volume: 271
  start-page: 20997
  year: 1996
  end-page: 21000
  ident: CR43
  article-title: The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.271.35.20997
– volume: 26
  start-page: 316
  year: 2013
  end-page: 325
  ident: CR69
  article-title: Cellular and molecular mechanisms controlling the migration of melanocytes and melanoma cells
  publication-title: Pigment Cell Melanoma Res.
  doi: 10.1111/pcmr.12080
– volume: 10
  start-page: 177
  year: 2015
  ident: CR36
  article-title: PAK4 confers the malignance of cervical cancers and contributes to the cisplatin-resistance in cervical cancer cells via PI3K/AKT pathway
  publication-title: Diagn. Pathol.
  doi: 10.1186/s13000-015-0404-z
– volume: 24
  start-page: 309
  year: 2011
  end-page: 325
  ident: CR81
  article-title: Wnt/beta-catenin signaling is stimulated by alpha-melanocyte-stimulating hormone in melanoma and melanocyte cells: implication in cell differentiation
  publication-title: Pigment Cell Melanoma Res.
  doi: 10.1111/j.1755-148X.2010.00800.x
– volume: 341
  start-page: 211
  issue: Pt 1
  year: 1999
  end-page: 216
  ident: CR91
  article-title: Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor
  publication-title: Biochem. J.
  doi: 10.1042/bj3410211
– volume: 2001
  start-page: pe1
  year: 2001
  ident: CR8
  article-title: New roles for introns: sites of combinatorial regulation of Ca2 + - and cyclic AMP-dependent gene transcription
  publication-title: Sci. STKE
  doi: 10.1126/stke.2001.94.pe1
– volume: 466
  start-page: S1
  year: 2010
  ident: CR51
  article-title: Parkinson’s disease
  publication-title: Nature
  doi: 10.1038/466S2a
– volume: 2
  year: 2013
  ident: CR19
  article-title: The Pak4 protein kinase is required for oncogenic transformation of MDA-MB-231 breast cancer cells
  publication-title: Oncogenesis
  doi: 10.1038/oncsis.2013.13
– volume: 14
  start-page: 301
  year: 2000
  end-page: 312
  ident: CR92
  article-title: c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi
  publication-title: Genes Dev.
  doi: 10.1101/gad.14.3.301
– volume: 30
  start-page: 553
  year: 2017
  end-page: 557
  ident: CR98
  article-title: Novel regulation of melanogenesis by adiponectin via the AMPK/CRTC pathway
  publication-title: Pigment Cell Melanoma Res.
  doi: 10.1111/pcmr.12596
– volume: 23
  start-page: 809
  year: 2010
  end-page: 819
  ident: CR96
  article-title: Downregulation of SIK2 expression promotes the melanogenic program in mice
  publication-title: Pigment Cell Melanoma Res.
  doi: 10.1111/j.1755-148X.2010.00760.x
– volume: 118
  start-page: 19
  year: 2005
  end-page: 26
  ident: CR40
  article-title: Cofilin takes the lead
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.01631
– volume: 466
  start-page: 622
  year: 2010
  end-page: 626
  ident: CR53
  article-title: Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry
  publication-title: Nature
  doi: 10.1038/nature09159
– volume: 10
  start-page: 55
  year: 2009
  end-page: 62
  ident: CR105
  article-title: CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2009.06.006
– volume: 23
  start-page: 7838
  year: 2003
  end-page: 7848
  ident: CR41
  article-title: Death receptor-induced activation of initiator caspase 8 is antagonized by serine/threonine kinase PAK4
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.23.21.7838-7848.2003
– volume: 2
  start-page: 599
  year: 2001
  end-page: 609
  ident: CR9
  article-title: Transcriptional regulation by the phosphorylation-dependent factor CREB
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/35085068
– volume: 128
  start-page: 853
  year: 2007
  end-page: 864
  ident: CR71
  article-title: Central role of p53 in the suntan response and pathologic hyperpigmentation
  publication-title: Cell
  doi: 10.1016/j.cell.2006.12.045
– volume: 14
  start-page: 1495
  year: 2015
  end-page: 1503
  ident: CR24
  article-title: Enhanced GAB2 expression is associated with improved survival in high-grade serous ovarian cancer and sensitivity to PI3K inhibition
  publication-title: Mol. Cancer Ther.
