A mathematical model of calcium dynamics: Obesity and mitochondria-associated ER membranes

Multiple cellular organelles tightly orchestrate intracellular calcium (Ca2+) dynamics to regulate cellular activities and maintain homeostasis. The interplay between the endoplasmic reticulum (ER), a major store of intracellular Ca2+, and mitochondria, an important source of adenosine triphosphate...

Full description

Saved in:
Bibliographic Details
Published inPLoS computational biology Vol. 15; no. 8; p. e1006661
Main Authors Han, Jung Min, Periwal, Vipul
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 01.08.2019
Public Library of Science (PLoS)
Subjects
Adenosine triphosphate
Adenosine Triphosphate - metabolism
Analysis
Animals
Apposition
ATP
Biology and Life Sciences
Calcium
Calcium (intracellular)
Calcium (Nutrient)
Calcium ions
Calcium Signaling - physiology
Calcium signalling
Chemical kinetics
Computational Biology
Computer Simulation
Correlation analysis
Diabetes
Dynamics
Endoplasmic reticulum
Endoplasmic Reticulum - metabolism
Hepatocytes
Hepatocytes - metabolism
Homeostasis
Humans
Inositol Phosphates - metabolism
Insulin resistance
Intracellular
Investigations
Kidney diseases
Laboratories
Liver
Mathematical analysis
Mathematical Concepts
Mathematical models
Medicine and Health Sciences
Membranes
Metabolic disorders
Metabolic Networks and Pathways
Mice
Mitochondria
Mitochondria - metabolism
Mitochondria, Liver - metabolism
Mitochondrial membrane
Models, Biological
Obesity
Obesity - metabolism
Organelles
Research and Analysis Methods
Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism
United States
United States > US
Maryland
Online AccessGet full text
ISSN1553-7358
1553-734X
1553-7358
DOI10.1371/journal.pcbi.1006661

Cover

Abstract Multiple cellular organelles tightly orchestrate intracellular calcium (Ca2+) dynamics to regulate cellular activities and maintain homeostasis. The interplay between the endoplasmic reticulum (ER), a major store of intracellular Ca2+, and mitochondria, an important source of adenosine triphosphate (ATP), has been the subject of much research, as their dysfunction has been linked with metabolic diseases. Interestingly, throughout the cell's cytosolic domain, these two organelles share common microdomains called mitochondria-associated ER membranes (MAMs), where their membranes are in close apposition. The role of MAMs is critical for intracellular Ca2+ dynamics as they provide hubs for direct Ca2+ exchange between the organelles. A recent experimental study reported correlation between obesity and MAM formation in mouse liver cells, and obesity-related cellular changes that are closely associated with the regulation of Ca2+ dynamics. We constructed a mathematical model to study the effects of MAM Ca2+ dynamics on global Ca2+ activities. Through a series of model simulations, we investigated cellular mechanisms underlying the altered Ca2+ dynamics in the cells under obesity. We predict that, as the dosage of stimulus gradually increases, liver cells from obese mice will reach the state of saturated cytosolic Ca2+ concentration at a lower stimulus concentration, compared to cells from healthy mice.
AbstractList Multiple cellular organelles tightly orchestrate intracellular calcium (Ca2+) dynamics to regulate cellular activities and maintain homeostasis. The interplay between the endoplasmic reticulum (ER), a major store of intracellular Ca2+, and mitochondria, an important source of adenosine triphosphate (ATP), has been the subject of much research, as their dysfunction has been linked with metabolic diseases. Interestingly, throughout the cell's cytosolic domain, these two organelles share common microdomains called mitochondria-associated ER membranes (MAMs), where their membranes are in close apposition. The role of MAMs is critical for intracellular Ca2+ dynamics as they provide hubs for direct Ca2+ exchange between the organelles. A recent experimental study reported correlation between obesity and MAM formation in mouse liver cells, and obesity-related cellular changes that are closely associated with the regulation of Ca2+ dynamics. We constructed a mathematical model to study the effects of MAM Ca2+ dynamics on global Ca2+ activities. Through a series of model simulations, we investigated cellular mechanisms underlying the altered Ca2+ dynamics in the cells under obesity. We predict that, as the dosage of stimulus gradually increases, liver cells from obese mice will reach the state of saturated cytosolic Ca2+ concentration at a lower stimulus concentration, compared to cells from healthy mice.
Multiple cellular organelles tightly orchestrate intracellular calcium (Ca 2+ ) dynamics to regulate cellular activities and maintain homeostasis. The interplay between the endoplasmic reticulum (ER), a major store of intracellular Ca 2+ , and mitochondria, an important source of adenosine triphosphate (ATP), has been the subject of much research, as their dysfunction has been linked with metabolic diseases. Interestingly, throughout the cell’s cytosolic domain, these two organelles share common microdomains called mitochondria-associated ER membranes (MAMs), where their membranes are in close apposition. The role of MAMs is critical for intracellular Ca 2+ dynamics as they provide hubs for direct Ca 2+ exchange between the organelles. A recent experimental study reported correlation between obesity and MAM formation in mouse liver cells, and obesity-related cellular changes that are closely associated with the regulation of Ca 2+ dynamics. We constructed a mathematical model to study the effects of MAM Ca 2+ dynamics on global Ca 2+ activities. Through a series of model simulations, we investigated cellular mechanisms underlying the altered Ca 2+ dynamics in the cells under obesity. We predict that, as the dosage of stimulus gradually increases, liver cells from obese mice will reach the state of saturated cytosolic Ca 2+ concentration at a lower stimulus concentration, compared to cells from healthy mice. It is well known that intracellular Ca 2+ oscillations carry encoded signals in their amplitude and frequency to regulate various cellular processes, and accumulating evidence supports the importance of the interplay between the ER and mitochondria in cellular Ca 2+ homeostasis. Miscommunications between the organelles may be involved in the development of metabolic diseases. Based on a recent experimental study that spotlighted a correlation between obesity and physical interactions of the ER and mitochondria in mouse hepatic cells, we constructed a mathematical model as a tool to probe the effects of the cellular changes linked with obesity on global cellular Ca 2+ dynamics. Our model successfully reproduced the experimental study that observed a positive correlation between an increase in ER-mitochondrial junctions and the magnitude of mitochondrial Ca 2+ responses. We postulate that hepatic cells from lean animals exhibit Ca 2+ oscillations that are more robust under higher concentrations of stimulus, compared to cells from obese animals.
