Gene expression analysis of membrane transporters and drug‐metabolizing enzymes in the lung of healthy and COPD subjects
This study describes for the first time the expression levels of genes encoding membrane transporters and drug‐metabolizing enzymes in the lungs of ex‐smoking patients with chronic obstructive pulmonary disease (COPD). Membrane transporters and drug‐metabolizing enzymes are key determinants of drug...
Saved in:
| Published in | Pharmacology research & perspectives Vol. 2; no. 4; pp. e00054 - n/a |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
John Wiley & Sons, Inc
01.08.2014
Blackwell Publishing Ltd |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2052-1707 2052-1707 |
| DOI | 10.1002/prp2.54 |
Cover
| Abstract | This study describes for the first time the expression levels of genes encoding membrane transporters and drug‐metabolizing enzymes in the lungs of ex‐smoking patients with chronic obstructive pulmonary disease (COPD). Membrane transporters and drug‐metabolizing enzymes are key determinants of drug uptake, metabolism, and elimination for systemically administered as well as inhaled drugs, with consequent influence on clinical efficacy and patient safety. In this study, while no difference in gene expression was found between healthy and COPD subjects, we identified a significant regional difference in mRNA expression of both membrane transporters and drug‐metabolizing enzymes between central and peripheral tissue in both healthy and COPD subjects. The majority of the differentially expressed genes were higher expressed in the central airways such as the transporters SLC2A1 (GLUT1), SLC28A3 (CNT3), and SLC22A4 (OCTN1) and the drug‐metabolizing enzymes GSTZ1, GSTO2, and CYP2F1. Together, this increased knowledge of local pharmacokinetics in diseased and normal lung may improve modeling of clinical outcomes of new chemical entities intended for inhalation therapy delivered to COPD patients. In addition, based on the similarities between COPD and healthy subjects regarding gene expression of membrane transporters and drug‐metabolizing enzymes, our results suggest that clinical pharmacological studies in healthy volunteers could be a valid model of COPD patients regarding drug disposition of inhaled drugs in terms of drug metabolism and drug transporters.
e00054 |
|---|---|
| AbstractList | This study describes for the first time the expression levels of genes encoding membrane transporters and drug‐metabolizing enzymes in the lungs of ex‐smoking patients with chronic obstructive pulmonary disease (COPD). Membrane transporters and drug‐metabolizing enzymes are key determinants of drug uptake, metabolism, and elimination for systemically administered as well as inhaled drugs, with consequent influence on clinical efficacy and patient safety. In this study, while no difference in gene expression was found between healthy and COPD subjects, we identified a significant regional difference in mRNA expression of both membrane transporters and drug‐metabolizing enzymes between central and peripheral tissue in both healthy and COPD subjects. The majority of the differentially expressed genes were higher expressed in the central airways such as the transporters SLC2A1 (GLUT1), SLC28A3 (CNT3), and SLC22A4 (OCTN1) and the drug‐metabolizing enzymes GSTZ1 , GSTO2 , and CYP2F1 . Together, this increased knowledge of local pharmacokinetics in diseased and normal lung may improve modeling of clinical outcomes of new chemical entities intended for inhalation therapy delivered to COPD patients. In addition, based on the similarities between COPD and healthy subjects regarding gene expression of membrane transporters and drug‐metabolizing enzymes, our results suggest that clinical pharmacological studies in healthy volunteers could be a valid model of COPD patients regarding drug disposition of inhaled drugs in terms of drug metabolism and drug transporters.
e00054 This study describes for the first time the expression levels of genes encoding membrane transporters and drug-metabolizing enzymes in the lungs of ex-smoking patients with chronic obstructive pulmonary disease (COPD). Membrane transporters and drug-metabolizing enzymes are key determinants of drug uptake, metabolism, and elimination for systemically administered as well as inhaled drugs, with consequent influence on clinical efficacy and patient safety. In this study, while no difference in gene expression was found between healthy and COPD subjects, we identified a significant regional difference in mRNA expression of both membrane transporters and drug-metabolizing enzymes between central and peripheral tissue in both healthy and COPD subjects. The majority of the differentially expressed genes were higher expressed in the central airways such as the transporters SLC2A1 (GLUT1), SLC28A3 (CNT3), and SLC22A4 (OCTN1) and the drug-metabolizing enzymes GSTZ1, GSTO2, and CYP2F1. Together, this increased knowledge of local pharmacokinetics in diseased and normal lung may improve modeling of clinical outcomes of new chemical entities intended for inhalation therapy delivered to COPD patients. In addition, based on the similarities between COPD and healthy subjects regarding gene expression of membrane transporters and drug-metabolizing enzymes, our results suggest that clinical pharmacological studies in healthy volunteers could be a valid model of COPD patients regarding drug disposition of inhaled drugs in terms of drug metabolism and drug transporters. This study describes for the first