Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair
John Perry and colleagues report the results of a large genome-wide association study meta-analysis to identify variants influencing age at natural menopause. They identify 54 independent signals and find enrichment near genes involved in delayed puberty and DNA damage response. Menopause timing has...
Saved in:
| Published in | Nature genetics Vol. 47; no. 11; pp. 1294 - 1303 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Nature Publishing Group US
01.11.2015
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1061-4036 1546-1718 1546-1718 |
| DOI | 10.1038/ng.3412 |
Cover
| Abstract | John Perry and colleagues report the results of a large genome-wide association study meta-analysis to identify variants influencing age at natural menopause. They identify 54 independent signals and find enrichment near genes involved in delayed puberty and DNA damage response.
Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ∼70,000 women to identify common and low-frequency protein-coding variation associated with age at natural menopause (ANM). We identified 44 regions with common variants, including two regions harboring additional rare missense alleles of large effect. We found enrichment of signals in or near genes involved in delayed puberty, highlighting the first molecular links between the onset and end of reproductive lifespan. Pathway analyses identified major association with DNA damage response (DDR) genes, including the first common coding variant in
BRCA1
associated with any complex trait. Mendelian randomization analyses supported a causal effect of later ANM on breast cancer risk (∼6% increase in risk per year;
P
= 3 × 10
−14
), likely mediated by prolonged sex hormone exposure rather than DDR mechanisms. |
|---|---|
| AbstractList | Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ∼70,000 women to identify common and low-frequency protein-coding variation associated with age at natural menopause (ANM). We identified 44 regions with common variants, including two regions harboring additional rare missense alleles of large effect. We found enrichment of signals in or near genes involved in delayed puberty, highlighting the first molecular links between the onset and end of reproductive lifespan. Pathway analyses identified major association with DNA damage response (DDR) genes, including the first common coding variant in BRCA1 associated with any complex trait. Mendelian randomization analyses supported a causal effect of later ANM on breast cancer risk (∼6% increase in risk per year; P = 3 × 10(-14)), likely mediated by prolonged sex hormone exposure rather than DDR mechanisms. Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in 70,000 women to identify common and low-frequency protein-coding variation associated with age at natural menopause (ANM). We identified 44 regions with common variants, including two regions harboring additional rare missense alleles of large effect. We found enrichment of signals in or near genes involved in delayed puberty, highlighting the first molecular links between the onset and end of reproductive lifespan. Pathway analyses identified major association with DNA damage response (DDR) genes, including the first common coding variant in BRCA1 associated with any complex trait. Mendelian randomization analyses supported a causal effect of later ANM on breast cancer risk (6% increase in risk per year; P = 3 10 super(-14)), likely mediated by prolonged sex hormone exposure rather than DDR mechanisms. Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ~70,000 women to identify common and low-frequency protein-coding variation associated with age at natural menopause (ANM). We identified 44 regions with common variants, including two regions harboring additional rare missense alleles of large effect. We found enrichment of signals in or near genes involved in delayed puberty, highlighting the first molecular links between the onset and end of reproductive lifespan. Pathway analyses identified major association with DNA damage response (DDR) genes, including the first common coding variant in BRCA1 associated with any complex trait. Mendelian randomization analyses supported a causal effect of later ANM on breast cancer risk (~6% increase in risk per year; P = 3 × 10^sup -14^), likely mediated by prolonged sex hormone exposure rather than DDR mechanisms. John Perry and colleagues report the results of a large genome-wide association study meta-analysis to identify variants influencing age at natural menopause. They identify 54 independent signals and find enrichment near genes involved in delayed puberty and DNA damage response. Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ∼70,000 women to identify common and low-frequency protein-coding variation associated with age at natural menopause (ANM). We identified 44 regions with common variants, including two regions harboring additional rare missense alleles of large effect. We found enrichment of signals in or near genes involved in delayed puberty, highlighting the first molecular links between the onset and end of reproductive lifespan. Pathway analyses identified major association with DNA damage response (DDR) genes, including the first common coding variant in BRCA1 associated with any complex trait. Mendelian randomization analyses supported a causal effect of later ANM on breast cancer risk (∼6% increase in risk per year; P = 3 × 10 −14 ), likely mediated by prolonged sex hormone exposure rather than DDR mechanisms. Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ~70,000 women to identify common and low-frequency protein-coding variation associated with age at natural menopause (ANM). We identified 44 regions with common variants, including two regions harboring additional rare missense alleles of large effect. We found enrichment of signals in or near genes involved in delayed puberty, highlighting the first molecular links between the onset and end of reproductive lifespan. Pathway analyses identified major association with DNA damage response (DDR) genes, including the first common coding variant in BRCA1 associated with any complex trait. Mendelian randomization analyses supported a causal effect of later ANM on breast cancer risk (~6% increase in risk per year; P = 3 x [10.sup.-14]), likely mediated by prolonged sex hormone exposure rather than DDR mechanisms. Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ∼70,000 women to identify common and low-frequency protein-coding variation associated with age at natural menopause (ANM). We identified 44 regions with common variants, including two regions harboring additional rare missense alleles of large effect. We found enrichment of signals in or near genes involved in delayed puberty, highlighting the first molecular links between the onset and end of reproductive lifespan. Pathway analyses identified major association with DNA damage response (DDR) genes, including the first common coding variant in BRCA1 associated with any complex trait. Mendelian randomization analyses supported a causal effect of later ANM on breast cancer risk (∼6% increase in risk per year; P = 3 × 10(-14)), likely mediated by prolonged sex hormone exposure rather than DDR mechanisms.Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ∼70,000 women to identify common and low-frequency protein-coding variation associated with age at natural menopause (ANM). We identified 44 regions with common variants, including two regions harboring additional rare missense alleles of large effect. We found enrichment of signals in or near genes involved in delayed puberty, highlighting the first molecular links between the onset and end of reproductive lifespan. Pathway analyses identified major association with DNA damage response (DDR) genes, including the first common coding variant in BRCA1 associated with any complex trait. Mendelian randomization analyses supported a causal effect of later ANM on breast cancer risk (∼6% increase in risk per year; P = 3 × 10(-14)), likely mediated by prolonged sex hormone exposure rather than DDR mechanisms. Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ~ 70,000 women to identify common and low-frequency protein-coding variation associated with age at natural menopause (ANM). We identified 44 regions with common variants, including two harbouring additional rare missense alleles of large effect. We found enrichment of signals in/near genes involved in delayed puberty, highlighting the first molecular links between the onset and end of reproductive lifespan. Pathway analyses revealed a major association with DNA damage-response (DDR) genes, including the first common coding variant in BRCA1 associated with any complex trait. Mendelian randomisation analyses supported a causal effect of later ANM on breast cancer risk ( ~ 6% risk increase per-year, P=3×10 −14 ), likely mediated by prolonged sex hormone exposure, rather than DDR mechanisms. |
| Audience | Academic |
| Author | Margolin, Sara Luan, Jian'an Couch, Fergus J Andrulis, Irene L Li, Xin Nutile, Teresa McKnight, Barbara Mihailov, Evelin Sanna, Serena Harris, Tamara B Anton-Culver, Hoda Gandin, Ilaria Amin, Najaf Stolk, Lisette Morrison, Alanna C Bolla, Manjeet K Figueroa, Jonine Knight, Julia A Guénel, Pascal Newman, Anne B Kardia, Sharon L R Swerdlow, Anthony Robino, Antonietta Altmaier, Elisabeth Kabisch, Maria Benitez, Javier Jakubowska, Anna González-Neira, Anna Neale, Benjamin M Wang, Qin Hu, Frank B Ruggiero, Daniela Uitterlinden, André G Campbell, Harry Murray, Anna Henderson, Brian E Nalls, Michael Garcia, Melissa E Langenberg, Claudia Beckmann, Matthias W Boerwinkle, Eric Gudbjartsson, Daniel F Czene, Kamila Ferrucci, Luigi Zhao, Wei Psaty, Bruce M Dunning, Alison M Lubinski, Jan Rose, Lynda M Smith, Albert V Coviello, Andrea D Kooperberg, Charles Neven, Patrick Price, Alkes L Chanock, Stephen J Ulivi, Sheila Lunetta, Kathryn L Lindström, Sara Porteous, David Hamann, Ute Faul, Jessica D Kosma, Veli-Matti Wright, Alan F Pylkäs, Katri Dennis, Joe Wareham, |
| AuthorAffiliation | 176 Department of Paediatrics,University of Cambridge,Cambridge, CB2 0QQ, UK 36 Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”, 34137 Trieste, Italy 106 Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, California, USA 115 Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA 38 Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA 54 Department of Epidemiology, University of California Irvine, Irvine, California, USA 12 Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA 154 National Institute on Aging, Intramural Research Program, Baltimore, MD 20892, USA 22 Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IN 46202, USA 70 Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway 104 Department of Medicine, McGill University, Montreal, Canada 140 Depar |