Multiple cellular organelles tightly orchestrate intracellular calcium (Ca.sup.2+) dynamics to regulate cellular activities and maintain homeostasis. The interplay between the endoplasmic reticulum (ER), a major store of intracellular Ca.sup.2+, and mitochondria, an important source of adenosine triphosphate (ATP), has been the subject of much research, as their dysfunction has been linked with metabolic diseases. Interestingly, throughout the cell's cytosolic domain, these two organelles share common microdomains called mitochondria-associated ER membranes (MAMs), where their membranes are in close apposition. The role of MAMs is critical for intracellular Ca.sup.2+ dynamics as they provide hubs for direct Ca.sup.2+ exchange between the organelles. A recent experimental study reported correlation between obesity and MAM formation in mouse liver cells, and obesity-related cellular changes that are closely associated with the regulation of Ca.sup.2+ dynamics. We constructed a mathematical model to study the effects of MAM Ca.sup.2+ dynamics on global Ca.sup.2+ activities. Through a series of model simulations, we investigated cellular mechanisms underlying the altered Ca.sup.2+ dynamics in the cells under obesity. We predict that, as the dosage of stimulus gradually increases, liver cells from obese mice will reach the state of saturated cytosolic Ca.sup.2+ concentration at a lower stimulus concentration, compared to cells from healthy mice.
Multiple cellular organelles tightly orchestrate intracellular calcium (Ca2+) dynamics to regulate cellular activities and maintain homeostasis. The interplay between the endoplasmic reticulum (ER), a major store of intracellular Ca2+, and mitochondria, an important source of adenosine triphosphate (ATP), has been the subject of much research, as their dysfunction has been linked with metabolic diseases. Interestingly, throughout the cell's cytosolic domain, these two organelles share common microdomains called mitochondria-associated ER membranes (MAMs), where their membranes are in close apposition. The role of MAMs is critical for intracellular Ca2+ dynamics as they provide hubs for direct Ca2+ exchange between the organelles. A recent experimental study reported correlation between obesity and MAM formation in mouse liver cells, and obesity-related cellular changes that are closely associated with the regulation of Ca2+ dynamics. We constructed a mathematical model to study the effects of MAM Ca2+ dynamics on global Ca2+ activities. Through a series of model simulations, we investigated cellular mechanisms underlying the altered Ca2+ dynamics in the cells under obesity. We predict that, as the dosage of stimulus gradually increases, liver cells from obese mice will reach the state of saturated cytosolic Ca2+ concentration at a lower stimulus concentration, compared to cells from healthy mice.Multiple cellular organelles tightly orchestrate intracellular calcium (Ca2+) dynamics to regulate cellular activities and maintain homeostasis. The interplay between the endoplasmic reticulum (ER), a major store of intracellular Ca2+, and mitochondria, an important source of adenosine triphosphate (ATP), has been the subject of much research, as their dysfunction has been linked with metabolic diseases. Interestingly, throughout the cell's cytosolic domain, these two organelles share common microdomains called mitochondria-associated ER membranes (MAMs), where their membranes are in close apposition. The role of MAMs is critical for intracellular Ca2+ dynamics as they provide hubs for direct Ca2+ exchange between the organelles. A recent experimental study reported correlation between obesity and MAM formation in mouse liver cells, and obesity-related cellular changes that are closely associated with the regulation of Ca2+ dynamics. We constructed a mathematical model to study the effects of MAM Ca2+ dynamics on global Ca2+ activities. Through a series of model simulations, we investigated cellular mechanisms underlying the altered Ca2+ dynamics in the cells under obesity. We predict that, as the dosage of stimulus gradually increases, liver cells from obese mice will reach the state of saturated cytosolic Ca2+ concentration at a lower stimulus concentration, compared to cells from healthy mice.
Audience Academic
Author Han, Jung Min
Periwal, Vipul
AuthorAffiliation Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
University of Auckland, UNITED STATES
AuthorAffiliation_xml – name: University of Auckland, UNITED STATES
– name: Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Author_xml – sequence: 1
  givenname: Jung Min
  orcidid: 0000-0002-2253-4156
  surname: Han
  fullname: Han, Jung Min
– sequence: 2
  givenname: Vipul
  orcidid: 0000-0002-8811-8884
  surname: Periwal
  fullname: Periwal, Vipul
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31437152$$D View this record in MEDLINE/PubMed
BookMark eNqVUl1v0zAUjdAQ2wr_AEEkXuChxd9J9oBUTQMqTUwa8MKLdWvftJ6SuLMTRP89Du2mdUJIKJJzbZ9z7z3X5zQ76nyHWfaSkhnlBX1_44fQQTPbmKWbUUKUUvRJdkKl5NOCy_LoQXycncZ4Q0gKK_UsO-ZUpBSSnWQ_5nkL_RrT4gw0eestNrmv87Qxbmhzu-2gdSae5VdLjK7f5tDZvHW9N2vf2eBgCjF646BHm19c5y22ywAdxufZ0xqaiC_2_0n2_ePFt_PP08urT4vz-eXUKM77KaMFqSmvIAW8RgtESCJLXqkCBKUoGUFLOANmKltWoq4kUEoYjDfMLvkke73Lu2l81PuxRM1YRUVBVEUSYrFDWA83ehNcC2GrPTj958CHlYaQ9DeoKyuKCog1slCirEUpsRSFQG6MQUgNT7IP-2rDskVrsOsDNAdJD286t9Yr_1Orgikmx2be7hMEfztg7HXrosGmSTPzw9h3KZM8Rcdabx5B_65utkOtIAlwXe1TXZM-i-nhkmlql87nihDBRFmUifDugJAwPf7qVzDEqBdfr_8D--UQ--rhaO5ncue2BBA7gAk-xoD1PYQSPZr6Tp8eTa33pk60s0c04_rkVz8O2DX_Jv8GAK39Ag