time the expression levels of genes encoding membrane transporters and drug-metabolizing enzymes in the lungs of ex-smoking patients with chronic obstructive pulmonary disease (COPD). Membrane transporters and drug-metabolizing enzymes are key determinants of drug uptake, metabolism, and elimination for systemically administered as well as inhaled drugs, with consequent influence on clinical efficacy and patient safety. In this study, while no difference in gene expression was found between healthy and COPD subjects, we identified a significant regional difference in mRNA expression of both membrane transporters and drug-metabolizing enzymes between central and peripheral tissue in both healthy and COPD subjects. The majority of the differentially expressed genes were higher expressed in the central airways such as the transporters SLC2A1 (GLUT1), SLC28A3 (CNT3), and SLC22A4 (OCTN1) and the drug-metabolizing enzymes GSTZ1 , GSTO2 , and CYP2F1 . Together, this increased knowledge of local pharmacokinetics in diseased and normal lung may improve modeling of clinical outcomes of new chemical entities intended for inhalation therapy delivered to COPD patients. In addition, based on the similarities between COPD and healthy subjects regarding gene expression of membrane transporters and drug-metabolizing enzymes, our results suggest that clinical pharmacological studies in healthy volunteers could be a valid model of COPD patients regarding drug disposition of inhaled drugs in terms of drug metabolism and drug transporters. This study describes for the first time the expression levels of genes encoding membrane transporters and drug-metabolizing enzymes in the lungs of ex-smoking patients with chronic obstructive pulmonary disease (COPD). Membrane transporters and drug-metabolizing enzymes are key determinants of drug uptake, metabolism, and elimination for systemically administered as well as inhaled drugs, with consequent influence on clinical efficacy and patient safety. In this study, while no difference in gene expression was found between healthy and COPD subjects, we identified a significant regional difference in mRNA expression of both membrane transporters and drug-metabolizing enzymes between central and peripheral tissue in both healthy and COPD subjects. The majority of the differentially expressed genes were higher expressed in the central airways such as the transporters SLC2A1 (GLUT1), SLC28A3 (CNT3), and SLC22A4 (OCTN1) and the drug-metabolizing enzymes GSTZ1, GSTO2, and CYP2F1. Together, this increased knowledge of local pharmacokinetics in diseased and normal lung may improve modeling of clinical outcomes of new chemical entities intended for inhalation therapy delivered to COPD patients. In addition, based on the similarities between COPD and healthy subjects regarding gene expression of membrane transporters and drug-metabolizing enzymes, our results suggest that clinical pharmacological studies in healthy volunteers could be a valid model of COPD patients regarding drug disposition of inhaled drugs in terms of drug metabolism and drug transporters.This study describes for the first time the expression levels of genes encoding membrane transporters and drug-metabolizing enzymes in the lungs of ex-smoking patients with chronic obstructive pulmonary disease (COPD). Membrane transporters and drug-metabolizing enzymes are key determinants of drug uptake, metabolism, and elimination for systemically administered as well as inhaled drugs, with consequent influence on clinical efficacy and patient safety. In this study, while no difference in gene expression was found between healthy and COPD subjects, we identified a significant regional difference in mRNA expression of both membrane transporters and drug-metabolizing enzymes between central and peripheral tissue in both healthy and COPD subjects. The majority of the differentially expressed genes were higher expressed in the central airways such as the transporters SLC2A1 (GLUT1), SLC28A3 (CNT3), and SLC22A4 (OCTN1) and the drug-metabolizing enzymes GSTZ1, GSTO2, and CYP2F1. Together, this increased knowledge of local pharmacokinetics in diseased and normal lung may improve modeling of clinical outcomes of new chemical entities intended for inhalation therapy delivered to COPD patients. In addition, based on the similarities between COPD and healthy subjects regarding gene expression of membrane transporters and drug-metabolizing enzymes, our results suggest that clinical pharmacological studies in healthy volunteers could be a valid model of COPD patients regarding drug disposition of inhaled drugs in terms of drug metabolism and drug transporters. |
| Author | Berg, Tove Nord, Magnus Werkström, Viktoria Hegelund Myrbäck, Tove Olsson, Marita Grunewald, Johan Gustavsson, Lena Seidegård, Janeric Zhou, Xiao‐Hong |
