LC3和VMP1在子宫内膜异位症在位内膜中表达的研究
目的：探讨子宫内膜异位症（EMs）患者在位内膜组织与正常子宫内膜组织中微管相关轻链蛋白3（LC3）和空泡膜蛋白1（VMP1）的表达及两者的相关性。方法：选择2010年1月—2016年6月于中国医科大学附属盛京医院手术治疗的患者子宫内膜组织，应用免疫组织化学方法检测LC3和VMP1在54例EMs患者的在位内膜组织和40例正常子宫内膜组织中的表达，并分析其相关性。结果：①EMs患者在位内膜组织中LC3（22/54，40.74%）和VMP1（26/54，48.15%）的阳性表达率均低于正常子宫内膜组织（36/40，90.00%；32/40，80.00%），差异有统计学意义（P＜0.05）；②Ⅲ～Ⅳ期...
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| Published in | 国际妇产科学杂志 Vol. 44; no. 4; pp. 473 - 475 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
中国医科大学附属盛京医院妇产科, 沈阳,110000
2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1674-1870 |
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| Abstract | 目的：探讨子宫内膜异位症（EMs）患者在位内膜组织与正常子宫内膜组织中微管相关轻链蛋白3（LC3）和空泡膜蛋白1（VMP1）的表达及两者的相关性。方法：选择2010年1月—2016年6月于中国医科大学附属盛京医院手术治疗的患者子宫内膜组织，应用免疫组织化学方法检测LC3和VMP1在54例EMs患者的在位内膜组织和40例正常子宫内膜组织中的表达，并分析其相关性。结果：①EMs患者在位内膜组织中LC3（22/54，40.74%）和VMP1（26/54，48.15%）的阳性表达率均低于正常子宫内膜组织（36/40，90.00%；32/40，80.00%），差异有统计学意义（P＜0.05）；②Ⅲ～Ⅳ期EMs患者组中LC3（8/34，23.53%）和VMP1（10/34，29.41%）的阳性表达率均低于Ⅰ～Ⅱ期患者组（14/20，70.00%；16/20，80.00%），差异有统计学意义（P＜0.05）；③LC3和VMP1在EMs患者在位内膜中的表达不存在相关性（P＞0.05）。结论：LC3和VMP1在EMs患者在位内膜中的表达降低，可能与EMs患者在位内膜自噬下调有关。 |
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| AbstractList | 目的：探讨子宫内膜异位症（EMs）患者在位内膜组织与正常子宫内膜组织中微管相关轻链蛋白3（LC3）和空泡膜蛋白1（VMP1）的表达及两者的相关性。方法：选择2010年1月—2016年6月于中国医科大学附属盛京医院手术治疗的患者子宫内膜组织，应用免疫组织化学方法检测LC3和VMP1在54例EMs患者的在位内膜组织和40例正常子宫内膜组织中的表达，并分析其相关性。结果：①EMs患者在位内膜组织中LC3（22/54，40.74%）和VMP1（26/54，48.15%）的阳性表达率均低于正常子宫内膜组织（36/40，90.00%；32/40，80.00%），差异有统计学意义（P＜0.05）；②Ⅲ～Ⅳ期EMs患者组中LC3（8/34，23.53%）和VMP1（10/34，29.41%）的阳性表达率均低于Ⅰ～Ⅱ期患者组（14/20，70.00%；16/20，80.00%），差异有统计学意义（P＜0.05）；③LC3和VMP1在EMs患者在位内膜中的表达不存在相关性（P＞0.05）。结论：LC3和VMP1在EMs患者在位内膜中的表达降低，可能与EMs患者在位内膜自噬下调有关。 目的:探讨子宫内膜异位症(EMs)患者在位内膜组织与正常子宫内膜组织中微管相关轻链蛋白3(LC3)和空泡膜蛋白1(VMP1)的表达及两者的相关性.方法:选择2010年1月—2016年6月于中国医科大学附属盛京医院手术治疗的患者子宫内膜组织,应用免疫组织化学方法检测LC3和VMP1在54例EMs患者的在位内膜组织和40例正常子宫内膜组织中的表达,并分析其相关性.结果:①EMs患者在位内膜组织中LC3(22/54,40.74%)和VMP1(26/54,48.15%)的阳性表达率均低于正常子宫内膜组织(36/40,90.00%;32/40,80.00%),差异有统计学意义(P<0.05);②Ⅲ~Ⅳ期EMs患者组中LC3(8/34,23.53%)和VMP1(10/34,29.41%)的阳性表达率均低于Ⅰ~Ⅱ期患者组(14/20,70.00%;16/20,80.00%),差异有统计学意义(P<0.05);③LC3和VMP1在EMs患者在位内膜中的表达不存在相关性(P>0.05).结论:LC3和VMP1在EMs患者在位内膜中的表达降低,可能与EMs患者在位内膜自噬下调有关. |
| Abstract_FL | Objective: To investigate the expression of LC3 and VMP1 in eutopic endometrium of endometriosis and normal endometrium and to evaluate the relationship of them. Methods:Specimens were selected from January 2010 to June 2016 in the endometrial tissue of patients treated by Shengjing Hospital of China Medical University, detection the expression and relationship of LC3 and VMP1 in eutopic endometrium in 54 cases of patients with ovarian endometriosis and 40 cases of patients without endometriosis by immunohistochemistry, further discuss the relationship of them. Results: ①The positive expression rate of LC3 (22/54, 40.74%) and