CitedBy_id crossref_primary_10_1097_SHK_0000000000001534
crossref_primary_10_1038_s41467_024_48272_7
crossref_primary_10_1109_TNB_2022_3155644
crossref_primary_10_1016_j_chaos_2021_110741
crossref_primary_10_1038_s41419_023_05905_x
crossref_primary_10_1007_s10863_023_09973_8
crossref_primary_10_1016_j_biosystems_2024_105227
crossref_primary_10_3724_abbs_2022115
crossref_primary_10_1016_j_coisb_2021_03_004
crossref_primary_10_1140_epjp_s13360_025_06144_z
crossref_primary_10_53391_mmnsa_1503948
crossref_primary_10_1016_j_acthis_2023_152000
crossref_primary_10_1007_s10867_023_09639_x
crossref_primary_10_1007_s12013_024_01306_9
crossref_primary_10_1142_S0218339025500044
crossref_primary_10_3390_ijms21239238
crossref_primary_10_1038_s41574_021_00575_1
crossref_primary_10_1016_j_jbc_2021_101174
crossref_primary_10_1016_j_jtbi_2021_110684
crossref_primary_10_3389_fendo_2022_1017387
crossref_primary_10_1063_5_0258151
crossref_primary_10_1007_s12013_024_01484_6
crossref_primary_10_1088_1402_4896_ad9361
crossref_primary_10_1007_s11062_023_09931_5
Cites_doi 10.1016/j.jtbi.2006.07.019
10.1016/j.ymeth.2008.09.012
10.1152/ajpcell.1997.273.2.C717
10.1038/nature09968
10.1371/journal.pone.0069598
10.1016/j.molcel.2010.04.003
10.1073/pnas.96.24.13807
10.7554/eLife.29968
10.1016/j.tem.2016.09.002
10.1152/ajpendo.90558.2008
10.1093/emboj/16.12.3533
10.1006/jtbi.2000.2292
10.1016/j.redox.2015.08.010
10.1038/srep19316
10.1103/PhysRevLett.122.088101
10.1016/S0006-3495(02)75151-5
10.1016/S0006-3495(03)75079-6
10.1016/j.bpj.2012.07.016
10.1016/j.cmet.2015.06.010
10.1152/physrev.1994.74.3.683
10.1016/S0005-2728(98)00118-2
10.1016/j.ceca.2012.04.009
10.1016/0143-4160(93)90052-8
10.1085/jgp.200609660
10.1006/jtbi.1994.1041
10.1152/ajpcell.1998.274.4.C1158
10.1073/pnas.89.20.9895
10.1016/j.rmu.2015.10.004
10.1242/jcs.149047
10.1007/s00125-015-3829-8
10.1196/annals.1341.012
10.1038/srep07984
10.1073/pnas.1103015108
10.1007/s00401-015-1528-7
10.1371/journal.pcbi.1003783
10.1088/1478-3975/10/3/035004
10.1038/nm.3735
10.1038/35036035
10.1073/pnas.1614613114
10.1126/science.280.5370.1763
10.1016/S0021-9258(19)49738-X
10.1101/cshperspect.a004317
10.1186/1478-811X-9-19
10.1152/ajpcell.00139.2004
ContentType Journal Article
Copyright COPYRIGHT 2019 Public Library of Science
This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: COPYRIGHT 2019 Public Library of Science
– notice: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
ISN
ISR
3V.
7QO
7QP
7TK
7TM
7X7
7XB
88E
8AL
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
HCIFZ
JQ2
K7-
K9.
LK8
M0N
M0S
M1P
M7P
P5Z
P62
P64
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
Q9U
RC3
7X8
5PM
DOA
DOI 10.1371/journal.pcbi.1006661
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Gale In Context: Canada
Gale In Context: Science
ProQuest Central (Corporate)
Biotechnology Research Abstracts
Calcium & Calcified Tissue Abstracts
Neurosciences Abstracts
Nucleic Acids Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Computing Database (Alumni Edition)
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni Edition)
ProQuest One Sustainability
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Collection
ProQuest Central Essentials - QC
Biological Science Collection
ProQuest Central
Technology Collection
Natural Science Collection
ProQuest One Community College
ProQuest Central Korea
Engineering Research Database
ProQuest Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Computer Science Collection
Computer Science Database
ProQuest Health & Medical Complete (Alumni)
ProQuest Biological Science Collection
Computing Database
ProQuest Health & Medical Collection
Medical Database
Biological Science Database
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
Computer Science Database
ProQuest Central Student
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
ProQuest Computer Science Collection
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Biotechnology Research Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
ProQuest Computing
ProQuest Central Basic
ProQuest Computing (Alumni Edition)
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE
Publicly Available Content Database




MEDLINE - Academic
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
DocumentTitleAlternate A mathematical model of calcium dynamics: Obesity and mitochondria-associated ER membranes
EISSN 1553-7358
ExternalDocumentID 2291470690
oai_doaj_org_article_9d479a0dc57648f485e8474e3cccea63
PMC6726250
A600424878
31437152
10_1371_journal_pcbi_1006661
Genre Journal Article
Research Support, N.I.H., Intramural
GeographicLocations United States
United States--US
Maryland
GeographicLocations_xml – name: United States
– name: Maryland
– name: United States--US
GrantInformation_xml – fundername: ;
GroupedDBID ---
123
29O
2WC
53G
5VS
7X7
88E
8FE
8FG
8FH
8FI
8FJ
AAFWJ
AAKPC
AAUCC
AAWOE
AAYXX
ABDBF
ABUWG
ACGFO
ACIHN
ACIWK
ACPRK
ACUHS
ADBBV
AEAQA
AENEX
AEUYN
AFKRA
AFPKN
AFRAH
AHMBA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
ARAPS
AZQEC
B0M
BAWUL
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
BWKFM
CCPQU
CITATION
CS3
DIK
DWQXO
E3Z
EAP
EAS
EBD
EBS
EJD
EMK
EMOBN
ESX
F5P
FPL
FYUFA
GNUQQ
GROUPED_DOAJ
GX1
HCIFZ
HMCUK
HYE
IAO
IGS
INH
INR
ISN
ISR
ITC
J9A
K6V
K7-
KQ8
LK8
M1P
M48
M7P
O5R
O5S
OK1
OVT
P2P
P62
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
PV9
RNS
RPM
RZL
SV3
TR2
TUS
UKHRP
WOW
XSB
~8M
3V.