| Author_xml | – sequence: 1 givenname: Tove surname: Berg fullname: Berg, Tove organization: Karolinska Institutet and Karolinska University Hospital Solna – sequence: 2 givenname: Tove surname: Hegelund Myrbäck fullname: Hegelund Myrbäck, Tove organization: AstraZeneca R&D Mölndal – sequence: 3 givenname: Marita surname: Olsson fullname: Olsson, Marita organization: AstraZeneca R&D Mölndal – sequence: 4 givenname: Janeric surname: Seidegård fullname: Seidegård, Janeric organization: AstraZeneca R&D Mölndal – sequence: 5 givenname: Viktoria surname: Werkström fullname: Werkström, Viktoria organization: AstraZeneca R&D Mölndal – sequence: 6 givenname: Xiao‐Hong surname: Zhou fullname: Zhou, Xiao‐Hong organization: AstraZeneca R&D Mölndal – sequence: 7 givenname: Johan surname: Grunewald fullname: Grunewald, Johan organization: Karolinska Institutet and Karolinska University Hospital Solna – sequence: 8 givenname: Lena surname: Gustavsson fullname: Gustavsson, Lena organization: Lund University – sequence: 9 givenname: Magnus surname: Nord fullname: Nord, Magnus organization: AstraZeneca R&D Mölndal |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25505599$$D View this record in MEDLINE/PubMed https://research.chalmers.se/publication/210752$$DView record from Swedish Publication Index http://kipublications.ki.se/Default.aspx?queryparsed=id:225505599$$DView record from Swedish Publication Index |
| BookMark | eNp1kstu1DAUhiNUREupeAMUiQVIaIrt2HG8QUIDFKRKHXFZW7ZzMvHgXGonlJkVj8Az8iQ4nZZe0GwSy_7Of_5zeZzstV0LSfIUo2OMEHnd-54cM_ogOSCIkRnmiO_dOu8nRyGsEEIYU4Qz8ijZJ4whxoQ4SDYn0EIKP3sPIdiuTVWr3DrYkHZV2kCjvYrvQ_yGvvMD-BCJMi39uPzz63cDg9KdsxvbLlNoN-sGQmrbdKghdWO8iyI1KDfU68uw-dniXRpGvQIzhCfJw0q5AEdX_8Pk24f3X-cfZ6dnJ5_mb09nJs8InWXKgKYFV5prEJjQDOtM0bzMBMo1cIZKXRWc5jpHmhQlqjTOCiG0AlFxrrPDZLbVDRfQj1r23jbKr2WnrLy6-h5PIBnOixxF_stOPnYJlDe1NLVyTezGFIdFZYSqcskzVkhKcSULZSqJcyCaM0bKcnKhdqpOnVXuRtyNk2yknDVqiFMJkosCEyCFNByBpFVlpCqFkECQwUjkVGdTjjfbHDG0gdJAGwfn7qa689LaWi67H5LiIo--o8DLKwHfnY8QBtnYYMC5uATdGGJFWaxHcDahz--hq270cXmCJCS2PyMi55F6dtvRPyvXC3gzHOO7EDxU0tjhsuZo0DqJkZx2XE47LhmN_It7_LXk_-SrLXlhHax3YXLxeUEi_Rcx0w-b |
| CitedBy_id | crossref_primary_10_1186_s12931_018_0760_9 crossref_primary_10_1186_s12931_018_0795_y crossref_primary_10_1002_prp2_405 crossref_primary_10_3390_ijms25095028 crossref_primary_10_1016_j_ajhg_2024_01_012 crossref_primary_10_1016_j_bcp_2023_115818 crossref_primary_10_3390_ijms25094671 crossref_primary_10_1021_acsomega_0c02329 crossref_primary_10_1371_journal_pcbi_1011472 crossref_primary_10_3390_pharmaceutics12020117 crossref_primary_10_1002_vms3_331 crossref_primary_10_1016_j_jpba_2018_02_044 crossref_primary_10_3390_ijms22136711 crossref_primary_10_1093_nar_gkw757 crossref_primary_10_2217_pgs_2021_0012 crossref_primary_10_3390_ijms21239168 crossref_primary_10_1124_dmd_120_000103 crossref_primary_10_1159_000519344 crossref_primary_10_1016_j_addr_2021_113862 crossref_primary_10_1016_j_heliyon_2024_e34386 crossref_primary_10_3390_ijms21093190 |
| Cites_doi | 10.1080/00498250600861751 10.1007/s00441-005-0150-8 10.1124/dmd.112.046896 10.1165/rcmb.2006-0230OC 10.1073/pnas.1530509100 10.1186/1465-9921-6-59 10.1186/1465-9921-8-49 10.1146/annurev.pharmtox.43.100901.140251 10.1016/j.taap.2003.11.015 10.1067/mai.2002.121409 10.1146/annurev.pharmtox.46.120604.141059 10.1021/mp900206j 10.1186/1465-9921-11-55 10.1002/jps.21995 10.1016/j.biochi.2011.02.012 10.1038/nrd3028 10.1126/science.1360704 10.1186/1479-5876-10-171 10.1002/jps.2600750502 10.1038/nrd2153 10.1136/thorax.58.3.258 10.1016/S0014-2999(02)01267-0 10.1164/rccm.200607-931OC 10.1016/S0940-2993(99)80031-1 10.2147/COPD.S2817 10.1016/S0022-3565(25)22379-5 10.2174/138920006779010575 10.1080/20024091064273 10.1006/bbrc.1998.9662 10.1124/dmd.107.015966 10.1016/j.ejphar.2012.08.015 10.1517/17425255.2013.754009 10.1089/jamp.2011.0916 |
| ContentType | Journal Article |
| Copyright | 2014 The Authors. published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics. 2014. This work is published under http://creativecommons.org/licenses/by-nc-nd/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2014 The Authors. published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics. 2014 |
| Copyright_xml | – notice: 2014 The Authors. published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics. – notice: 2014. This work is published under http://creativecommons.org/licenses/by-nc-nd/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2014 The Authors. published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics. 2014 |
| CorporateAuthor | Avdelningen för translationell cancerforskning Division of Clinical Chemistry and Pharmacology Division of Translational Cancer Research Lunds universitet Department of Clinical Sciences, Malmö Department of Laboratory Medicine Lund University Institutionen för laboratoriemedicin Family Medicine, Cardiovascular Epidemiology and Lifestyle Avdelningen för klinisk kemi och farmakologi Faculty of Medicine Medicinska fakulteten Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor Institutionen för kliniska vetenskaper, Malmö |
| CorporateAuthor_xml | – name: Faculty of Medicine – name: Medicinska fakulteten – name: Avdelningen för klinisk kemi och farmakologi – name: Department of Laboratory Medicine – name: Division of Translational Cancer Research – name: Family Medicine, Cardiovascular Epidemiology and Lifestyle – name: Institutionen för kliniska vetenskaper, Malmö – name: Lunds universitet – name: Division of Clinical Chemistry and Pharmacology – name: Lund University – name: Avdelningen för translationell cancerforskning – name: Institutionen för laboratoriemedicin – name: Department of Clinical Sciences, Malmö – name: Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor |
| DBID | 24P AAYXX CITATION NPM 3V. 7X7 7XB 8AO 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH K9. M0S PHGZM PHGZT PIMPY PKEHL PQEST PQQKQ PQUKI PRINS 7X8 5PM ADTPV AGCHP AOWAS D8T D95 ZZAVC F1S |
| DOI | 10.1002/prp2.54 |
