CCL5 promotes vascular endothelial growth factor expression and induces angiogenesis by down-regulating miR-199a in human chondrosarcoma cells - Liu, Guan-Ting; Huang, Yuan-Li; Tzeng, Huey-En; Tsai, Chun-Hao; Wang, Shih-Wei; Tang, Chih-Hsin (Cancer letters, 2015)
Keywords: 3' Untranslated Regions - genetics; Angiogenesis; Animals; Base Sequence; Blotting, Western; Bone cancer; Bone Neoplasms - blood supply; Bone Neoplasms - drug therapy; Bone Neoplasms - genetics; Breast cancer; CCL5; Cell growth; Cell Line, Tumor; Cells, Cultured; Chemokine CCL5 - genetics; Chemokine CCL5 - metabolism; Chemokine CCL5 - pharmacology; Chemokines; Chick Embryo; Chondrosarcoma; Chondrosarcoma - blood supply; Chondrosarcoma - drug therapy; Chondrosarcoma - genetics; Dose-Response Relationship, Drug; Down-Regulation - drug effects; Down-Regulation - genetics; Endothelial Progenitor Cells - drug effects; Endothelial Progenitor Cells - metabolism; Gene amplification; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; Hematology, Oncology and Palliative Medicine; Humans; Male; Metastasis; Mice, SCID; MicroRNAs - genetics; Migration; miR-199a; Molecular weight; Motility; Neovascularization, Pathologic - genetics; Neovascularization, Pathologic - metabolism; Reverse Transcriptase Polymerase Chain Reaction; Rodents; Sequence Homology, Nucleic Acid; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - genetics; Vascular Endothelial Growth Factor A - metabolism; VEGF; Xenograft Model Antitumor Assays; CCR1; Chondrosarcoma; miRNAs; JJ012; VEGF; CM; miR-199a; PBMCs; CAM; Angiogenesis; CCL5; MMP-3; EPCs; CCR5; CCR3; microRNAs; conditioned medium; CC-chemokine receptor 5; matrix metalloproteinase-3; CC-chemokine receptor 3; CC-chemokine receptor 1; endothelial progenitor cells; peripheral blood mononuclear cells; human chondrosarcoma cell line; vascular endothelial growth factor; chorioallantoic membranes assay