ADRAZ
C1A
CGR
CUY
CVF
ECM
EIF
H13
IPNFZ
M0N
M~E
NPM
PGMZT
RIG
WOQ
PMFND
7QO
7QP
7TK
7TM
7XB
8AL
8FD
8FK
FR3
JQ2
K9.
P64
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
Q9U
RC3
7X8
PUEGO
5PM
-
AAPBV
ABPTK
ADACO
BBAFP
ID FETCH-LOGICAL-c633t-2170f139a2173feda0450583967a411e520ed032a2c9d894f95a1102ae5202db3
IEDL.DBID M48
ISSN 1553-7358
1553-734X
IngestDate Fri Nov 26 17:12:07 EST 2021
Wed Aug 27 01:20:33 EDT 2025
Thu Aug 21 18:32:45 EDT 2025
Fri Sep 05 13:28:20 EDT 2025
Fri Jul 25 11:58:57 EDT 2025
Tue Jun 10 20:15:49 EDT 2025
Fri Jun 27 04:25:22 EDT 2025
Fri Jun 27 05:01:51 EDT 2025
Wed Feb 19 02:30:23 EST 2025
Tue Jul 01 02:23:18 EDT 2025
Thu Apr 24 22:55:13 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 8
Language English
License This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
Creative Commons CC0 public domain
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c633t-2170f139a2173feda0450583967a411e520ed032a2c9d894f95a1102ae5202db3
Notes new_version
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
The authors have declared that no competing interests exist.
ORCID 0000-0002-2253-4156
0000-0002-8811-8884
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1371/journal.pcbi.1006661
PMID 31437152
PQID 2291470690
PQPubID 1436340
ParticipantIDs plos_journals_2291470690
doaj_primary_oai_doaj_org_article_9d479a0dc57648f485e8474e3cccea63
pubmedcentral_primary_oai_pubmedcentral_nih_gov_6726250
proquest_miscellaneous_2285102613
proquest_journals_2291470690
gale_infotracacademiconefile_A600424878
gale_incontextgauss_ISR_A600424878
gale_incontextgauss_ISN_A600424878
pubmed_primary_31437152
crossref_primary_10_1371_journal_pcbi_1006661
crossref_citationtrail_10_1371_journal_pcbi_1006661
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2019-08-01
PublicationDateYYYYMMDD 2019-08-01
PublicationDate_xml – month: 08
  year: 2019
  text: 2019-08-01
  day: 01
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: San Francisco
– name: San Francisco, CA USA
PublicationTitle PLoS computational biology
PublicationTitleAlternate PLoS Comput Biol
PublicationYear 2019
Publisher Public Library of Science
Public Library of Science (PLoS)
Publisher_xml – name: Public Library of Science
– name: Public Library of Science (PLoS)
References GW De Young (pcbi.1006661.ref011) 1992; 89
P Szopa (pcbi.1006661.ref020) 2013; 10
S Tang (pcbi.1006661.ref039) 2011; 108
AP Arruda (pcbi.1006661.ref002) 2015; 22
H Qi (pcbi.1006661.ref021) 2015; 5
ME O’Donnell (pcbi.1006661.ref031) 1994; 74
J Rieusset (pcbi.1006661.ref043) 2016; 59
MHT Nguyen (pcbi.1006661.ref017) 2005; 1047
M Patterson (pcbi.1006661.ref019) 2007; 129
G Magnus (pcbi.1006661.ref016) 1997; 273
CJ Penny (pcbi.1006661.ref023) 2014; 127
G Magnus (pcbi.1006661.ref032) 1998; 274
AP Arruda (pcbi.1006661.ref044) 2017; 6
JE Galgani (pcbi.1006661.ref041) 2008; 295
B Ermentrout (pcbi.1006661.ref033) 2003; 45
D Mekahli (pcbi.1006661.ref006) 2011; 3
B Wacquier (pcbi.1006661.ref022) 2016; 6
YX Li (pcbi.1006661.ref010) 1994; 166
S Cortassa (pcbi.1006661.ref014) 2003; 84
PS Brookes (pcbi.1006661.ref008) 2004; 287
G Hajnóczky (pcbi.1006661.ref027) 1997; 16
LD Robb-Gaspers (pcbi.1006661.ref034) 1998; 1366
LD Gaspers (pcbi.1006661.ref035) 2008; 46
R Bertram (pcbi.1006661.ref015) 2006; 243
CP Fall (pcbi.1006661.ref018) 2001; 210
J Lytton (pcbi.1006661.ref030) 1992; 267
P Cao (pcbi.1006661.ref024) 2014; 10
MJ Berridge (pcbi.1006661.ref001) 2000; 1
I Siekmann (pcbi.1006661.ref025) 2012; 103
JW Shuai (pcbi.1006661.ref012) 2002; 87
LD Gaspers (pcbi.1006661.ref036) 2012; 52
S Patergnani (pcbi.1006661.ref004) 2011; 9
RE Cárdenas-Pérez (pcbi.1006661.ref005) 2016; 18
R Rizzuto (pcbi.1006661.ref029) 1998; 280
LS Jouaville (pcbi.1006661.ref037) 1999; 96
M Giacomello (pcbi.1006661.ref038) 2010; 38
AP Arruda (pcbi.1006661.ref009) 2014; 20
J Sneyd (pcbi.1006661.ref028) 2017; 114
P Theurey (pcbi.1006661.ref042) 2017; 28
V Voorsluijs (pcbi.1006661.ref045) 2019; 122
G Dupont (pcbi.1006661.ref013) 1993; 14
A Görlach (pcbi.1006661.ref003) 2015; 6
H Croisier (pcbi.1006661.ref026) 2013; 8
S Fu (pcbi.1006661.ref040) 2011; 473
M Krols (pcbi.1006661.ref007) 2016; 131
References_xml – volume: 243
  start-page: 575
  year: 2006
  ident: pcbi.1006661.ref015
  article-title: A simplified model for mitochondrial ATP production
  publication-title: J Theor Biol
  doi: 10.1016/j.jtbi.2006.07.019
– volume: 46
  start-page: 224
  year: 2008
  ident: pcbi.1006661.ref035
  article-title: Calcium-dependent activation of mitochondria metabolism in mammalian cells
  publication-title: Methods
  doi: 10.1016/j.ymeth.2008.09.012
– volume: 273
  start-page: C717
  issue: 2 Pt 1
  year: 1997
  ident: pcbi.1006661.ref016
  article-title: Minimal model of β-cell mitochondrial Ca2+ handling
  publication-title: Am J Physiol
  doi: 10.1152/ajpcell.1997.273.2.C717
– volume: 473
  start-page: 528
  year: 2011
  ident: pcbi.1006661.ref040
  article-title: Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
  publication-title: Nature
  doi: 10.1038/nature09968
– volume: 8
  start-page: e69598
  issue: 7
  year: 2013