| DatabaseName | Wiley Online Library Open Access CrossRef PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) ProQuest Pharma Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials - QC ProQuest Central ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) SwePub SWEPUB Lunds universitet full text SwePub Articles SWEPUB Freely available online SWEPUB Lunds universitet SwePub Articles full text SWEPUB Chalmers tekniska högskola |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest One Academic Eastern Edition ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Pharma Collection ProQuest Central China ProQuest Hospital Collection (Alumni) ProQuest Central ProQuest Health & Medical Complete Health Research Premium Collection ProQuest One Academic UKI Edition Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest Central (New) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | CrossRef PubMed MEDLINE - Academic Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: 24P name: Wiley Online Library Open Access url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 2052-1707 |
| EndPage | n/a |
| ExternalDocumentID | oai_swepub_ki_se_516860 oai_research_chalmers_se_19fc9af6_7358_441f_8acf_16e2b7552ddb oai_portal_research_lu_se_publications_79812e28_c70e_4ffc_ad99_e20c10964b3b PMC4186441 25505599 10_1002_prp2_54 PRP254 |
| Genre | article Journal Article |
| GrantInformation_xml | – fundername: Swedish Heart‐Lung Foundation – fundername: Swedish Research Council – fundername: Karolinska Institutet |
| GroupedDBID | 0R~ 1OC 24P 53G 5VS 7X7 8-1 8AO 8FI 8FJ AAHHS AAZKR ABDBF ABUWG ACCFJ ACCMX ACUHS ACXQS ADBBV ADKYN ADRAZ ADZMN AEEZP AEQDE AFKRA AIWBW AJBDE ALIPV ALMA_UNASSIGNED_HOLDINGS ALUQN AOIJS AVUZU BCNDV BENPR BPHCQ BVXVI CCPQU DIK EBD EBS EJD ESX FYUFA GODZA GROUPED_DOAJ HMCUK HYE IAO IHR INH ITC KQ8 M48 M~E O9- OK1 PIMPY PQQKQ PROAC RPM TUS UKHRP WIN AAYXX CITATION PHGZM PHGZT AAMMB AEFGJ AGXDD AIDQK AIDYY NPM 3V. 7XB 8FK AZQEC DWQXO K9. PKEHL PQEST PQUKI PRINS 7X8 PUEGO 5PM ADTPV AGCHP AOWAS D8T D95 ZZAVC F1S |
| ID | FETCH-LOGICAL-c6324-3aceb487ab7be912431b3a46d3906be750dbf8746b60b28d0fb13899bae9f77b3 |
| IEDL.DBID | 7X7 |
| ISSN | 2052-1707 |
| IngestDate | Wed Sep 24 03:44:36 EDT 2025 Tue Sep 09 23:10:57 EDT 2025 Tue Sep 09 23:42:39 EDT 2025 Thu Aug 21 18:14:43 EDT 2025 Thu Sep 04 23:11:38 EDT 2025 Sat Aug 23 12:58:36 EDT 2025 Mon Jul 21 06:03:40 EDT 2025 Thu Apr 24 22:59:09 EDT 2025 Tue Jul 01 05:07:35 EDT 2025 Wed Jan 22 16:26:00 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | TLDA expression pattern peripheral tissue human lung tissue pharmacokinetics mRNA ex-smoker PCR central airways PCA |
| Language | English |
| License | Attribution-NonCommercial-NoDerivs http://creativecommons.org/licenses/by-nc-nd/3.0 This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c6324-3aceb487ab7be912431b3a46d3906be750dbf8746b60b28d0fb13899bae9f77b3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Funding Information Tove Hegelund Myrbäck, Marita Olsson, Janeric Seidegård, Viktoria Werkström, Xiao-Hong Zhou, Lena Gustavsson, and Magnus Nord are full-time employees of Astra Zeneca R&D. The work was supported by the Swedish Heart-Lung Foundation; the Swedish Research Council; the regional agreement on medical training and clinical research (ALF) between Stockholm County Council and Karolinska Institutet; and Karolinska Institutet. |
| OpenAccessLink | https://www.proquest.com/docview/2289932967?pq-origsite=%requestingapplication% |
| PMID | 25505599 |
| PQID | 2289932967 |
| PQPubID | 2034609 |
| PageCount | 14 |
| ParticipantIDs | swepub_primary_oai_swepub_ki_se_516860 swepub_primary_oai_research_chalmers_se_19fc9af6_7358_441f_8acf_16e2b7552ddb swepub_primary_oai_portal_research_lu_se_publications_79812e28_c70e_4ffc_ad99_e20c10964b3b pubmedcentral_primary_oai_pubmedcentral_nih_gov_4186441 proquest_miscellaneous_1637559751 proquest_journals_2289932967 pubmed_primary_25505599 crossref_citationtrail_10_1002_prp2_54 crossref_primary_10_1002_prp2_54 wiley_primary_10_1002_prp2_54_PRP254 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | August 2014 |
| PublicationDateYYYYMMDD | 2014-08-01 |
| PublicationDate_xml | – month: 08 year: 2014 text: August 2014 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Bognor Regis – name: Oxford, UK |
| PublicationTitle | Pharmacology research & perspectives |
| PublicationTitleAlternate | Pharmacol Res Perspect |
| PublicationYear | 2014 |
| Publisher | John Wiley & Sons, Inc Blackwell Publishing Ltd |
| Publisher_xml | – name: John Wiley & Sons, Inc – name: Blackwell Publishing Ltd |
| References | 2010; 99 2010; 11 1986; 75 1994; 270 2006; 36 2002; 32 2006; 7 2002; 437 2003; 58 2008; 3 2012; 10 2007; 35 2007; 36 2013; 9 1998; 252 2004; 199 2012; 696 2006; 46 2011; 93 1992; 258 2007; 175 2007; 8 2007; 6 2005; 6 1999; 51 2002; 109 2012; 25 2006; 324 2010; 7 2003; 100 2003; 43 2010; 9 2012; 40 e_1_2_8_28_1 e_1_2_8_29_1 e_1_2_8_24_1 e_1_2_8_25_1 e_1_2_8_26_1 e_1_2_8_27_1 e_1_2_8_3_1 e_1_2_8_2_1 e_1_2_8_5_1 e_1_2_8_4_1 e_1_2_8_7_1 e_1_2_8_6_1 e_1_2_8_9_1 e_1_2_8_8_1 e_1_2_8_20_1 e_1_2_8_21_1 e_1_2_8_22_1 e_1_2_8_23_1 e_1_2_8_17_1 e_1_2_8_18_1 e_1_2_8_19_1 e_1_2_8_13_1 e_1_2_8_15_1 e_1_2_8_16_1 e_1_2_8_32_1 e_1_2_8_10_1 e_1_2_8_11_1 Deen M (e_1_2_8_14_1) 2008; 3 Shimada T (e_1_2_8_31_1) 1994; 270 e_1_2_8_34_1 e_1_2_8_12_1 e_1_2_8_33_1 e_1_2_8_30_1 19950388 - J Pharm Sci. 2010 May;99(5):2240-55 11864633 - Eur J Pharmacol. 2002 Feb 15;437(1-2):9-17 23294005 - Expert Opin Drug Metab Toxicol. 2013 Apr;9(4):487-505 12389869 - Crit Rev Toxicol. 2002 Sep;32(5):391-411 8035341 - J Pharmacol Exp Ther. 1994 Jul;270(1):414-23 16402901 - Annu Rev Pharmacol Toxicol. 2006;46:123-49 16501997 - Cell Tissue Res. 2006 Jun;324(3):423-32 21376776 - Biochimie. 