AD dementia risk in late MCI, in early MCI, and in subjective memory impairment

Abstract Objective To compare the risk of developing Alzheimer’s disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory impairment (SMI) with normal test performance. Methods The baseline sample (n = 2892) of the prospective cohort study in nondemente...

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Published inAlzheimer's & dementia Vol. 10; no. 1; pp. 76 - 83
Main Authors Jessen, Frank, Wolfsgruber, Steffen, Wiese, Birgitt, Bickel, Horst, Mösch, Edelgard, Kaduszkiewicz, Hanna, Pentzek, Michael, Riedel-Heller, Steffi G, Luck, Tobias, Fuchs, Angela, Weyerer, Siegfried, Werle, Jochen, van den Bussche, Hendrik, Scherer, Martin, Maier, Wolfgang, Wagner, Michael
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.2014
ALZHEIMER'S & DEMENTIA
Subjects
Online AccessGet full text
ISSN1552-5260
1552-5279
1552-5279
DOI10.1016/j.jalz.2012.09.017

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Abstract Abstract Objective To compare the risk of developing Alzheimer’s disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory impairment (SMI) with normal test performance. Methods The baseline sample (n = 2892) of the prospective cohort study in nondemented individuals (German Study on Aging, Cognition and Dementia in Primary Care Patients) was divided into LMCI, EMCI, SMI, and control subjects by delayed recall performance. These groups were subdivided by the presence of self-reported concerns associated with experienced memory impairment. AD dementia risk was assessed over 6 years. Results Across all groups, risk of AD dementia was greatest in LMCI. In those with self-reported concerns regarding their memory impairment, SMI and EMCI were associated with a similarly increased risk of AD dementia. In those subgroups without concerns, SMI was not associated with increased risk of AD dementia, but EMCI remained an at-risk condition. Conclusions SMI and EMCI with self-reported concerns were associated with the same risk of AD dementia, suggesting that pre-LMCI risk conditions should be extended to SMI with concerns.
AbstractList Objective: To compare the risk of developing Alzheimeras disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory impairment (SMI) with normal test performance.
Abstract Objective To compare the risk of developing Alzheimer’s disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory impairment (SMI) with normal test performance. Methods The baseline sample (n = 2892) of the prospective cohort study in nondemented individuals (German Study on Aging, Cognition and Dementia in Primary Care Patients) was divided into LMCI, EMCI, SMI, and control subjects by delayed recall performance. These groups were subdivided by the presence of self-reported concerns associated with experienced memory impairment. AD dementia risk was assessed over 6 years. Results Across all groups, risk of AD dementia was greatest in LMCI. In those with self-reported concerns regarding their memory impairment, SMI and EMCI were associated with a similarly increased risk of AD dementia. In those subgroups without concerns, SMI was not associated with increased risk of AD dementia, but EMCI remained an at-risk condition. Conclusions SMI and EMCI with self-reported concerns were associated with the same risk of AD dementia, suggesting that pre-LMCI risk conditions should be extended to SMI with concerns.
Objective: To compare the risk of developing Alzheimer's disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory impairment (SMI) with normal test performance. Methods: The baseline sample (n = 2892) of the prospective cohort study in nondemented individuals (German Study on Aging, Cognition and Dementia in Primary Care Patients) was divided into LMCI, EMCI, SMI, and control subjects by delayed recall performance. These groups were subdivided by the presence of self-reported concerns associated with experienced memory impairment. AD dementia risk was assessed over 6 years. Results: Across all groups, risk of AD dementia was greatest in LMCI. In those with self-reported concerns regarding their memory impairment, SMI and EMCI were associated with a similarly increased risk of AD dementia. In those subgroups without concerns, SMI was not associated with increased risk of AD dementia, but EMCI remained an at-risk condition. Conclusions: SMI and EMCI with self-reported concerns were associated with the same risk of AD dementia, suggesting that pre-LMCI risk conditions should be extended to SMI with concerns. [Copyright Elsevier B.V.]