  ident: pcbi.1006661.ref026
  article-title: Activation of store-operated calcium entry in airway smooth muscle cells: insight from a mathematical model
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0069598
– volume: 38
  start-page: 280
  issue: 2
  year: 2010
  ident: pcbi.1006661.ref038
  article-title: Ca2+ Hot Spots on the Mitochondrial Surface AreGenerated by Ca2+ Mobilization from Stores, but Not by Activation of Store-Operated Ca2+ Channels
  publication-title: Mol Cel
  doi: 10.1016/j.molcel.2010.04.003
– volume: 45
  start-page: 150
  issue: 1
  year: 2003
  ident: pcbi.1006661.ref033
  article-title: Simulating, analyzing, and animating dynamical systems: A guide to XPPAUT for researchers and students
  publication-title: SIAM Reviews
– volume: 96
  start-page: 13807
  issue: 24
  year: 1999
  ident: pcbi.1006661.ref037
  article-title: Regulation of mitochondrial ATP synthesis by calcium: Evidence for a long-term metabolic priming
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.96.24.13807
– volume: 6
  start-page: e29968
  year: 2017
  ident: pcbi.1006661.ref044
  article-title: Defective STIM-mediated store operated Ca2+ entry in hepatocytes leads to metabolic dysfunction in obesity
  publication-title: eLife
  doi: 10.7554/eLife.29968
– volume: 28
  start-page: 32
  issue: 1
  year: 2017
  ident: pcbi.1006661.ref042
  article-title: Mitochondria-associated membranes response to nutrient availability and role in metabolic diseases
  publication-title: Trends in Endocrinology & Metabolism
  doi: 10.1016/j.tem.2016.09.002
– volume: 295
  start-page: E1009
  issue: 5
  year: 2008
  ident: pcbi.1006661.ref041
  article-title: Metabolic flexibility and insulin resistance
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.90558.2008
– volume: 16
  start-page: 3533
  issue: 12
  year: 1997
  ident: pcbi.1006661.ref027
  article-title: Minimal requirements for calcium oscillations driven by the IP3 receptor
  publication-title: EMBO J
  doi: 10.1093/emboj/16.12.3533
– volume: 210
  start-page: 151
  year: 2001
  ident: pcbi.1006661.ref018
  article-title: Mitochondrial modulation of intracellular Ca2+ signaling
  publication-title: J Theor Biol
  doi: 10.1006/jtbi.2000.2292
– volume: 6
  start-page: 260
  year: 2015
  ident: pcbi.1006661.ref003
  article-title: Calcium and ROS: A mutual interplay
  publication-title: Redox Biol
  doi: 10.1016/j.redox.2015.08.010
– volume: 6
  start-page: 19316
  year: 2016
  ident: pcbi.1006661.ref022
  article-title: Interplay between intracellular Ca2+ oscillations and Ca2+-stimulated mitochondrial metabolism
  publication-title: Sci Rep
  doi: 10.1038/srep19316
– volume: 122
  start-page: 088101
  year: 2019
  ident: pcbi.1006661.ref045
  article-title: Deterministic Limit of Intracellular Calcium Spikes
  publication-title: Phys Rev Lett
  doi: 10.1103/PhysRevLett.122.088101
– volume: 87
  start-page: 87
  issue: 1
  year: 2002
  ident: pcbi.1006661.ref012
  article-title: Stochastic properties of Ca2+ release of inositol 1,4,5-trisphosphate receptor clusters
  publication-title: Biophys J
  doi: 10.1016/S0006-3495(02)75151-5
– volume: 84
  start-page: 2734
  issue: 4
  year: 2003
  ident: pcbi.1006661.ref014
  article-title: An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics
  publication-title: Biophys J
  doi: 10.1016/S0006-3495(03)75079-6
– volume: 103
  start-page: 658
  year: 2012
  ident: pcbi.1006661.ref025
  article-title: A kinetic model for type I and II IPR accounting for mode changes
  publication-title: Biophysical Journal
  doi: 10.1016/j.bpj.2012.07.016
– volume: 22
  start-page: 381
  issue: 3
  year: 2015
  ident: pcbi.1006661.ref002
  article-title: Calcium homeostasis and organelle function in the pathogenesis of obesity and diabetes
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2015.06.010
– volume: 74
  start-page: 683
  year: 1994
  ident: pcbi.1006661.ref031
  article-title: Regulation of ion pumps and carriers in vascular smooth muscle
  publication-title: Physiol Rev
  doi: 10.1152/physrev.1994.74.3.683
– volume: 1366
  start-page: 17
  year: 1998
  ident: pcbi.1006661.ref034
  article-title: Coupling between cytosolic and mitochondrial calcium oscillations: role in the regulation of hepatic metabolism
  publication-title: Biochim Biophys Acta
  doi: 10.1016/S0005-2728(98)00118-2
– volume: 52
  start-page: 93
  year: 2012
  ident: pcbi.1006661.ref036
  article-title: Calcium-dependent physiologic and pathologic stimulus-metabolic response coupling in hepatocytes
  publication-title: Cell Calcium
  doi: 10.1016/j.ceca.2012.04.009
– volume: 14
  start-page: 311
  year: 1993
  ident: pcbi.1006661.ref013
  article-title: One-pool model for Ca2+ oscillations involving Ca2+ and inositol 1,4,5-trisphosphate as co-agonist for Ca2+ release
  publication-title: Cell Calcium
  doi: 10.1016/0143-4160(93)90052-8
– volume: 129
  start-page: 29
  issue: 1
  year: 2007
  ident: pcbi.1006661.ref019
  article-title: Depolarization-induced calcium responses in Sympathetic Neurons: Relative Contributions from Ca2+ Entry, Extrusion, ER/Mitochondrial Ca2+ Uptake and Release, and Ca2+ Buffering
