抵抗素基因多态性与脑梗死的关系
目的研究抵抗素基因-420C/G位点多态性与脑梗死之间是否存在相关性。方法采用聚合酶链反应-高温连接酶检测反应技术,对426例脑梗死患者和305例健康对照者抵抗素基因-420C/G的多态性进行分析。结果脑梗死组的总胆固醇（TC）与对照组比较,差异无统计学意义。脑梗死组的三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、血糖和血压高于对照组,而高密度脂蛋白胆固醇（HDL-C）则降低。脑梗死组患者的-420C/G基因型频率和等位基因频率与对照组比较,差异无统计学意义,两组样本都符合H-W检验。脑梗死危险因素的logistic回归分析显示,收缩压、空腹血糖、LDL-C和TG水平的差异是脑梗死的独立...
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| Published in | 上海交通大学学报（医学版） Vol. 36; no. 2; pp. 229 - 232 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
上海交通大学医学院附属瑞金医院神经内科,上海,200025
2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1674-8115 |
| DOI | 10.3969/j.issn.1674-8115.2016.02.015 |
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| Abstract | 目的研究抵抗素基因-420C/G位点多态性与脑梗死之间是否存在相关性。方法采用聚合酶链反应-高温连接酶检测反应技术,对426例脑梗死患者和305例健康对照者抵抗素基因-420C/G的多态性进行分析。结果脑梗死组的总胆固醇（TC）与对照组比较,差异无统计学意义。脑梗死组的三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、血糖和血压高于对照组,而高密度脂蛋白胆固醇（HDL-C）则降低。脑梗死组患者的-420C/G基因型频率和等位基因频率与对照组比较,差异无统计学意义,两组样本都符合H-W检验。脑梗死危险因素的logistic回归分析显示,收缩压、空腹血糖、LDL-C和TG水平的差异是脑梗死的独立危险因素。结论抵抗素基因-420C/G位点多态性与脑梗死无相关性。 |
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| AbstractList | 目的研究抵抗素基因-420C/G位点多态性与脑梗死之间是否存在相关性。方法采用聚合酶链反应-高温连接酶检测反应技术,对426例脑梗死患者和305例健康对照者抵抗素基因-420C/G的多态性进行分析。结果脑梗死组的总胆固醇（TC）与对照组比较,差异无统计学意义。脑梗死组的三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、血糖和血压高于对照组,而高密度脂蛋白胆固醇（HDL-C）则降低。脑梗死组患者的-420C/G基因型频率和等位基因频率与对照组比较,差异无统计学意义,两组样本都符合H-W检验。脑梗死危险因素的logistic回归分析显示,收缩压、空腹血糖、LDL-C和TG水平的差异是脑梗死的独立危险因素。结论抵抗素基因-420C/G位点多态性与脑梗死无相关性。 R743.33; 目的 研究抵抗素基因-420C/G位点多态性与脑梗死之间是否存在相关性.方法 采用聚合酶链反应-高温连接酶检测反应技术,对426例脑梗死患者和305例健康对照者抵抗素基因-420C/G的多态性进行分析.结果 脑梗死组的总胆固醇(TC)与对照组比较,差异无统计学意义.脑梗死组的三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、血糖和血压高于对照组,而高密度脂蛋白胆固醇(HDL-C)则降低.脑梗死组患者的-420C/G基因型频率和等位基因频率与对照组比较,差异无统计学意义,两组样本都符合H-W检验.脑梗死危险因素的logistic回归分析显示,收缩压、空腹血糖、LDL-C和TG水平的差异是脑梗死的独立危险因素.结论 抵抗素基因-420C/G位点多态性与脑梗死无相关性. |
| Author | 顾琳 蔡高宇 陈淳 傅毅 |
| AuthorAffiliation | 上海交通大学医学院附属瑞金医院神经内科,上海200025 |
| AuthorAffiliation_xml | – name: 上海交通大学医学院附属瑞金医院神经内科,上海,200025 |
| Author_FL | FU Yi CHEN Chun CAI Gao-yu GU Lin |
| Author_FL_xml | – sequence: 1 fullname: GU Lin – sequence: 2 fullname: CAI Gao-yu – sequence: 3 fullname: CHEN Chun – sequence: 4 fullname: FU Yi |
| Author_xml | – sequence: 1 fullname: 顾琳 蔡高宇 陈淳 傅毅 |
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| DocumentTitleAlternate | Correlation between polymorphism of resistin gene and cerebral infraction |
| DocumentTitle_FL | Correlation between polymorphism of resistin gene and cerebral infraction |
| EndPage | 232 |
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| Keywords | 抵抗素 resistin gene polymorphism 基因多态性 脑梗死 cerebral infraction |
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| Notes | 31-1259/R cerebral infraction; resistin; gene polymorphism GU Lin, CAI Gao-yu, CHEN Chun, FU Yi（ Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China） Objective To investigate the correlation between the polymorphism of locus-420C/G of the resistin gene and cerebral infraction.Methods The polymorphism of locus-420 C /G of the resistin gene of426 patients with cerebral infraction and 305 healthy controls was analyzed by PCR-LDR.Results The difference of TC between the cerebral infraction group and control group were not statistically significant.The TG,LDL-C,fasting blood glucose,and blood pressure of the cerebral infraction group were higher than those of the control group,while HDL-C was lower than that of the control group.The differences of genotype frequency and allele frequency of-420 C /G gene between the cerebral infraction group and control group were not statistically significant.Samples of both groups accorded with the H-W test.The logistic |
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| PublicationTitle | 上海交通大学学报（医学版） |
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| PublicationYear | 2016 |
| Publisher | 上海交通大学医学院附属瑞金医院神经内科,上海,200025 |
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| Snippet | ... R743.33; 目的 研究抵抗素基因-420C/G位点多态性与脑梗死之间是否存在相关性.方法 采用聚合酶链反应-高温连接酶检测反应技术,对426例脑梗死患者和305例健康对照者抵抗素基因-420C/G的多态性进行分析.结果... |
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| StartPage | 229 |
| SubjectTerms | 基因多态性 抵抗素 脑梗死 |
| Title | 抵抗素基因多态性与脑梗死的关系 |
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