Caveolin-1 function at the plasma membrane and in intracellular compartments in cancer

Caveolin-1 (CAV1) is commonly considered to function as a cell surface protein, for instance in the genesis of caveolae. Nonetheless, it is also present in many intracellular organelles and compartments. The contributions of these intracellular pools to CAV1 function are generally less well understo...

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Published inCancer and metastasis reviews Vol. 39; no. 2; pp. 435 - 453
Main Authors Simón, L., Campos, A., Leyton, L., Quest, A. F. G.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.06.2020
Springer
Springer Nature B.V
Subjects
Animals
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Caveolae
Caveolin
Caveolin 1 - metabolism
Caveolin-1
Cell Communication - physiology
Cell interactions
Cell Membrane - metabolism
Cell membranes
Cell surface
Exosomes
Humans
Intracellular
Intracellular signalling
Intracellular Space
Metastases
Metastasis
Neoplasms - metabolism
Neoplasms - pathology
Oncology
Organelles
Organelles - metabolism
Tumor suppressor genes
Caveolin-1
Metastasis
Localization
Organelles
Online AccessGet full text
ISSN0167-7659
1573-7233
1573-7233
DOI10.1007/s10555-020-09890-x

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Abstract Caveolin-1 (CAV1) is commonly considered to function as a cell surface protein, for instance in the genesis of caveolae. Nonetheless, it is also present in many intracellular organelles and compartments. The contributions of these intracellular pools to CAV1 function are generally less well understood, and this is also the case in the context of cancer. This review will summarize literature available on the role of CAV1 in cancer, highlighting particularly our understanding of the canonical (CAV1 in the plasma membrane) and non-canonical pathways (CAV1 in organelles and exosomes) linked to the dual role of the protein as a tumor suppressor and promoter of metastasis. With this in mind, we will focus on recently emerging concepts linking CAV1 function to the regulation of intracellular organelle communication within the same cell where CAV1 is expressed. However, we now know that CAV1 can be released from cells in exosomes and generate systemic effects. Thus, we will also elaborate on how CAV1 participates in intracellular communication between organelles as well as signaling between cells (non-canonical pathways) in cancer.
AbstractList Caveolin-1 (CAV1) is commonly considered to function as a cell surface protein, for instance in the genesis of caveolae. Nonetheless, it is also present in many intracellular organelles and compartments. The contributions of these intracellular pools to CAV1 function are generally less well understood, and this is also the case in the context of cancer. This review will summarize literature available on the role of CAV1 in cancer, highlighting particularly our understanding of the canonical (CAV1 in the plasma membrane) and non-canonical pathways (CAV1 in organelles and exosomes) linked to the dual role of the protein as a tumor suppressor and promoter of metastasis. With this in mind, we will focus on recently emerging concepts linking CAV1 function to the regulation of intracellular organelle communication within the same cell where CAV1 is expressed. However, we now know that CAV1 can be released from cells in exosomes and generate systemic effects. Thus, we will also elaborate on how CAV1 participates in intracellular communication between organelles as well as signaling between cells (non-canonical pathways) in cancer.Caveolin-1 (CAV1) is commonly considered to function as a cell surface protein, for instance in the genesis of caveolae. Nonetheless, it is also present in many intracellular organelles and compartments. The contributions of these intracellular pools to CAV1 function are generally less well understood, and this is also the case in the context of cancer. This review will summarize literature available on the role of CAV1 in cancer, highlighting particularly our understanding of the canonical (CAV1 in the plasma membrane) and non-canonical pathways (CAV1 in organelles and exosomes) linked to the dual role of the protein as a tumor suppressor and promoter of metastasis. With this in mind, we will focus on recently emerging concepts linking CAV1 function to the regulation of intracellular organelle communication within the same cell where CAV1 is expressed. However, we now know that CAV1 can be released from cells in exosomes and generate systemic effects. Thus, we will also elaborate on how CAV1 participates in intracellular communication between organelles as well as signaling between cells (non-canonical pathways) in cancer.
Caveolin-1 (CAV1) is commonly considered to function as a cell surface protein, for instance in the genesis of caveolae. Nonetheless, it is also present in many intracellular organelles and compartments. The contributions of these intracellular pools to CAV1 function are generally less well understood, and this is also the case in the context of cancer. This review will summarize literature available on the role of CAV1 in cancer, highlighting particularly our understanding of the canonical (CAV1 in the plasma membrane) and non-canonical pathways (CAV1 in organelles and exosomes) linked to the dual role of the protein as a tumor suppressor and promoter of metastasis. With this in mind, we will focus on recently emerging concepts linking CAV1 function to the regulation of intracellular organelle communication within the same cell where CAV1 is expressed. However, we now know that CAV1 can be released from cells in exosomes and generate systemic effects. Thus, we will also elaborate on how CAV1 participates in intracellular communication between organelles as well as signaling between cells (non-canonical pathways) in cancer.
Audience Academic
Author Leyton, L.
Campos, A.
Simón, L.
Quest, A. F. G.
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Issue 2
Keywords Caveolin-1
Metastasis
Localization
Organelles
Language English
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Snippet Caveolin-1 (CAV1) is commonly considered to function as a cell surface protein, for instance in the genesis of caveolae. Nonetheless, it is also present in...
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SubjectTerms Animals
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Caveolae
Caveolin
Caveolin 1 - metabolism
Caveolin-1
Cell Communication - physiology
Cell interactions
Cell Membrane - metabolism
Cell membranes
Cell surface
Exosomes
Humans
Intracellular
Intracellular signalling
Intracellular Space
Metastases
Metastasis
Neoplasms - metabolism
Neoplasms - pathology
Oncology
Organelles
Organelles - metabolism
Tumor suppressor genes
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Title Caveolin-1 function at the plasma membrane and in intracellular compartments in cancer
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Volume 39
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