  publication-title: J Gen Physiol
  doi: 10.1085/jgp.200609660
– volume: 166
  start-page: 461
  year: 1994
  ident: pcbi.1006661.ref010
  article-title: Equations for InsP3 receptor-mediated [Ca2+] oscillations derived from a detailed kinetic model: a Hodgkin-Huxley like formalism
  publication-title: J Theor Biol
  doi: 10.1006/jtbi.1994.1041
– volume: 274
  start-page: C1158
  issue: 4 Pt 1
  year: 1998
  ident: pcbi.1006661.ref032
  article-title: Model of beta-cell mitochondrial calcium handling and electrical activity. I. Cytoplasmic variables
  publication-title: Am J Physiol
  doi: 10.1152/ajpcell.1998.274.4.C1158
– volume: 89
  start-page: 9895
  year: 1992
  ident: pcbi.1006661.ref011
  article-title: A single-pool inositol 1,4,5-trisphosphate- receptor-based model for agonist-stimulated oscillations in Ca2+ concentration
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.89.20.9895
– volume: 18
  start-page: 23
  issue: 70
  year: 2016
  ident: pcbi.1006661.ref005
  article-title: Roles of calcium and mitochondria-associated membranes in the development of obesity and diabetes
  publication-title: Medicina Universitaria
  doi: 10.1016/j.rmu.2015.10.004
– volume: 127
  start-page: 2934
  year: 2014
  ident: pcbi.1006661.ref023
  article-title: A computational model of lysosome-ER Ca2+ microdomains
  publication-title: J Cell Sci
  doi: 10.1242/jcs.149047
– volume: 59
  start-page: 614
  issue: 3
  year: 2016
  ident: pcbi.1006661.ref043
  article-title: Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance
  publication-title: Diabetologia
  doi: 10.1007/s00125-015-3829-8
– volume: 1047
  start-page: 127
  year: 2005
  ident: pcbi.1006661.ref017
  article-title: Mitochondrial calcium signaling and energy metabolism
  publication-title: Ann N Y Acad Sci
  doi: 10.1196/annals.1341.012
– volume: 5
  start-page: 7984
  year: 2015
  ident: pcbi.1006661.ref021
  article-title: Optimal microdomain crosstalk between endoplasmic reticulum and mitochondria for Ca2+ oscillations
  publication-title: Sci Rep
  doi: 10.1038/srep07984
– volume: 108
  start-page: 16265
  issue: 39
  year: 2011
  ident: pcbi.1006661.ref039
  article-title: Design and application of a class of sensors to monitor Ca2+ dynamics in high Ca2+ concentration cellular compartments
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1103015108
– volume: 131
  start-page: 505
  year: 2016
  ident: pcbi.1006661.ref007
  article-title: Mitochondria-associated membranes as hubs for neurodegeneration
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-015-1528-7
– volume: 10
  start-page: e1003783
  issue: 8
  year: 2014
  ident: pcbi.1006661.ref024
  article-title: A deterministic model predicts the properties of stochastic calcium oscillations in airway smooth muscle cells
  publication-title: PLoS Comput Biol
  doi: 10.1371/journal.pcbi.1003783
– volume: 10
  start-page: 035004
  issue: 3
  year: 2013
  ident: pcbi.1006661.ref020
  article-title: Membrane associated complexes in calcium dynamics modelling
  publication-title: Phys Biol
  doi: 10.1088/1478-3975/10/3/035004
– volume: 20
  start-page: 1427
  issue: 12
  year: 2014
  ident: pcbi.1006661.ref009
  article-title: Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity
  publication-title: Nat Med
  doi: 10.1038/nm.3735
– volume: 1
  start-page: 11
  year: 2000
  ident: pcbi.1006661.ref001
  article-title: The versatility and universality of calcium signalling
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/35036035
– volume: 114
  start-page: 1456
  issue: 7
  year: 2017
  ident: pcbi.1006661.ref028
  article-title: On the dynamical structure of calcium oscillations
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1614613114
– volume: 280
  start-page: 1763
  issue: 5370
  year: 1998
  ident: pcbi.1006661.ref029
  article-title: Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca2+ Responses
  publication-title: Science
  doi: 10.1126/science.280.5370.1763
– volume: 267
  start-page: 14483
  year: 1992
  ident: pcbi.1006661.ref030
  article-title: Functional comparisons between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(19)49738-X
– volume: 3
  start-page: a004317
  issue: 6
  year: 2011
  ident: pcbi.1006661.ref006
  article-title: Endoplasmic-reticulum calcium depletion and disease
  publication-title: Cold Spring Harb Perspect Biol
  doi: 10.1101/cshperspect.a004317
– volume: 9
  start-page: 19
  year: 2011
  ident: pcbi.1006661.ref004
  article-title: Calcium signaling around Mitochondria associated membranes (MAMs)
  publication-title: Cell Commun Signal
  doi: 10.1186/1478-811X-9-19
– volume: 287
  start-page: C817
  year: 2004
  ident: pcbi.1006661.ref008
  article-title: Calcium, ATP, and ROS: a mitochondrial love-hate triangle
  publication-title: Am J Physiol, Cell Physiol
  doi: 10.1152/ajpcell.00139.2004
SSID ssj0035896
Score 2.4022026
Snippet Multiple cellular organelles tightly orchestrate intracellular calcium (Ca2+) dynamics to regulate cellular activities and maintain homeostasis. The interplay...