| AuthorAffiliation_xml | – name: 139 Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA – name: 110 Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA – name: 69 Department of Genetics, Institute for Cancer Research, Radiumhospitalet, Oslo University Hospital, Oslo University Hospital, Oslo, Norway – name: 85 Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, UK – name: 169 LifeLines Cohort Study and Biobank, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands – name: 132 Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany – name: 173 Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA – name: 65 Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA – name: 159 Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada – name: 74 Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany – name: 160 Department of Pathology, The University of Melbourne, Melbourne, Australia – name: 99 Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA – name: 2 Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK – name: 56 Department of Biostatistics, University of Washington, Seattle, WA, USA – name: 66 Department of Radiation Oncology, Hannover Medical School, Hannover, Germany – name: 35 Center for Statistical Genetics, Ann Arbor, University of Michigan, Michigan 48109-2029, USA – name: 164 NIHR Oxford Biomedical Research Centre, Churchill Hospital, OX3 7LE Oxford, UK – name: 168 Department of Endocrinology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands – name: 7 Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia – name: 175 A Collaboration between the University Medical Schools and NHS in Aberdeen, Dundee, Edinburgh and Glasgow, UK – name: 172 Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands – name: 10 Department of Internal Medicine, Erasmus MC, 3015GE Rotterdam, the Netherlands – name: 40 Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy – name: 84 Boston University School of Medicine, Department of Medicine, Sections of Preventive Medicine and Endocrinology, Boston, MA – name: 68 Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark – name: 118 Hebrew SeniorLife Institute for Aging Research, Boston, MA, 02131, USA – name: 49 Icelandic Heart Association, Kopavogur, Iceland – name: 106 Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, California, USA – name: 58 Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA – name: 31 Program in Personalized Medicine, Division of Endocrinology, Diabetes and Nutrition - University of Maryland School of Medicine, USA. Baltimore, MD 21201 – name: 142 IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy – name: 174 Peter MacCallum Cancer Centre, The University of Melbourne, Melbourne, Australia – name: 47 Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK – name: 53 Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada – name: 130 Department of Oncology - Pathology, Karolinska Institutet, Stockholm 17177, Sweden – name: 166 Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA – name: 9 Harvard Medical School, Boston, MA 02115, USA – name: 152 Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany – name: 109 University Paris-Sud, UMRS 1018, Villejuif, France – name: 141 British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK – name: 117 Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland – name: 122 Cancer Center, Kuopio University Hospital, Kuopio, Finland – name: 158 Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany – name: 77 Molecular Biology of Breast Cancer, Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany – name: 14 deCODE genetics/Amgen, Inc., IS-101 Reykjavik, Iceland – name: 154 National Institute on Aging, Intramural Research Program, Baltimore, MD 20892, USA – name: 44 Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland – name: 57 Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany – name: 78 Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK – name: 89 Department of Human Genetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands – name: 26 Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany – name: 144 Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98195, USA – name: 76 Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany – name: 105 Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, Canada – name: 116 State Key Laboratory of Medical Genomics,Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China – name: 24 Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany – name: 126 Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway – name: 8 Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA 02215 – name: 113 Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany – name: 147 Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry, University of Oulu, Oulu, Finland – name: 161 Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, 81377 Munich, Germany – name: 94 David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, CA, USA – name: 25 Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany – name: 28 Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands – name: 43 Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, 3015 GE, Rotterdam, the Netherlands – name: 92 Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK – name: 115 Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA – name: 136 Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland – name: 18 Division of Endocrinology, Boston Children’s Hospital, Boston, MA 02115, USA – name: 137 KULeuven (University of Leuven), Department of Oncology, Multidisciplinary Breast Center, University Hospitals Leuven, Belgium – name: 165 Icelandic Cancer Registry, Reykjavik, Iceland – name: 86 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden – name: 11 Netherlands Consortium on Health Aging and National Genomics Initiative, 2300 RC Leiden, the Netherlands – name: 111 Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany – name: 114 Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands – name: 151 UCLA Clinical & Translational Science Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA – name: 21 Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA – name: 101 Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK – name: 104 Department of Medicine, McGill University, Montreal, Canada – name: 27 Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle Washington 98101 USA – name: 125 German Center for Diabetes Research, 85764 Neuherberg, Germany – name: 15 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA – name: 41 Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, 34149 Trieste, Italy – name: 128 Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium – name: 45 Swiss Institute of Bioinformatics, CH-1015, Lausanne, Switzerland – name: 82 Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia – name: 38 Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA – name: 79 Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland – name: 121 Faculty of Medicine, University of Split, Split, Croatia – name: 177 Boston University School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, MA 02118, USA – name: 72 University of Tübingen, Tübingen, Germany – name: 112 Musculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Aberdeen AB25 2ZD, UK – name: 52 Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada – name: 107 School of Engineering and Natural Sciences, University of Iceland, IS-101 Reykjavik, Iceland – name: 133 Department of Medicine I, Ludwig-Maximilians-University Munich, 81377 Munich, Germany – name: 62 Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA – name: 129 Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine – name: 96 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA – name: 12 Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA – name: 91 Gynaecology Research Unit, Hannover Medical School, Hannover, Germany |
| Author_xml | – sequence: 3 givenname: Deborah J surname: Thompson fullname: Thompson, Deborah J organization: Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge – sequence: 5 givenname: Natalia surname: Pervjakova fullname: Pervjakova, Natalia organization: Estonian Genome Center, University of Tartu, Institute of Molecular and Cell Biology, University of Tartu – sequence: 6 givenname: Daniel I surname: Chasman fullname: Chasman, Daniel I organization: Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School – sequence: 11 givenname: Tõnu surname: Esko fullname: Esko, Tõnu organization: Estonian Genome Center, University of Tartu, Division of Endocrinology, Boston Children's Hospital, Department of Genetics, Harvard Medical School, Broad Institute of MIT and Harvard – sequence: 13 givenname: Cathy E surname: Elks fullname: Elks, Cathy E organization: Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus – sequence: 15 givenname: Chunyan surname: He fullname: He, Chunyan organization: Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indiana University Melvin and Bren Simon Cancer Center – sequence: 16 givenname: Elisabeth surname: Altmaier fullname: Altmaier, Elisabeth organization: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Institute of Genetic Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Institute of Epidemiology II, Helmholtz Zentrum München–German Research Center for Environmental Health – sequence: 19 givenname: Jennifer E surname: Huffman fullname: Huffman, Jennifer E organization: National Heart, Lung, and Blood Institute and Boston University's Framingham Heart Study, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh – sequence: 20 givenname: Margaux F surname: Keller fullname: Keller, Margaux F organization: Merck Pharmaceuticals – sequence: 21 givenname: Patrick F surname: McArdle fullname: McArdle, Patrick F organization: Division of Endocrinology, Program in Personalized Medicine, Diabetes and Nutrition, University of Maryland School of Medicine – sequence: 22 givenname: Teresa surname: Nutile fullname: Nutile, Teresa organization: Institute of Genetics and Biophysics, National Research Council – sequence: 23 givenname: Eleonora surname: Porcu fullname: Porcu, Eleonora organization: Institute of Genetics and Biomedical Research, National Research Council, Department of Biomedical Sciences, University of Sassari, Center for Statistical Genetics, University of Michigan – sequence: 35 givenname: Tanguy surname: Corre fullname: Corre, Tanguy organization: Department of Medical Genetics, University of Lausanne, Swiss Institute of Bioinformatics – sequence: 38 givenname: Albert V surname: Smith fullname: Smith, Albert V organization: Icelandic Heart Association, Faculty of Medicine, University of Iceland – sequence: 43 givenname: Antonis C surname: Antoniou fullname: Antoniou, Antonis C