  doi: 10.1158/1535-7163.MCT-15-0039
– volume: 31
  start-page: 1001
  year: 2012
  end-page: 1012
  ident: CR17
  article-title: A Rac1/PAK1 cascade controls beta-catenin activation in colon cancer cells
  publication-title: Oncogene
  doi: 10.1038/onc.2011.294
– volume: 44
  start-page: 363
  year: 2015
  end-page: 369
  ident: CR29
  article-title: The role of p21-activated kinases in pancreatic cancer
  publication-title: Pancreas
  doi: 10.1097/MPA.0000000000000276
– volume: 367
  start-page: 40
  year: 1994
  end-page: 46
  ident: CR1
  article-title: A brain serine/threonine protein kinase activated by Cdc42 and Rac1
  publication-title: Nature
  doi: 10.1038/367040a0
– volume: 22
  start-page: 115
  year: 1999
  end-page: 133
  ident: CR3
  article-title: Roles of PAK family kinases
  publication-title: Prog. Mol. Subcell. Biol.
  doi: 10.1007/978-3-642-58591-3_6
– volume: 31
  start-page: 469
  year: 2012
  end-page: 479
  ident: CR95
  article-title: Altered LKB1/CREB-regulated transcription co-activator (CRTC) signaling axis promotes esophageal cancer cell migration and invasion
  publication-title: Oncogene
  doi: 10.1038/onc.2011.247
– volume: 3
  start-page: 461
  year: 2013
  end-page: 491
  ident: CR62
  article-title: The role of oxidative stress in Parkinson’s disease
  publication-title: J. Parkinsons Dis.
  doi: 10.3233/JPD-130230
– volume: 144
  start-page: 646
  year: 2011
  end-page: 674
  ident: CR13
  article-title: Hallmarks of cancer: the next generation
  publication-title: Cell
  doi: 10.1016/j.cell.2011.02.013
– volume: 1823
  start-page: 465
  year: 2012
  end-page: 475
  ident: CR38
  article-title: Nucleo-cytoplasmic shuttling of PAK4 modulates beta-catenin intracellular translocation and signaling
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbamcr.2011.11.013
– volume: 100
  start-page: 97
  year: 2008
  end-page: 108
  ident: CR4
  article-title: A tale of two Paks
  publication-title: Biol. Cell
  doi: 10.1042/BC20070109
– volume: 273
  start-page: 32377
  year: 1998
  end-page: 32379
  ident: CR7
  article-title: CREB is a regulatory target for the protein kinase Akt/PKB
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.273.49.32377
– volume: 193
  start-page: 29
  year: 2009
  end-page: 37
  ident: CR27
  article-title: Chromosomal changes in aggressive breast cancers with basal-like features
  publication-title: Cancer Genet. Cytogenet.
  doi: 10.1016/j.cancergencyto.2009.03.017
– volume: 27
  start-page: 699
  year: 2014
  end-page: 720
  ident: CR72
  article-title: MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation
  publication-title: Pigment Cell Melanoma Res.
  doi: 10.1111/pcmr.12257
– volume: 165
  start-page: 2099
  year: 2004
  end-page: 2109
  ident: CR87
  article-title: Biphasic expression of two paracrine melanogenic cytokines, stem cell factor and endothelin-1, in ultraviolet B-induced human melanogenesis
  publication-title: Am. J. Pathol.
  doi: 10.1016/S0002-9440(10)63260-9
– volume: 9
  start-page: 45
  year: 2016
  end-page: 46
  ident: CR63
  article-title: Down-regulation of p21-activated serine/threonine kinase 1 is involved in loss of mesencephalic dopamine neurons
  publication-title: Mol. Brain
  doi: 10.1186/s13041-016-0230-6
– volume: 705
  start-page: 141
  year: 2010
  end-page: 153
  ident: CR102
  article-title: Genetics of pigmentation in skin cancer--a review
  publication-title: Mutat. Res.
  doi: 10.1016/j.mrrev.2010.06.002
– volume: 53
  start-page: S23
  issue: Suppl 3
  year: 2003
  end-page: 15
  ident: CR55
  article-title: Genetic and environmental factors in the cause of Parkinson’s disease
  publication-title: Ann. Neurol.