To compare the risk of developing Alzheimer's disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory impairment (SMI) with normal test performance.OBJECTIVETo compare the risk of developing Alzheimer's disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory impairment (SMI) with normal test performance.The baseline sample (n = 2892) of the prospective cohort study in nondemented individuals (German Study on Aging, Cognition and Dementia in Primary Care Patients) was divided into LMCI, EMCI, SMI, and control subjects by delayed recall performance. These groups were subdivided by the presence of self-reported concerns associated with experienced memory impairment. AD dementia risk was assessed over 6 years.METHODSThe baseline sample (n = 2892) of the prospective cohort study in nondemented individuals (German Study on Aging, Cognition and Dementia in Primary Care Patients) was divided into LMCI, EMCI, SMI, and control subjects by delayed recall performance. These groups were subdivided by the presence of self-reported concerns associated with experienced memory impairment. AD dementia risk was assessed over 6 years.Across all groups, risk of AD dementia was greatest in LMCI. In those with self-reported concerns regarding their memory impairment, SMI and EMCI were associated with a similarly increased risk of AD dementia. In those subgroups without concerns, SMI was not associated with increased risk of AD dementia, but EMCI remained an at-risk condition.RESULTSAcross all groups, risk of AD dementia was greatest in LMCI. In those with self-reported concerns regarding their memory impairment, SMI and EMCI were associated with a similarly increased risk of AD dementia. In those subgroups without concerns, SMI was not associated with increased risk of AD dementia, but EMCI remained an at-risk condition.SMI and EMCI with self-reported concerns were associated with the same risk of AD dementia, suggesting that pre-LMCI risk conditions should be extended to SMI with concerns.CONCLUSIONSSMI and EMCI with self-reported concerns were associated with the same risk of AD dementia, suggesting that pre-LMCI risk conditions should be extended to SMI with concerns.
To compare the risk of developing Alzheimer’s disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory impairment (SMI) with normal test performance. The baseline sample (n = 2892) of the prospective cohort study in nondemented individuals (German Study on Aging, Cognition and Dementia in Primary Care Patients) was divided into LMCI, EMCI, SMI, and control subjects by delayed recall performance. These groups were subdivided by the presence of self-reported concerns associated with experienced memory impairment. AD dementia risk was assessed over 6 years. Across all groups, risk of AD dementia was greatest in LMCI. In those with self-reported concerns regarding their memory impairment, SMI and EMCI were associated with a similarly increased risk of AD dementia. In those subgroups without concerns, SMI was not associated with increased risk of AD dementia, but EMCI remained an at-risk condition. SMI and EMCI with self-reported concerns were associated with the same risk of AD dementia, suggesting that pre-LMCI risk conditions should be extended to SMI with concerns.
Objective: To compare the risk of developing Alzheimer's disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory impairment (SMI) with normal test performance. Methods: The baseline sample (n = 2892) of the prospective cohort study in nondemented individuals (German Study on Aging, Cognition and Dementia in Primary Care Patients) was divided into LMCI, EMCI, SMI, and control subjects by delayed recall performance. These groups were subdivided by the presence of self-reported concerns associated with experienced memory impairment. AD dementia risk was assessed over 6 years. Results: Across all groups, risk of AD dementia was greatest in LMCI. In those with self-reported concerns regarding their memory impairment, SMI and EMCI were associated with a similarly increased risk of AD dementia. In those subgroups without concerns, SMI was not associated with increased risk of AD dementia, but EMCI remained an at-risk condition. Conclusions: SMI and EMCI with self-reported concerns were associated with the same risk of AD dementia, suggesting that pre-LMCI risk conditions should be extended to SMI with concerns.
Objective To compare the risk of developing Alzheimer's disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory impairment (SMI) with normal test performance. Methods The baseline sample (n = 2892) of the prospective cohort study in nondemented individuals (German Study on Aging, Cognition and Dementia in Primary Care Patients) was divided into LMCI, EMCI, SMI, and control subjects by delayed recall performance. These groups were subdivided by the presence of self‐reported concerns associated with experienced memory impairment. AD dementia risk was assessed over 6 years. Results Across all groups, risk of AD dementia was greatest in LMCI. In those with self‐reported concerns regarding their memory impairment, SMI and EMCI were associated with a similarly increased risk of AD dementia. In those subgroups without concerns, SMI was not associated with increased risk of AD dementia, but EMCI remained an at‐risk condition. Conclusions SMI and EMCI with self‐reported concerns were associated with the same risk of AD dementia, suggesting that pre‐LMCI risk conditions should be extended to SMI with concerns.