organization: Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge – sequence: 46 givenname: Caterina surname: Barbieri fullname: Barbieri, Caterina organization: Institute for Maternal and Child Health, Scientific Institute for Research, Hospitalisation and Health Care 'Burlo Garofolo', Division of Genetics and Cell Biology, San Raffaele Scientific Institute – sequence: 51 givenname: Suzette J surname: Bielinski fullname: Bielinski, Suzette J organization: Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic – sequence: 52 givenname: Carl surname: Blomqvist fullname: Blomqvist, Carl organization: Department of Oncology, University of Helsinki and Helsinki University Central Hospital – sequence: 53 givenname: Eric surname: Boerwinkle fullname: Boerwinkle, Eric organization: Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Human Genome Sequencing Center, Baylor College of Medicine – sequence: 54 givenname: Natalia V surname: Bogdanova fullname: Bogdanova, Natalia V organization: Department of Radiation Oncology, Hannover Medical School – sequence: 55 givenname: Stig E surname: Bojesen fullname: Bojesen, Stig E organization: Faculty of Health and Medical Sciences, University of Copenhagen, Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen – sequence: 57 givenname: Anne-Lise surname: Borresen-Dale fullname: Borresen-Dale, Anne-Lise organization: Department of Genetics, Institute for Cancer Research, Radiumhospitalet, Oslo University Hospital, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo – sequence: 66 givenname: J Ross surname: Chapman fullname: Chapman, J Ross organization: Wellcome Trust Centre for Human Genetics, University of Oxford – sequence: 69 givenname: Fergus J surname: Couch fullname: Couch, Fergus J organization: Department of Laboratory Medicine and Pathology, Mayo Clinic – sequence: 70 givenname: Andrea D surname: Coviello fullname: Coviello, Andrea D organization: Department of Medicine, Section of Preventive Medicine, Boston University School of Medicine, Department of Medicine, Section of Endocrinology, Boston University School of Medicine – sequence: 71 givenname: Angela surname: Cox fullname: Cox, Angela organization: Department of Oncology, Sheffield Cancer Research, University of Sheffield – sequence: 72 givenname: Kamila surname: Czene fullname: Czene, Kamila organization: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet – sequence: 75 givenname: Ellen W surname: Demerath fullname: Demerath, Ellen W organization: Division of Epidemiology and Community Health, University of Minnesota – sequence: 77 givenname: Peter surname: Devilee fullname: Devilee, Peter organization: Department of Human Genetics, Leiden University Medical Center, Department of Pathology, Leiden University Medical Center – sequence: 78 givenname: Thilo surname: Dörk fullname: Dörk, Thilo organization: Gynaecology Research Unit, Hannover Medical School – sequence: 79 givenname: Isabel surname: dos-Santos-Silva fullname: dos-Santos-Silva, Isabel organization: Non-Communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine – sequence: 80 givenname: Alison M surname: Dunning fullname: Dunning, Alison M organization: Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge – sequence: 81 givenname: John D surname: Eicher fullname: Eicher, John D organization: National Heart, Lung, and Blood Institute and Boston University's Framingham Heart Study – sequence: 82 givenname: Peter A surname: Fasching fullname: Fasching, Peter A organization: Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA – sequence: 83 givenname: Jessica D surname: Faul fullname: Faul, Jessica D organization: Survey Research Center, Institute for Social Research, University of Michigan – sequence: 87 givenname: Melissa E surname: Garcia fullname: Garcia, Melissa E organization: Laboratory of Epidemiology and Population Sciences, National Institute on Aging – sequence: 90 givenname: Giorgia G surname: Girotto fullname: Girotto, Giorgia G organization: Department of Clinical Medical Sciences, Surgical and Health, University of Trieste – sequence: 91 givenname: Mark S surname: Goldberg fullname: Goldberg, Mark S organization: Department of Medicine, McGill University, Montreal, Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University – sequence: 95 givenname: Daniel F surname: Gudbjartsson fullname: Gudbjartsson, Daniel F organization: deCODE Genetics/Amgen, Inc., School of Engineering and Natural Sciences, University of Iceland – sequence: 98 givenname: Christopher A surname: Haiman fullname: Haiman, Christopher A organization: Department of Preventive Medicine, Keck School of Medicine, University of Southern California – sequence: 104 givenname: Georg surname: Homuth fullname: Homuth, Georg organization: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald – sequence: 107 givenname: Frank B surname: Hu fullname: Hu, Frank B organization: Department of Epidemiology, Harvard School of Public Health, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Department of Nutrition, Harvard School of Public Health – sequence: 110 givenname: David J surname: Hunter fullname: Hunter, David J organization: Department of Epidemiology, Harvard School of Public Health, Broad Institute of MIT and Harvard, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Department of Nutrition, Harvard School of Public Health – sequence: 111 givenname: Anna surname: Jakubowska fullname: Jakubowska, Anna organization: Department of Genetics and Pathology, Pomeranian Medical University – sequence: 118 givenname: Veli-Matti surname: Kosma fullname: Kosma, Veli-Matti organization: Cancer Center, Kuopio University Hospital, School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Department of Clinical Pathology, Imaging Center, Kuopio University Hospital – sequence: 119 givenname: Jennifer surname: Kriebel fullname: Kriebel, Jennifer organization: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Institute of Epidemiology II, Helmholtz Zentrum München–German Research Center for Environmental Health, German Center for Diabetes Research – sequence: 120 givenname: Vessela surname: Kristensen fullname: Kristensen, Vessela organization: Department of Genetics, Institute for Cancer Research, Radiumhospitalet, Oslo University Hospital, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo – sequence: 122 givenname: Claudia surname: Langenberg fullname: Langenberg, Claudia organization: Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus – sequence: 126 givenname: Yongmei surname: Liu fullname: Liu, Yongmei organization: Division of Public Health Sciences, Center for Human Genetics, Wake Forest School of Medicine – sequence: 127 givenname: Jian'an surname: Luan fullname: Luan, Jian'an organization: Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus – sequence: 131 givenname: Judith surname: Manz fullname: Manz, Judith organization: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Institute of Epidemiology II, Helmholtz Zentrum München–German Research Center for Environmental Health – sequence: 135 givenname: Corrado surname: Masciullo fullname: Masciullo, Corrado organization: Division of Genetics and Cell Biology, San Raffaele Scientific Institute – sequence: 139 givenname: Lili surname: Milani fullname: Milani, Lili organization: Estonian Genome Center, University of Tartu – sequence: 140 givenname: Roger L surname: Milne fullname: Milne, Roger L organization: Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Cancer Epidemiology Centre, Cancer Council Victoria – sequence: 141 givenname: Martina surname: Müller-Nurasyid fullname: Müller-Nurasyid, Martina organization: Institute of Genetic Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Department of Medicine I, Ludwig Maximilians University Munich, German Center for Cardiovascular Research (DZHK), partner site Munich Heart Alliance – sequence: 143 givenname: Benjamin M surname: Neale fullname: Neale, Benjamin M organization: Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Department of Medicine, Analytic and Translational Genetics Unit, Massachusetts General Hospital, Medical and Population Genetics, Broad Institute – sequence: 145 givenname: Patrick surname: Neven fullname: Neven, Patrick organization: Department of Oncology, University Hospitals Leuven – sequence: 146 givenname: Anne B surname: Newman fullname: Newman, Anne B organization: Department of Epidemiology, University of Pittsburgh, Department of Medicine, University of Pittsburgh, Department of Clinical and Translational Science, University of Pittsburgh – sequence: 147 givenname: Børge G surname: Nordestgaard fullname: Nordestgaard, Børge G organization: Faculty of Health and Medical Sciences, University of Copenhagen, Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen – sequence: 149 givenname: Sandosh surname: Padmanabhan fullname: Padmanabhan, Sandosh organization: British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow – sequence: 151 givenname: Ulrike surname: Peters fullname: Peters, Ulrike organization: Public Health Sciences Division, Fred Hutchinson Cancer Research Center – sequence: 153 givenname: Julian surname: Peto fullname: Peto, Julian organization: Non-Communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine – sequence: 156 givenname: Ailith surname: Pirie fullname: Pirie, Ailith organization: Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge – sequence: 157 givenname: Giorgio surname: Pistis fullname: Pistis, Giorgio organization: Institute of Genetics and Biomedical Research, National Research Council, Department of Biomedical Sciences, University of Sassari, Center for Statistical Genetics, University of Michigan – sequence: 159 givenname: David surname: Porteous fullname: Porteous, David organization: Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh – sequence: 160 givenname: Bruce M surname: Psaty fullname: Psaty, Bruce M organization: Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Department of Epidemiology, School of Public Health, University of Washington, Group Health Research Institute, Group Health Cooperative, Department of Health Services, University of Washington – sequence: 161 givenname: Katri surname: Pylkäs fullname: Pylkäs, Katri organization: Department of Clinical Chemistry, Laboratory of Cancer Genetics and Tumor Biology, University of Oulu, Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab – sequence: 162 givenname: Paolo surname: Radice fullname: Radice, Paolo organization: Department of Preventive and Predictive Medicine, Unit of Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS Istituto Nazionale dei Tumori (INT) – sequence: 164 givenname: Fernando surname: Rivadeneira fullname: Rivadeneira, Fernando organization: Department of Internal Medicine, Erasmus Medical Center, Netherlands Consortium on Health Aging and National Genomics Initiative, Department of Epidemiology, Genetic