– volume: 125
  start-page: 4969
  year: 1998
  end-page: 4976
  ident: CR77
  article-title: Wnt signaling from the dorsal neural tube is required for the formation of the medial dermomyotome
  publication-title: Development
  doi: 10.1242/dev.125.24.4969
– volume: 103
  start-page: 2401
  year: 2007
  end-page: 2407
  ident: CR58
  article-title: Functional protein kinase arrays reveal inhibition of p-21-activated kinase 4 by alpha-synuclein oligomers
  publication-title: J. Neurochem.
  doi: 10.1111/j.1471-4159.2007.04933.x
– volume: 273
  start-page: 17983
  year: 1998
  end-page: 17986
  ident: CR90
  article-title: Lineage-specific signaling in melanocytes. C-kit stimulation recruits p300/CBP to microphthalmia
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.273.29.17983
– volume: 10
  start-page: 314
  year: 2017
  end-page: 322
  ident: CR99
  article-title: The serum/PDGF-dependent “melanogenic” role of the minute level of the oncogenic kinase PAK1 in melanoma cells proven by the highly sensitive kinase assay
  publication-title: Drug Discov. Ther.
– volume: 53
  start-page: 549
  year: 1988
  end-page: 554
  ident: CR32
  article-title: Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
  publication-title: Cell
  doi: 10.1016/0092-8674(88)90571-5
– volume: 8
  start-page: 14173
  year: 2017
  end-page: 14191
  ident: CR37
  article-title: Deciphering the link between PI3K and PAK: an opportunity to target key pathways in pancreatic cancer?
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.13309
– volume: 33
  start-page: 637
  year: 2018
  end-page: 645
  ident: CR79
  article-title: Activation of Wnt/beta-catenin signaling is involved in hair growth-promoting effect of 655-nm red light and LED in in vitro culture model
  publication-title: Lasers Med. Sci.
  doi: 10.1007/s10103-018-2455-3
– volume: 100
  start-page: 1908
  year: 2009
  end-page: 1916
  ident: CR28
  article-title: Identification of PAK4 as a putative target gene for amplification within 19q13.12-q13.2 in oral squamous-cell carcinoma
  publication-title: Cancer Sci.
  doi: 10.1111/j.1349-7006.2009.01252.x
– volume: 31
  start-page: 47
  year: 2002
  end-page: 54
  ident: CR64
  article-title: Disruption of CREB function in brain leads to neurodegeneration
  publication-title: Nat. Genet.
  doi: 10.1038/ng882
– volume: 115
  start-page: 531
  year: 2018
  end-page: 536
  ident: CR6
  article-title: CDC42 binds PAK4 via an extended GTPase-effector interface
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1717437115
– volume: 131
  start-page: 554
  year: 2014
  end-page: 565
  ident: CR59
  article-title: LRRK2 pathobiology in Parkinson’s disease
  publication-title: J. Neurochem.
  doi: 10.1111/jnc.12949
– volume: 14
  start-page: 13
  year: 2014
  end-page: 25
  ident: CR101
  article-title: PAK signalling during the development and progression of cancer
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc3645
– volume: 14
  start-page: 158
  year: 2000
  end-page: 162
  ident: CR82
  article-title: Direct regulation of nacre, a zebrafish MITF homolog required for pigment cell formation, by the Wnt pathway
  publication-title: Genes Dev.
  doi: 10.1101/gad.14.2.158
– volume: 17
  start-page: 3108
  year: 2006
  end-page: 3121
  ident: CR5
  article-title: Multiple sequence elements facilitate Chp Rho GTPase subcellular location, membrane association, and transforming activity
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e05-09-0896
– volume: 21
  start-page: 3523
  year: 2001
  end-page: 3533
  ident: CR31
  article-title: Activated PAK4 regulates cell adhesion and anchorage-independent growth
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.21.10.3523-3533.2001
– volume: 7
  year: 2017
  ident: CR35
  article-title: PAK4 interacts with p85 alpha: implications for pancreatic cancer cell migration
  publication-title: Sci. Rep.
  doi: 10.1038/srep42575
– volume: 133
  start-page: 191
  year: 2013
  end-page: 200
  ident: CR83
  article-title: Reduced WIF-1 expression stimulates skin hyperpigmentation in patients with melasma
  publication-title: J. Invest. Dermatol.
  doi: 10.1038/jid.2012.270
– volume: 255
  start-page: 135
  year: 2000
  end-page: 143
  ident: CR93
  article-title: Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9
  publication-title: Exp. Cell Res.
  doi: 10.1006/excr.2000.4803
– volume: 133
  start-page: 2753
  year: 2013
  end-page: 2762
  ident: CR84
  article-title: Wnt/beta-catenin and kit signaling sequentially regulate melanocyte stem cell differentiation in UVB-induced epidermal pigmentation
  publication-title: J. Invest. Dermatol.