2011 Jun;93(6):1012-27 3735078 - J Pharm Sci. 1986 May;75(5):433-8 9826540 - Biochem Biophys Res Commun. 1998 Nov 18;252(2):392-5 17627976 - Drug Metab Dispos. 2007 Oct;35(10):1797-805 16917073 - Am J Respir Cell Mol Biol. 2007 Jan;36(1):53-60 17168693 - Curr Drug Metab. 2006 Dec;7(8):939-48 20190787 - Nat Rev Drug Discov. 2010 Mar;9(3):215-36 11842317 - J Allergy Clin Immunol. 2002 Feb;109 (2 Suppl):S447-60 20020740 - Mol Pharm. 2010 Feb 1;7(1):187-95 17118916 - Xenobiotica. 2006 Oct-Nov;36(10-11):963-88 12883005 - Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9440-5 22982023 - Eur J Pharmacol. 2012 Dec 5;696(1-3):136-42 1360704 - Science. 1992 Dec 4;258(5088):1650-4 22798553 - Drug Metab Dispos. 2012 Oct;40(10):1953-65 17617921 - Respir Res. 2007 Jul 07;8:49 22913419 - J Transl Med. 2012 Aug 22;10 :171 17158281 - Am J Respir Crit Care Med. 2007 Mar 15;175(6):577-86 12171978 - Annu Rev Pharmacol Toxicol. 2003;43:149-73 17195033 - Nat Rev Drug Discov. 2007 Jan;6(1):67-74 12612308 - Thorax. 2003 Mar;58(3):258-60 15967026 - Respir Res. 2005 Jun 20;6:59 18990976 - Int J Chron Obstruct Pulmon Dis. 2008;3(3):469-75 20459817 - Respir Res. 2010 May 11;11:55 15364538 - Toxicol Appl Pharmacol. 2004 Sep 15;199(3):210-9 10445407 - Exp Toxicol Pathol. 1999 Jul;51(4-5):412-7 22686623 - J Aerosol Med Pulm Drug Deliv. 2012 Jun;25(3):140-7 |
| References_xml | – volume: 109 start-page: S447 year: 2002 end-page: S460 article-title: Therapeutic significance of distal airway inflammation in asthma publication-title: J Allergy Clin Immunol – volume: 6 start-page: 59 year: 2005 article-title: ATP‐binding cassette (ABC) transporters in normal and pathological lung publication-title: Respir Res – volume: 10 start-page: 171 year: 2012 article-title: Enhanced ROCK1 dependent contractility in fibroblast from chronic obstructive pulmonary disease patients publication-title: J Transl Med – volume: 40 start-page: 1953 year: 2012 end-page: 1965 article-title: Xenobiotic metabolism and disposition in human lung cell models: comparison with in vivo expression profiles publication-title: Drug Metab Dispos – volume: 36 start-page: 53 year: 2007 end-page: 60 article-title: Epithelial organic cation transporters ensure pH‐dependent drug absorption in the airway publication-title: Am J Respir Cell Mol Biol – volume: 324 start-page: 423 year: 2006 end-page: 432 article-title: Expression patterns and novel splicing variants of glutathione‐S‐transferase isoenzymes of human lung and hepatocyte cell lines publication-title: Cell Tissue Res – volume: 32 start-page: 391 year: 2002 end-page: 411 article-title: Expression and regulation of xenobiotic‐metabolizing cytochrome P450 (CYP) enzymes in human lung publication-title: Crit Rev Toxicol – volume: 199 start-page: 210 year: 2004 end-page: 219 article-title: Expression of cytochromes P450 1A1 and 1B1 in human lung from smokers, non‐smokers, and ex‐smokers publication-title: Toxicol Appl Pharmacol – volume: 3 start-page: 469 year: 2008 end-page: 475 article-title: Effect of COPD treatments on MRP1‐mediated transport in bronchial epithelial cells publication-title: Int J Chron Obstruct Pulmon Dis – volume: 58 start-page: 258 year: 2003 end-page: 260 article-title: Plasma concentrations of fluticasone propionate and budesonide following inhalation from dry powder inhalers by healthy and asthmatic subjects publication-title: Thorax – volume: 75 start-page: 433 year: 1986 end-page: 438 article-title: Prediction of drug residence times in regions of the human respiratory tract following aerosol inhalation publication-title: J Pharm Sci – volume: 9 start-page: 215 year: 2010 end-page: 236 article-title: Membrane transporters in drug development publication-title: Nat Rev Drug Discovery – volume: 100 start-page: 9440 year: 2003 end-page: 9445 article-title: Statistical significance for genomewide studies publication-title: Proc Natl Acad Sci USA – volume: 99 start-page: 2240 year: 2010 end-page: 2255 article-title: Drug transporters in the lung–do they play a role in the biopharmaceutics of inhaled drugs? publication-title: J Pharm Sci – volume: 11 start-page: 55 year: 2010 article-title: Altered fibroblast proteoglycan production in COPD publication-title: Respir Res – volume: 696 start-page: 136 year: 2012 end-page: 142 article-title: Multidrug resistance‐associated protein 1 and lung function decline with or without long‐term corticosteroids treatment in COPD publication-title: Eur J Pharmacol – volume: 258 start-page: 1650 year: 1992 end-page: 1654 article-title: Overexpression of a transporter gene in a multidrug‐resistant human lung cancer cell line publication-title: Science – volume: 6 start-page: 67 year: 2007 end-page: 74 article-title: Inhaling medicines: delivering drugs to the body through the lungs publication-title: Nat Rev Drug Discovery – volume: 7 start-page: 187 year: 2010 end-page: 195 article-title: Transport of ipratropium, an anti‐chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier‐mediated pulmonary absorption publication-title: Mol Pharm – volume: 252 start-page: 392 year: 1998 end-page: 395 article-title: Modulation of MDR1 and CYP3A expression by dexamethasone: evidence for an inverse regulation in adrenals publication-title: Biochem Biophys Res Commun – volume: 7 start-page: 939 year: 2006 end-page: 948 article-title: Xenobiotic‐metabolizing enzymes in human lung publication-title: Curr Drug Metab – volume: 8 start-page: 49 year: 2007 article-title: Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice publication-title: Respir Res – volume: 270 start-page: 414 