Author Wiese, Birgitt
Riedel-Heller, Steffi G
Mösch, Edelgard
Wolfsgruber, Steffen
Kaduszkiewicz, Hanna
Pentzek, Michael
Maier, Wolfgang
Scherer, Martin
Jessen, Frank
Weyerer, Siegfried
van den Bussche, Hendrik
Luck, Tobias
Werle, Jochen
Wagner, Michael
Bickel, Horst
Fuchs, Angela
Author_xml – sequence: 1
  fullname: Jessen, Frank
– sequence: 2
  fullname: Wolfsgruber, Steffen
– sequence: 3
  fullname: Wiese, Birgitt
– sequence: 4
  fullname: Bickel, Horst
– sequence: 5
  fullname: Mösch, Edelgard
– sequence: 6
  fullname: Kaduszkiewicz, Hanna
– sequence: 7
  fullname: Pentzek, Michael
– sequence: 8
  fullname: Riedel-Heller, Steffi G
– sequence: 9
  fullname: Luck, Tobias
– sequence: 10
  fullname: Fuchs, Angela
– sequence: 11
  fullname: Weyerer, Siegfried
– sequence: 12
  fullname: Werle, Jochen
– sequence: 13
  fullname: van den Bussche, Hendrik
– sequence: 14
  fullname: Scherer, Martin
– sequence: 15
  fullname: Maier, Wolfgang
– sequence: 16
  fullname: Wagner, Michael
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23375567$$D View this record in MEDLINE/PubMed
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Copyright The Alzheimer's Association
2014 The Alzheimer's Association
Copyright © 2014 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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Keywords Risk
Alzheimer's disease dementia
Mild cognitive impairment
Prospective cohort study
Subjective memory impairment
Language English
License Copyright © 2014 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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Snippet Abstract Objective To compare the risk of developing Alzheimer’s disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and...
To compare the risk of developing Alzheimer’s disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory...
Objective To compare the risk of developing Alzheimer's disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory...
To compare the risk of developing Alzheimer's disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory...
Objective: To compare the risk of developing Alzheimeras disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective...
Objective: To compare the risk of developing Alzheimer's disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective...
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StartPage 76
SubjectTerms Aged
Aged, 80 and over
Ageing
Alzheimer Disease - diagnosis
Alzheimer Disease - epidemiology
Alzheimer Disease - mortality
Alzheimer Disease - psychology
Alzheimer's disease
Alzheimer's disease dementia
Apolipoprotein E4 - genetics
At risk
Cognitive Dysfunction - diagnosis
Cognitive Dysfunction - epidemiology
Cognitive Dysfunction - mortality
Cohort analysis
Cohort Studies
Female
Humans
Male
Memory
Memory Disorders - diagnosis
Memory Disorders - epidemiology
Mild cognitive impairment
Neurology
Neuropsychological Tests
Primary health care
Prospective cohort study
Psychiatric Status Rating Scales
Risk
Subjective memory impairment
Survival Analysis
Title AD dementia risk in late MCI, in early MCI, and in subjective memory impairment
URI https://www.clinicalkey.es/playcontent/1-s2.0-S1552526012025782
https://dx.doi.org/10.1016/j.jalz.2012.09.017
https://onlinelibrary.wiley.com/doi/abs/10.1016%2Fj.jalz.2012.09.017
https://www.ncbi.nlm.nih.gov/pubmed/23375567
https://www.proquest.com/docview/1490747663
https://www.proquest.com/docview/1500802523
https://www.proquest.com/docview/1534818905
https://www.proquest.com/docview/1558987478
Volume 10
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