  doi: 10.1038/jid.2013.235
– volume: 15
  start-page: 2583
  year: 2009
  end-page: 2587
  ident: CR46
  article-title: CREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapy
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-08-1137
– volume: 8
  start-page: 367ra170
  year: 2016
  ident: CR49
  article-title: Nigral dopaminergic PAK4 prevents neurodegeneration in rat models of Parkinson’s disease
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.aaf1629
– volume: 10
  start-page: 384
  year: 2010
  end-page: 391
  ident: CR50
  article-title: Targeting CREB for cancer therapy: friend or foe
  publication-title: Curr. Cancer Drug Targets
  doi: 10.2174/156800910791208535
– volume: 107
  start-page: 111
  year: 2016
  end-page: 121
  ident: CR68
  article-title: The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: possible relevance for treatment-resistant depression
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2016.03.012
– volume: 546
  start-page: 656
  year: 2017
  end-page: 661
  ident: CR52
  article-title: T cells from patients with Parkinson’s disease recognize alpha-synuclein peptides
  publication-title: Nature
  doi: 10.1038/nature22815
– volume: 125
  start-page: 299
  year: 2017
  end-page: 314
  ident: CR106
  article-title: K-Ras and its inhibitors towards personalized cancer treatment: pharmacological and structural perspectives
  publication-title: Eur. J. Med. Chem.
  doi: 10.1016/j.ejmech.2016.09.049
– volume: 37
  start-page: 5147
  year: 2018
  end-page: 5159
  ident: CR30
  article-title: The p21-activated kinase 4-Slug transcription factor axis promotes epithelial-mesenchymal transition and worsens prognosis in prostate cancer
  publication-title: Oncogene
  doi: 10.1038/s41388-018-0327-8
– volume: 64
  start-page: 5484
  year: 2016
  end-page: 5489
  ident: CR100
  article-title: Effect of okinawa propolis on PAK1 activity, Caenorhabditis elegans longevity, melanogenesis, and growth of cancer cells
  publication-title: J. Agric. Food Chem.
  doi: 10.1021/acs.jafc.6b01785
– volume: 103
  start-page: 504
  year: 1994
  end-page: 508
  ident: CR86
  article-title: Comparative cytokine release from human monocytes, monocyte-derived immature mast cells, and a human mast cell line (HMC-1)
  publication-title: J. Invest. Dermatol.
  doi: 10.1111/1523-1747.ep12395649
– volume: 7
  start-page: 1793
  year: 2008
  end-page: 1802
  ident: CR25
  article-title: Copy number alterations in pancreatic cancer identify recurrent PAK4 amplification
  publication-title: Cancer Biol. Ther.
  doi: 10.4161/cbt.7.11.6840
– volume: 8
  start-page: 159
  year: 2014
  ident: CR56
  article-title: Alpha-synuclein spreading in Parkinson’s disease
  publication-title: Front. Neuroanat.
  doi: 10.3389/fnana.2014.00159
– volume: 126
  start-page: 2325
  year: 2013
  end-page: 2328
  ident: CR88
  article-title: A novel mutation of the KIT gene in a Chinese family with piebaldism
  publication-title: Chin. Med. J.
– volume: 40
  start-page: 99
  year: 2017
  end-page: 115
  ident: CR94
  article-title: Recent development of signaling pathways inhibitors of melanogenesis
  publication-title: Cell. Signal.
  doi: 10.1016/j.cellsig.2017.09.004
– volume: 7
  start-page: 45171
  year: 2016
  end-page: 45185
  ident: CR48
  article-title: GRK3 is a direct target of CREB activation and regulates neuroendocrine differentiation of prostate cancer cells
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.9359
– volume: 10
  start-page: e1004741
  year: 2014
  ident: CR57
  article-title: Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1004741
– volume: 7
  start-page: 85
  year: 1997
  end-page: 94
  ident: CR44
  article-title: Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck
  publication-title: Curr. Biol.
  doi: 10.1016/S0960-9822(06)00052-2
– ident: CR76
– volume: 1
  start-page: 275
  year: 1992
  end-page: 282
  ident: CR33
  article-title: K-ras gene mutations in adenomas and carcinomas of the colon
  publication-title: Surg. Oncol.