Epidemiology Unit, Erasmus Medical Center – sequence: 165 givenname: Igor surname: Rudan fullname: Rudan, Igor organization: Institute for Population Health Sciences and Informatics, University of Edinburgh – sequence: 170 givenname: Elinor J surname: Sawyer fullname: Sawyer, Elinor J organization: Research Oncology, Guy's Hospital, King's College London – sequence: 171 givenname: David surname: Schlessinger fullname: Schlessinger, David organization: National Institute on Aging, Intramural Research Program – sequence: 172 givenname: Marjanka K surname: Schmidt fullname: Schmidt, Marjanka K organization: Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital – sequence: 173 givenname: Frank surname: Schmidt fullname: Schmidt, Frank organization: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald – sequence: 177 givenname: Caroline M surname: Seynaeve fullname: Seynaeve, Caroline M organization: Department of Medical Oncology, Erasmus University Medical Center – sequence: 178 givenname: Jacques surname: Simard fullname: Simard, Jacques organization: Centre Hospitalier Universitaire de Québec Research Center, Laval University – sequence: 180 givenname: Melissa C surname: Southey fullname: Southey, Melissa C organization: Department of Pathology, University of Melbourne, Melbourne – sequence: 181 givenname: Doris surname: Stöckl fullname: Stöckl, Doris organization: Institute of Epidemiology II, Helmholtz Zentrum München–German Research Center for Environmental Health – sequence: 182 givenname: Konstantin surname: Strauch fullname: Strauch, Konstantin organization: Institute of Genetic Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Chair of Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians Universität – sequence: 186 givenname: Amanda E surname: Toland fullname: Toland, Amanda E organization: Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University – sequence: 187 givenname: Ian surname: Tomlinson fullname: Tomlinson, Ian organization: Wellcome Trust Centre for Human Genetics, University of Oxford, NIHR Oxford Biomedical Research Centre, Churchill Hospital – sequence: 189 givenname: Laufey surname: Tryggvadottir fullname: Tryggvadottir, Laufey organization: Icelandic Cancer Registry – sequence: 190 givenname: Stephen T surname: Turner fullname: Turner, Stephen T organization: Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic – sequence: 194 givenname: Gonneke surname: Willemsen fullname: Willemsen, Gonneke organization: Department of Biological Psychology, VU University Amsterdam – sequence: 198 givenname: Alan F surname: Wright fullname: Wright, Alan F organization: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh – sequence: 202 givenname: Marek surname: Zygmunt fullname: Zygmunt, Marek organization: Department of Obstetrics and Gynecology, University Medicine Greifswald – sequence: 203 givenname: Sven surname: Bergmann fullname: Bergmann, Sven organization: Department of Medical Genetics, University of Lausanne, Swiss Institute of Bioinformatics – sequence: 204 givenname: Dorret I surname: Boomsma fullname: Boomsma, Dorret I organization: Department of Biological Psychology, VU University Amsterdam – sequence: 207 givenname: Grant W surname: Montgomery fullname: Montgomery, Grant W organization: QIMR Berghofer Medical Research Institute – sequence: 210 givenname: Cornelia M surname: van Duijn fullname: van Duijn, Cornelia M organization: Department of Epidemiology, Genetic Epidemiology Unit, Erasmus Medical Center – sequence: 211 givenname: Behrooz Z surname: Alizadeh fullname: Alizadeh, Behrooz Z organization: Department of Epidemiology, University of Groningen, University Medical Center Groningen – sequence: 213 givenname: Laura surname: Crisponi fullname: Crisponi, Laura organization: Institute of Genetics and Biomedical Research, National Research Council – sequence: 214 givenname: Douglas F surname: Easton fullname: Easton, Douglas F organization: Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge – sequence: 217 givenname: Tamara B surname: Harris fullname: Harris, Tamara B organization: Laboratory of Epidemiology and Population Sciences, National Institute on Aging – sequence: 220 givenname: Peter surname: Kraft fullname: Kraft, Peter organization: Department of Epidemiology, Harvard School of Public Health, Department of Biostatistics, Harvard School of Public Health – sequence: 221 givenname: Barbara surname: McKnight fullname: McKnight, Barbara organization: Department of Biostatistics, University of Washington – sequence: 226 givenname: Jerome I surname: Rotter fullname: Rotter, Jerome I organization: Department of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center – sequence: 229 givenname: Sheila surname: Ulivi fullname: Ulivi, Sheila organization: Institute for Maternal and Child Health, Scientific Institute for Research, Hospitalisation and Health Care 'Burlo Garofolo' – sequence: 231 givenname: Nicholas J surname: Wareham fullname: Wareham, Nicholas J organization: Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus – sequence: 233 givenname: Laura M surname: Yerges-Armstrong fullname: Yerges-Armstrong, Laura M organization: Division of Endocrinology, Program in Personalized Medicine, Diabetes and Nutrition, University of Maryland School of Medicine |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26414677$$D View this record in MEDLINE/PubMed http://kipublications.ki.se/Default.aspx?queryparsed=id:132348371$$DView record from Swedish Publication Index |
| BookMark | eNqNk8tu1DAUhiNURC8g3gBZYgFIpNix4ySbSsNwqzSiUrlsLcc5Tt1m7MF2CvMKPDWOOqWdwqLKIpbP9_85-Y-9n-1YZyHLnhJ8SDCt39j-kDJSPMj2SMl4TipS76Q15iRnmPLdbD-Ec4wJY7h-lO0WnBHGq2ov-72Qvoc8KDkA6sG6pVFIWjmsAwQ0GHuBPKy860YVzSUg2Rvbo-jQ2Xrl4pkc5CQIpk-SVHmNWg8yRKSkVeBRGIOCVTStGUxcJ-MOvT2dz0i-hM7ICB1693k2fUEa_zh7qOUQ4MnmfZB9-_D-6_xTvjj5eDyfLXLFKY85L1XJVdG1nGip6qJkbcmZ1C2lmGKtlaIdVlo3BdXQ6Iox0mgJLe9KXBLF6EGWX_mGn7AaW7HyZin9WjhpxGbrIq1AlCnahif-6IpPldS2Ahu9HLZk2xVrzkTvLgXjnFQNSQYvNwbe_RghRLE0KZZhkBbcGASpcc15g6t7oFWR_rhu-NTW8zvouRt9GsNEUcwrTsryhurTgIWx2qUW1WQqZoyyomC4rBN1-B8qPR2k8aajpk3a3xK82hIkJsKv2MsxBHH85fT-7Mn3bfbZ7az_hnx9YG-Gp7wLwYMWykQZjZuiN4MgWEwXQtheTBci8S_u8NeW_5Kb6EMibA_-Vp530D9xdRbk |
| CitedBy_id | crossref_primary_10_1093_bioinformatics_btz138 crossref_primary_10_1093_jnci_djx281 crossref_primary_10_1016_j_jgg_2022_07_002 crossref_primary_10_1093_humrep_deac028 crossref_primary_10_1055_s_0040_1721796 crossref_primary_10_1093_humrep_dew350 crossref_primary_10_1152_physrev_00032_2022 crossref_primary_10_1016_j_nicl_2022_103239 crossref_primary_10_1093_humupd_dmaf002 crossref_primary_10_1210_clinem_dgaa505 crossref_primary_10_1126_sciadv_abf1444 crossref_primary_10_1200_JCO_20_02880 crossref_primary_10_1016_j_arr_2020_101168 crossref_primary_10_1038_s41586_021_03552_w crossref_primary_10_1186_s12885_018_4834_3 crossref_primary_10_1007_s10549_018_05098_4 crossref_primary_10_1093_humrep_dead247 crossref_primary_10_1016_j_trci_2019_09_004 crossref_primary_10_3390_ijms232213691 crossref_primary_10_1055_a_1426_2908 crossref_primary_10_1007_s12026_024_09470_z crossref_primary_10_1007_s00109_021_02055_5 crossref_primary_10_1016_j_maturitas_2017_12_016 crossref_primary_10_1093_humrep_dew242 crossref_primary_10_1038_s41586_021_03307_7 crossref_primary_10_3389_fendo_2023_1133260 crossref_primary_10_3390_genes11050578 crossref_primary_10_1016_j_critrevonc_2025_104696 crossref_primary_10_1186_s12905_024_02914_6 crossref_primary_10_1007_s00439_021_02291_2 crossref_primary_10_1016_j_arr_2024_102245 crossref_primary_10_1042_EBC20170051 crossref_primary_10_1371_journal_pone_0200486 crossref_primary_10_1016_j_fertnstert_2019_05_005 crossref_primary_10_1126_science_aat7693 crossref_primary_10_1530_EC_22_0024 crossref_primary_10_1016_j_ajog_2023_12_040 crossref_primary_10_1016_j_maturitas_2021_06_013 crossref_primary_10_1007_s40471_018_0144_1 crossref_primary_10_1016_j_fertnstert_2018_12_017 crossref_primary_10_1210_endocr_bqab069 crossref_primary_10_1002_mgg3_1896 crossref_primary_10_1186_s12920_023_01658_w crossref_primary_10_1001_jama_2020_0150 crossref_primary_10_1038_s41588_018_0279_5 crossref_primary_10_1101_gr_198044_115 crossref_primary_10_1016_j_ajhg_2016_03_008 crossref_primary_10_1038_s41588_018_0101_4 crossref_primary_10_1186_s13048_022_01032_x crossref_primary_10_1016_j_numecd_2023_01_011 crossref_primary_10_1093_bioinformatics_bty187 crossref_primary_10_2139_ssrn_3927054 crossref_primary_10_1146_annurev_pathmechdis_051122_093128 crossref_primary_10_1016_j_fertnstert_2019_05_018 crossref_primary_10_3389_fgene_2021_676546 crossref_primary_10_1093_humrep_deac256 crossref_primary_10_1038_s41591_023_02405_5 crossref_primary_10_1002_evl3_97 crossref_primary_10_1093_bioinformatics_btz947 crossref_primary_10_7717_peerj_13941 crossref_primary_10_3389_fgene_2020_00507 crossref_primary_10_1093_humrep_dew022 crossref_primary_10_1159_000532072 crossref_primary_10_1038_s41576_019_0183_6 crossref_primary_10_1055_s_0040_1722318 crossref_primary_10_1016_j_rbmo_2022_11_017 crossref_primary_10_18632_oncotarget_12818 crossref_primary_10_3389_fimmu_2018_02600 crossref_primary_10_1016_j_bone_2018_09_015 crossref_primary_10_1186_s12978_024_01770_9 crossref_primary_10_1038_ng_3954 crossref_primary_10_1093_humupd_dmz043 crossref_primary_10_1038_s41585_023_00820_4 crossref_primary_10_1186_s13075_021_02495_x crossref_primary_10_1371_journal_pbio_2002458 crossref_primary_10_1016_j_fertnstert_2023_01_043 crossref_primary_10_1016_j_xhgg_2021_100079 crossref_primary_10_1097_MD_0000000000038318 crossref_primary_10_2147_DMSO_S292041 crossref_primary_10_1038_s41467_019_12522_w crossref_primary_10_1007_s10654_019_00485_7 crossref_primary_10_1186_s13073_017_0491_4 crossref_primary_10_1530_REP_22_0325 crossref_primary_10_1093_jnci_djy204 crossref_primary_10_1242_dmm_031930 crossref_primary_10_1210_clinem_dgab597 crossref_primary_10_1016_j_rechem_2023_101072 crossref_primary_10_1038_s41467_024_47219_2 crossref_primary_10_1038_s41598_020_78554_1 crossref_primary_10_1055_a_2074_0551 crossref_primary_10_1093_humrep_dez279 crossref_primary_10_1038_s41562_023_01528_6 crossref_primary_10_1097_JBR_0000000000000043 crossref_primary_10_1210_endocr_bqaa181 crossref_primary_10_3390_ijms221910274 crossref_primary_10_1093_schbul_sbaa133 crossref_primary_10_18632_aging_104123 crossref_primary_10_1038_s42003_023_05737_7 crossref_primary_10_1093_humrep_dew204 crossref_primary_10_1186_s12916_023_03051_x crossref_primary_10_3389_fendo_2023_1234324 crossref_primary_10_1038_ng_3698 crossref_primary_10_1016_j_tem_2025_01_005 crossref_primary_10_1093_humrep_deaa342 crossref_primary_10_1002_jgm_3738 crossref_primary_10_1097_GME_0000000000001775 crossref_primary_10_3390_jcm10194299 crossref_primary_10_1055_a_1270_7208 crossref_primary_10_1038_s41467_018_05427_7 crossref_primary_10_1161_CIRCULATIONAHA_120_051775 crossref_primary_10_1038_s41586_021_03779_7 