year: 1994 end-page: 423 article-title: Interindividual variations in human liver cytochrome P‐450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians publication-title: J Pharmacol Exp Ther – volume: 437 start-page: 9 year: 2002 end-page: 17 article-title: Budesonide reduces multidrug resistance‐associated protein 1 expression in an airway epithelial cell line (Calu‐1) publication-title: Eur J Pharmacol – volume: 43 start-page: 149 year: 2003 end-page: 173 article-title: Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue‐selective chemical toxicity in the respiratory and gastrointestinal tracts publication-title: Annu Rev Pharmacol Toxicol – volume: 175 start-page: 577 year: 2007 end-page: 586 article-title: Expression of genes involved in oxidative stress responses in airway epithelial cells of smokers with chronic obstructive pulmonary disease publication-title: Am J Respir Crit Care Med – volume: 36 start-page: 963 year: 2006 end-page: 988 article-title: Expression profiles of 50 xenobiotic transporter genes in humans and pre‐clinical species: a resource for investigations into drug disposition publication-title: Xenobiotica – volume: 51 start-page: 412 year: 1999 end-page: 417 article-title: Expression of xenobiotic‐metabolizing CYPs in human pulmonary tissue publication-title: Exp Toxicol Pathol – volume: 93 start-page: 1012 year: 2011 end-page: 1027 article-title: Xenobiotic metabolism and disposition in human lung: transcript profiling in non‐tumoral and tumoral tissues publication-title: Biochimie – volume: 35 start-page: 1797 year: 2007 end-page: 1805 article-title: A comparison of the expression and metabolizing activities of phase I and II enzymes in freshly isolated human lung parenchymal cells and cryopreserved human hepatocytes publication-title: Drug Metab Dispos – volume: 46 start-page: 123 year: 2006 end-page: 149 article-title: Regulation of drug‐metabolizing enzymes and transporters in inflammation publication-title: Annu Rev Pharmacol Toxicol – volume: 25 start-page: 140 year: 2012 end-page: 147 article-title: Aerosol deposition in health and disease publication-title: J Aerosol Med Pulm Drug Deliv – volume: 9 start-page: 487 year: 2013 end-page: 505 article-title: The development of models for the evaluation of pulmonary drug disposition publication-title: Expert Opin Drug Metab Toxicol – ident: e_1_2_8_5_1 doi: 10.1080/00498250600861751 – ident: e_1_2_8_4_1 doi: 10.1007/s00441-005-0150-8 – ident: e_1_2_8_10_1 doi: 10.1124/dmd.112.046896 – ident: e_1_2_8_20_1 doi: 10.1165/rcmb.2006-0230OC – ident: e_1_2_8_33_1 doi: 10.1073/pnas.1530509100 – ident: e_1_2_8_12_1 doi: 10.1186/1465-9921-6-59 – ident: e_1_2_8_13_1 doi: 10.1186/1465-9921-8-49 – ident: e_1_2_8_15_1 doi: 10.1146/annurev.pharmtox.43.100901.140251 – ident: e_1_2_8_22_1 doi: 10.1016/j.taap.2003.11.015 – ident: e_1_2_8_25_1 doi: 10.1067/mai.2002.121409 – ident: e_1_2_8_2_1 doi: 10.1146/annurev.pharmtox.46.120604.141059 – ident: e_1_2_8_26_1 doi: 10.1021/mp900206j – ident: e_1_2_8_17_1 doi: 10.1186/1465-9921-11-55 – ident: e_1_2_8_6_1 doi: 10.1002/jps.21995 – ident: e_1_2_8_23_1 doi: 10.1016/j.biochi.2011.02.012 – ident: e_1_2_8_16_1 doi: 10.1038/nrd3028 – ident: e_1_2_8_9_1 doi: 10.1126/science.1360704 – ident: e_1_2_8_18_1 doi: 10.1186/1479-5876-10-171 – ident: e_1_2_8_8_1 doi: 10.1002/jps.2600750502 – ident: e_1_2_8_27_1 doi: 10.1038/nrd2153 – ident: e_1_2_8_19_1 doi: 10.1136/thorax.58.3.258 – ident: e_1_2_8_3_1 doi: 10.1016/S0014-2999(02)01267-0 – ident: e_1_2_8_28_1 doi: 10.1164/rccm.200607-931OC – ident: e_1_2_8_29_1 doi: 10.1016/S0940-2993(99)80031-1 – volume: 3 start-page: 469 year: 2008 ident: e_1_2_8_14_1 article-title: Effect of COPD treatments on MRP1‐mediated transport in bronchial epithelial cells publication-title: Int J Chron Obstruct Pulmon Dis doi: 10.2147/COPD.S2817 – volume: 270 start-page: 414 year: 1994 ident: e_1_2_8_31_1 article-title: Interindividual variations in human liver cytochrome P‐450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians publication-title: J Pharmacol Exp Ther doi: 10.1016/S0022-3565(25)22379-5 – ident: e_1_2_8_34_1 doi: 10.2174/138920006779010575 – ident: e_1_2_8_21_1 doi: 10.1080/20024091064273 – ident: e_1_2_8_30_1 doi: 10.1006/bbrc.1998.9662 – ident: e_1_2_8_32_1 doi: 10.1124/dmd.107.015966 – ident: e_1_2_8_7_1 doi: 10.1016/j.ejphar.2012.08.015 – ident: e_1_2_8_24_1 doi: 10.1517/17425255.2013.754009 – ident: e_1_2_8_11_1 doi: 10.1089/jamp.2011.0916 – reference: 16501997 - Cell Tissue Res. 2006 Jun;324(3):423-32 – reference: 21376776 - Biochimie. 2011 Jun;93(6):1012-27 – reference: 17158281 - Am J Respir Crit Care Med. 2007 Mar 15;175(6):577-86 – reference: 11864633 - Eur J Pharmacol. 2002 Feb 15;437(1-2):9-17 – reference: 17627976 - Drug Metab Dispos. 2007 Oct;35(10):1797-805 – reference: 9826540 - Biochem Biophys Res Commun. 1998 Nov 18;252(2):392-5 – reference: 16917073 - Am J Respir Cell Mol Biol. 2007 Jan;36(1):53-60 – reference: 12612308 - Thorax. 2003 Mar;58(3):258-60 – reference: 22686623 - J Aerosol Med Pulm Drug Deliv. 2012 Jun;25(3):140-7 – reference: 11842317 - J Allergy Clin Immunol. 2002 Feb;109 (2 Suppl):S447-60 – reference: 22913419 - J Transl Med. 2012 Aug 22;10 :171 – reference: 23294005 - Expert Opin Drug Metab Toxicol. 2013 Apr;9(4):487-505 – reference: 22982023 - Eur J Pharmacol. 2012 Dec 5;696(1-3):136-42 – reference: 20020740 - Mol Pharm. 2010 Feb 1;7(1):187-95 – reference: 12171978 - Annu Rev Pharmacol Toxicol. 2003;43:149-73 – reference: 16402901 - Annu Rev Pharmacol Toxicol. 