  doi: 10.1016/0960-7404(92)90088-3
– volume: 66
  start-page: 9108
  year: 2006
  end-page: 9116
  ident: CR47
  article-title: beta2-microglobulin is a signaling and growth-promoting factor for human prostate cancer bone metastasis
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-06-1996
– volume: 84
  start-page: 92
  year: 2014
  end-page: 106
  ident: CR12
  article-title: Region-specific activation of CRTC1-CREB signaling mediates long-term fear memory
  publication-title: Neuron
  doi: 10.1016/j.neuron.2014.08.049
– volume: 276
  start-page: 32115
  year: 2001
  end-page: 32121
  ident: CR39
  article-title: Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M100871200
– volume: 107
  start-page: 111
  year: 2016
  ident: 204_CR68
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2016.03.012
– volume: 291
  start-page: 6786
  year: 2016
  ident: 204_CR18
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M115.697292
– volume: 193
  start-page: 29
  year: 2009
  ident: 204_CR27
  publication-title: Cancer Genet. Cytogenet.
  doi: 10.1016/j.cancergencyto.2009.03.017
– volume: 84
  start-page: 539
  year: 2008
  ident: 204_CR70
  publication-title: Photochem. Photobiol.
  doi: 10.1111/j.1751-1097.2007.00226.x
– volume: 115
  start-page: 531
  year: 2018
  ident: 204_CR6
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1717437115
– volume: 31
  start-page: 47
  year: 2002
  ident: 204_CR64
  publication-title: Nat. Genet.
  doi: 10.1038/ng882
– volume: 705
  start-page: 141
  year: 2010
  ident: 204_CR102
  publication-title: Mutat. Res.
  doi: 10.1016/j.mrrev.2010.06.002
– volume: 3
  start-page: 1069
  year: 1994
  ident: 204_CR75
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/3.7.1069
– volume: 103
  start-page: 2401
  year: 2007
  ident: 204_CR58
  publication-title: J. Neurochem.
  doi: 10.1111/j.1471-4159.2007.04933.x
– volume: 4
  start-page: 345
  year: 2011
  ident: 204_CR20
  publication-title: Transl. Oncol.
  doi: 10.1593/tlo.11145
– volume: 126
  start-page: 2325
  year: 2013
  ident: 204_CR88
  publication-title: Chin. Med. J.
  doi: 10.3760/cma.j.issn.0366-6999.20130463
– volume: 27
  start-page: 699
  year: 2014
  ident: 204_CR72
  publication-title: Pigment Cell Melanoma Res.
  doi: 10.1111/pcmr.12257
– volume: 3
  start-page: 461
  year: 2013
  ident: 204_CR62
  publication-title: J. Parkinsons Dis.
  doi: 10.3233/JPD-130230
– volume: 466
  start-page: 622
  year: 2010
  ident: 204_CR53
  publication-title: Nature
  doi: 10.1038/nature09159
– volume: 100
  start-page: 1908
  year: 2009
  ident: 204_CR28
  publication-title: Cancer Sci.
  doi: 10.1111/j.1349-7006.2009.01252.x
– volume: 255
  start-page: 135
  year: 2000
  ident: 204_CR93
  publication-title: Exp. Cell Res.
  doi: 10.1006/excr.2000.4803
– volume: 18
  start-page: 634
  year: 2009
  ident: 204_CR103
  publication-title: Exp. Dermatol.
  doi: 10.1111/j.1600-0625.2009.00846.x
– volume: 21
  start-page: 3523
  year: 2001
  ident: 204_CR31
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.21.10.3523-3533.2001
– volume: 133
  start-page: 191
  year: 2013
  ident: 204_CR83
  publication-title: J. Invest. Dermatol.
  doi: 10.1038/jid.2012.270
– volume: 185
  start-page: 6413
  year: 2010
  ident: 204_CR10
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1001829
– volume: 125
  start-page: 4969
  year: 1998
  ident: 204_CR77
  publication-title: Development
  doi: 10.1242/dev.125.24.4969
– volume: 66
  start-page: 9108
  year: 2006
  ident: 204_CR47
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-06-1996
– volume: 8
  start-page: 14173
  year: 2017
  ident: 204_CR37
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.13309
– volume: 1823
  start-page: 465
  year: 2012
  ident: 204_CR38
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbamcr.2011.11.013
– volume: 55
  start-page: 1444
  year: 1995
  ident: 204_CR34
  publication-title: Cancer Res.