crossref_primary_10_1073_pnas_2112376119 crossref_primary_10_1038_s41431_022_01196_6 crossref_primary_10_1096_fj_202200468RR crossref_primary_10_1093_humrep_deae117 crossref_primary_10_1210_clinem_dgab377 crossref_primary_10_1210_endrev_bnac001 crossref_primary_10_1093_humupd_dmw028 crossref_primary_10_1186_s13048_023_01306_y crossref_primary_10_18370_2309_4117_2019_49_58_61 crossref_primary_10_1007_s11255_017_1686_8 crossref_primary_10_1371_journal_pmed_1002893 crossref_primary_10_18632_aging_203384 crossref_primary_10_1016_j_isci_2024_109113 crossref_primary_10_3389_fendo_2022_876775 crossref_primary_10_1210_js_2016_1014 crossref_primary_10_1038_s41591_022_02194_3 crossref_primary_10_1111_1471_0528_18052 crossref_primary_10_1126_sciadv_abb4591 crossref_primary_10_1097_GME_0000000000001785 crossref_primary_10_1002_ijc_34006 crossref_primary_10_3389_fpubh_2022_941067 crossref_primary_10_1016_j_tem_2018_07_002 crossref_primary_10_1016_j_ajhg_2017_09_022 crossref_primary_10_1038_s41388_025_03324_0 crossref_primary_10_3390_cells9010200 crossref_primary_10_1038_nrendo_2015_167 crossref_primary_10_1016_j_fertnstert_2020_09_009 crossref_primary_10_1038_s41467_023_44459_6 crossref_primary_10_1177_1933719118776788 crossref_primary_10_3389_fendo_2023_1113765 crossref_primary_10_1055_a_1678_1259 crossref_primary_10_1161_CIRCULATIONAHA_120_052293 crossref_primary_10_3390_ijms22052556 crossref_primary_10_1016_j_tem_2016_04_011 crossref_primary_10_1093_brain_awad297 crossref_primary_10_1186_s12916_022_02585_w crossref_primary_10_1210_en_2019_00441 crossref_primary_10_3389_fendo_2022_912648 crossref_primary_10_1161_CIRCRESAHA_123_322984 crossref_primary_10_1038_ejhg_2017_148 crossref_primary_10_3389_fsoc_2019_00074 crossref_primary_10_1002_cam4_5772 crossref_primary_10_1186_s13148_019_0648_7 crossref_primary_10_1038_s41467_018_08054_4 crossref_primary_10_1038_s41467_024_46064_7 crossref_primary_10_3389_fcell_2021_652407 crossref_primary_10_1038_s41467_021_22653_8 crossref_primary_10_1016_j_ebiom_2024_105262 crossref_primary_10_1186_s13048_023_01151_z crossref_primary_10_1186_s12967_022_03435_2 crossref_primary_10_1007_s10654_022_00903_3 crossref_primary_10_1093_hmg_ddab163 crossref_primary_10_1186_s12916_018_1008_8 crossref_primary_10_1097_GME_0000000000001367 crossref_primary_10_1530_REP_18_0580 crossref_primary_10_1371_journal_pone_0213953 crossref_primary_10_1093_humupd_dmab046 crossref_primary_10_3233_JHD_200445 crossref_primary_10_1186_s12916_022_02246_y crossref_primary_10_1016_j_ctrv_2017_07_001 crossref_primary_10_1038_s41588_024_01798_4 crossref_primary_10_1002_ijc_34026 crossref_primary_10_3390_jcm12010347 crossref_primary_10_1093_humrep_dev318 crossref_primary_10_1183_13993003_02421_2018 crossref_primary_10_32749_nucleodoconhecimento_com_br_health_risk_factors crossref_primary_10_1016_j_cell_2020_06_024 crossref_primary_10_1002_gepi_22354 crossref_primary_10_1007_s00439_024_02650_9 crossref_primary_10_1093_narmme_ugae010 crossref_primary_10_1016_j_coemr_2020_12_002 crossref_primary_10_1186_s12916_022_02293_5 crossref_primary_10_1360_SSV_2023_0197 crossref_primary_10_1111_cge_12718 crossref_primary_10_1016_j_cub_2024_09_040 crossref_primary_10_1016_j_maturitas_2016_07_006 crossref_primary_10_1111_cts_13827 crossref_primary_10_1038_s41420_024_02041_z crossref_primary_10_1016_j_maturitas_2020_06_007 crossref_primary_10_1016_j_xcrm_2022_100542 crossref_primary_10_1038_s41419_019_1334_6 crossref_primary_10_1186_s12916_020_01797_2 crossref_primary_10_1038_s41588_023_01527_3 crossref_primary_10_3389_fendo_2024_1361289 crossref_primary_10_17116_repro20232901194 crossref_primary_10_1158_0008_5472_CAN_16_2346 crossref_primary_10_1371_journal_pone_0236904 crossref_primary_10_1002_jbmr_4632 crossref_primary_10_1016_j_xcrm_2022_100776 crossref_primary_10_1093_humupd_dmx026 crossref_primary_10_1136_ijgc_2019_000626 crossref_primary_10_1016_j_psyneuen_2019_03_013 crossref_primary_10_1016_j_ebiom_2024_105175 crossref_primary_10_1038_s41416_021_01576_7 crossref_primary_10_1097_GME_0000000000000741 crossref_primary_10_1038_srep24710 crossref_primary_10_1038_nn_4495 crossref_primary_10_1093_biolre_ioad008 crossref_primary_10_1038_s41588_019_0359_1 crossref_primary_10_1073_pnas_1604558113 crossref_primary_10_1038_s42003_024_06403_2 crossref_primary_10_1093_hmg_ddz015 crossref_primary_10_1038_s41467_018_04398_z crossref_primary_10_12688_f1000research_26423_1 crossref_primary_10_1038_s41467_021_21286_1 crossref_primary_10_1186_s13058_020_1247_4 crossref_primary_10_1038_s41419_017_0163_8 crossref_primary_10_18632_aging_203206 crossref_primary_10_1016_j_rbmo_2018_12_009 crossref_primary_10_1093_humrep_deaa173 crossref_primary_10_1016_j_molmed_2022_03_002 crossref_primary_10_1016_j_semcdb_2020_12_007 crossref_primary_10_1080_14728222_2019_1599359 crossref_primary_10_1007_s00125_017_4346_8 crossref_primary_10_1134_S2079057017030055 crossref_primary_10_1038_s41588_020_0610_9 crossref_primary_10_1038_s41598_020_65565_1 crossref_primary_10_1161_CIR_0000000000000912 crossref_primary_10_1155_2019_8732023 crossref_primary_10_1093_humrep_dew044 crossref_primary_10_1016_j_crmeth_2024_100911 crossref_primary_10_1016_j_fertnstert_2021_04_021 crossref_primary_10_1215_00703370_11054960 crossref_primary_10_1210_jc_2016_4013 crossref_primary_10_3389_fnut_2024_1428844 crossref_primary_10_1016_j_fertnstert_2017_03_018 crossref_primary_10_1055_a_1331_8551 crossref_primary_10_1002_sim_8028 crossref_primary_10_3390_ijerph19021019 crossref_primary_10_1371_journal_pgen_1006933 crossref_primary_10_1096_fj_202100756R crossref_primary_10_1097_GME_0000000000000633 crossref_primary_10_1016_j_jadohealth_2020_07_016 crossref_primary_10_1016_j_rbmo_2023_103584 crossref_primary_10_18597_rcog_3806 crossref_primary_10_1038_s41525_018_0068_1 crossref_primary_10_1038_s41586_024_07931_x crossref_primary_10_1038_s41588_020_0600_y crossref_primary_10_1016_j_maturitas_2020_03_002 crossref_primary_10_1210_clinem_dgab775 crossref_primary_10_1055_a_1464_0953 crossref_primary_10_1093_humupd_dmaa044 crossref_primary_10_1038_s42003_022_03272_5 crossref_primary_10_1093_ije_dyac215 crossref_primary_10_1016_j_mad_2020_111230 crossref_primary_10_1177_0962280217690414 crossref_primary_10_1093_ije_dyw165 crossref_primary_10_1097_GME_0000000000001017 crossref_primary_10_1161_JAHA_122_028132 crossref_primary_10_1210_jc_2017_00765 crossref_primary_10_31083_j_rcm2308269 crossref_primary_10_1097_MED_0000000000000509 crossref_primary_10_1007_s00129_021_04774_9 crossref_primary_10_1007_s10654_017_0321_4 crossref_primary_10_1016_j_xcrm_2023_101035 crossref_primary_10_1210_clinem_dgae480 crossref_primary_10_23736_S2724_606X_21_04813_2 crossref_primary_10_1016_j_ajhg_2018_08_017 crossref_primary_10_18027_2224_5057_2024_14_3s1_42_48 crossref_primary_10_1038_s41431_020_00712_w crossref_primary_10_1038_s41598_017_06158_3 crossref_primary_10_1038_s41562_018_0476_3 crossref_primary_10_1016_j_ajhg_2023_07_006 crossref_primary_10_1158_1055_9965_EPI_17_0696 crossref_primary_10_1371_journal_pone_0257628 crossref_primary_10_1038_s41586_019_1765_3 crossref_primary_10_1038_s43587_024_00733_w crossref_primary_10_1038_s41416_018_0108_8 crossref_primary_10_3389_fendo_2023_1279493 crossref_primary_10_1007_s00223_024_01220_5 crossref_primary_10_1186_s13148_023_01572_z crossref_primary_10_3390_ani14152153 crossref_primary_10_1210_jc_2017_01860 crossref_primary_10_3390_cancers13184598 crossref_primary_10_1038_d41586_021_01710_8 crossref_primary_10_1210_clinem_dgac171 crossref_primary_10_1093_humupd_dmy031 |
| Cites_doi | 10.1086/375404 10.1038/ng0609-637 10.1200/JCO.2013.49.3007 10.1371/journal.pgen.1000534 10.1038/nature02517 10.1016/j.peptides.2008.05.016 10.1093/nar/gks1284 10.1016/j.cell.2013.09.053 10.1196/annals.1434.009 10.1038/ng.2354 10.1038/ng.340 10.1371/journal.pgen.1004542 10.1038/ng.2504 10.1200/JCO.2007.12.5922 10.1530/EJE-07-0400 10.1093/bioinformatics/btq340 10.1200/JCO.2009.24.2057 10.1001/jama.2013.278040 10.1210/en.2014-1110 10.1016/j.ajhg.2010.11.011 10.1038/nature13545 10.1172/JCI78473 10.1126/science.284.5418.1354 10.1074/jbc.M111.324582 10.1016/j.molcel.2012.07.029 10.1038/ng.2560 10.1186/1471-2164-15-532 10.1111/joim.12085 10.1186/1753-6561-8-S1-S33 10.1093/aje/kwr447 10.1126/scitranslmed.3004925 10.1093/humupd/8.2.141 10.1016/S2213-8587(14)70113-5 10.1016/j.ajpath.2013.07.003 10.1038/nature10530 10.1074/jbc.M113.484493 10.1016/j.maturitas.2009.06.007 10.1016/j.ajhg.2014.11.002 10.1371/journal.pgen.1001058 10.1210/jc.2012-3550 10.1093/hmg/ddt620 10.1371/journal.pbio.1000294 10.1038/nature12787 10.1038/sj.bjc.6603535 10.1038/ng.1051 10.1093/bioinformatics/bth457 10.1038/nature08467 10.1101/gad.2011011 10.1093/humrep/deu247 10.1093/nar/gku1202 10.1038/ng.2563 10.1038/nature13595 10.1093/hmg/ddn219 10.1016/S0140-6736(12)62129-1 10.1016/S1470-2045(12)70425-4 10.1038/nature11632 10.1038/nature10405 10.1086/519795 10.1038/ng.686 |
| ContentType | Journal Article |
| Copyright | Springer Nature America, Inc. 2015 COPYRIGHT 2015 Nature Publishing Group Copyright Nature Publishing Group Nov 2015 |
| Copyright_xml | – notice: Springer Nature America, Inc. 2015 – notice: COPYRIGHT 2015 Nature Publishing Group – notice: Copyright Nature Publishing Group Nov 2015 |
| CorporateAuthor | The PRACTICAL Consortium EPIC-InterAct Consortium kConFab Investigators AOCS Investigators Generation Scotland LifeLines Cohort Study PRACTICAL consortium |
| CorporateAuthor_xml | – name: The PRACTICAL Consortium – name: AOCS Investigators – name: Generation Scotland – name: kConFab Investigators – name: EPIC-InterAct Consortium – name: LifeLines Cohort Study – name: PRACTICAL consortium |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QL 7QP 7QR 7SS 7T7 7TK 7TM 7U9 7X7 7XB 88A 88E 8AO 8C1 8FD 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. LK8 M0S M1P M2O M7N M7P MBDVC P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U RC3 7X8 5PM ADTPV AOWAS D8T ZZAVC |
| DOI | 10.1038/ng.3412 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Opposing Viewpoints in Context (Gale) Gale In Context: Science ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Entomology Abstracts (Full archive) Industrial and Applied Microbiology Abstracts (Microbiology A) Neurosciences Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Journals Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Research Library ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest : Biological Science Collection journals [unlimited simultaneous users] ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database ProQuest Research Library Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Research Library (Corporate) Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) SwePub SwePub Articles SWEPUB Freely available online SwePub Articles full text |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Research Library Prep ProQuest Central Student ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Public Health ProQuest Central Basic ProQuest SciTech Collection ProQuest Medical Library ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Genetics Abstracts Research Library Prep MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Agriculture Biology |