Multiple cellular organelles tightly orchestrate intracellular calcium (Ca.sup.2+) dynamics to regulate cellular activities and maintain homeostasis. The...
Multiple cellular organelles tightly orchestrate intracellular calcium (Ca 2+ ) dynamics to regulate cellular activities and maintain homeostasis. The...
SourceID plos
doaj
pubmedcentral
proquest
gale
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage e1006661
SubjectTerms Adenosine triphosphate
Adenosine Triphosphate - metabolism
Analysis
Animals
Apposition
ATP
Biology and Life Sciences
Calcium
Calcium (intracellular)
Calcium (Nutrient)
Calcium ions
Calcium Signaling - physiology
Calcium signalling
Chemical kinetics
Computational Biology
Computer Simulation
Correlation analysis
Diabetes
Dynamics
Endoplasmic reticulum
Endoplasmic Reticulum - metabolism
Hepatocytes
Hepatocytes - metabolism
Homeostasis
Humans
Inositol Phosphates - metabolism
Insulin resistance
Intracellular
Investigations
Kidney diseases
Laboratories
Liver
Mathematical analysis
Mathematical Concepts
Mathematical models
Medicine and Health Sciences
Membranes
Metabolic disorders
Metabolic Networks and Pathways
Mice
Mitochondria
Mitochondria - metabolism
Mitochondria, Liver - metabolism
Mitochondrial membrane
Models, Biological
Obesity
Obesity - metabolism
Organelles
Research and Analysis Methods
Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELbQSkhcEO8GCjIIiZOp40ccc1tQq4JED4VKKy6W13boSk2yYncP_HvGsTdqUFEv3JJ4cvDMZPxNPP4GobeNVrBuu4aUnjdESMpJLSUjYekoC7LyMsQf-l_PqtML8WUhF9dafcWasEQPnBR3pL1Q2lLvABiLuhG1DBBQReDOuWCrgeeTarpPplIM5rIeOnPFpjhEcbHIh-a4Ko-yjd6v3XIVawQAv5eTRWng7h8j9Gx91W9ugp9_V1FeW5ZOHqD7GU_ieZrHQ3QndI_Q3dRh8vdj9GOO25GYFeSGxje4bzDcuNWuxT51pN98wLlFALadxy185xAXOw_uSWy2YPD4-By3oYUEGwLkE3Rxcvz90ynJ7RSIqzjfEkg-aAOAz8IFb4K3gOaoBIBUKSvKMkhGg6ecWea0r7VotLQADpiNI8wv-VM06_ouHCBcaSe99VZaKQQAHM21CCVTjAepfWgKxPf6NC5zjceWF1dm2EBTkHMk9ZhoBZOtUCAyvrVOXBu3yH-MphplI1P28AD8x2T_Mbf5T4HeREObyIXRxWKbn3a32ZjP387MvBo2hmtV_1PofCL0Lgs1PUzW2XzAAVQWObYmkgfRq_aT2hjGdClUJI0u0OHe024efj0OQxyImztg8X4XZQA7x4QaZvQsOeaoGA6gWAFQK5CauOxEc9ORbnU5cI1XikGGTJ__D1W_QPcAbupUPnmIZttfu_ASIN12-Wr4ev8AkIhHdA
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3db9MwELegCIkXxPcCAxmExJNZ4o845gUVtGkgsYfBpIqXyLWdUWlJytI-8N9zl7iBoAFvTX2V6rvz-Xf25X6EvKyMhn3bVSzzomJSpYIVSnEWli7lQeVeBTzQ_3SSH5_Jjwu1iAduXSyr3MXEPlD71uEZ-QHnJpMa--q-XX9nyBqFt6uRQuM6uZEBVEGv1osx4RKq6Pm5kBqHaSEX8dU5obODaKnXa7dcYaUAoPhssjX1HfzHOD1bX7TdVSD0z1rK3zanozvkdkSVdD64wV1yLTT3yM2BZ_LHffJ1TuuxPSvI9fQ3tK0oPLjVtqZ-4KXv3tBIFEBt42kNqx2iY-PBSZmNdgyeHp7SOtSQZkOYfEDOjg6_vD9mkVSBuVyIDYMUJK0A9ln4IKrgLWC6VAFMyrWVWRYUT4NPBbfcGV8YWRllASJwiyPcL8VDMmvaJuwRmhunvPVWWSUlwBwjjAwZ11wEZXyoEiJ2-ixd7DiOxBcXZX-NpiHzGNRTohXKaIWEsPFX66Hjxn_k36GpRlnsl91_0V6el3H5lcZLbWzqHaRXsqhkoQJsyzII51ywuUjICzR0iR0xGiy5Obfbris_fD4p53l_PVzo4q9CpxOhV1GoamGyzsbXHEBl2GlrIrmHXrWbVFf-cvGE7O887erh5-MwRAO84gGLt1uUAQSNaTXM6NHgmKNiBEBjDXAtIXrishPNTUea1be-43iuOeTJ6eN__60n5BbASTOUR-6T2eZyG54CZNssn_Xr8icXFT6q
  priority: 102
  providerName: ProQuest
Title A mathematical model of calcium dynamics: Obesity and mitochondria-associated ER membranes
URI https://www.ncbi.nlm.nih.gov/pubmed/31437152
https://www.proquest.com/docview/2291470690
https://www.proquest.com/docview/2285102613
https://pubmed.ncbi.nlm.nih.gov/PMC6726250
https://doaj.org/article/9d479a0dc57648f485e8474e3cccea63