– volume: 31
  start-page: 469
  year: 2012
  ident: 204_CR95
  publication-title: Oncogene
  doi: 10.1038/onc.2011.247
– volume: 29
  start-page: 41
  year: 2008
  ident: 204_CR23
  publication-title: Tumour Biol.
  doi: 10.1159/000132570
– volume: 69
  start-page: 106
  year: 2011
  ident: 204_CR66
  publication-title: Neuron
  doi: 10.1016/j.neuron.2010.12.004
– volume: 139
  start-page: 216
  issue: Suppl 1
  year: 2016
  ident: 204_CR60
  publication-title: J. Neurochem.
  doi: 10.1111/jnc.13731
– volume: 12
  start-page: 141
  year: 2011
  ident: 204_CR65
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3072
– volume: 7
  start-page: 35454
  year: 2016
  ident: 204_CR45
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.7721
– volume: 11
  start-page: 109
  year: 2013
  ident: 204_CR14
  publication-title: Mol. Cancer Res.
  doi: 10.1158/1541-7786.MCR-12-0466
– volume: 7
  start-page: 45171
  year: 2016
  ident: 204_CR48
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.9359
– volume: 125
  start-page: 299
  year: 2017
  ident: 204_CR106
  publication-title: Eur. J. Med. Chem.
  doi: 10.1016/j.ejmech.2016.09.049
– volume: 91
  start-page: 133
  year: 2003
  ident: 204_CR54
  publication-title: Adv. Neurol.
– volume: 16
  start-page: 76
  year: 2017
  ident: 204_CR107
  publication-title: Mol. Cancer Ther.
  doi: 10.1158/1535-7163.MCT-16-0205
– volume: 341
  start-page: 211
  issue: Pt 1
  year: 1999
  ident: 204_CR91
  publication-title: Biochem. J.
  doi: 10.1042/bj3410211
– volume: 15
  start-page: 2583
  year: 2009
  ident: 204_CR46
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-08-1137
– volume: 24
  start-page: 309
  year: 2011
  ident: 204_CR81
  publication-title: Pigment Cell Melanoma Res.
  doi: 10.1111/j.1755-148X.2010.00800.x
– ident: 204_CR76
  doi: 10.1101/cshperspect.a008029
– volume: 17
  start-page: 3108
  year: 2006
  ident: 204_CR5
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e05-09-0896
– volume: 10
  start-page: 55
  year: 2009
  ident: 204_CR105
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2009.06.006
– volume: 7
  start-page: 85
  year: 1997
  ident: 204_CR44
  publication-title: Curr. Biol.
  doi: 10.1016/S0960-9822(06)00052-2
– volume: 14
  start-page: 301
  year: 2000
  ident: 204_CR92
  publication-title: Genes Dev.
  doi: 10.1101/gad.14.3.301
– volume: 12
  start-page: 406
  year: 2006
  ident: 204_CR73
  publication-title: Trends Mol. Med.
  doi: 10.1016/j.molmed.2006.07.008
– volume: 19
  start-page: 2177
  year: 2017
  ident: 204_CR97
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2017.05.042
– volume: 7
  start-page: 509
  year: 1994
  ident: 204_CR74
  publication-title: Nat. Genet.
  doi: 10.1038/ng0894-509
– volume: 64
  start-page: 5484
  year: 2016
  ident: 204_CR100
  publication-title: J. Agric. Food Chem.
  doi: 10.1021/acs.jafc.6b01785
– volume: 276
  start-page: 32115
  year: 2001
  ident: 204_CR39
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M100871200
– volume: 449
  start-page: 366
  year: 2007
  ident: 204_CR104
  publication-title: Nature
  doi: 10.1038/nature06128
– volume: 26
  start-page: 316
  year: 2013
  ident: 204_CR69
  publication-title: Pigment Cell Melanoma Res.
  doi: 10.1111/pcmr.12080
– volume: 14
  start-page: 13
  year: 2014
  ident: 204_CR101
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc3645
– volume: 10
  start-page: 314
  year: 2017
  ident: 204_CR99
  publication-title: Drug Discov. Ther.
  doi: 10.5582/ddt.2016.01062
– volume: 131
  start-page: 554
  year: 2014
  ident: 204_CR59
  publication-title: J. Neurochem.
  doi: 10.1111/jnc.12949
– volume: 14
  start-page: 158
  year: 2000
  ident: 204_CR82
  publication-title: Genes Dev.
  doi: 10.1101/gad.14.2.158
– volume: 10
  start-page: 384
  year: 2010
  ident: 204_CR50
  publication-title: Curr. Cancer Drug Targets
  doi: 10.2174/156800910791208535
– volume: 133
  start-page: 2753
  year: 2013
  ident: 204_CR84
  publication-title: J. Invest. Dermatol.