| EISSN | 1546-1718 |
| EndPage | 1303 |
| ExternalDocumentID | oai_swepub_ki_se_510396 PMC4661791 3858315791 A434224058 26414677 10_1038_ng_3412 |
| Genre | Research Support, U.S. Gov't, Non-P.H.S Research Support, American Recovery and Reinvestment Act Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural Feature |
| GrantInformation_xml | – fundername: Cancer Research UK grantid: 10119 – fundername: NHGRI NIH HHS grantid: HG006513 – fundername: NHLBI NIH HHS grantid: N02-HL-6-4278 – fundername: NHLBI NIH HHS grantid: R01 HL119443 – fundername: Wellcome Trust grantid: 090532 – fundername: NHGRI NIH HHS grantid: HHSN268200782096C – fundername: NHGRI NIH HHS grantid: HG007089 – fundername: NCI NIH HHS grantid: 1U19 CA148537 – fundername: NIA NIH HHS grantid: N01AG62106 – fundername: NHLBI NIH HHS grantid: 5RC2HL102419 |
| GroupedDBID | --- -DZ -~X .55 .GJ 0R~ 123 29M 2FS 36B 39C 3O- 3V. 4.4 53G 5BI 5M7 5RE 5S5 70F 7X7 85S 88A 88E 8AO 8C1 8FE 8FH 8FI 8FJ 8G5 8R4 8R5 AAEEF AAHBH AARCD AAYOK AAYZH AAZLF ABAWZ ABCQX ABDBF ABDPE ABEFU ABJNI ABLJU ABOCM ABTAH ABUWG ACBWK ACGFO ACGFS ACIWK ACMJI ACNCT ACPRK ACUHS ADBBV ADFRT AENEX AEUYN AFBBN AFFNX AFKRA AFRAH AFSHS AGAYW AGCDD AGHTU AHBCP AHMBA AHOSX AHSBF AIBTJ ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH ARMCB ASPBG AVWKF AXYYD AZFZN AZQEC B0M BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CCPQU CS3 DB5 DU5 DWQXO EAD EAP EBC EBD EBS EE. EJD EMB EMK EMOBN EPL ESX EXGXG F5P FEDTE FQGFK FSGXE FYUFA GNUQQ GUQSH GX1 HCIFZ HMCUK HVGLF HZ~ IAO IH2 IHR INH INR IOV ISR ITC L7B LGEZI LK8 LOTEE M0L M1P M2O M7P MVM N9A NADUK NNMJJ NXXTH ODYON P2P PKN PQQKQ PROAC PSQYO Q2X RIG RNS RNT RNTTT RVV SHXYY SIXXV SJN SNYQT SOJ SV3 TAOOD TBHMF TDRGL TN5 TSG TUS UKHRP VQA X7M XJT XOL Y6R YHZ ZGI ZXP ZY4 ~8M ~KM AAYXX ABFSG ACMFV ACSTC AETEA AFANA ALPWD ATHPR CITATION PHGZM PHGZT AEZWR AFHIU AHWEU AIXLP CGR CUY CVF ECM EIF NFIDA NPM PJZUB PPXIY PQGLB AEIIB PMFND 7QL 7QP 7QR 7SS 7T7 7TK 7TM 7U9 7XB 8FD 8FK C1K FR3 H94 K9. M7N MBDVC P64 PKEHL PQEST PQUKI PRINS PUEGO Q9U RC3 7X8 5PM ADTPV AOWAS D8T ZZAVC |
| ID | FETCH-LOGICAL-c636t-65c56c2db61fac8254b564afb33030ffcc3d0cff923fe9f74419faeb6d5051c43 |
| IEDL.DBID | 8C1 |
| ISSN | 1061-4036 1546-1718 |
| IngestDate | Wed Sep 24 03:49:14 EDT 2025 Thu Aug 21 14:04:55 EDT 2025 Fri Sep 05 05:14:53 EDT 2025 Thu Sep 04 23:21:37 EDT 2025 Sat Aug 23 12:22:34 EDT 2025 Tue Jun 17 21:38:01 EDT 2025 Tue Jun 10 20:36:16 EDT 2025 Fri Jun 27 04:39:02 EDT 2025 Fri Jun 27 04:57:04 EDT 2025 Mon Jul 21 05:58:54 EDT 2025 Tue Jul 01 01:50:13 EDT 2025 Thu Apr 24 23:03:34 EDT 2025 Fri Feb 21 02:39:05 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Language | English |
| License | Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c636t-65c56c2db61fac8254b564afb33030ffcc3d0cff923fe9f74419faeb6d5051c43 |
| Notes | SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 These authors jointly supervised this work |
| OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC4661791 |
| PMID | 26414677 |
| PQID | 1730676155 |
| PQPubID | 33429 |
| PageCount | 10 |
| ParticipantIDs | swepub_primary_oai_swepub_ki_se_510396 pubmedcentral_primary_oai_pubmedcentral_nih_gov_4661791 proquest_miscellaneous_1808669071 proquest_miscellaneous_1728258966 proquest_journals_1730676155 gale_infotracmisc_A434224058 gale_infotracacademiconefile_A434224058 gale_incontextgauss_ISR_A434224058 gale_incontextgauss_IOV_A434224058 pubmed_primary_26414677 crossref_citationtrail_10_1038_ng_3412 crossref_primary_10_1038_ng_3412 springer_journals_10_1038_ng_3412 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2015-11-01 |
| PublicationDateYYYYMMDD | 2015-11-01 |
| PublicationDate_xml | – month: 11 year: 2015 text: 2015-11-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | New York |
| PublicationPlace_xml | – name: New York – name: United States |
| PublicationTitle | Nature genetics |
| PublicationTitleAbbrev | Nat Genet |
| PublicationTitleAlternate | Nat Genet |
| PublicationYear | 2015 |
| Publisher | Nature Publishing Group US Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group US – name: Nature Publishing Group |
| References | Titus (CR24) 2013; 5 Raychaudhuri (CR45) 2009; 5 Speliotes (CR60) 2010; 42 Palavalli, Prickett, Wunderlich, Wei, Burrell, Porter-Gill, Davis, Wang, Cronin, Agrawal, Lin, Westbroek, Hoogstraten-Miller, Molinolo, Fetsch, Filie, O'Connell, Banister, Howard, Buckhaults, Weeraratna, Brody, Rosenberg, Samuels (CR6) 2009; 41 Zhou (CR42) 2014; 8 Hoffman (CR48) 2013; 41 Morris (CR16) 2012; 175 Vimaleswaran (CR19) 2014; 2 Stolk (CR4) 2012; 44 Levy-Lahad, Friedman (CR34) 2007; 96 te Velde, Pearson (CR3) 2002; 8 Gaytan (CR38) 2014; 155 Michailidou (CR20) 2013; 45 Trynka (CR52) 2013; 45 García-Ortega (CR37) 2014; 29 Hu (CR26) 2011; 25 Linder (CR14) 2008; 17 Andersson (CR51) 2014; 507 Mandon-Pépin (CR13) 2008; 158 Yang, Lee, Goddard, Visscher (CR43) 2011; 88 Eeles (CR57) 2013; 45 Oktay, Kim, Barad, Babayev (CR31) 2010; 28 Willer, Li, Abecasis (CR40) 2010; 26 Fogli (CR11) 2003; 72 Lindblad-Toh (CR49) 2011; 478 Weischer, Bojesen, Ellervik, Tybjaerg-Hansen, Nordestgaard (CR9) 2008; 26 Barrett, Fry, Maller, Daly (CR44) 2005; 21 Hartge (CR1) 2009; 41 Oktem, Oktay (CR7) 2008; 1127 Fan (CR25) 1999; 284 Tsutsui (CR27) 2014; 10 CR18 Monteiro, Freedman (CR22) 2013; 274 Simandlova (CR28) 2013; 288 CR58 Lambalk, van Disseldorp, de Koning, Broekmans (CR2) 2009; 63 CR56 CR55 Guler (CR8) 2012; 287 CR53 Howie, Fuchsberger, Stephens, Marchini, Abecasis (CR54) 2012; 44 Trifunovic (CR12) 2004; 429 Palavalli, Prickett, Wunderlich, Wei, Burrell, Porter-Gill, Davis, Wang, Cronin, Agrawal, Lin, Westbroek, Hoogstraten-Miller, Molinolo, Fetsch, Filie, O'Connell, Banister, Howard, Buckhaults, Weeraratna, Brody, Rosenberg, Samuels (CR59) 2009; 41 Perry (CR5) 2014; 23 Manson (CR33) 2013; 310 Wood-Trageser (CR30) 2014; 95 Rance (CR35) 2009; 30 Zhang (CR46) 2014; 15 Hnisz (CR50) 2013; 155 Segrè (CR47) 2010; 6 Ghoussaini, Pharoah, Easton (CR23) 2013; 183 Collins (CR32) 2013; 31 Eicher (CR15) 2015; 43 Dickson, Wang, Krantz, Hakonarson, Goldstein (CR21) 2010; 8 AlAsiri (CR10) 2015; 125 Silveira, Latronico (CR36) 2013; 98 Chapman, Taylor, Boulton (CR29) 2012; 47 Jackson, Bartke (CR39) 2009; 461 Purcell (CR41) 2007; 81 Perry (CR17) 2014; 514 JJ Zhou (BFng3412_CR42) 2014; 8 A Trifunovic (BFng3412_CR12) 2004; 429 F Gaytan (BFng3412_CR38) 2014; 155 BFng3412_CR53 K Michailidou (BFng3412_CR20) 2013; 45 S Purcell (BFng3412_CR41) 2007; 81 BFng3412_CR55 S Titus (BFng3412_CR24) 2013; 5 M Weischer (BFng3412_CR9) 2008; 26 KS Vimaleswaran (BFng3412_CR19) 2014; 2 IM Collins (BFng3412_CR32) 2013; 31 BFng3412_CR56 JR Chapman (BFng3412_CR29) 2012; 47 BFng3412_CR58 B Howie (BFng3412_CR54) 2012; 44 BFng3412_CR18 B Linder (BFng3412_CR14) 2008; 17 D Hnisz (BFng3412_CR50) 2013; 155 X Zhang (BFng3412_CR46) 2014; 15 J Yang (BFng3412_CR43) 2011; 88 S Fan (BFng3412_CR25) 1999; 284 MA Wood-Trageser (BFng3412_CR30) 2014; 95 NE Rance (BFng3412_CR35) 2009; 30 CJ Willer (BFng3412_CR40) 2010; 26 JC Barrett (BFng3412_CR44) 2005; 21 EK Speliotes (BFng3412_CR60) 2010; 42 Y Hu (BFng3412_CR26) 2011; 25 K Oktay (BFng3412_CR31) 2010; 28 O Oktem (BFng3412_CR7) 2008; 1127 SP Jackson (BFng3412_CR39) 2009; 461 R Andersson (BFng3412_CR51) 2014; 507 L Stolk (BFng3412_CR4) 2012; 44 J García-Ortega (BFng3412_CR37) 2014; 29 Lavanya H Palavalli (BFng3412_CR6) 2009; 41 RA Eeles (BFng3412_CR57) 2013; 45 CB Lambalk (BFng3412_CR2) 2009; 63 JD Eicher (BFng3412_CR15) 2015; 43 ER te Velde (BFng3412_CR3) 2002; 8 LF Silveira (BFng3412_CR36) 2013; 98 JR Perry (BFng3412_CR5) 2014; 23 DH Morris (BFng3412_CR16) 2012; 175 JR Perry (BFng3412_CR17) 2014; 514 J Simandlova (BFng3412_CR28) 2013; 288 G Trynka (BFng3412_CR52) 2013; 45 B Mandon-Pépin (BFng3412_CR13) 2008; 158 Lavanya H Palavalli (BFng3412_CR59) 2009; 41 K Lindblad-Toh (BFng3412_CR49) 2011; 478 SP Dickson (BFng3412_CR21) 2010; 8 M Ghoussaini (BFng3412_CR23) 2013; 183 A Fogli (BFng3412_CR11) 2003; 72 E Levy-Lahad (BFng3412_CR34) 2007; 96 AV Segrè (BFng3412_CR47) 2010; 6 GD Guler (BFng3412_CR8) 2012; 287 P Hartge (BFng3412_CR1) 2009; 41 Y Tsutsui (BFng3412_CR27) 2014; 10 MM Hoffman (BFng3412_CR48) 2013; 41 JE Manson (BFng3412_CR33) 2013; 310 S Raychaudhuri (BFng3412_CR45) 2009; 5 AN Monteiro (BFng3412_CR22) 2013; 274 S AlAsiri (BFng3412_CR10) 2015; 125 |
| References_xml | – volume: 72 start-page: 1544 year: 2003 end-page: 1550 ident: CR11 article-title: Ovarian failure related to eukaryotic initiation factor 2B mutations publication-title: Am. J. Hum. Genet. doi: 10.1086/375404 – volume: 41 start-page: 637 year: 2009 end-page: 638 ident: CR1 article-title: Genetics of reproductive lifespan publication-title: Nat. Genet. doi: 10.1038/ng0609-637 – volume: 31 start-page: 3920 year: 2013 end-page: 3925 ident: CR32 article-title: Do and mutation carriers have earlier natural menopause than their noncarrier relatives? Results from the Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2013.49.3007 – volume: 5 start-page: e1000534 year: 2009 ident: CR45 article-title: Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1000534 – volume: 429 start-page: 417 year: 2004 end-page: 423 ident: CR12 article-title: Premature ageing in mice expressing defective mitochondrial DNA polymerase publication-title: Nature doi: 10.1038/nature02517 – volume: 45 start-page: 353 year: 2013 end-page: 361 ident: CR20 article-title: Large-scale genotyping identifies 41 new loci associated with breast cancer risk publication-title: Nat. Genet. – volume: 30 start-page: 111 year: 2009 end-page: 122 ident: CR35 article-title: Menopause and the human hypothalamus: evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback publication-title: Peptides doi: 10.1016/j.peptides.2008.05.016 – volume: 41 start-page: 827 year: 2013 end-page: 841 ident: CR48 article-title: Integrative annotation of chromatin elements from ENCODE data publication-title: Nucleic Acids Res. doi: 10.1093/nar/gks1284 – volume: 155 start-page: 934 year: 2013 end-page: 947 ident: CR50 article-title: Super-enhancers in the control of cell identity and disease publication-title: Cell doi: 10.1016/j.cell.2013.09.053 – volume: 42 start-page: 937 year: 2010 end-page: 948 ident: CR60 article-title: Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index publication-title: Nat. Genet. – volume: 1127 start-page: 1 year: 2008 end-page: 9 ident: CR7 article-title: The ovary: anatomy and function throughout human life publication-title: Ann. NY Acad. Sci. doi: 10.1196/annals.1434.009 – volume: 44 start-page: 955 year: 2012 end-page: 959 ident: CR54 article-title: Fast and accurate genotype imputation in genome-wide association studies through pre-phasing publication-title: Nat. Genet. doi: 10.1038/ng.2354 – ident: CR58 – volume: 41 start-page: 518 issue: 5 year: 2009 end-page: 520 ident: CR6 article-title: Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma publication-title: Nature Genetics doi: 10.1038/ng.340 – volume: 10 start-page: e1004542 year: 2014 ident: CR27 article-title: Multiple regulation of Rad51-mediated homologous recombination by fission yeast Fbh1 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1004542 – volume: 41 start-page: 518 issue: 5 year: 2009 end-page: 520 ident: CR59 article-title: Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma publication-title: Nature Genetics doi: 10.1038/ng.340 – volume: 45 start-page: 124 year: 2013 end-page: 130 ident: CR52 article-title: Chromatin marks identify critical cell types for fine mapping complex trait variants publication-title: Nat. Genet. doi: 10.1038/ng.2504 – volume: 26 start-page: 542 year: 2008 end-page: 548 ident: CR9 article-title: *1100delC genotyping for clinical assessment of breast cancer risk: meta-analyses of 26,000 patient cases and 27,000 controls publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2007.12.5922 – volume: 158 start-page: 107 year: 2008 end-page: 115 ident: CR13 article-title: Genetic investigation of four meiotic genes in women with premature ovarian failure publication-title: Eur. J. Endocrinol. doi: 10.1530/EJE-07-0400 – volume: 26 start-page: 2190 year: 2010 end-page: 2191 ident: CR40 article-title: METAL: fast and efficient meta-analysis of genomewide association scans publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq340 – volume: 28 start-page: 240 year: 2010 end-page: 244 ident: CR31 article-title: Association of mutations with occult primary ovarian insufficiency: a possible explanation for the link between infertility and breast/ovarian cancer risks publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2009.24.2057 – volume: 310 start-page: 1353 year: 2013 end-page: 1368 ident: CR33 article-title: Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women's Health Initiative randomized trials publication-title: J. Am. Med. Assoc. doi: 10.1001/jama.2013.278040 – volume: 155 start-page: 3088 year: 2014 end-page: 3097 ident: CR38 article-title: Kisspeptin receptor haplo-insufficiency causes premature ovarian failure despite preserved gonadotropin secretion publication-title: Endocrinology doi: 10.1210/en.2014-1110 – volume: 88 start-page: 76 year: 2011 end-page: 82 ident: CR43 article-title: GCTA: a tool for genome-wide complex trait analysis publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2010.11.011 – volume: 514 start-page: 92 year: 2014 end-page: 97 ident: CR17 article-title: Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche publication-title: Nature doi: 10.1038/nature13545 – volume: 125 start-page: 258 year: 2015 end-page: 262 ident: CR10 article-title: Exome sequencing reveals mutation underlies ovarian failure and chromosomal instability publication-title: J. Clin. Invest. doi: 10.1172/JCI78473 – volume: 284 start-page: 1354 year: 1999 end-page: 1356 ident: CR25 article-title: BRCA1 inhibition of estrogen receptor signaling in transfected cells publication-title: Science doi: 10.1126/science.284.5418.1354 – volume: 287 start-page: 6469 year: 2012 end-page: 6481 ident: CR8 article-title: Human DNA helicase B (HDHB) binds to replication protein A and facilitates cellular recovery from replication stress publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.324582 – ident: CR18 – volume: 47 start-page: 497 year: 2012 end-page: 510 ident: CR29 article-title: Playing the end game: DNA double-strand break repair pathway choice publication-title: Mol. Cell doi: 10.1016/j.molcel.2012.07.029 – volume: 45 start-page: 385 year: 2013 end-page: 391 ident: CR57 article-title: Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array publication-title: Nat. Genet. doi: 10.1038/ng.2560 – volume: 15 start-page: 532 year: 2014 ident: CR46 article-title: Synthesis of 53 tissue and cell line expression QTL datasets reveals master eQTLs publication-title: BMC Genomics doi: 10.1186/1471-2164-15-532 – ident: CR53 – volume: 274 start-page: 414 year: 2013 end-page: 424 ident: CR22 article-title: Lessons from postgenome-wide association studies: functional analysis of cancer predisposition loci publication-title: J. Intern. Med. doi: 10.1111/joim.12085 – volume: 8 start-page: S33 year: 2014 ident: CR42 article-title: A comparative analysis of family-based and population-based association tests using whole genome sequence data publication-title: BMC Proc. doi: 10.1186/1753-6561-8-S1-S33 – volume: 175 start-page: 998 year: 2012 end-page: 1005 ident: CR16 article-title: Body mass index, exercise, and other lifestyle factors in relation to age at natural menopause: analyses from the Breakthrough Generations study publication-title: Am. J. Epidemiol. doi: 10.1093/aje/kwr447 – volume: 5 start-page: 172ra21 year: 2013 ident: CR24 article-title: Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.3004925 – volume: 8 start-page: 141 year: 2002 end-page: 154 ident: CR3 article-title: The variability of female reproductive ageing publication-title: Hum. Reprod. Update doi: 10.1093/humupd/8.2.141 – volume: 2 start-page: 719 year: 2014 end-page: 729 ident: CR19 article-title: Association of vitamin D status with arterial blood pressure and hypertension risk: a Mendelian randomisation study publication-title: Lancet Diabetes Endocrinol. doi: 10.1016/S2213-8587(14)70113-5 – volume: 81 start-page: 559 year: 2007 end-page: 575 ident: CR41 article-title: PLINK: a tool set for whole-genome association and population-based linkage analyses publication-title: Am. J. Hum. Genet. – volume: 183 start-page: 1038 year: 2013 end-page: 1051 ident: CR23 article-title: Inherited genetic susceptibility to breast cancer: the beginning of the end or the end of the beginning? publication-title: Am. J. Pathol. doi: 10.1016/j.ajpath.2013.07.003 – ident: CR56 – volume: 478 start-page: 476 year: 2011 end-page: 482 ident: CR49 article-title: A high-resolution map of human evolutionary constraint using 29 mammals publication-title: Nature doi: 10.1038/nature10530 – volume: 288 start-page: 34168 year: 2013 end-page: 34180 ident: CR28 article-title: FBH1 helicase disrupts RAD51 filaments and modulates homologous recombination in mammalian cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.M113.484493 – volume: 63 start-page: 280 year: 2009 end-page: 291 ident: CR2 article-title: Testing ovarian reserve to predict age at menopause publication-title: Maturitas doi: 10.1016/j.maturitas.2009.06.007 – volume: 95 start-page: 754 year: 2014 end-page: 762 ident: CR30 article-title: mutations are associated with ovarian failure, short stature, and chromosomal instability publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2014.11.002 – volume: 6 start-page: e1001058 year: 2010 ident: CR47 article-title: Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1001058 – volume: 98 start-page: 1781 year: 2013 end-page: 1788 ident: CR36 article-title: Approach to the patient with hypogonadotropic hypogonadism publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2012-3550 – volume: 23 start-page: 2490 year: 2014 end-page: 2497 ident: CR5 article-title: DNA mismatch repair gene implicated in determining age at natural menopause publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddt620 – volume: 8 start-page: e1000294 year: 2010 ident: CR21 article-title: Rare variants create synthetic genome-wide associations publication-title: PLoS Biol. doi: 10.1371/journal.pbio.1000294 – volume: 507 start-page: 455 year: 2014 end-page: 461 ident: CR51 article-title: An atlas of active enhancers across human cell types and tissues publication-title: Nature doi: 10.1038/nature12787 – volume: 17 start-page: 3236 year: 2008 end-page: 3246 ident: CR14 article-title: Tdrd3 is a novel stress granule–associated protein interacting with the Fragile-X syndrome protein FMRP publication-title: Hum. Mol. Genet. – volume: 96 start-page: 11 year: 2007 end-page: 15 ident: CR34 article-title: Cancer risks among and mutation carriers publication-title: Br. J. Cancer doi: 10.1038/sj.bjc.6603535 – volume: 44 start-page: 260 year: 2012 end-page: 268 ident: CR4 article-title: Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways publication-title: Nat. Genet. doi: 10.1038/ng.1051 – ident: CR55 – volume: 21 start-page: 263 year: 2005 end-page: 265 ident: CR44 article-title: Haploview: analysis and visualization of LD and haplotype maps publication-title: Bioinformatics doi: 10.1093/bioinformatics/bth457 – volume: 461 start-page: 1071 year: 2009 end-page: 1078 ident: CR39 article-title: The DNA damage response in human biology and disease publication-title: Nature doi: 10.1038/nature08467 – volume: 25 start-page: 685 year: 2011 end-page: 700 ident: CR26 article-title: RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation–induced nuclear foci publication-title: Genes Dev. doi: 10.1101/gad.2011011 – volume: 29 start-page: 2736 year: 2014 end-page: 2746 ident: CR37 article-title: Expression of neurokinin B/NK3 receptor and kisspeptin/KISS1 receptor in human granulosa cells publication-title: Hum. Reprod. doi: 10.1093/humrep/deu247 – volume: 43 start-page: D799 year: 2015 end-page: D804 ident: CR15 article-title: GRASP v2.0: an update on the Genome-Wide Repository of Associations between SNPs and phenotypes publication-title: Nucleic Acids Res. doi: 10.1093/nar/gku1202 – volume: 183 start-page: 1038 year: 2013 ident: BFng3412_CR23 publication-title: Am. J. Pathol. doi: 10.1016/j.ajpath.2013.07.003 – volume: 155 start-page: 934 year: 2013 ident: BFng3412_CR50 publication-title: Cell doi: 10.1016/j.cell.2013.09.053 – volume: 45 start-page: 353 year: 2013 ident: BFng3412_CR20 publication-title: Nat. Genet. doi: 10.1038/ng.2563 – ident: BFng3412_CR53 doi: 10.1038/nature13595 – volume: 5 start-page: e1000534 year: 2009 ident: BFng3412_CR45 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1000534 – volume: 23 start-page: 2490 year: 2014 ident: BFng3412_CR5 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddt620 – volume: 28 start-page: 240 year: 2010 ident: BFng3412_CR31 publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2009.24.2057 – volume: 41 start-page: 518 issue: 5 year: 2009 ident: BFng3412_CR6 publication-title: Nature Genetics doi: 10.1038/ng.340 – volume: 8 start-page: 141 year: 2002 ident: BFng3412_CR3 publication-title: Hum. Reprod. Update doi: 10.1093/humupd/8.2.141 – volume: 29 start-page: 2736 year: 2014 ident: BFng3412_CR37 publication-title: Hum. Reprod. doi: 10.1093/humrep/deu247 – volume: 288 start-page: 34168 year: 2013 ident: BFng3412_CR28 