2006;46:123-49 – reference: 8035341 - J Pharmacol Exp Ther. 1994 Jul;270(1):414-23 – reference: 19950388 - J Pharm Sci. 2010 May;99(5):2240-55 – reference: 12389869 - Crit Rev Toxicol. 2002 Sep;32(5):391-411 – reference: 20190787 - Nat Rev Drug Discov. 2010 Mar;9(3):215-36 – reference: 1360704 - Science. 1992 Dec 4;258(5088):1650-4 – reference: 22798553 - Drug Metab Dispos. 2012 Oct;40(10):1953-65 – reference: 20459817 - Respir Res. 2010 May 11;11:55 – reference: 12883005 - Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9440-5 – reference: 15364538 - Toxicol Appl Pharmacol. 2004 Sep 15;199(3):210-9 – reference: 3735078 - J Pharm Sci. 1986 May;75(5):433-8 – reference: 10445407 - Exp Toxicol Pathol. 1999 Jul;51(4-5):412-7 – reference: 15967026 - Respir Res. 2005 Jun 20;6:59 – reference: 18990976 - Int J Chron Obstruct Pulmon Dis. 2008;3(3):469-75 – reference: 17168693 - Curr Drug Metab. 2006 Dec;7(8):939-48 – reference: 17118916 - Xenobiotica. 2006 Oct-Nov;36(10-11):963-88 – reference: 17195033 - Nat Rev Drug Discov. 2007 Jan;6(1):67-74 – reference: 17617921 - Respir Res. 2007 Jul 07;8:49 |
| SSID | ssj0001140132 |
| Score | 2.074456 |
| Snippet | This study describes for the first time the expression levels of genes encoding membrane transporters and drug‐metabolizing enzymes in the lungs of ex‐smoking... This study describes for the first time the expression levels of genes encoding membrane transporters and drug-metabolizing enzymes in the lungs of ex-smoking... |
| SourceID | swepub pubmedcentral proquest pubmed crossref wiley |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | e00054 |
| SubjectTerms | Basic Medicine Cancer and Oncology Cancer och onkologi central airways Chronic obstructive pulmonary disease Clinical Medicine Cytochrome Cytokines Disease Drugs Enzymes expression pattern ex‐smoker Farmakologi och toxikologi Gene expression human lung tissue Klinisk medicin Lungs Medical and Health Sciences Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Metabolism mRNA Original Patients PCA PCR peripheral tissue pharmacokinetics Pharmacology Pharmacology and Toxicology Polycyclic aromatic hydrocarbons Principal components analysis Proteins Studies TLDA Transplants & implants Tumor necrosis factor-TNF |
| SummonAdditionalLinks | – databaseName: Scholars Portal Journals: Open Access dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1fb9MwELfGeOEF8Z_AQEaa-rSMxHHs-AEhNJgmxKBCqzTxYsX_1oo27ZpWWvfER-Az8kk4J263qoXX2rk0ubvc72zf7xDap445QZIitsSyGCKeiYXISawJt0RlRKfGFziffmUnPfr5PD_fQcuK6_AC662pne8n1ZsOD68uF-_B4d8FAtG3k-mEHOa0M7mMfTcpv-saWmvcQXchQhFv7acB9jdrL01WQdoa2tsi1oPTBuLcPDgZ6EXXkW0Tmo4foPsBU-IPrRE8RDu2eoQ63ZaUenGAz25qrOoD3MHdG7rqxWN07Zmnsb0KJ2IrXAaeEjx2eGRHkE7D-GxFgj6tYYbBZjq_-PPr98jOwIyGg2sIgdhW14uRrfGgwoAr8RA-JF5IW2u5aC47-tb9iOu58ss_9RPUO_50dnQSh44Msfa07nFWaqsgxSkVV1YANMhSlZWUmUwkTFlAH0a5glOmWKJIYRKn_EaoUKUVjnOVPUW71biyzxE2loK0QpdEcQqiRGGUZTAzMXmWlEWEOktVSB3oyn3XjKFsiZaJ9DqTOY0QXk2ctAwdm1P2lrqUSwuTxKeaGRGMR-jNahicy--YwIsdz2sJYJX7lCtPI_SsVf3qHsTndrkQEeJrRrGa4Im710eqQb8h8KZp4WFohH605rN-SWPxMnA99eVwLmsrJ7cWcSUXAMssKaTmiZXUOS1LI4S0JNEp5KRUZSpCX7YIX0nV_aY9T-1lp8JpUTomeZYXEv6Yk0WpHTw9uCs8PzEGxHW2iAs__Rx4MXnKCpZEaL9xhX_pQna_d0lOX_xfJS_RPUCmtD1puYd2Z9O5fQXob6ZeN678F3_5ZXU priority: 102 providerName: Scholars Portal – databaseName: Wiley Online Library Open Access dbid: 24P link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1bb9MwFLZgvPCCuBMYk5GmPi0scRxfHtHYNCEuEdqkiRcrvtGKNq2aVqJ94ifwG_klHCdZuqpD4jU-Pk5yfHy-48tnhA6pZ16SRMSOOBZDxLOxlDmJDeGO6IyY1IYDzp8-s_NL-uEqv7px1VfLD9FPuAXPaMbr4OClro83pKGz-Yy8zelddC8NMT-QOtNiM73SJA5hDYEk0HTKE94emQ21j7u627FoB2Du7pPs2ES3gWwTic4eogcdhMTvWps_Qndc9RgNipaDenWELzZHquojPMDFhp169QStA9E0dj-7DbAVLjtaEjz1eOIm8EugfNFzns9rkLDYzpff__z6PXEL6DXj0RoiHnbVejVxNR5VGGAkHsO4EZS0RytXTbWTL8V7XC91mO2pn6LLs9OLk_O4u4AhNoHFPc5K4zRkNKXm2klAAlmqs5Iym8mEaQdgw2ovOGWaJZoIm3gd1j2lLp30nOvsGdqrppV7gbB1FLQJUxLNKaiSwmrHQDKxeZaUIkKDa1Mo07GTh0syxqrlVSYq2EzlNEK4F5y1hBy7IvvXtlSdR9aKhMwyI5LxCL3pi8GXwgIJ_NjpslaATXnIsPI0Qs9b0_dtkJDK5VJGiG91il4g8HRvl1SjYcPXTVMRUGeEvrXdZ7tKk2WpjtppqMZLVTs1uzFnq7gEFOaIUIYnTlHvjSqtlMqRxKSQglKd6Qh9vEV5r9UMm9t46qA7ld7I0jPFs1woeDGvRGk8fD14J3w_sRbUDW5R1z36MQpq8pQJlkTosHGFf9lCFV8LktOX_yf2Ct0HQErbDZb7aG8xX7rXAPoW-qBx779orV1O priority: 102 providerName: Wiley-Blackwell |
| Title | Gene expression analysis of membrane transporters and drug‐metabolizing enzymes in the lung of healthy and COPD subjects |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fprp2.54 https://www.ncbi.nlm.nih.gov/pubmed/25505599 https://www.proquest.com/docview/2289932967 https://www.proquest.com/docview/1637559751 https://pubmed.ncbi.nlm.nih.gov/PMC4186441 https://research.chalmers.se/publication/210752 http://kipublications.ki.se/Default.aspx?queryparsed=id:225505599 |