  doi: 10.1038/jid.2013.235
– volume: 14
  start-page: 1495
  year: 2015
  ident: 204_CR24
  publication-title: Mol. Cancer Ther.
  doi: 10.1158/1535-7163.MCT-15-0039
– volume: 22
  start-page: 115
  year: 1999
  ident: 204_CR3
  publication-title: Prog. Mol. Subcell. Biol.
  doi: 10.1007/978-3-642-58591-3_6
– volume: 271
  start-page: 20997
  year: 1996
  ident: 204_CR43
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.271.35.20997
– volume: 30
  start-page: 553
  year: 2017
  ident: 204_CR98
  publication-title: Pigment Cell Melanoma Res.
  doi: 10.1111/pcmr.12596
– volume: 115
  start-page: 3947
  year: 2002
  ident: 204_CR15
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.00080
– volume: 34
  start-page: 48
  year: 2015
  ident: 204_CR22
  publication-title: J. Exp. Clin. Cancer Res.
  doi: 10.1186/s13046-015-0165-2
– volume: 44
  start-page: 363
  year: 2015
  ident: 204_CR29
  publication-title: Pancreas
  doi: 10.1097/MPA.0000000000000276
– volume: 135
  start-page: 1385
  year: 2015
  ident: 204_CR85
  publication-title: J. Invest. Dermatol.
  doi: 10.1038/jid.2014.548
– volume: 53
  start-page: 549
  year: 1988
  ident: 204_CR32
  publication-title: Cell
  doi: 10.1016/0092-8674(88)90571-5
– volume: 2
  start-page: 599
  year: 2001
  ident: 204_CR9
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/35085068
– volume: 19
  start-page: 1411
  year: 2013
  ident: 204_CR26
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-12-3433
– volume: 7
  start-page: 1793
  year: 2008
  ident: 204_CR25
  publication-title: Cancer Biol. Ther.
  doi: 10.4161/cbt.7.11.6840
– volume: 10
  start-page: e1004741
  year: 2014
  ident: 204_CR57
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1004741
– volume: 32
  start-page: 2475
  year: 2013
  ident: 204_CR21
  publication-title: Oncogene
  doi: 10.1038/onc.2012.255
– volume: 100
  start-page: 97
  year: 2008
  ident: 204_CR4
  publication-title: Biol. Cell
  doi: 10.1042/BC20070109
– volume: 2001
  start-page: pe1
  year: 2001
  ident: 204_CR8
  publication-title: Sci. STKE
  doi: 10.1126/stke.2001.94.pe1
– volume: 8
  start-page: 159
  year: 2014
  ident: 204_CR56
  publication-title: Front. Neuroanat.
  doi: 10.3389/fnana.2014.00159
– volume: 23
  start-page: 7838
  year: 2003
  ident: 204_CR41
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.23.21.7838-7848.2003
– volume: 23
  start-page: 809
  year: 2010
  ident: 204_CR96
  publication-title: Pigment Cell Melanoma Res.
  doi: 10.1111/j.1755-148X.2010.00760.x
– volume: 103
  start-page: 504
  year: 1994
  ident: 204_CR86
  publication-title: J. Invest. Dermatol.
  doi: 10.1111/1523-1747.ep12395649
– volume: 391
  start-page: 298
  year: 1998
  ident: 204_CR89
  publication-title: Nature
  doi: 10.1038/34681
– volume: 2
  year: 2013
  ident: 204_CR19
  publication-title: Oncogenesis
  doi: 10.1038/oncsis.2013.13
– volume: 273
  start-page: 32377
  year: 1998
  ident: 204_CR7
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.273.49.32377
– volume: 118
  start-page: 19
  year: 2005
  ident: 204_CR40
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.01631
– volume: 10
  start-page: 177
  year: 2015
  ident: 204_CR36
  publication-title: Diagn. Pathol.
  doi: 10.1186/s13000-015-0404-z
– volume: 7
  year: 2017
  ident: 204_CR35
  publication-title: Sci. Rep.
  doi: 10.1038/srep42575
– volume: 1
  start-page: 275
  year: 1992
  ident: 204_CR33
  publication-title: Surg. Oncol.
  doi: 10.1016/0960-7404(92)90088-3
– volume: 466
  start-page: S1
  year: 2010
  ident: 204_CR51
  publication-title: Nature
  doi: 10.1038/466S2a
– volume: 33
  start-page: 637
  year: 2018
  ident: 204_CR79
  publication-title: Lasers Med. Sci.