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M113.484493 – volume: 96 start-page: 11 year: 2007 ident: BFng3412_CR34 publication-title: Br. J. Cancer doi: 10.1038/sj.bjc.6603535 – volume: 284 start-page: 1354 year: 1999 ident: BFng3412_CR25 publication-title: Science doi: 10.1126/science.284.5418.1354 – volume: 25 start-page: 685 year: 2011 ident: BFng3412_CR26 publication-title: Genes Dev. doi: 10.1101/gad.2011011 – volume: 26 start-page: 2190 year: 2010 ident: BFng3412_CR40 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq340 – volume: 158 start-page: 107 year: 2008 ident: BFng3412_CR13 publication-title: Eur. J. Endocrinol. doi: 10.1530/EJE-07-0400 – volume: 17 start-page: 3236 year: 2008 ident: BFng3412_CR14 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddn219 – ident: BFng3412_CR58 doi: 10.1016/S0140-6736(12)62129-1 – volume: 429 start-page: 417 year: 2004 ident: BFng3412_CR12 publication-title: Nature doi: 10.1038/nature02517 – volume: 310 start-page: 1353 year: 2013 ident: BFng3412_CR33 publication-title: J. Am. Med. Assoc. doi: 10.1001/jama.2013.278040 – volume: 8 start-page: e1000294 year: 2010 ident: BFng3412_CR21 publication-title: PLoS Biol. doi: 10.1371/journal.pbio.1000294 – volume: 461 start-page: 1071 year: 2009 ident: BFng3412_CR39 publication-title: Nature doi: 10.1038/nature08467 – volume: 43 start-page: D799 year: 2015 ident: BFng3412_CR15 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gku1202 – volume: 41 start-page: 518 issue: 5 year: 2009 ident: BFng3412_CR59 publication-title: Nature Genetics doi: 10.1038/ng.340 – volume: 31 start-page: 3920 year: 2013 ident: BFng3412_CR32 publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2013.49.3007 – volume: 41 start-page: 637 year: 2009 ident: BFng3412_CR1 publication-title: Nat. Genet. doi: 10.1038/ng0609-637 – ident: BFng3412_CR18 doi: 10.1016/S1470-2045(12)70425-4 – volume: 274 start-page: 414 year: 2013 ident: BFng3412_CR22 publication-title: J. Intern. Med. doi: 10.1111/joim.12085 – ident: BFng3412_CR55 doi: 10.1038/nature11632 – volume: 175 start-page: 998 year: 2012 ident: BFng3412_CR16 publication-title: Am. J. Epidemiol. doi: 10.1093/aje/kwr447 – volume: 88 start-page: 76 year: 2011 ident: BFng3412_CR43 publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2010.11.011 – volume: 514 start-page: 92 year: 2014 ident: BFng3412_CR17 publication-title: Nature doi: 10.1038/nature13545 – volume: 41 start-page: 827 year: 2013 ident: BFng3412_CR48 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gks1284 – volume: 45 start-page: 124 year: 2013 ident: BFng3412_CR52 publication-title: Nat. Genet. doi: 10.1038/ng.2504 – volume: 72 start-page: 1544 year: 2003 ident: BFng3412_CR11 publication-title: Am. J. Hum. Genet. doi: 10.1086/375404 – volume: 47 start-page: 497 year: 2012 ident: BFng3412_CR29 publication-title: Mol. Cell doi: 10.1016/j.molcel.2012.07.029 – ident: BFng3412_CR56 doi: 10.1038/nature10405 – volume: 1127 start-page: 1 year: 2008 ident: BFng3412_CR7 publication-title: Ann. NY Acad. Sci. doi: 10.1196/annals.1434.009 – volume: 155 start-page: 3088 year: 2014 ident: BFng3412_CR38 publication-title: Endocrinology doi: 10.1210/en.2014-1110 – volume: 30 start-page: 111 year: 2009 ident: BFng3412_CR35 publication-title: Peptides doi: 10.1016/j.peptides.2008.05.016 – volume: 95 start-page: 754 year: 2014 ident: BFng3412_CR30 publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2014.11.002 – volume: 98 start-page: 1781 year: 2013 ident: BFng3412_CR36 publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2012-3550 – volume: 44 start-page: 260 year: 2012 ident: BFng3412_CR4 publication-title: Nat. Genet. doi: 10.1038/ng.1051 – volume: 44 start-page: 955 year: 2012 ident: BFng3412_CR54 publication-title: Nat. Genet. doi: 10.1038/ng.2354 – volume: 63 start-page: 280 year: 2009 ident: BFng3412_CR2 publication-title: Maturitas doi: 10.1016/j.maturitas.2009.06.007 – volume: 6 start-page: e1001058 year: 2010 ident: BFng3412_CR47 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1001058 – volume: 507 start-page: 455 year: 2014 ident: BFng3412_CR51 publication-title: Nature doi: 10.1038/nature12787 – volume: 26 start-page: 542 year: 2008 ident: BFng3412_CR9 publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2007.12.5922 – volume: 81 start-page: 559 year: 2007 ident: BFng3412_CR41 publication-title: Am. J. Hum. Genet. doi: 10.1086/519795 – volume: 21 start-page: 263 year: 2005 ident: BFng3412_CR44 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bth457 – volume: 5 start-page: 172ra21 year: 2013 ident: BFng3412_CR24 publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.3004925 – volume: 287 start-page: 6469 year: 2012 ident: BFng3412_CR8 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.324582 – volume: 10 start-page: e1004542 year: 2014 ident: BFng3412_CR27 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1004542 – volume: 42 start-page: 937 year: 2010 ident: BFng3412_CR60 publication-title: Nat. Genet. doi: 10.1038/ng.686 – volume: 45 start-page: 385 year: 2013 ident: BFng3412_CR57 publication-title: Nat. Genet. doi: 10.1038/ng.2560 – volume: 478 start-page: 476 year: 2011 ident: BFng3412_CR49 publication-title: Nature doi: 10.1038/nature10530 – volume: 2 start-page: 719 year: 2014 ident: BFng3412_CR19 publication-title: Lancet Diabetes Endocrinol. doi: 10.1016/S2213-8587(14)70113-5 – volume: 125 start-page: 258 year: 2015 ident: BFng3412_CR10 publication-title: J. Clin. Invest. doi: 10.1172/JCI78473 – volume: 8 start-page: S33 year: 2014 ident: BFng3412_CR42 publication-title: BMC Proc. doi: 10.1186/1753-6561-8-S1-S33 – volume: 15 start-page: 532 year: 2014 ident: BFng3412_CR46 publication-title: BMC Genomics doi: 10.1186/1471-2164-15-532 |
| SSID | ssj0014408 |
| Score | 2.622056 |
| Snippet | John Perry and colleagues report the results of a large genome-wide association study meta-analysis to identify variants influencing age at natural menopause.... Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We... |
| SourceID | swepub pubmedcentral proquest gale pubmed crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1294 |
| SubjectTerms | 45 45/43 631/208/205/2138 692/699/67/1347 Adult Age Factors Aging - genetics Agriculture Animal Genetics and Genomics Biomedicine BRCA1 Protein - genetics Breast cancer Breast Neoplasms - genetics Cancer Research Cellular signal transduction Consortia Deoxyribonucleic acid Development and progression Disease susceptibility DNA DNA Repair Female Gene Function Gene Regulatory Networks - genetics Genealogy Genetic aspects Genetic Predisposition to Disease - genetics Genetic Variation Genome-Wide Association Study - methods Genomes Genomics - methods Genotype Health aspects Health risks Human Genetics Humans Hypothalamus - metabolism Identification and classification Infertility Menopause Menopause - genetics Meta-analysis Middle Aged Models, Genetic Phenotype Reproduction - genetics Signal Transduction - genetics Studies Womens health |
| Title | Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair |
| URI | https://link.springer.com/article/10.1038/ng.3412 https://www.ncbi.nlm.nih.gov/pubmed/26414677 https://www.proquest.com/docview/1730676155 https://www.proquest.com/docview/1728258966 https://www.proquest.com/docview/1808669071 https://pubmed.ncbi.nlm.nih.gov/PMC4661791 http://kipublications.ki.se/Default.aspx?queryparsed=id:132348371 |
| Volume | 47 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1fb9MwELfYJiReJv6TMSoPofFCWLI4jvOEurJpICioMNS3yHHsrmJLS5M-9Cvwqblz3LAUsbeqvrqJ7-y78939jpBXPJHgVujUj0C7-Ywp5ovCSF-A6g1CrY2RGNH9POTnF-zjOB67C7fKpVWuz0R7UBczhXfkR2GCxi1G0d7Nf_nYNQqjq66FxhbZwRpQdL7EoE3xwLhlUwrH0U_CMOVuU2YujsrJWzi_jzvaaPNMvqGUNhMm26jpBsKo1Upn98muMydpv-H_A3JHlw_J3abB5OoR-f0JE739ChihKcKxXk8VlRaHRFcUg7cUUS0t6Csce9S2LKL1jF6u5sBCeYXd6inmeEgsW39Dc8xhr6lCWVnQalnZrBibYLuCiQt6Mhr0Q9_Wo4AtS98P-_gPcrp4TC7OTr8Pzn3XfcFXPOK1z2MVc3Vc5Dw0UqEjmcecSZNHoPUCY5SKikAZAxai0alJgLmpkTrnBRhVoWLRE7Jdzkr9jFBmuGZpJHQCBpAu4jwNgD7XUmhpeBF45HDNhUw5aHLskHGV2RB5JLJykiG7PEJbwnmDxvEvyUtkY4bYFiUmz0zksqqyD19-ZH0WMbRgYvE_om-jDtFrR2Rm8DRKuoIFeCfEzOpQ7ncoYYeq7vBapDJ3QlTZX3n2yEE7jL_ErLdSz5ZIg5XFAjzSW2gEOKV4xRF65Gkjpe3SgLGLijDxSNKR35YAscW7I-X00mKMM7DbkhTmPFhL-o1H31zxw2YLdKZ1X_2ETzpD2MaU792-Ds_JPbBG46bQc59s14ulfgEWX533yFYyTnp2c_fIzsnp8OvoD4a6Wkk |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELfGEIKXie8VBngIxgvZksZxkgeEysbUsq5IY0N9M45jdxWQlqYV6r_AH8PfyJ3zwVLE3vZW1RfX9Z3vI3f3MyEveCghrNCx44N1cxhTzIlSI50ITK_raW2MxIzu8YB3z9iHYTBcI7-rXhgsq6x0olXU6UThO_I9L0TnFrNob6c_HLw1CrOr1RUahVgc6eVPCNnyN70D4O_Ldvvw_el-1ylvFXAU9_nc4YEKuGqnCfeMVBggJQFn0iQQ2fuuMUr5qauMAc_H6NiEsOjYSJ3wFJwFTzEf5r1GrjNMMcL5CYd1gId50qL1jmNchmnRjaKtPdrLRrtgL9oN67dqAy4YwdUCzTpLu4Joaq3g4W2yUbqvtFPI2x2yprO75EZxoeXyHvnVx8JyJwfGa4rwr9_HikqLe6JzisliiiiaFmQW1Cy1VyTR-YSeL6cgMhLEEx7AmhKJbfKvaYI183OqUDZnNF_ktgrHFvQuYeKUvjvZ73iO7X8B35keDDr4C3I8u0_OroQvD8h6Nsn0JqHMcM1iP9IhOFw6DZLYBfpEy0hLw1O3RXYqLghVQqHjjRzfhE3J-5HIRgLZ1SK0JpwW6B__kjxHNgrE0siwWGckF3kueh8_iw7zGXpMQfQ_ok8nDaJXJZGZwGqULBsk4D8hRleDcqtBCRpBNYcrkRKlRsrF3_PTItv1MD6JVXaZniyQBjuZI4iAL6GJIAjGVypeizwspLTeGnCu0fCGLRI25LcmQCzz5kg2PreY5gz8xDCGObcrSb-w9NUd3ymOQGPa8quv8EkLhImM-aPL9-EZudk9Pe6Lfm9w9JjcAk84KJpMt8j6fLbQT8DbnCdP7RGn5MtV65Q_0iiWGg |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELfGJhAvE98UBngIxguhTeM4ycOEunXVykaZCkN7M45jdxWQlqYV6r_An8ZfxZ3zwVLE3vZWxRc3sc_3kbv7HSEveCDBrdCR44F2cxhTzAkTI50QVG_L1doYiRHd9wN-eMrenflna-R3WQuDaZWlTLSCOpko_EbedAM0bjGK1jRFWsRJt_d2-sPBDlIYaS3baciizUKya-HGiiKPI738Ce5cttvvwt6_bLd7B5_2D52i44CjuMfnDveVz1U7iblrpELnKfY5kyYGr99rGaOUl7SUMWAVGR2ZAF4oMlLHPAFDwlXMg3mvkY0AtD44ght7B4OTYRXTwN7ONvbK0WvDoOlmXvQeNtPRG9Am7ZpuXNUQF1TkavpmFcNdwTu1OrJ3i2wWxi3t5Nx4m6zp9A65nre7XN4lv44x7dzJgC00RXDY72NFpUVF0RnFUDJFjE0LQQtCmNoGSnQ-oefLKTCUBOaFGzDjRGIR_WsaY0b9nCrk3BnNFpnN0bHpvkuYOKF7w_2O69jqGLCsaXfQwX-Q49k9cnolO3OfrKeTVD8klBmuWeSFOgBzTCd-HLWAPtYy1NLwpNUgO-UuCFUApWO_jm_CBuy9UKQjgdvVILQinObYIP-SPMdtFIi0kSLPjuQiy0T_w2fRYR5De8oP_0f0cVgjelUQmQk8jZJF-QS8EyJ41Si3apQgL1R9uGQpUcirTPw9XQ2yXQ3jnZiDl-rJAmmwzjkE__gSmhBcZPzg4jbIg5xLq6UB0xvVctAgQY1_KwJEOq-PpONzi3jOwIoMIphzu-T0C4--uuI7-RGoTVtc-gq_tEAQyYg_unwdnpEbIF_EcX9w9JjcBDPZzytQt8j6fLbQT8AUncdPizNOyZerFit_AEcyoPU |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Large-scale+genomic+analyses+link+reproductive+aging+to+hypothalamic+signaling%2C+breast+cancer+susceptibility+and+BRCA1-mediated+DNA+repair&rft.jtitle=Nature+genetics&rft.au=Day%2C+Felix+R&rft.au=Ruth%2C+Katherine+S&rft.au=Thompson%2C+Deborah+J&rft.au=Lunetta%2C+Kathryn+L&rft.date=2015-11-01&rft.issn=1061-4036&rft.eissn=1546-1718&rft.volume=47&rft.issue=11&rft.spage=1294&rft.epage=1303&rft_id=info:doi/10.1038%2Fng.3412&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_ng_3412 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1061-4036&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1061-4036&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1061-4036&client=summon |