| Volume | 2 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 2052-1707 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001140132 issn: 2052-1707 databaseCode: KQ8 dateStart: 20130101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAON databaseName: DOAJ Open Access Full Text customDbUrl: eissn: 2052-1707 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001140132 issn: 2052-1707 databaseCode: DOA dateStart: 20130101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVEBS databaseName: EBSCO Academic Search Ultimate customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn eissn: 2052-1707 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001140132 issn: 2052-1707 databaseCode: ABDBF dateStart: 20140401 isFulltext: true titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn providerName: EBSCOhost – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 2052-1707 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001140132 issn: 2052-1707 databaseCode: DIK dateStart: 20130101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2052-1707 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001140132 issn: 2052-1707 databaseCode: M~E dateStart: 20130101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 2052-1707 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001140132 issn: 2052-1707 databaseCode: RPM dateStart: 20130101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2052-1707 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001140132 issn: 2052-1707 databaseCode: 7X7 dateStart: 20131001 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: http://www.proquest.com/pqcentral?accountid=15518 eissn: 2052-1707 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001140132 issn: 2052-1707 databaseCode: BENPR dateStart: 20131001 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVFZP databaseName: Scholars Portal Journals: Open Access customDbUrl: eissn: 2052-1707 dateEnd: 20250831 omitProxy: true ssIdentifier: ssj0001140132 issn: 2052-1707 databaseCode: M48 dateStart: 20131001 isFulltext: true titleUrlDefault: http://journals.scholarsportal.info providerName: Scholars Portal – providerCode: PRVWIB databaseName: KBPluse Wiley Online Library: Open Access customDbUrl: eissn: 2052-1707 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001140132 issn: 2052-1707 databaseCode: AVUZU dateStart: 20130101 isFulltext: true titleUrlDefault: https://www.kbplus.ac.uk/kbplus7/publicExport/pkg/559 providerName: Wiley-Blackwell – providerCode: PRVWIB databaseName: Wiley Online Library Open Access customDbUrl: eissn: 2052-1707 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001140132 issn: 2052-1707 databaseCode: 24P dateStart: 20130101 isFulltext: true titleUrlDefault: https://authorservices.wiley.com/open-science/open-access/browse-journals.html providerName: Wiley-Blackwell |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9NAEF7R9sIF8cZQokWqcqqpvV7v44SgtKoQLVbVShGXlffhJiJxQpxIpCd-Ar-RX8Ks7SREKVx8yI7HdmZ295vZ3W8QOqAFKySJROiIYyHMeDaUMiWhIdwRnRATW3_A-fyCnV3TT7201ybcqnZb5XJMrAdqOzY-R35EfGSQEMn4u8n30FeN8qurbQmNHbQXA1TxXs17fJ1jqaMH0pyV9VyjR5PphLxN6eYktIUstzdItjSimwi2noJOH6IHLXbE7xtjP0L3XPkYdbOGfHpxiK_WZ6mqQ9zF2ZqWevEE3XqGaex-tDtfS5y3fCR4XOCRG0HYDO2zFdn5tAIJi-10fvP756-Rm4G7DAe3MNVhV94uRq7CgxIDfsRDGDC8kuZM5aK-7fhL9hFXc-3TPNVTdH16cnV8FraVF0Lj6dvDJDdOQyiTa66dBAiQxDrJKbOJjJh2gDKsLgSnTLNIE2GjQvsFT6lzJwvOdfIM7Zbj0r1A2DoK2oTJieYUVElhtWMgGdk0iXIRoO7SFMq0tOS-OsZQNYTKRHmbqZQGCK8EJw0Tx7bI_tKWqu2KlVo7ToDerJqhE_mVEfhjx_NKASjlPrRK4wA9b0y_egbxMVwqZYD4hlOsBDxB92ZLOejXRN00Fh5uBuhr4z6bt9ThlWo5nfpqOFeVU5O_krWKS4BfjghleOQULQqjciulciQyMcSeVCc6QJ_vUL7Savp1GZ7K645lYWReMMWTVCh4sUKJ3BTw9dAt4fuJtaCue4e69qdvA68mjZlgUYAO6q7wL1uo7DIjKX35f5O8QvcBgdJmR-U-2p1N5-41oLyZ7qAdQrNO3aE7aO_DyUV22akzJnA9p-IP3PNg0w |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3NbtNAEF6VcoAL4h9DgUUqOdXUXq-93gNCqKVKaVoilEoRl633xyQicUKcCJITj8CT8FA8CbO24xClcOs1u57EmdmZb3Z3vkFol6ZRyokXu4aYyIWIp13OQ-IqwgyRAVG-tgXOp2dR85y-74bdLfRrWQtjr1UufWLhqPVI2T3yfWIzg4DwiL0Zf3Vt1yh7urpsoVGaxYmZf4OULX99fAj6fUnI0bvOQdOtugq4ylKTu0GijASYnkgmDYfwFvgySGikIfuPpIEIqmUaMxrJyJMk1l4q7WEel4nhKWMyALnX0HUaeNRy9bMuW-3pFNkKKWtzLbfp_ngyJq9Cuh70NpDs5oXMirZ0HTEXIe_oNrpVYVX8tjSuO2jLZHdRo12SXc_3cGdVu5Xv4QZur2iw5_fQwjJaY_O9ummb4aTiP8GjFA_NENJ0GJ_W5OqTHGZorCezz79__ByaKZjnoL-A0IpNtpgPTY77GQa8igfgoKyQsoZzXjx28KF9iPOZtNtK-X10fiU6eYC2s1FmHiGsDQVpsUqIZBRE8VhLE8FMT4eBl8QOaixVIVRFg267cQxESeBMhNWZCKmDcD1xXDJ_bE7ZWepSVEs_FytDddCLehgWrT2JgT92NMsFgGBmU7nQd9DDUvX1dxCbM4acO4itGUU9wRKCr49k_V5BDE792MJbB30qzWf9kSKdExWHVE8MZiI3YvzX5rBgHOCeIbFQzDOCpqkSieZcGOIpH3JdKgPpoNYlwmupqle0_cmtbJ-niidpJFgQxgJ-WCriRKXw9uAG4P2J1iCucYm46qMvfSsm9KM48hy0WyyFf-lCtD-2SUgf_18lz9GNZue0JVrHZydP0E1Av7S8zbmDtqeTmXkKCHMqnxXLGqOLq_YjfwCqWZl7 |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3NbtNAEF6VIiEuiH8MBRap5FQTe732eg8IoYaopaVEqJUqLov3j0QkTogTQXLiEXgeHocnYdZ2EqIUbr1mx5M4Mzs_uzPfILRLbWI5CVLfEJP44PG0z3lMfEWYITIiKtSuwfndSXJwRt-ex-db6NeiF8aVVS5sYmmo9VC5M_ImcZlBRHjCmrYui-i02q9GX303QcrdtC7GaVQqcmRm3yB9K14etkDWzwlpvzndP_DrCQO-cjDlfpQpIyFkzySThoOri0IZZTTREQ8SacCbamlTRhOZBJKkOrDSXexxmRluGZMR8L2CrrKIRq6cjJ2z1flOmbmQqk_X4Zw2R-MReRHTdQe4EdVuFmfWEKbr0XPp_to30Y06bsWvK0W7hbZMfhs1OhXw9WwPn676uIo93MCdFST27A6aO3RrbL7XVbc5zmosFDy0eGAGkLLD-mQJtD4ugEJjPZ5-_v3j58BMQFX7vTm4WWzy-WxgCtzLMcSuuA_GyjGp-jln5WP77zstXEylO2Iq7qKzS5HJPbSdD3PzAGFtKHBLVUYko8CKp1qaBCgDHUdBlnqosRCFUDUkupvM0RcVmDMRTmYiph7CS8JRhQKySbKzkKWozUAhVkrroWfLZdjA7lYG_tjhtBAQEDOX1sWhh-5Xol9-B3H5Y8y5h9iaUiwJHDj4-kre65Yg4TRMXajroY-V-qw_UqZ2osaT6or-VBRGjP46KBaMQ-hnSCoUC4yg1iqRac6FIYEKIe-lMpIeOr6A-ZKr6pYjgArHO-RW8cwmgkVxKuCHWZFmysLbg0mA9ydaA7vGBezqj770HJs4TNIk8NBuuRX-JQvR-dAhMX34f5E8RdfAgojjw5OjR-g6BMK0KuzcQduT8dQ8hmBzIp-UuxqjT5dtRv4AZgGdtg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Gene+expression+analysis+of+membrane+transporters+and+drug%E2%80%90metabolizing+enzymes+in+the+lung+of+healthy+and+COPD+subjects&rft.jtitle=Pharmacology+research+%26+perspectives&rft.au=Berg%2C+Tove&rft.au=Myrb%C3%A4ck%2C+Tove+Hegelund&rft.au=Olsson%2C+Marita&rft.au=Seideg%C3%A5rd%2C+Janeric&rft.date=2014-08-01&rft.pub=John+Wiley+%26+Sons%2C+Inc&rft.eissn=2052-1707&rft.volume=2&rft.issue=4&rft_id=info:doi/10.1002%2Fprp2.54&rft.externalDBID=HAS_PDF_LINK |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2052-1707&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2052-1707&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2052-1707&client=summon |