  doi: 10.1007/s10103-018-2455-3
– volume: 211
  start-page: 863
  year: 2015
  ident: 204_CR42
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201501072
– volume: 68
  start-page: 821
  year: 1999
  ident: 204_CR11
  publication-title: Annu. Rev. Biochem.
  doi: 10.1146/annurev.biochem.68.1.821
– volume: 165
  start-page: 2099
  year: 2004
  ident: 204_CR87
  publication-title: Am. J. Pathol.
  doi: 10.1016/S0002-9440(10)63260-9
– volume: 6
  start-page: 120
  year: 2015
  ident: 204_CR78
  publication-title: Stem Cell Res. Ther.
  doi: 10.1186/s13287-015-0103-4
– ident: 204_CR16
  doi: 10.1042/BSR20130102
– volume: 53
  start-page: S23
  issue: Suppl 3
  year: 2003
  ident: 204_CR55
  publication-title: Ann. Neurol.
– volume: 8
  start-page: 367ra170
  year: 2016
  ident: 204_CR49
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.aaf1629
– volume: 40
  start-page: 99
  year: 2017
  ident: 204_CR94
  publication-title: Cell. Signal.
  doi: 10.1016/j.cellsig.2017.09.004
– volume: 128
  start-page: 853
  year: 2007
  ident: 204_CR71
  publication-title: Cell
  doi: 10.1016/j.cell.2006.12.045
– volume: 94
  start-page: 909
  year: 2014
  ident: 204_CR61
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00026.2013
– volume: 13
  start-page: 720
  year: 2013
  ident: 204_CR80
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2013.10.003
– volume: 367
  start-page: 40
  year: 1994
  ident: 204_CR1
  publication-title: Nature
  doi: 10.1038/367040a0
– volume: 31
  start-page: 1001
  year: 2012
  ident: 204_CR17
  publication-title: Oncogene
  doi: 10.1038/onc.2011.294
– volume: 37
  start-page: 5147
  year: 2018
  ident: 204_CR30
  publication-title: Oncogene
  doi: 10.1038/s41388-018-0327-8
– volume: 9
  start-page: 45
  year: 2016
  ident: 204_CR63
  publication-title: Mol. Brain
  doi: 10.1186/s13041-016-0230-6
– volume: 546
  start-page: 656
  year: 2017
  ident: 204_CR52
  publication-title: Nature
  doi: 10.1038/nature22815
– volume: 144
  start-page: 646
  year: 2011
  ident: 204_CR13
  publication-title: Cell
  doi: 10.1016/j.cell.2011.02.013
– volume: 273
  start-page: 17983
  year: 1998
  ident: 204_CR90
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.273.29.17983
– volume: 67
  start-page: 155
  year: 2015
  ident: 204_CR67
  publication-title: Sheng Li Xue Bao
– volume: 84
  start-page: 92
  year: 2014
  ident: 204_CR12
  publication-title: Neuron
  doi: 10.1016/j.neuron.2014.08.049
– volume: 144
  start-page: 1235
  year: 1999
  ident: 204_CR2
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.144.6.1235
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Snippet p21-Activated kinase 4 (PAK4), a member of the PAK family, regulates a wide range of cellular functions, including cell adhesion, migration, proliferation, and...
Gene expression: The role of a regulatory enzyme in disease An enzyme that regulates an important controller of gene expression may offer a therapeutic target...
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StartPage 1
SubjectTerms 13
38
631/378/1934
631/80/86
692/308/1426
Animals
Antineoplastic drugs
Antitumor agents
Biomedical and Life Sciences
Biomedicine
Cell adhesion
Cell adhesion & migration
Cell migration
Cyclic AMP response element-binding protein
Cyclic AMP Response Element-Binding Protein - metabolism
Disease Susceptibility
Drug development
Embryogenesis
Humans
Medical Biochemistry
Melanins - biosynthesis
Mesenchyme
Metastases
Molecular Medicine
Neoplasms - etiology
Neoplasms - metabolism
Neoplasms - pathology
Neuroprotection
p21-activated kinase
p21-Activated Kinases - chemistry
p21-Activated Kinases - metabolism
Parkinson Disease - etiology
Parkinson Disease - metabolism
Parkinson's disease
Prostate cancer
Protein Binding
Protein Interaction Domains and Motifs
Review
Review Article
Signal Transduction
Stem Cells
Therapeutic applications
생화학
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Title PAK4 signaling in health and disease: defining the PAK4–CREB axis
URI https://link.springer.com/article/10.1038/s12276-018-0204-0
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