The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury - Barbier-Torres, Lucía; Iruzubieta, Paula; Fernández-Ramos, David; Delgado, Teresa C.; Taibo, Daniel; Guitiérrez-de-Juan, Virginia; Varela-Rey, Marta; Azkargorta, Mikel; Navasa, Nicolas; Fernández-Tussy, Pablo; Zubiete-Franco, Imanol; Simon, Jorge; et al. (Nature communications, 2017)
Keywords: 631/80/642/333; 692/4020/4021/1607/2749; Acetaminophen; Acetaminophen - toxicity; Acetylcysteine; Adolescent; Adult; Analgesics; Animals; Biocompatibility; Chemical and Drug Induced Liver Injury - drug therapy; Chemical and Drug Induced Liver Injury - etiology; Chemical and Drug Induced Liver Injury - pathology; Disease Models, Animal; Down-regulation; Drug Overdose - complications; Drug Overdose - etiology; Electron Transport Complex I - metabolism; Female; Fever; Gene Knockout Techniques; Hepatocytes; HSP40 Heat-Shock Proteins - antagonists & inhibitors; HSP40 Heat-Shock Proteins - metabolism; Humanities and Social Sciences; Humans; Injury prevention; Liver; Liver - cytology; Liver - pathology; Liver diseases; Male; Mice; Mice, Inbred C57BL; Middle Aged; Mitochondria; Mitochondria, Liver - metabolism; Mitochondrial Proteins - antagonists & inhibitors; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; Molecular Chaperones - antagonists & inhibitors; Molecular Chaperones - genetics; Molecular Chaperones - metabolism; multidisciplinary; Overdose; Pain; Primary Cell Culture; RNA, Small Interfering - metabolism; Rotenone - pharmacology; Rotenone - therapeutic use; Science; Science (multidisciplinary); Toxicity; Uncoupling Agents - pharmacology; Uncoupling Agents - therapeutic use; Young Adult