Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice - Kawahara, K.; Suenobu, M.; Yoshida, A.; Koga, K.; Hyodo, A.; Ohtsuka, H.; Kuniyasu, A.; Tamamaki, N.; Sugimoto, Y.; Nakayama, H. (Neuroscience, 2012)
Keywords: Aging - genetics; Alzheimer Disease - genetics; Alzheimer Disease - immunology; Alzheimer Disease - therapy; Alzheimer's disease; Amyloid beta-Peptides - antagonists & inhibitors; Amyloid beta-Peptides - genetics; Amyloid beta-Peptides - metabolism; Animals; Biological and medical sciences; CD36; Cognition Disorders - genetics; Cognition Disorders - immunology; Cognition Disorders - therapy; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Disease Models, Animal; Fundamental and applied biological sciences. Psychology; Humans; Injections, Intraventricular; Interleukin-13 - administration & dosage; Interleukin-13 - physiology; Interleukin-4 - administration & dosage; Interleukin-4 - physiology; interleukin-4/interleukin-13; Male; Medical sciences; memory improvement; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microinjections; neprilysin; Neurology; Plaque, Amyloid - immunology; Plaque, Amyloid - pathology; Plaque, Amyloid - therapy; Vertebrates: nervous system and sense organs; β-amyloid; PBS; APP; MWM; AD; IL; TSA; Aβ; neprilysin; TNF-α; ANOVA; memory improvement; interleukin-4/interleukin-13; NEP; CD36; Alzheimer's disease; WT; β-amyloid; ELISA; IL-4Rα; Th2; Morris water maze; phosphate-buffered saline; analysis of variance; amyloid precursor protein; interleukin; IL-4 receptor α chain; tyramide signal amplification; T helper type 2; tumor necrosis factor-α; enzyme-linked immunosorbent assay; wild-type; Cognitive disorder; Alzheimer disease; Memory; Metalloendopeptidases; Interleukin 4; Degenerative disease; Nervous system diseases; Enzyme; Cytokine; Rodentia; Interleukin 13; Amyloid precursor protein; Cerebral disorder; Peptidases; Vertebrata; Mammalia; Mouse; β Amyloid protein; Animal; Central nervous system disease; Hydrolases; Neprilysin; Biological accumulation