http://dx.doi.org/10.1371/journal.pcbi.1006661
Volume 15
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3di9NAEF_OHoIv4vf1PMsqgk85kv3IZgWRVltP4YpUC8WXsN3dnIU26TUteP-9s8k2GOmhL_3aSWFnZnd-k9nMD6HXmRQQt3UWRIZmAeMhDRLOSWDnOiSWx4Zbd0P_chxfTNmXGZ8doT1nq1dgeTC1c3xS083y_Nf1zXtY8O8q1gYR7S86X-v5wlX9AZFDPnQMsYk4P79kTV2B8qRi7HJkOYGgbOYfprvtX1rBqurp3-zcnfWyKA_B0r9PV_4RrkYP0H2PM3G_doyH6Mjmj9Ddmnny5jH60cerpmEryFWEOLjIMHzRi90Km5qpvnyLPXUAVrnBK1j_oLLcgNsGylvWGjyc4JVdQeING-cTNB0Nv3-4CDzNQqBjSrcBJCVhBkBQwQeaWaMA5YUcgFMsFIsiy0loTUiJIlqaRLJMcgWggSg3QsycPkWdvMjtCcKx1Nwoo7jijAHwkVQyGxFBqOXS2KyL6F6fqfY9yB0VxjKtCmsCcpFaPamzQuqt0EVBc9W67sHxD_mBM1Uj6zpoVz8Um6vUL8hUGiakCo2GhIslGUu4hUDNLNVaWxXTLnrlDJ26Hhm5O4RzpXZlmX7-Nk77cVUwTkRyq9CkJfTGC2UFTFYr_-ADqMz13mpJnjiv2k-qTAmREROumXQXne097fDwy2YY9gdX9AGLFzsnA5jaJdowo2e1YzaKoQCWBQC4LhItl21prj2SL35WPchjQSBzDk__RwHP0T2AmbI-NnmGOtvNzr4AKLed99AdMRPwmow-9dBxf_BxMIL3wXD8ddKrbo_0qvX7G57_TEA
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELdGJwQviO8VBgQE4ilb4o84RppQB51atlWobFLFS3BtZ1RakrK2Qv3n-Ns4J04gaMDT3tr6WtV357vfxfb9EHqZCg55W6V-qEnqUxYQP2YM-2aqAmxYpJmxD_SPR9HglH6YsMkG-lHfhbHHKuuYWAZqXSj7jHwXYxFSbvvqvp1_8y1rlN1drSk0pKNW0HtlizF3sePQrL9DCbfYG74He7_C-KB_8m7gO5YBX0WELH3A5EEKOEjCC5IaLQHkBAxwQ8QlDUPDcGB0QLDESuhY0FQwCTkTSzuC9ZTA715DmwA7CKyqzf3-6OO4zgWExSVDmCXn8TmhE3d5j_Bw1_nKzlxNZ_asAtQRYSs5lhwCTabozM-LxWUw-M_TnL-lx4Pb6JbDtV6vcsQ7aMPkd9H1iulyfQ997nlZ0yAW5EoCHq9IPXijZqvM0-tcZjO1eOM5qgJP5trLIN5AfM41LBNfOk8y2uuPvcxkUOhDoL6PTq9E4Q9QJy9ys4W8SCimpZZMMkoBaAkiqAkxx8QwoU3aRaTWZ6Jcz3NLvXGelBt5HGqfSj2JtULirNBFfvOtedXz4z_y-9ZUjazt2F1-UFycJS4AJEJTLmSgFRR4NE5pzAwAA2qIUsrIiHTRC2voxPbkyO2hnzO5WiyS4adR0ovKDeqYx38VGreEXjuhtIDJKukuWoDKbK-vluSW9ap6Uovk1yLrou3a0y4fft4MQzyym0xg8WJlZQDD28IeZvSwcsxGMQTAOQfA2EW85bItzbVH8tnXsud5xDFU6sGjf_-tZ-jG4OT4KDkajg4fo5sAbkV1WHMbdZYXK_MEAORy-tStUg99uerA8BM_6X_E
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELdGEYgXxPcKAwwC8RSa-COOkRAqbGVlMKGxSRUvwbWdUWlJytIK9V_jr-OcOIGiAU97a-trVd-d734X2_dD6EkmBeRtnQWRoVnAeEiDhHMS2KkOieWx4dY90P-wH-8esXcTPtlAP9q7MO5YZRsT60BtSu2ekQ8IkRETrq_uIPPHIj5uj17NvwWOQcrttLZ0Go2L7NnVdyjfqpfjbbD1U0JGO4dvdgPPMBDomNJFAHg8zAADKXhBM2sUAJyQA2aIhWJRZDkJrQkpUURLk0iWSa4gXxLlRoiZUvjdC-iio3pxKyoZvW2zAOVJzQ3maHkCQdnEX9ujIhp4L3k-19OZO6UAFUS0lhZr9oAuR_TmJ2V1FgD-8xznb4lxdA1d9YgWDxsXvI42bHEDXWo4Llc30echzrvWsCBXU-_gMsPwRs-WOTarQuUzXb3AnqQAq8LgHCINRObCwAIJlPcha_DOAc5tDiU-hOhb6Ohc1H0b9YqysJsIx1Jzo4ziijMGEEtSyWxEBKGWS2OzPqKtPlPtu5070o2TtN7CE1D1NOpJnRVSb4U-CrpvzZtuH_-Rf-1M1cm6Xt31B-XpceqXfioNE1KFRkNpx5KMJdwCJGCWaq2timkfPXaGTl03jsL59bFaVlU6_rSfDuN6azoRyV-FDtaEnnmhrITJauWvWIDKXJevNclN51XtpKr01_Lqo63W084eftQNQyRy20tg8XLpZAC9u5IeZnSnccxOMRRguQCo2EdizWXXNLc-Usy-1t3OY0GgRg_v_vtvPUSXIRyk78f7e_fQFUC1sjmluYV6i9OlvQ_IcTF9UC9RjL6cd0z4CbwvfWA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+mathematical+model+of+calcium+dynamics%3A+Obesity+and+mitochondria-associated+ER+membranes&rft.jtitle=PLoS+computational+biology&rft.au=Han%2C+Jung+Min&rft.au=Periwal%2C+Vipul&rft.date=2019-08-01&rft.pub=Public+Library+of+Science&rft.issn=1553-734X&rft.volume=15&rft.issue=8&rft_id=info:doi/10.1371%2Fjournal.pcbi.1006661&rft.externalDBID=ISR&rft.externalDocID=A600424878
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1553-7358&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1553-7358&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1553-7358&client=summon