VMP1 (26/54, 48.15%) in eutopic endometrium of endometriosis was significantly lower than that in normal endometrium (36/40, 90.00%;32/40, 80.00%), the difference was statistically significant (P<0.05);②The positive expression rate of LC3 (8/34, 23.53%) and VMP1 (10/34, 29.41%) in stageⅢandⅣendometriosis patients was significantly lower than that in stageⅠandⅡpatients (14/20, 70%;16/20, 80%);③The expression of LC3 was not correlated with the expression of VMP1 in eutopic endometrium of endometriosis (P>0.05). Conclusions: LC3 and VMP1 in eutopic endometrium of patients with endometriosis are lower and eutopic endometrium of patients with endometriosis is related to the down-regulation of autophagy. |
| Author | 李琳;刘岿然 |
| AuthorAffiliation | 中国医科大学附属盛京医院妇产科,沈阳110000 |
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| Author_FL | LIU Kui-ran LI Lin |
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| DocumentTitleAlternate | The Research of Expression of LC3and VMP1in Eutopic Endometrium of Endometriosis |
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| Keywords | Immunohistochemistry 子宫内膜异位症 膜蛋白质类 Microtubule-associated proteins 微管相关蛋白质类 Endometriosis 免疫组织化学 Membrane proteins |
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| Notes | Objective:To investigate the expression of LC3and VMP1in eutopic endometrium of endometriosis and normal endometrium and to evaluate the relationship of them.Methods:Specimens were selected from January2010to June2016in the endometrial tissue of patients treated by Shengjing Hospital of China Medical University,detection the expression and relationship of LC3and VMP1in eutopic endometrium in54cases of patients with ovarian endometriosis and40cases of patients without endometriosis by immunohistochemistry,further discuss the relationship of them.Results:①The positive expression rate of LC3(22/54,40.74%)and VMP1(26/54,48.15%)in eutopic endometrium of endometriosis was significantly lower than that in normal endometrium(36/40,90.00%;32/40,80.00%),the difference was statistically significant(P<0.05);②The positive expression rate of LC3(8/34,23.53%)and VMP1(10/34,29.41%)in stageⅢandⅣendometriosis patients was significantly lower than that in stageⅠandⅡpatients(14/20,70%;16/20,80%);③The expression of LC3was not |
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| Publisher | 中国医科大学附属盛京医院妇产科, 沈阳,110000 |
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| Snippet | 目的：探讨子宫内膜异位症（EMs）患者在位内膜组织与正常子宫内膜组织中微管相关轻链蛋白3（LC3）和空泡膜蛋白1（VMP1）的表达及两者的相关性。方法：选择2010年1月—2016... 目的:探讨子宫内膜异位症(EMs)患者在位内膜组织与正常子宫内膜组织中微管相关轻链蛋白3(LC3)和空泡膜蛋白1(VMP1)的表达及两者的相关性.方法:选择2010年1月—2016年6月于中... |
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| SubjectTerms | 子宫内膜异位症;微管相关蛋白质类;膜蛋白质类;免疫组织化学 |
| Title | LC3和VMP1在子宫内膜异位症在位内膜中表达的研究 |
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